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OPTOFRAX SIGNED

Optopharmacological brain mapping of autism mouse models

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OPTOFRAX project word cloud

Explore the words cloud of the OPTOFRAX project. It provides you a very rough idea of what is the project "OPTOFRAX" about.

extremely    brain    light    resolution    depression    selective    glutamate    neurons    structural    laser    powerful    diseases    drugs    unprecedented    tools    proteins    disorders    phyisological    multidisciplinary    induces    illuminating    tool    optical    map    physiological    single    true    space    opened    mit    strategy    progression    autism    laboratory    valuable    mglur    phototherapies    receptors    responsible    acquired    finely    patterned    position    excellent    manipulation    area    therapeutic    scientific    host    site    commercial    opportunity    modulator    locally    regions    synapses    function    regulated    medical    neuronal    activated    effect    inactivated    technique    drug    fragile    prove    individual    inhibition    countless    action    photoswitchable    synaptic    functional    unknown    optopharmacological    neurological    independence    synapse    metabotropic    original    activation    time    utility    contribution    undergoes    possibilities    minimal    spatial    inactivate    researcher    career    mapping    region    environment    levels    plasticity    first   

Project "OPTOFRAX" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://ibecbarcelona.eu/nanoprobes
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 170˙121.00

Map

 Project objective

Manipulation of neurons with light-regulated proteins and drugs has opened unprecedented possibilities for phototherapies for neurological diseases. The host laboratory has developed a powerful new optopharmacological tool: a selective photoswitchable modulator of metabotropic glutamate receptors (mGluR). This drug can be activated or inactivated with light so that its action can be finely patterned in space and time. We aim at developing a novel application for this optical tool: a brain functional mapping technique. We will test it at two different levels of resolution. First, we will map the therapeutic site of action at whole-brain level. Inhibition of mGluR is a promising therapeutic strategy for autism disorders, including Fragile X, but the brain region responsible for this effect is not known. We will inactivate the drug locally by illuminating specific regions of the brain and will identify which region is the target for the therapeutic effect. Second, we will map the physiological contribution of mGluR to neuronal plasticity at the minimal spatial resolution: the individual synapse. Activation of mGluR induces long-term synaptic depression at the level of neurons, but it is unknown if it is also true at the level of single synapses. We will inactivate the drug in a single synapse using laser light and will test whether this specific synapse undergoes structural depression. This project will prove the utility of optopharmacological tools to map the therapeutic and phyisological mGluR function. This original approach could open countless possibilities for scientific, medical, and commercial applications. The project is an excellent opportunity for the Researcher to further develop his knowledge and to position him in unique multidisciplinary environment that will foster his career progression towards independence. At the same time, the Researcher’s experience acquired at MIT will be extremely valuable for the host institution and the European Research Area.

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The information about "OPTOFRAX" are provided by the European Opendata Portal: CORDIS opendata.

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