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CRYOMAT SIGNED

Antifreeze GlycoProtein Mimetic Polymers

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EC-Contrib. €

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 CRYOMAT project word cloud

Explore the words cloud of the CRYOMAT project. It provides you a very rough idea of what is the project "CRYOMAT" about.

human    needle    defense    accessible    crystals    diverse    road    modern    chemistry    mechanisms    food    takes    revealed    effect    employ    turbines    crystal    whereby    resource    cryopreservation    summary    glyco    afgps    antifreeze    oceans    wind    nature    membranes    ice    transfused    materials    found    frozen    killing    scenarios    inspired    solution    proteins    reproduce    biophysical    surfaces    recrystallization    red    indications    sources    platelets    peptide    vinyl    maximize    slow    polymer    biological    extremely    borne    synthetic    enhanced    rate    settings    contributor    elegant    cell    cytotoxicity    mimetics    polymers    bio    interactions    polar    sub    clinically    water    living    pierces    shaping    thawing    multidisciplinary    inspiration    later    environments    macromolecular    inhibition    natural    cells    shapes    donor    iri    death    desirable    storage    zero    extreme    blood    life    fish    scalable    tunable    flourish    oil    translation    synthesis    survive    precision    limited    clinical    secrete    stem   

Project "CRYOMAT" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙496˙439 €
 EC max contribution 1˙496˙439 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 1˙496˙439.00

Map

 Project objective

Fish living in polar oceans have evolved an elegant, macromolecular, solution to survive in sub-zero water: they secrete antifreeze (glyco)proteins (AFGPs) which have several ‘antifreeze’ effects, including ice recrystallization inhibition (IRI) - they slow the rate of ice crystal growth. Ice crystal growth is a major problem in settings as diverse as oil fields, wind turbines, road surfaces and frozen food. Analysis of the process of cryopreservation, whereby donor cells are frozen for later use, has revealed that ice recrystallization is a major contributor to cell death upon thawing. Enhanced cryopreservation methods are particularly needed for stem cell storage to maximize the use of this currently limited resource, but also to enable storage of clinically transfused cells such as platelets and red blood cells. AFGPs have thus far not found application in cryopreservation due to their low availability from natural sources, extremely challenging synthesis, indications of cytotoxicity, but more importantly they have a side effect of shaping ice crystals into needle-shapes which pierces cells’ membranes, killing them. The aim of this ambitious project is to take a multidisciplinary approach to develop synthetic polymers as tunable, scalable and accessible bio-mimetics of AFGPs, which specifically reproduce only the desirable IRI properties. Precision synthetic and biological methods will be applied to access both vinyl- and peptide- based materials with IRI activity. The bio-inspired approach taken here will include detailed biophysical analysis of the polymer-ice interactions and translation of this understanding to real cryopreservation scenarios using blood-borne cells and human stem cells. In summary, this ambitious project takes inspiration from Nature's defense mechanisms that have evolved to allow life to flourish in extreme environments and will employ modern polymer chemistry to apply it to a real clinical problem; cryopreservation.

