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ECM_INK SIGNED

Cells-self Extracellular Matrices-based Bioinks to create accurate 3D diseased skin tissue models

Total Cost €

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EC-Contrib. €

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Partnership

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 ECM_INK project word cloud

Explore the words cloud of the ECM_INK project. It provides you a very rough idea of what is the project "ECM_INK" about.

chronic    followed    types    strategies    phenotype    functionalities    diseases    technologies    respective    relationship    human    deposition    structural    structure    random    2d    ecm    vitro    platforms    complexity    demanding    formulation    self    cultures    suffering    attain    genetic    comprising    microfunctionalities    tissues    mostly    confirmation    matrices    structures    speed    gap    policy    complete    extracellular    it    compositional    bioinks    create    animal    issue    advantage    reflecting    diseased    paving    ink    reduces    tackle    accurate    drug    validation    resolution    experimentation    bioprinting    3d    tissue    components    intrinsic    culture    elimination    reinforcing    generate    3rs    native    varied    bioengineer    cells    nonetheless    physiologically    free    recreating    rely    designed    models    skin    accuracy    ultimate    intends    neoplastic    patients    cell    reflected    regarding    microenvironments    pathophysiological    physiology    found   

Project "ECM_INK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO MINHO 

Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553
website: www.uminho.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙998˙938 €
 EC max contribution 1˙998˙938 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 1˙998˙938.00

Map

 Project objective

It has been recognized that growing cells within 3D structures reduces the gap between 2D in vitro cell cultures and native tissue physiology. This has been paving the way for the development of reliable 3D in vitro cell-based platforms with major impact in the reduction/elimination of animal experimentation, diseases modelling and drug development. So far, the many strategies that have been followed to bioengineer in vitro 3D human tissue models mostly rely on the random culture of cells within a 3D structure without reflecting the compositional and structural complexity of the native tissues. Recently proposed bioprinting technologies that allow accurate and high speed deposition of various cells and matrices at high resolution, have therefore great potential in the development of physiologically reliable 3D in vitro tissue models by recreating the different microenvironments/microfunctionalities found in each tissue. Nonetheless, among the components required for bioprinting, bioinks in particular have demanding requirements and much has still to be done regarding their intrinsic formulation to lead cell behaviour and support specific functionalities. ECM_INK intends to tackle this issue by developing cells-self extracellular matrices-based bioinks to create accurate and pathophysiological relevant 3D in vitro diseased skin tissue models. The development of cell phenotype-driven bioinks will generate complex microenvironments comprising varied cell types within matrices that were specifically designed to attain a particular response from each one of those cell types. The use of cells from patients suffering from chronic, genetic and neoplastic skin diseases represents a major advantage that will be reflected in the accuracy and functionality of the respective 3D in vitro models. The ultimate confirmation of their potential will be complete after validation using animal-free approaches reinforcing the intrinsic relationship of ECM_INK with the 3Rs policy.

