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Hi-SynVir

High-throughput characterization of host promiscuity for precisely designed synthetic viral capsid

Total Cost €

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EC-Contrib. €

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Partnership

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 Hi-SynVir project word cloud

Explore the words cloud of the Hi-SynVir project. It provides you a very rough idea of what is the project "Hi-SynVir" about.

biocontrol    sequences    select    minimizing    host    environment    technologies    single    swiftly    variants    specificity    molecular    vary    viruses    arthropods    leverage    relate    amongst    vectors    mosquitoes    grasshoppers    subjected    libraries    regulatory    sequencing    data    106    agriculture    generate    health    behavior    deepened    sites    hypotheses    synthesis    variety    pathogenic    pests    traditional    ecology    threats    bioinformatic    aphids    underlying    risk    human    assays    altered    structure    solutions    populations    mechanisms    densoviruses    start    sequence    insect    natural    virulence    precisely    capsid    multiplexed    closely    propagation    viral    genome    genomes    precise    pythophagous    climate    throughput    ranges    determinants    reconstitute    translation    geographic    efficiency    appear    discover    enhancers    considerably    relationships    unintended    scalable    ecosystems    deep    densovirinae    designed    inform    permit    models    predict    functional    splicing    evolution    informed    contain    stranded    disease    small    dna    ing    urgent    globalization    safe    caterpillars   

Project "Hi-SynVir" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www6.montpellier.inra.fr/dgimi_eng/Research-groups/Dynamics-of-Interactions-between-Densovirus-and-Insects-DIDI
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 185˙076.00

Map

 Project objective

Traditional geographic ranges of insect pests are altered by globalization and climate change, resulting in emerging threats for natural ecosystems, agriculture and human health. It is urgent to improve our ability to swiftly develop targeted solutions to contain such threats, while minimizing unintended side effects on the environment. Densovirinae are very small, single-stranded DNA viruses pathogenic to a variety of arthropods, including pythophagous caterpillars and grasshoppers, as well as disease vectors such as aphids and mosquitoes. Host ranges appear to vary considerably amongst even closely related densoviruses. A better understanding of the molecular mechanisms underlying virulence and specificity is necessary to evaluate the risk and opportunities associated with potential use in controlling natural insect populations.

We propose to discover these molecular determinants through the use of precisely designed libraries of viral genomes. We will leverage cost-effective and scalable DNA synthesis and sequencing technologies to generate high-throughput implementation and testing of precise molecular hypotheses. These will be informed by currently available knowledge and further deepened by bioinformatic analysis of natural sequences. We will produce ~106 controlled variants of the viral capsid as well as select viral regulatory sequence elements (enhancers, splicing and translation start sites). Resulting libraries will be subjected to multiplexed, deep-sequencing-based functional assays.

The scale of this approach will permit to reconstitute the sequence-structure-activity relationships required to relate viral genomes to host specificity and propagation efficiency. These data will support the development of models to predict the behavior of a viral genome in a new ecology, assess its potential for future evolution and inform the safe use of viral vectors for the targeted biocontrol of insect populations.

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The information about "HI-SYNVIR" are provided by the European Opendata Portal: CORDIS opendata.

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