 Publications

year authors and title journal last update
List of publications.
2019 Daniel E. Mitchell, Alice E. R. Fayter, Robert C. Deller, Muhammad Hasan, Jose Gutierrez-Marcos, Matthew I. Gibson
Ice-recrystallization inhibiting polymers protect proteins against freeze-stress and enable glycerol-free cryostorage
published pages: 364-368, ISSN: 2051-6347, DOI: 10.1039/c8mh00727f
Materials Horizons 6/2 2019-08-05
2018 Ruben M. F. Tomás, Benjamin Martyn, Trisha L. Bailey, Matthew I. Gibson
Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans
published pages: 1289-1294, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00675
ACS Macro Letters 7/11 2019-08-05
2019 Christopher Stubbs, Thomas R Congdon, Matthew I. Gibson
Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers
published pages: 330-336, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.11.047
European Polymer Journal 110 2019-08-05
2018 Christopher Stubbs, Laura E. Wilkins, Alice E. R Fayter, Marc Walker, Matthew I. Gibson
Multivalent Presentation of Ice Recrystallization Inhibiting Polymers on Nanoparticles Retains Activity
published pages: 7347-7353, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b01952
Langmuir 35/23 2019-08-05
2018 Muhammad Hasan, Alice E. R. Fayter, Matthew I. Gibson
Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Microorganisms
published pages: 3371-3376, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00660
Biomacromolecules 19/8 2019-08-05
2018 Benjamin Martyn, Caroline I. Biggs, Matthew I. Gibson
Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors
published pages: 40-47, ISSN: 0887-624X, DOI: 10.1002/pola.29279
Journal of Polymer Science Part A: Polymer Chemistry 57/1 2019-08-05
2018 Alice E. R. Fayter, Matthew I. Gibson, Emily R. Draper
Sub-zero temperature mechanically stable low molecular weight hydrogels
published pages: 7274-7279, ISSN: 2050-7518, DOI: 10.1039/c8tb01668b
Journal of Materials Chemistry B 6/44 2019-08-05
2019 Caroline I. Biggs, Christopher Stubbs, Ben Graham, Alice E. R. Fayter, Muhammad Hasan, Matthew I. Gibson
Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active”?
published pages: 1900082, ISSN: 1616-5187, DOI: 10.1002/mabi.201900082
Macromolecular Bioscience Mater. Horiz., 2019,6, 364-368 2019-08-05
2019 Laura E. Wilkins, Muhammad Hasan, Alice E. R. Fayter, Caroline Biggs, Marc Walker, Matthew I. Gibson
Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles
published pages: 2986-2990, ISSN: 1759-9954, DOI: 10.1039/c8py01719k
Polymer Chemistry 10/23 2019-08-05
2015 Daniel E. Mitchell, Matthew I. Gibson
Latent Ice Recrystallization Inhibition Activity in Nonantifreeze Proteins: Ca 2+ -Activated Plant Lectins and Cation-Activated Antimicrobial Peptides
published pages: 3411-3416, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.5b01118
Biomacromolecules 16/10 2019-05-28
2015 Helen R. Thomas, Daniel J. Phillips, Neil R. Wilson, Matthew I. Gibson, Jonathan P. Rourke
One-step grafting of polymers to graphene oxide
published pages: 8270-8274, ISSN: 1759-9954, DOI: 10.1039/C5PY01358E
Polym. Chem. 6/48 2019-05-28
2017 Lewis D. Blackman, Kay E. B. Doncom, Matthew I. Gibson, Rachel K. O\'Reilly
Comparison of photo- and thermally initiated polymerization-induced self-assembly: a lack of end group fidelity drives the formation of higher order morphologies
published pages: 2860-2871, ISSN: 1759-9954, DOI: 10.1039/c7py00407a
Polymer Chemistry 8/18 2019-05-28
2017 L. D. Blackman, M. I. Gibson, R. K. O\'Reilly
Probing the causes of thermal hysteresis using tunable N agg micelles with linear and brush-like thermoresponsive coronas
published pages: 233-244, ISSN: 1759-9954, DOI: 10.1039/C6PY01191H
Polymer Chemistry 8/1 2019-05-28
2018 Ben Graham, Alice E. R. Fayter, Judith E. Houston, Rachel C. Evans, Matthew I. Gibson
Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization
published pages: 5682-5685, ISSN: 0002-7863, DOI: 10.1021/jacs.8b02066
Journal of the American Chemical Society 140/17 2019-05-28
2016 Sangho Won, Daniel J. Phillips, Marc Walker, Matthew I. Gibson
Co-operative transitions of responsive-polymer coated gold nanoparticles; precision tuning and direct evidence for co-operative aggregation
