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CRYOMAT SIGNED
Antifreeze GlycoProtein Mimetic Polymers
Total Cost €
0EC-Contrib. €
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0CRYOMAT project word cloud
Explore the words cloud of the CRYOMAT project. It provides you a very rough idea of what is the project "CRYOMAT" about.
chemistry
antifreeze
zero
interactions
flourish
needle
cell
afgps
sources
maximize
synthesis
food
inspired
revealed
nature
cells
clinically
extremely
inhibition
peptide
inspiration
polymer
multidisciplinary
effect
killing
bio
clinical
crystals
fish
found
vinyl
human
pierces
defense
ice
tunable
accessible
frozen
mechanisms
reproduce
takes
whereby
diverse
water
proteins
crystal
biological
cytotoxicity
shapes
polymers
survive
solution
elegant
road
recrystallization
death
slow
red
oceans
cryopreservation
transfused
turbines
scalable
summary
employ
storage
surfaces
extreme
synthetic
indications
scenarios
blood
sub
settings
rate
living
desirable
secrete
environments
enhanced
modern
later
mimetics
thawing
natural
iri
donor
precision
resource
macromolecular
membranes
glyco
translation
life
biophysical
wind
polar
oil
limited
materials
borne
stem
platelets
shaping
contributor
Project "CRYOMAT" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF WARWICK
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙496˙439 € |
| EC max contribution | 1˙496˙439 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2020-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF WARWICK | UK (COVENTRY) | coordinator | 1˙496˙439.00 |
Map
Project objective
Fish living in polar oceans have evolved an elegant, macromolecular, solution to survive in sub-zero water: they secrete antifreeze (glyco)proteins (AFGPs) which have several ‘antifreeze’ effects, including ice recrystallization inhibition (IRI) - they slow the rate of ice crystal growth. Ice crystal growth is a major problem in settings as diverse as oil fields, wind turbines, road surfaces and frozen food. Analysis of the process of cryopreservation, whereby donor cells are frozen for later use, has revealed that ice recrystallization is a major contributor to cell death upon thawing. Enhanced cryopreservation methods are particularly needed for stem cell storage to maximize the use of this currently limited resource, but also to enable storage of clinically transfused cells such as platelets and red blood cells. AFGPs have thus far not found application in cryopreservation due to their low availability from natural sources, extremely challenging synthesis, indications of cytotoxicity, but more importantly they have a side effect of shaping ice crystals into needle-shapes which pierces cells’ membranes, killing them. The aim of this ambitious project is to take a multidisciplinary approach to develop synthetic polymers as tunable, scalable and accessible bio-mimetics of AFGPs, which specifically reproduce only the desirable IRI properties. Precision synthetic and biological methods will be applied to access both vinyl- and peptide- based materials with IRI activity. The bio-inspired approach taken here will include detailed biophysical analysis of the polymer-ice interactions and translation of this understanding to real cryopreservation scenarios using blood-borne cells and human stem cells. In summary, this ambitious project takes inspiration from Nature's defense mechanisms that have evolved to allow life to flourish in extreme environments and will employ modern polymer chemistry to apply it to a real clinical problem; cryopreservation.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Daniel E. Mitchell, Alice E. R. Fayter, Robert C. Deller, Muhammad Hasan, Jose Gutierrez-Marcos, Matthew I. Gibson Ice-recrystallization inhibiting polymers protect proteins against freeze-stress and enable glycerol-free cryostorage published pages: 364-368, ISSN: 2051-6347, DOI: 10.1039/c8mh00727f |
Materials Horizons 6/2 | 2019-08-05 |
| 2018 |
Ruben M. F. Tomás, Benjamin Martyn, Trisha L. Bailey, Matthew I. Gibson Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans published pages: 1289-1294, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00675 |
