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IF-EBOla SIGNED

Control of the Ebola Oubreak by both innovative Ultrasensitive Detection of EBOV and therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 IF-EBOla project word cloud

Explore the words cloud of the IF-EBOla project. It provides you a very rough idea of what is the project "IF-EBOla" about.

profile    antibody    anti    understand    convalescent    originally    horse    ebola    self    spreading    detection    obligated    data    pathology    validation    sierra    once    evolution    outstanding    individuals    sequencing    usdep    diversity    survivors    therapy    consisting    neutralizing    form    treatment    sites    ema    cured    innovative    modify    health    passive    viremia    arrays    cure    emergency    microorganisms    evd    if    qualified    phases    virus    action    revisited    antibodies    carry    2010    polyclonal    follow    infectious    liberia    foreseen    levels    clinical    authorizations    regulatory    public    period    metagenomics    experimental    validated    save    status    preparation    epidemic    ultrasensitive    diagnostics    quality    diagnosed    designed    homeostasis    complementary    prepare    companies    ethical    organization    site    pernicious    ec    beginning    sharing    ngs    rules    preclinical    ebov    outbreak    dna    experts    mortality    story    lives    initial    homeostatic    accurate    strategically    scientific    mds    officer    patients    technological    transcriptomes    equine    effect    absence    actions    therapeutic    unforeseen    ab    reduce    critical    diagnostic    contacts    capacity    immune    extend    generate    convalescents    mainly    leone    safe    profiling   

Project "IF-EBOla" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT 

Organization address
address: BOULEVARD DE DUNKERQUE 44 CS 90009
city: MARSEILLE
postcode: 13572
website: www.ird.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://infightebola.eu/
 Total cost 2˙037˙770 €
 EC max contribution 1˙992˙770 € (98%)
 Programme 1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
 Code Call H2020-Adhoc-2014-20
 Funding Scheme RIA
 Starting year 2014
 Duration (year-month-day) from 2014-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT FR (MARSEILLE) coordinator 360˙895.00
2    FABENTECH FR (LYON) participant 972˙750.00
3    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) participant 199˙350.00
4    ORION INTEGRATED BIOSCIENCES INC. US (NEW ROCHELLE) participant 135˙000.00
5    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 127˙075.00
6    METABIOTA INC US (SAN FRANCISCO) participant 100˙000.00
7    ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO IT (ROMA) participant 52˙700.00
8    ABSISKEY FR (ANGERS) participant 45˙000.00
9    ABSISKEY CP FR (GRENOBLE) participant 0.00
10    UNIVERSITY OF MANITOBA CA (MANITOBA) participant 0.00

Map

 Project objective

IF-EBOLA has been strategically designed to efficiently respond to critical needs required to control Ebola outbreak from spreading and prepare a therapeutic approach to save lives. The work involves two of the main EVD outbreak sites, Sierra Leone and Liberia. MDs, public health authorities and virus experts working on site, under ethical regulatory rules, will extend their collaboration to companies and institutions to form a consortium of outstanding complementary partners, sharing their innovative technological approaches for a common goal. The main goal of our project is to contribute to provide innovative ultrasensitive diagnostics and therapeutic approaches for an early and accurate diagnostic for an early therapeutic treatment to control the epidemic and safe lives.

We have been obligated to modify and extend for one year our initial two-year period IF-EBOLA action program due to both major foreseen and unforeseen changes produced during this “non-emergency” period: consisting mainly now in 3 main actions: (i) Preclinical validation of the therapeutic equine anti-Ebola antibodies; (ii) Clinical validation of the ultrasensitive detection (iii) homeostasis (“pathology”) profiling of patients and survivors. Originally (“emergency period”) IF-EBOLA included 2 phases: (I) a phase of preparation including, ethical authorizations, antibody production, technical and field organization as well as the beginning a follow-up of the homeostatic profile of contacts early-EBOV diagnosed and self-cured convalescent individuals in the absence of existing treatment, (with an ultrasensitive detection method of pernicious microorganisms, from the EC USDEP project qualified as a European success story “USDEP” project in 2010 by the EC-Project Officer) and (II) phase of a clinical study using a wide validated approach revisited with an innovative concept (strongly supported EC/EMA-WHO), we propose to carry out an experimental passive-immune therapy based on neutralizing capacity of horse anti-EBOV polyclonal F(ab’)2 on early-diagnosed patients to impact and reduce their pre-existing viremia, their mortality, the evolution of their homeostasis profile, during and after this treatment (once patients become convalescents). The homeostasis status evolution will help to generate high quality scientific data to understand the EVD, the effect of this therapy and cure parameters characterized at 3 different levels: immune (transcriptomes, NGS, metagenomics); infectious (other than EBOV, DNA arrays), and EBOV diversity (sequencing and metagenomics).

