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Hi-SynVir

High-throughput characterization of host promiscuity for precisely designed synthetic viral capsid

Total Cost €

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EC-Contrib. €

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Partnership

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 Hi-SynVir project word cloud

Explore the words cloud of the Hi-SynVir project. It provides you a very rough idea of what is the project "Hi-SynVir" about.

minimizing    sequences    data    disease    single    reconstitute    inform    pests    functional    models    translation    sequencing    ing    small    threats    unintended    vectors    106    enhancers    scalable    agriculture    multiplexed    natural    efficiency    traditional    vary    swiftly    climate    behavior    throughput    molecular    evolution    health    host    populations    variants    geographic    dna    pythophagous    underlying    splicing    amongst    synthesis    risk    contain    urgent    specificity    permit    ecosystems    variety    ecology    genomes    predict    precisely    mosquitoes    bioinformatic    virulence    assays    leverage    biocontrol    capsid    relationships    appear    solutions    relate    determinants    mechanisms    deep    deepened    densoviruses    grasshoppers    safe    precise    closely    generate    libraries    altered    sequence    aphids    human    start    propagation    informed    stranded    arthropods    ranges    designed    environment    technologies    regulatory    globalization    subjected    insect    viral    select    hypotheses    caterpillars    pathogenic    discover    viruses    densovirinae    considerably    sites    genome    structure   

Project "Hi-SynVir" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www6.montpellier.inra.fr/dgimi_eng/Research-groups/Dynamics-of-Interactions-between-Densovirus-and-Insects-DIDI
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 185˙076.00

Map

 Project objective

Traditional geographic ranges of insect pests are altered by globalization and climate change, resulting in emerging threats for natural ecosystems, agriculture and human health. It is urgent to improve our ability to swiftly develop targeted solutions to contain such threats, while minimizing unintended side effects on the environment. Densovirinae are very small, single-stranded DNA viruses pathogenic to a variety of arthropods, including pythophagous caterpillars and grasshoppers, as well as disease vectors such as aphids and mosquitoes. Host ranges appear to vary considerably amongst even closely related densoviruses. A better understanding of the molecular mechanisms underlying virulence and specificity is necessary to evaluate the risk and opportunities associated with potential use in controlling natural insect populations.

We propose to discover these molecular determinants through the use of precisely designed libraries of viral genomes. We will leverage cost-effective and scalable DNA synthesis and sequencing technologies to generate high-throughput implementation and testing of precise molecular hypotheses. These will be informed by currently available knowledge and further deepened by bioinformatic analysis of natural sequences. We will produce ~106 controlled variants of the viral capsid as well as select viral regulatory sequence elements (enhancers, splicing and translation start sites). Resulting libraries will be subjected to multiplexed, deep-sequencing-based functional assays.

The scale of this approach will permit to reconstitute the sequence-structure-activity relationships required to relate viral genomes to host specificity and propagation efficiency. These data will support the development of models to predict the behavior of a viral genome in a new ecology, assess its potential for future evolution and inform the safe use of viral vectors for the targeted biocontrol of insect populations.

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The information about "HI-SYNVIR" are provided by the European Opendata Portal: CORDIS opendata.

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