ACS Macro Letters 7/11 | 2019-08-05 |
| 2019 |
Christopher Stubbs, Thomas R Congdon, Matthew I. Gibson Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers published pages: 330-336, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.11.047 |
European Polymer Journal 110 | 2019-08-05 |
| 2018 |
Christopher Stubbs, Laura E. Wilkins, Alice E. R Fayter, Marc Walker, Matthew I. Gibson Multivalent Presentation of Ice Recrystallization Inhibiting Polymers on Nanoparticles Retains Activity published pages: 7347-7353, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b01952 |
Langmuir 35/23 | 2019-08-05 |
| 2018 |
Muhammad Hasan, Alice E. R. Fayter, Matthew I. Gibson Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Microorganisms published pages: 3371-3376, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00660 |
Biomacromolecules 19/8 | 2019-08-05 |
| 2018 |
Benjamin Martyn, Caroline I. Biggs, Matthew I. Gibson Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors published pages: 40-47, ISSN: 0887-624X, DOI: 10.1002/pola.29279 |
Journal of Polymer Science Part A: Polymer Chemistry 57/1 | 2019-08-05 |
| 2018 |
Alice E. R. Fayter, Matthew I. Gibson, Emily R. Draper Sub-zero temperature mechanically stable low molecular weight hydrogels published pages: 7274-7279, ISSN: 2050-7518, DOI: 10.1039/c8tb01668b |
Journal of Materials Chemistry B 6/44 | 2019-08-05 |
| 2019 |
Caroline I. Biggs, Christopher Stubbs, Ben Graham, Alice E. R. Fayter, Muhammad Hasan, Matthew I. Gibson Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active� published pages: 1900082, ISSN: 1616-5187, DOI: 10.1002/mabi.201900082 |
Macromolecular Bioscience Mater. Horiz., 2019,6, 364-368 | 2019-08-05 |
| 2019 |
Laura E. Wilkins, Muhammad Hasan, Alice E. R. Fayter, Caroline Biggs, Marc Walker, Matthew I. Gibson Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles published pages: 2986-2990, ISSN: 1759-9954, DOI: 10.1039/c8py01719k |
Polymer Chemistry 10/23 | 2019-08-05 |
| 2015 |
Daniel E. Mitchell, Matthew I. Gibson Latent Ice Recrystallization Inhibition Activity in Nonantifreeze Proteins: Ca 2+ -Activated Plant Lectins and Cation-Activated Antimicrobial Peptides published pages: 3411-3416, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.5b01118 |
Biomacromolecules 16/10 | 2019-05-28 |
| 2015 |
Helen R. Thomas, Daniel J. Phillips, Neil R. Wilson, Matthew I. Gibson, Jonathan P. Rourke One-step grafting of polymers to graphene oxide published pages: 8270-8274, ISSN: 1759-9954, DOI: 10.1039/C5PY01358E |
Polym. Chem. 6/48 | 2019-05-28 |
| 2017 |
Lewis D. Blackman, Kay E. B. Doncom, Matthew I. Gibson, Rachel K. O\'Reilly Comparison of photo- and thermally initiated polymerization-induced self-assembly: a lack of end group fidelity drives the formation of higher order morphologies published pages: 2860-2871, ISSN: 1759-9954, DOI: 10.1039/c7py00407a |
Polymer Chemistry 8/18 | 2019-05-28 |
| 2017 |
L. D. Blackman, M. I. Gibson, R. K. O\'Reilly Probing the causes of thermal hysteresis using tunable N agg micelles with linear and brush-like thermoresponsive coronas published pages: 233-244, ISSN: 1759-9954, DOI: 10.1039/C6PY01191H |
Polymer Chemistry 8/1 | 2019-05-28 |
| 2018 |
Ben Graham, Alice E. R. Fayter, Judith E. Houston, Rachel C. Evans, Matthew I. Gibson Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization published pages: 5682-5685, ISSN: 0002-7863, DOI: 10.1021/jacs.8b02066 |
Journal of the American Chemical Society 140/17 | 2019-05-28 |
| 2016 |
Sangho Won, Daniel J. Phillips, Marc Walker, Matthew I. Gibson Co-operative transitions of responsive-polymer coated gold nanoparticles; precision tuning and direct evidence for co-operative aggregation published pages: 5673-5682, ISSN: 2050-7518, DOI: 10.1039/C6TB01336H |
J. Mater. Chem. B 4/34 | 2019-05-28 |
| 2017 |
Antonio Laezza, Angela Casillo, Sandro Cosconati, Caroline I. Biggs, Antonio Fabozzi, Luigi Paduano, Alfonso Iadonisi, Ettore Novellino, Matthew I. Gibson, Antonio Randazzo, Maria M. Corsaro, Emiliano Bedini Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity published pages: 2267-2276, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00326 |
