Opendata, web and dolomites

APTALAPS

Investigation of the interaction of mesenchymal stem cells with aptamer modified surfaces using Light-Addressable Potentiometric Sensors (LAPS)

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 APTALAPS project word cloud

Explore the words cloud of the APTALAPS project. It provides you a very rough idea of what is the project "APTALAPS" about.

finished    patterned    immobilize    substrates    oligonucleic    2020    economic    competencies    electrochemical    china    sensors    theme    health    techniques    photo    university    grant    aptamer    cell    care    photon    impedance    images    fellowship    channel    attachment    affinity    differentiation    stem    scanning    interface    advantage    bind    accessible    japan    inform    single    specificity    multidisciplinary    sapphire    capture    mechanism    interaction    integrin    addressable    gain    fluorescence    horizon    young    resolution    tissue    technique    cells    lot    onto    career    surface    silicon    electrochemistry    independent    central    materials    papers    dimensional    microscopy    aptamers    engineering    acids    personalizing    writing    biosensors    electrical    scientist    laps    authored    network    imaging    subcellular    biomaterials    co    ion    expand    phd    local    semiconductor    charge    he    worked    light    functional    14    skills    ongoing    potentiometric    artificial    heterodimers    regulated    peking    brings    industries    outstanding   

Project "APTALAPS" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.sems.qmul.ac.uk/research/projects/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-20   to  2017-07-19

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques. The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020. The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semiconductor processing and single cell analysis, expand his research network and gain skills such as project management and grant writing allowing him to develop an independent research career.

 Publications

year authors and title journal last update
List of publications.
2017 De-Wen Zhang, Fan Wu, Steffi Krause
LAPS and SPIM Imaging Using ITO-Coated Glass as the Substrate Material
published pages: 8129-8133, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b01898
Analytical Chemistry 89/15 2019-07-24
2016 De-Wen Zhang, Fan Wu, Jian Wang, Michael Watkinson, Steffi Krause
Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS)
published pages: 41-45, ISSN: 1388-2481, DOI: 10.1016/j.elecom.2016.08.017
Electrochemistry Communications 72 2019-07-24
2017 Fan Wu, Inmaculada Campos, De-Wen Zhang, Steffi Krause
Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy
published pages: 20170130, ISSN: 1364-5021, DOI: 10.1098/rspa.2017.0130
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Science 473/2201 2019-07-24
2017 Fan Wu, De-Wen Zhang, Jian Wang, Michael Watkinson, Steffi Krause
Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIM
published pages: 3170-3177, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b03831
Langmuir 33/13 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "APTALAPS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "APTALAPS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More  

GLORIOUS (2019)

Digital Poetry in Today’s Russia: Canonisation and Translation

Read More