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OPTOFRAX SIGNED

Optopharmacological brain mapping of autism mouse models

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OPTOFRAX project word cloud

Explore the words cloud of the OPTOFRAX project. It provides you a very rough idea of what is the project "OPTOFRAX" about.

medical    true    action    spatial    brain    illuminating    prove    environment    excellent    synapses    effect    opportunity    depression    unknown    laser    extremely    diseases    phyisological    mapping    progression    individual    laboratory    time    synaptic    resolution    regions    structural    region    function    opened    proteins    powerful    contribution    countless    autism    regulated    researcher    manipulation    scientific    site    tool    mit    map    acquired    area    activation    phototherapies    valuable    neurological    independence    metabotropic    neurons    undergoes    plasticity    position    modulator    inactivated    photoswitchable    functional    host    levels    unprecedented    synapse    tools    technique    commercial    patterned    therapeutic    career    optical    neuronal    optopharmacological    finely    locally    mglur    light    first    inactivate    fragile    physiological    strategy    drug    activated    induces    utility    single    glutamate    drugs    possibilities    disorders    inhibition    receptors    original    space    minimal    selective    multidisciplinary    responsible   

Project "OPTOFRAX" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://ibecbarcelona.eu/nanoprobes
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 170˙121.00

Map

 Project objective

Manipulation of neurons with light-regulated proteins and drugs has opened unprecedented possibilities for phototherapies for neurological diseases. The host laboratory has developed a powerful new optopharmacological tool: a selective photoswitchable modulator of metabotropic glutamate receptors (mGluR). This drug can be activated or inactivated with light so that its action can be finely patterned in space and time. We aim at developing a novel application for this optical tool: a brain functional mapping technique. We will test it at two different levels of resolution. First, we will map the therapeutic site of action at whole-brain level. Inhibition of mGluR is a promising therapeutic strategy for autism disorders, including Fragile X, but the brain region responsible for this effect is not known. We will inactivate the drug locally by illuminating specific regions of the brain and will identify which region is the target for the therapeutic effect. Second, we will map the physiological contribution of mGluR to neuronal plasticity at the minimal spatial resolution: the individual synapse. Activation of mGluR induces long-term synaptic depression at the level of neurons, but it is unknown if it is also true at the level of single synapses. We will inactivate the drug in a single synapse using laser light and will test whether this specific synapse undergoes structural depression. This project will prove the utility of optopharmacological tools to map the therapeutic and phyisological mGluR function. This original approach could open countless possibilities for scientific, medical, and commercial applications. The project is an excellent opportunity for the Researcher to further develop his knowledge and to position him in unique multidisciplinary environment that will foster his career progression towards independence. At the same time, the Researcher’s experience acquired at MIT will be extremely valuable for the host institution and the European Research Area.

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The information about "OPTOFRAX" are provided by the European Opendata Portal: CORDIS opendata.

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