Biomacromolecules 18/8 | 2019-05-28 |
| 2017 |
Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson Synthesis of star-branched poly(vinyl alcohol) and ice recrystallization inhibition activity published pages: 320-327, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2017.01.039 |
European Polymer Journal 88 | 2019-05-28 |
| 2016 |
Christopher Stubbs, Julia Lipecki, Matthew I. Gibson Regioregular Alternating Polyampholytes Have Enhanced Biomimetic Ice Recrystallization Activity Compared to Random Copolymers and the Role of Side Chain versus Main Chain Hydrophobicity published pages: 295-302, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b01691 |
Biomacromolecules 18/1 | 2019-05-28 |
| 2016 |
Caroline I. Biggs, Marc Walker, Matthew I. Gibson “Grafting to†of RAFTed Responsive Polymers to Glass Substrates by Thiol–Ene and Critical Comparison to Thiol–Gold Coupling published pages: 2626-2633, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b00662 |
Biomacromolecules 17/8 | 2019-05-28 |
| 2017 |
Angela Casillo, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, Sandro Cosconati, Ettore Novellino, Antonio Randazzo, Maria L. Tutino, M. Michela Corsaro Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection published pages: 364-371, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2016.09.037 |
Carbohydrate Polymers 156 | 2019-05-28 |
| 2017 |
Ben Graham, Trisha L. Bailey, Joseph R. J. Healey, Moreno Marcellini, Sylvain Deville, Matthew I. Gibson Polyproline as a Minimal Antifreeze Protein Mimic That Enhances the Cryopreservation of Cell Monolayers published pages: 15941-15944, ISSN: 1433-7851, DOI: 10.1002/anie.201706703 |
Angewandte Chemie International Edition 56/50 | 2019-05-28 |
| 2016 |
Lucienne Otten, Denise Vlachou, Sarah-Jane Richards, Matthew I. Gibson Glycan heterogeneity on gold nanoparticles increases lectin discrimination capacity in label-free multiplexed bioassays published pages: 4305-4312, ISSN: 0003-2654, DOI: 10.1039/C6AN00549G |
The Analyst 141/14 | 2019-05-28 |
| 2015 |
Thomas Congdon, Bethany T. Dean, James Kasperczak-Wright, Caroline I. Biggs, Rebecca Notman, Matthew I. Gibson Probing the Biomimetic Ice Nucleation Inhibition Activity of Poly(vinyl alcohol) and Comparison to Synthetic and Biological Polymers published pages: 2820-2826, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.5b00774 |
Biomacromolecules 16/9 | 2019-05-28 |
| 2017 |
Daniel E. Mitchell, Guy Clarkson, David J. Fox, Rebecca A. Vipond, Peter Scott, Matthew I. Gibson Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity published pages: 9835-9838, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05822 |
Journal of the American Chemical Society 139/29 | 2019-05-28 |
| 2017 |
Daniel J. Phillips, James Harrison, Sarah-Jane Richards, Daniel E. Mitchell, Esther Tichauer, Alasdair T. M. Hubbard, Collette Guy, Ian Hands-Portman, Elizabeth Fullam, Matthew I. Gibson Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules published pages: 1592-1599, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00210 |
Biomacromolecules 18/5 | 2019-05-28 |
| 2016 |
Lucienne Otten, Elizabeth Fullam, Matthew I. Gibson Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile published pages: 341-344, ISSN: 1742-206X, DOI: 10.1039/C5MB00720H |
Mol. BioSyst. 12/2 | 2019-05-28 |
| 2017 |
Angela Casillo, Jonas Ståhle, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Giuseppina Pieretti, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, Göran Widmalm, Maria L. Tutino, Maria M. Corsaro Erratum to: Structural characterization of an all-aminosugar-containing capsular polysaccharide from Colwellia psychrerythraea 34H published pages: 1389-1389, ISSN: 0003-6072, DOI: 10.1007/s10482-017-0900-0 |
Antonie van Leeuwenhoek 110/11 | 2019-05-28 |
| 2017 |
Caroline I. Biggs, Christopher Packer, Steven Hindmarsh, Marc Walker, Neil R. Wilson, Jonathan P. Rourke, Matthew I. Gibson Impact of sequential surface-modification of graphene oxide on ice nucleation published pages: 21929-21932, ISSN: 1463-9076, DOI: 10.1039/C7CP03219F |
