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ParaplegiaERDros

Roles of spastic paraplegia proteins in organisation of axonal endoplasmic reticulum

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EC-Contrib. €

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Partnership

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Project "ParaplegiaERDros" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.gen.cam.ac.uk/research-groups/okane
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

Axonal endoplasmic reticulum (ER) is a poorly characterised compartment that is mainly tubular, smooth, and forms a network for long distances along axons. Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape. The Fellow will test the model that these proteins help form axonal ER, which is disrupted when these proteins are mutated. The time for this is opportune; the host lab has developed tools to detect impaired axon ER organisation in Drosophila; and new HSP genes, some encoding ER proteins of unknown function, are being identified continuously in human patients. To identify proteins involved in its formation, the Fellow will test ER-localized HSP gene products, both singly and in multiply mutant genotypes, for roles in ER organisation in larval motor axons. She will also test whether similar defects appear in long motor and sensory axons in live adults as they age. Finally she will test the effects of HSP protein loss on the finer structure of ER and its association with mitochondria. Through this work the Fellow will help pioneer characterisation of a poorly understood but important cell compartment: how it is formed and some effects of disrupting it. Along with the broader research and training environment, this will help her to develop a profile for her own work in this area.

 Publications

year authors and title journal last update
List of publications.
2016 Belgin Yalçın, Lu Zhao, Martin Stofanko, Niamh C O\'Sullivan, Zi Han Kang, Annika Roost, Matthew R Thomas, Sophie Zaessinger, Olivier Blard, Alex L Patto, Valentina Baena, Mark Terasaki, Cahir J. O\'Kane
Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins
published pages: , ISSN: , DOI: 10.1101/069005
BioRxiv 2019-06-18
2017 Yalçın B, Zhao L, Stofanko M, O\'Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M, O\'Kane CJ
\"Research data supporting \"\"Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins\"\"\"
published pages: , ISSN: , DOI: 10.17863/CAM.12206
University of Cambridge Repository 2019-06-18
2017 Belgin Yalçın, Lu Zhao, Martin Stofanko, Niamh C O\'Sullivan, Zi Han Kang, Annika Roost, Matthew R Thomas, Sophie Zaessinger, Olivier Blard, Alex L Patto, Anood Sohail, Valentina Baena, Mark Terasaki, Cahir J O\'Kane
Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.23882
eLife 6 2019-06-18

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