 Publications

year authors and title journal last update
List of publications.
2019 D. P. Reis, C. Fidalgo, L. Gasperini, R. L. Reis, A. P. Marques
Bio-tailored Gellan Gum-Based Bioinks
published pages: , ISSN: , DOI:
TERMIS-EU Workshop “3D Bioprinting in Cancer Research” 2020-01-28
2019 L.P. da Silva, J.P. Pires, R.L. Reis, A.P. Marques
Bioprinting of a skin analogue
published pages: , ISSN: , DOI:
FoReCaST Second Workshop 2020-01-28
2019 A.I. Soares, J.A. Macedo, R.L. Reis, A.P. Marques
A skin model based on cell sheet technology to study the role of macrophages on melanoma progression
published pages: , ISSN: , DOI:
Forecast 2nd Workshop 2020-01-28
2019 L.P. Da Silva, J.A. Macedo, R.L. Reis, A.P. Marques
Gellan Gum-based hydrogels to modulate inflammatory responses
published pages: , ISSN: , DOI:
TermStem 2019 2020-01-28
2019 D. P. Reis, C. Fidalgo, R. L. Reis, A. P. Marques
Gellan Gum Hydrogels containing Extracellular Matrix (dECM) from Human Dermal Fibroblasts
published pages: , ISSN: , DOI:
Forecats 2nd Workshop 2020-01-28
2019 A.P. Marques
Prospects of tissue engineering in wound management
published pages: , ISSN: , DOI:
TERMIS EU Meeting 2019 2020-01-28
2019 C. Fidalgo, D.P. Reis, Â. Ferreira, R.L. Reis, A.P. Marques
Unravelling the differences between human dermal fibroblasts and adipose stem cells extracellular matrices
published pages: , ISSN: , DOI:
TERM STEM 2019 2020-01-28
2019 M.D. Malta, C. Gruber, E. Murauer, A. Klausegger, R.L. Reis, M.T. Cerqueira, A.P. Marques
Cellular-self Extracellular Matrix fingerprint of Dystrophic Epidermolysis Bullosa patients
published pages: , ISSN: , DOI:
Forecast 2nd Workshop 2020-01-28
2019 L.P. da Silva, J.P. Pires, R.L. Reis, A.P. Marques
Bioprinting the vascularized dermis compartment of the skin
published pages: , ISSN: , DOI:
1st Discoveries Forum – On Regenerative and Precision Medicine 2020-01-28
2019 C. Fidalgo, D.P. Reis, Â. Ferreira, R.L. Reis, A.P. Marques
Unravelling the differences between human dermal fibroblasts and adipose stem cells extracellular matrices
published pages: , ISSN: , DOI:
1st Discoveries Forum on Regenerative and Precision Medicine 2020-01-28
2019 D. P. Reis, C. Fidalgo, L. Gasperini, R. L. Reis, A. P. Marques
Improvement of the biological features of Gellan Gum-Based Bioinks
published pages: , ISSN: , DOI:
1st Discoveries Forum on Regenerative and Precision Medicine 2020-01-28
2019 D. P. Reis, M. D. Malta, M. T. Cerqueira, L. Gasperini, R. L. Reis, A. P. Marques
Cell phenotype-driven Bioinks for 3D disease models
published pages: , ISSN: , DOI:
TermStem, 2019 2020-01-28
2019 C.A. Mandon*, J. Pires*, L.P. da Silva, R.L. Reis, A.P. Marques
GG-based material with TGF-β to modulate fibroblast-to-myofibroblast transition in scarring control
published pages: , ISSN: , DOI:
TermStem 2019 2020-01-28
2019 M.D. Malta, C. Gruber, E. Murauer, A. Klausegger, R.L. Reis, M.T. Cerqueira, A.P. Marques
Extracellular Matrix Signature of Dystrophic Epidermolysis Bullosa patients Skin Cells
published pages: , ISSN: , DOI:
1st Discoveries Forum 2020-01-28
2019 C. Fidalgo, D.P. Reis, Â. Ferreira, R.L. Reis, A.P. Marques
Unravelling the differences between human dermal fibroblasts and adipose stem cells extracellular matrices
published pages: , ISSN: , DOI:
Forecast 2nd Workshop 2020-01-28
2019 M. T. Cerqueira, R. P. Pirraco, R. L. Reis, A. P. Marques
Cell Sheets-based system to promote re-epithelialization via keratinocyte growth factor in artificial wounds
published pages: , ISSN: , DOI:
EWMA Conference 2020-01-28
2019 A.I. Soares, J.A. Macedo, R.L. Reis, A.P. Marques
Skin Immunocompetent model: integrating macrophages in a skin-like microenvironment to investigate their crosstalk with melanoma cells
published pages: , ISSN: , DOI:
1st Discoveries Forum 2020-01-28
2019 C.A. Mandon, L.P. da Silva, R.L. Reis, A.P. Marques
TGF-β-laden polysaccharide material to modulate fibroblast-to-myofibroblast transition for scarring contro
published pages: , ISSN: , DOI:
TERMIS EU 2019 2020-01-28
2018 L. P. da Silva, G. Paulat, M. E. L. Lago, C. M. Abreu, A. F. Carvalho, R. L. Reis, A. P. Marques
Skin-Tailored Bioinks
published pages: , ISSN: , DOI:
Gene2Skin Final conference 2019-02-11
2018 S. R. Oliveira, M. E. L. Lago, R. L. Reis, A. P. Marques
Tuning 3D Adipose-Like Tissue Analogues’ Secretome To Target Skin-Related Events
published pages: , ISSN: , DOI:
Gene2Skin Final conference 2019-02-11
2018 J. A. Macedo, T. C. Santos, R. L. Reis, A. P. Marques
Development Of Immune-Tailored Skin Models Based On Cell Sheet Technology
published pages: , ISSN: , DOI:
Gene2Skin Final conference 2019-02-11
2018 D. P. Reis, R. L Reis, A. P. Marques
Establishing A Dynamic In Vitro System To Enhance The Functionality Of 3D-Bioprinted Skin-Like Constructs
published pages: , ISSN: , DOI:
Gene2Skin Final conference 2019-02-11
2018 C. Fidalgo, D. P. Reis, M. D. Malta, S. R. Oliveira, R. L. Reis, A. P. Marques
Human Adipose Stem Cells Extracellular Matrix Role In Wound Healing
published pages: , ISSN: , DOI:
Gene2Skin Final conference 2019-02-11
2018 M. D. Malta, M. T. Cerqueira, R. L. Reis, A. P. Marques
Unravelling The Epidermolysis Bullosa -Extracellular Matrix - Cutaneous Squamous Cell Carcinoma Development Triad
published pages: , ISSN: , DOI:
Gene2Skin Final conference 2019-02-11
2018 G. Paulat, L. P. da Silva, R. L. Reis, A. P. Marques
Biofeature-Tuned Bioinks For 3D-Printing Skin Analogues
published pages: , ISSN: , DOI:
Gene2Skin Summer School 2019-02-11
2018 L. P. da Silva, G. Paulat, M. E. L. Lago, C. M. Abreu, A. F. Carvalho, R. L. Reis, A. P. Marques
Tailoring bioink biofeatures to meet skin microenvironments specificities
published pages: , ISSN: , DOI:
6th TERMIS World Congress 2019-02-11

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