Physical Chemistry Chemical Physics 19/33 | 2019-05-28 |
| 2017 |
Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Alice Fayter, Matthew I. Gibson, Rachel K. O’Reilly Permeable Protein-Loaded Polymersome Cascade Nanoreactors by Polymerization-Induced Self-Assembly published pages: 1263-1267, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00725 |
ACS Macro Letters 6/11 | 2019-05-28 |
| 2017 |
Guillaume Hedir, Christopher Stubbs, Phillip Aston, Andrew P. Dove, Matthew I. Gibson Synthesis of Degradable Poly(vinyl alcohol) by Radical Ring-Opening Copolymerization and Ice Recrystallization Inhibition Activity published pages: 1404-1408, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00905 |
ACS Macro Letters 6/12 | 2019-05-28 |
| 2016 |
Daniel E. Mitchell, Joseph R. Lovett, Steven P. Armes, Matthew I. Gibson Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells published pages: 2801-2804, ISSN: 1433-7851, DOI: 10.1002/anie.201511454 |
Angewandte Chemie International Edition 55/8 | 2019-05-28 |
| 2017 |
Nicholas S. Vail, Christopher Stubbs, Caroline I. Biggs, Matthew I. Gibson Ultralow Dispersity Poly(vinyl alcohol) Reveals Significant Dispersity Effects on Ice Recrystallization Inhibition Activity published pages: 1001-1004, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00595 |
ACS Macro Letters 6/9 | 2019-05-28 |
| 2016 |
Daniel J. Phillips, Thomas R. Congdon, Matthew I. Gibson Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger published pages: 1701-1704, ISSN: 1759-9954, DOI: 10.1039/c5py01948f |
Polymer Chemistry 7/9 | 2019-05-28 |
| 2017 |
Collette S Guy, Esther Tichauer, Gemma L Kay, Daniel J Phillips, Trisha L Bailey, James Harrison, Christopher M Furze, Andrew D Millard, Matthew I Gibson, Mark J Pallen, Elizabeth Fullam Identification of the anti-mycobacterial functional properties of piperidinol derivatives published pages: 2183-2193, ISSN: 0007-1188, DOI: 10.1111/bph.13744 |
British Journal of Pharmacology 174/14 | 2019-05-28 |
| 2017 |
Sangho Won, Sarah-Jane Richards, Marc Walker, Matthew I. Gibson Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition published pages: 106-109, ISSN: 2055-6756, DOI: 10.1039/c6nh00202a |
Nanoscale Horizons 2/2 | 2019-05-28 |
| 2017 |
Caroline I. Biggs, Trisha L. Bailey, Ben Graham, Christopher Stubbs, Alice Fayter, Matthew I. Gibson Polymer mimics of biomacromolecular antifreezes published pages: 1546, ISSN: 2041-1723, DOI: 10.1038/s41467-017-01421-7 |
Nature Communications 8/1 | 2019-05-28 |
| 2018 |
Sangho Won, Steven Hindmarsh, Matthew I. Gibson Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate–Carbohydrate Interactions published pages: 178-183, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00891 |
ACS Macro Letters 7/2 | 2019-05-28 |
| 2016 |
Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson Influence of Block Copolymerization on the Antifreeze Protein Mimetic Ice Recrystallization Inhibition Activity of Poly(vinyl alcohol) published pages: 3033-3039, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b00915 |
Biomacromolecules 17/9 | 2019-05-28 |
| 2016 |
Robert C. Deller, Jeffrey E. Pessin, Manu Vatish, Daniel A. Mitchell, Matthew I. Gibson Enhanced non-vitreous cryopreservation of immortalized and primary cells by ice-growth inhibiting polymers published pages: 1079-1084, ISSN: 2047-4830, DOI: 10.1039/C6BM00129G |
Biomater. Sci. 4/7 | 2019-05-28 |
| 2017 |
Sarah-Jane Richards, Klea Isufi, Laura E. Wilkins, Julia Lipecki, Elizabeth Fullam, Matthew I. Gibson Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms published pages: 256-264, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01561 |
Biomacromolecules 19/1 | 2019-05-28 |
| 2018 |
Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Zachary H. Houston, Nicholas L. Fletcher, Kristofer J. Thurecht, Muhammad Hasan, Matthew I. Gibson, Rachel K. O’Reilly Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility published pages: 718-723, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00168 |
ACS Central Science 4/6 | 2019-03-11 |
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