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Investigation of the interaction of mesenchymal stem cells with aptamer modified surfaces using Light-Addressable Potentiometric Sensors (LAPS)

Total Cost €


EC-Contrib. €






 APTALAPS project word cloud

Explore the words cloud of the APTALAPS project. It provides you a very rough idea of what is the project "APTALAPS" about.

capture    theme    independent    microscopy    14    network    differentiation    subcellular    electrochemical    outstanding    personalizing    channel    heterodimers    artificial    ongoing    advantage    images    substrates    photo    aptamer    aptamers    charge    japan    china    cell    accessible    interface    peking    impedance    inform    surface    immobilize    lot    expand    attachment    grant    addressable    electrochemistry    single    potentiometric    sapphire    authored    materials    multidisciplinary    oligonucleic    bind    brings    laps    technique    young    university    care    competencies    phd    he    scientist    resolution    techniques    writing    acids    stem    horizon    patterned    finished    fellowship    specificity    integrin    tissue    engineering    functional    onto    semiconductor    biosensors    biomaterials    photon    local    2020    silicon    imaging    central    dimensional    worked    health    fluorescence    sensors    electrical    papers    interaction    light    mechanism    regulated    cells    scanning    affinity    industries    co    career    economic    skills    ion    gain   

Project "APTALAPS" data sheet

The following table provides information about the project.


Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-20   to  2017-07-19


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques. The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020. The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semiconductor processing and single cell analysis, expand his research network and gain skills such as project management and grant writing allowing him to develop an independent research career.


year authors and title journal last update
List of publications.
2017 De-Wen Zhang, Fan Wu, Steffi Krause
LAPS and SPIM Imaging Using ITO-Coated Glass as the Substrate Material
published pages: 8129-8133, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b01898
Analytical Chemistry 89/15 2019-07-24
2016 De-Wen Zhang, Fan Wu, Jian Wang, Michael Watkinson, Steffi Krause
Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS)
published pages: 41-45, ISSN: 1388-2481, DOI: 10.1016/j.elecom.2016.08.017
Electrochemistry Communications 72 2019-07-24
2017 Fan Wu, Inmaculada Campos, De-Wen Zhang, Steffi Krause
Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy
published pages: 20170130, ISSN: 1364-5021, DOI: 10.1098/rspa.2017.0130
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Science 473/2201 2019-07-24
2017 Fan Wu, De-Wen Zhang, Jian Wang, Michael Watkinson, Steffi Krause
Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIM
published pages: 3170-3177, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b03831
Langmuir 33/13 2019-07-24

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