 Deliverables

List of deliverables.
Whole infectious profiles Documents, reports 2019-10-29 14:07:31
Ebola virus diversity assessed by sequencing Documents, reports 2019-10-28 17:21:42
Ethical regulations, security and safety set up for diagnostic and follow-up of patients of the phase 1 (without treatment) Documents, reports 2019-10-28 17:21:42
Creation of the specific website of the project Websites, patent fillings, videos etc. 2019-10-28 17:21:42

Take a look to the deliverables list in detail:  detailed list of IF-EBOla deliverables.

 Publications

year authors and title journal last update
List of publications.
2015 W. Valdivia, D. Sheoran, & F. Veas
Ebola virus Genomic and Metagenomic signature Analyses of the 2014-15 West African Outbreak
published pages: , ISSN: , DOI:
7th Filovirus Conference 2019-10-28
2017 Aly Shamseddin, Céline Crauste, Erwann Durand, Pierre Villeneuve, Gregor Dubois, Thierry Durand, Joseph Vercauteren, Francisco Veas
Resveratrol formulated with a natural deep eutectic solvent inhibits active matrix metalloprotease-9 in hormetic conditions
published pages: 1700171, ISSN: 1438-7697, DOI: 10.1002/ejlt.201700171
European Journal of Lipid Science and Technology 119/11 2019-10-28
2017 F.Veas
Efficiency of innovative preparedness IF-EBOLA technologies: Ultrasensitive diagnostics, horse anti-Ebola virus polyclonal Fabs & metagenomic analyses of Ebola variants and co-infections
published pages: , ISSN: , DOI:
2019-10-28
2017 Y. Eskira A Sobarzo, F Veas L Lobel
Atypical immune response of EVD Long-term survivors
published pages: , ISSN: , DOI:
2019-10-28
2015 W. Valdivia-, D. Sheoran, G. Dubois, S. Tigrett, F. Veas
Metagenomic analyses and genomic fingerprint of co-infections of the EBOLA viral disease
published pages: , ISSN: , DOI:
2019-10-28
2015 C. Herbreteau & IF Ebola
Development of a specific polyclonal immunoglobulin against Ebola
published pages: , ISSN: , DOI:
2019-10-28
2015 F.Veas
Multi-technological platforms to solve unmet needs for rapid and efficient management of emerging diseases
published pages: , ISSN: , DOI:
2019-10-28
2017 M. Denizot, T. Racine, D. Pannetier, A. Pasquier, H. Raoul, JF Saluzzo, G. Kobinger, F. Veas, C. Herbreteau
Specific polyclonal F(ab’)2immunoglobulin fragments; in vitro characterization and in vivo effectiveness in post-exposure treatment against Zaire Ebola virus in mice
published pages: , ISSN: , DOI:
2019-10-28
2018 A Shamseddin, C Crauste, E Durand, P Villeneuve, G Dubois, T Pavlickova, Th Durand, J. Vercauteren, and F Veas
Resveratrol-Linoleate protects from exacerbated endothelial permeability via a drastic inhibition of the MMP-9 activity
published pages: , ISSN: , DOI:
2019-10-28
2017 R Metrop, JF Saluzzo, F Veas, C. Herbreteau
Lessons Learned from the Development of an Ebola Immunotherapy
published pages: , ISSN: , DOI:
2019-10-28
2017 S Tigrett, L Lobel, F Veas
A Universal virus capture method leading to a rapid and ultrasensitive detection of pathogens for early & late post-exposure countermeasures
published pages: , ISSN: , DOI:
2019-10-28
2015 W. Valdivia, D. Sheoran & F. Veas
RIGEL as a Powerful Computational Architecture for Genomic & Metagenomic Signature Discrimination: Analysis of the 2014-15 West African EBOLA Outbreak”
published pages: March 8-13, 2015, ISSN: , DOI:
Gordon Research Conferences, on 2019-10-28
2016 F.Veas
The preparedness IF-EBOLA toolbox for rapid and efficient mitigation of upcoming outbreaks. A platform model for emerging diseases
published pages: , ISSN: , DOI:
2019-10-28

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