APTALAPS
Investigation of the interaction of mesenchymal stem cells with aptamer modified surfaces using Light-Addressable Potentiometric Sensors (LAPS)
Total Cost €
0EC-Contrib. €
0Partnership
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Project "APTALAPS" data sheet
The following table provides information about the project.
| Coordinator |
QUEEN MARY UNIVERSITY OF LONDON
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://www.sems.qmul.ac.uk/research/projects/ |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-07-20 to 2017-07-19 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | QUEEN MARY UNIVERSITY OF LONDON | UK (LONDON) | coordinator | 183˙454.00 |
Map
Project objective
The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques. The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020. The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semiconductor processing and single cell analysis, expand his research network and gain skills such as project management and grant writing allowing him to develop an independent research career.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
De-Wen Zhang, Fan Wu, Steffi Krause LAPS and SPIM Imaging Using ITO-Coated Glass as the Substrate Material published pages: 8129-8133, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b01898 |
Analytical Chemistry 89/15 | 2019-07-24 |
| 2016 |
De-Wen Zhang, Fan Wu, Jian Wang, Michael Watkinson, Steffi Krause Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS) published pages: 41-45, ISSN: 1388-2481, DOI: 10.1016/j.elecom.2016.08.017 |
Electrochemistry Communications 72 | 2019-07-24 |
| 2017 |
Fan Wu, Inmaculada Campos, De-Wen Zhang, Steffi Krause Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy published pages: 20170130, ISSN: 1364-5021, DOI: 10.1098/rspa.2017.0130 |
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Science 473/2201 | 2019-07-24 |
| 2017 |
Fan Wu, De-Wen Zhang, Jian Wang, Michael Watkinson, Steffi Krause Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click†Reaction Characterized with LAPS and SPIM published pages: 3170-3177, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b03831 |
Langmuir 33/13 | 2019-07-24 |
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