published pages: 5673-5682, ISSN: 2050-7518, DOI: 10.1039/C6TB01336H
J. Mater. Chem. B 4/34 2019-05-28
2017 Antonio Laezza, Angela Casillo, Sandro Cosconati, Caroline I. Biggs, Antonio Fabozzi, Luigi Paduano, Alfonso Iadonisi, Ettore Novellino, Matthew I. Gibson, Antonio Randazzo, Maria M. Corsaro, Emiliano Bedini
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity
published pages: 2267-2276, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00326
Biomacromolecules 18/8 2019-05-28
2017 Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson
Synthesis of star-branched poly(vinyl alcohol) and ice recrystallization inhibition activity
published pages: 320-327, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2017.01.039
European Polymer Journal 88 2019-05-28
2016 Christopher Stubbs, Julia Lipecki, Matthew I. Gibson
Regioregular Alternating Polyampholytes Have Enhanced Biomimetic Ice Recrystallization Activity Compared to Random Copolymers and the Role of Side Chain versus Main Chain Hydrophobicity
published pages: 295-302, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b01691
Biomacromolecules 18/1 2019-05-28
2016 Caroline I. Biggs, Marc Walker, Matthew I. Gibson
“Grafting to” of RAFTed Responsive Polymers to Glass Substrates by Thiol–Ene and Critical Comparison to Thiol–Gold Coupling
published pages: 2626-2633, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b00662
Biomacromolecules 17/8 2019-05-28
2017 Angela Casillo, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, Sandro Cosconati, Ettore Novellino, Antonio Randazzo, Maria L. Tutino, M. Michela Corsaro
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection
published pages: 364-371, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2016.09.037
Carbohydrate Polymers 156 2019-05-28
2017 Ben Graham, Trisha L. Bailey, Joseph R. J. Healey, Moreno Marcellini, Sylvain Deville, Matthew I. Gibson
Polyproline as a Minimal Antifreeze Protein Mimic That Enhances the Cryopreservation of Cell Monolayers
published pages: 15941-15944, ISSN: 1433-7851, DOI: 10.1002/anie.201706703
Angewandte Chemie International Edition 56/50 2019-05-28
2016 Lucienne Otten, Denise Vlachou, Sarah-Jane Richards, Matthew I. Gibson
Glycan heterogeneity on gold nanoparticles increases lectin discrimination capacity in label-free multiplexed bioassays
published pages: 4305-4312, ISSN: 0003-2654, DOI: 10.1039/C6AN00549G
The Analyst 141/14 2019-05-28
2015 Thomas Congdon, Bethany T. Dean, James Kasperczak-Wright, Caroline I. Biggs, Rebecca Notman, Matthew I. Gibson
Probing the Biomimetic Ice Nucleation Inhibition Activity of Poly(vinyl alcohol) and Comparison to Synthetic and Biological Polymers
published pages: 2820-2826, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.5b00774
Biomacromolecules 16/9 2019-05-28
2017 Daniel E. Mitchell, Guy Clarkson, David J. Fox, Rebecca A. Vipond, Peter Scott, Matthew I. Gibson
Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity
published pages: 9835-9838, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05822
Journal of the American Chemical Society 139/29 2019-05-28
2017 Daniel J. Phillips, James Harrison, Sarah-Jane Richards, Daniel E. Mitchell, Esther Tichauer, Alasdair T. M. Hubbard, Collette Guy, Ian Hands-Portman, Elizabeth Fullam, Matthew I. Gibson
Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules
published pages: 1592-1599, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00210
Biomacromolecules 18/5 2019-05-28
2016 Lucienne Otten, Elizabeth Fullam, Matthew I. Gibson
Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile
published pages: 341-344, ISSN: 1742-206X, DOI: 10.1039/C5MB00720H
Mol. BioSyst. 12/2 2019-05-28
2017 Angela Casillo, Jonas Ståhle, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Giuseppina Pieretti, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, Göran Widmalm, Maria L. Tutino, Maria M. Corsaro
Erratum to: Structural characterization of an all-aminosugar-containing capsular polysaccharide from Colwellia psychrerythraea 34H
published pages: 1389-1389, ISSN: 0003-6072, DOI: 10.1007/s10482-017-0900-0
Antonie van Leeuwenhoek 110/11 2019-05-28
