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High-throughput characterization of host promiscuity for precisely designed synthetic viral capsid

Total Cost €


EC-Contrib. €






 Hi-SynVir project word cloud

Explore the words cloud of the Hi-SynVir project. It provides you a very rough idea of what is the project "Hi-SynVir" about.

natural    enhancers    bioinformatic    traditional    leverage    aphids    vectors    genomes    propagation    densoviruses    single    viral    underlying    grasshoppers    globalization    relationships    closely    environment    deepened    multiplexed    informed    virulence    start    106    assays    structure    behavior    ing    mechanisms    pythophagous    variants    precise    considerably    scalable    efficiency    discover    splicing    arthropods    appear    ecosystems    throughput    variety    dna    caterpillars    ecology    molecular    human    urgent    designed    generate    densovirinae    vary    biocontrol    functional    models    libraries    solutions    mosquitoes    sequences    unintended    swiftly    small    altered    contain    hypotheses    determinants    regulatory    viruses    host    precisely    sites    health    threats    data    safe    technologies    disease    amongst    evolution    insect    predict    relate    translation    sequence    geographic    minimizing    genome    stranded    permit    deep    specificity    climate    reconstitute    sequencing    select    risk    pests    ranges    agriculture    capsid    inform    pathogenic    subjected    synthesis    populations   

Project "Hi-SynVir" data sheet

The following table provides information about the project.


Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Traditional geographic ranges of insect pests are altered by globalization and climate change, resulting in emerging threats for natural ecosystems, agriculture and human health. It is urgent to improve our ability to swiftly develop targeted solutions to contain such threats, while minimizing unintended side effects on the environment. Densovirinae are very small, single-stranded DNA viruses pathogenic to a variety of arthropods, including pythophagous caterpillars and grasshoppers, as well as disease vectors such as aphids and mosquitoes. Host ranges appear to vary considerably amongst even closely related densoviruses. A better understanding of the molecular mechanisms underlying virulence and specificity is necessary to evaluate the risk and opportunities associated with potential use in controlling natural insect populations.

We propose to discover these molecular determinants through the use of precisely designed libraries of viral genomes. We will leverage cost-effective and scalable DNA synthesis and sequencing technologies to generate high-throughput implementation and testing of precise molecular hypotheses. These will be informed by currently available knowledge and further deepened by bioinformatic analysis of natural sequences. We will produce ~106 controlled variants of the viral capsid as well as select viral regulatory sequence elements (enhancers, splicing and translation start sites). Resulting libraries will be subjected to multiplexed, deep-sequencing-based functional assays.

The scale of this approach will permit to reconstitute the sequence-structure-activity relationships required to relate viral genomes to host specificity and propagation efficiency. These data will support the development of models to predict the behavior of a viral genome in a new ecology, assess its potential for future evolution and inform the safe use of viral vectors for the targeted biocontrol of insect populations.

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The information about "HI-SYNVIR" are provided by the European Opendata Portal: CORDIS opendata.

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