2017 Caroline I. Biggs, Christopher Packer, Steven Hindmarsh, Marc Walker, Neil R. Wilson, Jonathan P. Rourke, Matthew I. Gibson
Impact of sequential surface-modification of graphene oxide on ice nucleation
published pages: 21929-21932, ISSN: 1463-9076, DOI: 10.1039/C7CP03219F
Physical Chemistry Chemical Physics 19/33 2019-05-28
2017 Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Alice Fayter, Matthew I. Gibson, Rachel K. O’Reilly
Permeable Protein-Loaded Polymersome Cascade Nanoreactors by Polymerization-Induced Self-Assembly
published pages: 1263-1267, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00725
ACS Macro Letters 6/11 2019-05-28
2017 Guillaume Hedir, Christopher Stubbs, Phillip Aston, Andrew P. Dove, Matthew I. Gibson
Synthesis of Degradable Poly(vinyl alcohol) by Radical Ring-Opening Copolymerization and Ice Recrystallization Inhibition Activity
published pages: 1404-1408, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00905
ACS Macro Letters 6/12 2019-05-28
2016 Daniel E. Mitchell, Joseph R. Lovett, Steven P. Armes, Matthew I. Gibson
Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells
published pages: 2801-2804, ISSN: 1433-7851, DOI: 10.1002/anie.201511454
Angewandte Chemie International Edition 55/8 2019-05-28
2017 Nicholas S. Vail, Christopher Stubbs, Caroline I. Biggs, Matthew I. Gibson
Ultralow Dispersity Poly(vinyl alcohol) Reveals Significant Dispersity Effects on Ice Recrystallization Inhibition Activity
published pages: 1001-1004, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00595
ACS Macro Letters 6/9 2019-05-28
2016 Daniel J. Phillips, Thomas R. Congdon, Matthew I. Gibson
Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger
published pages: 1701-1704, ISSN: 1759-9954, DOI: 10.1039/c5py01948f
Polymer Chemistry 7/9 2019-05-28
2017 Collette S Guy, Esther Tichauer, Gemma L Kay, Daniel J Phillips, Trisha L Bailey, James Harrison, Christopher M Furze, Andrew D Millard, Matthew I Gibson, Mark J Pallen, Elizabeth Fullam
Identification of the anti-mycobacterial functional properties of piperidinol derivatives
published pages: 2183-2193, ISSN: 0007-1188, DOI: 10.1111/bph.13744
British Journal of Pharmacology 174/14 2019-05-28
2017 Sangho Won, Sarah-Jane Richards, Marc Walker, Matthew I. Gibson
Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
published pages: 106-109, ISSN: 2055-6756, DOI: 10.1039/c6nh00202a
Nanoscale Horizons 2/2 2019-05-28
2017 Caroline I. Biggs, Trisha L. Bailey, Ben Graham, Christopher Stubbs, Alice Fayter, Matthew I. Gibson
Polymer mimics of biomacromolecular antifreezes
published pages: 1546, ISSN: 2041-1723, DOI: 10.1038/s41467-017-01421-7
Nature Communications 8/1 2019-05-28
2018 Sangho Won, Steven Hindmarsh, Matthew I. Gibson
Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate–Carbohydrate Interactions
published pages: 178-183, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00891
ACS Macro Letters 7/2 2019-05-28
2016 Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson
Influence of Block Copolymerization on the Antifreeze Protein Mimetic Ice Recrystallization Inhibition Activity of Poly(vinyl alcohol)
published pages: 3033-3039, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b00915
Biomacromolecules 17/9 2019-05-28
2016 Robert C. Deller, Jeffrey E. Pessin, Manu Vatish, Daniel A. Mitchell, Matthew I. Gibson
Enhanced non-vitreous cryopreservation of immortalized and primary cells by ice-growth inhibiting polymers
published pages: 1079-1084, ISSN: 2047-4830, DOI: 10.1039/C6BM00129G
Biomater. Sci. 4/7 2019-05-28
2017 Sarah-Jane Richards, Klea Isufi, Laura E. Wilkins, Julia Lipecki, Elizabeth Fullam, Matthew I. Gibson
Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms
published pages: 256-264, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01561
Biomacromolecules 19/1 2019-05-28
2018 Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Zachary H. Houston, Nicholas L. Fletcher, Kristofer J. Thurecht, Muhammad Hasan, Matthew I. Gibson, Rachel K. O’Reilly
Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility
published pages: 718-723, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00168
ACS Central Science 4/6 2019-03-11

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