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ProPlantStress SIGNED

Proteolytic processing in plant stress signal transduction and responses to abiotic stress and pathogen attack

Total Cost €

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EC-Contrib. €

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Partnership

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 ProPlantStress project word cloud

Explore the words cloud of the ProPlantStress project. It provides you a very rough idea of what is the project "ProPlantStress" about.

thereby    time    generates    acclimation    positional    hypotheses    regulates    fundamental    proplantstress    substrate    gt    intensity    host    implicated    insights    recognition    crop    testable    rarely    hormonal    hundreds    postdoctoral    identification    catalogue    merely    sites    effector    co    protein    examined    phosphorylation    pathogen    systemic    stress    immune    chloroplast    proteomics    800    genomes    post    mitigation    protection    largely    strategies    modifications    mapping    retrograde    subcellular    despite    plants    protease    metabolic    locations    translational    function    triggered    plant    proteases    unattainable    processed    harvest    termini    transduction    combined    signaling    linked    signal    quantitative    site    profiling    bacterial    irreversible    mechanisms    underlying    employ    biotic    resolved    modification    light    repertoires    reveal    proteolytic    correlation    domains    interactions    substrates    arabidopsis    cleavage    abiotic    few    serendipitously    proteins    functions    encoded    species   

Project "ProPlantStress" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSZENTRUM JULICH GMBH 

Organization address
address: WILHELM JOHNEN STRASSE
city: JULICH
postcode: 52428
website: www.fz-juelich.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.proteasedegradomics.org/plant-degradomics.html
 Total cost 1˙804˙663 €
 EC max contribution 1˙804˙663 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙804˙663.00

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 Project objective

Site-specific proteolytic processing is an irreversible post-translational protein modification that generates distinct protein species with new functions, interactions and subcellular locations. In plants, proteolytic processing regulates hormonal and stress signaling leading to adaptation of metabolic pathways and is implicated in plant-pathogen interactions. Despite their importance, proteolytic processes have largely been identified serendipitously, specific cleavage sites have rarely been identified and only a few of the hundreds of proteases encoded in plant genomes (>800 in Arabidopsis) have been linked to any substrates. Positional proteomics enables system-wide identification of proteolytic processing and protease substrate repertoires through quantitative determination of protein N- or C-termini. ProPlantStress will employ these approaches, which I co-developed during my postdoctoral research, to two linked abiotic and biotic stress conditions: i) Time-resolved mapping of chloroplast protein processing induced by high intensity light will reveal novel mechanisms of retrograde signal transduction, stress response and acclimation; ii) Profiling of protein processing triggered by pathogen recognition, combined with substrate identification for selected host and bacterial pathogen effector proteases will identify proteins with novel functions in plant immune responses and systemic signaling. Importantly, ProPlantStress will not merely catalogue termini and substrates: Mapping of cleavage sites to the protein domains and correlation with other modifications, such as phosphorylation, generates testable hypotheses on the function of processed protein species that will be examined in detail. ProPlantStress will thereby provide fundamental insights into proteolytic mechanisms underlying plant stress responses that are unattainable by other means. In the long term such knowledge is needed to develop new strategies for crop protection and mitigation of harvest loss.

 Publications

year authors and title journal last update
List of publications.
2020 Wai Tuck Soh, Fatih Demir, Elfriede Dall, Andreas Perrar, Sven O. Dahms, Maithreyan Kuppusamy, Hans Brandstetter, Pitter F. Huesgen
ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease
published pages: 2961-2971, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b03604
Analytical Chemistry 92/4 2020-03-23
2020 Stefan Niedermaier, Trang Schneider, Marc-Oliver Bahl, Shizue Matsubara, Pitter F. Huesgen
Photoprotective Acclimation of the Arabidopsis thaliana Leaf Proteome to Fluctuating Light
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2020.00154
Frontiers in Genetics 11 2020-03-23
2019 Samuel SH Weng, Fatih Demir, Enes K. Ergin, Sabrina Dirnberger, Anuli Uzozie, Domenic Tuscher, Lorenz Nierves, Janice Tsui, Pitter F. Huesgen, Philipp F. Lange
Sensitive determination of proteolytic proteoforms in limited microscale proteome samples
published pages: mcp.TIR119.00156, ISSN: 1535-9476, DOI: 10.1074/mcp.TIR119.001560
Molecular & Cellular Proteomics 2020-01-24
2019 Catharina V Huber, Barbara D Jakobs, Laxmi S Mishra, Stefan Niedermaier, Marc Stift, Gudrun Winter, Iwona Adamska, Christiane Funk, Pitter F Huesgen, Dietmar Funck
DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erz294
Journal of Experimental Botany 2020-01-24
2017 Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. Völker, Eva-Maria Schurek, Julie Binz, Martin Höhne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton
published pages: 2867-2878, ISSN: 1046-6673, DOI: 10.1681/ASN.2016101119
Journal of the American Society of Nephrology 28/10 2020-01-24
2019 Johana C. Misas Villamil, André N. Mueller, Fatih Demir, Ute Meyer, Bilal Ökmen, Jan Schulze Hüynck, Marlen Breuer, Helen Dauben, Joe Win, Pitter F. Huesgen, Gunther Doehlemann
A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09472-8
Nature Communications 10/1 2020-01-24
2018 Fatih Demir, Stefan Niedermaier, Joji Grace Villamor, Pitter Florian Huesgen
Quantitative proteomics in plant protease substrate identification
published pages: 936-943, ISSN: 0028-646X, DOI: 10.1111/nph.14587
New Phytologist 218/3 2020-01-24
2019 Andreas Perrar, Nico Dissmeyer, Pitter F Huesgen
New beginnings and new ends – Methods for large-scale characterization of protein termini and their use in plant biology
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erz104
Journal of Experimental Botany 2020-01-24
2019 Fatih Demir, Andreas Perrar, Pitter F. Huesgen
Das maßgeschneiderte Proteom: Proteinmodifikation durch Proteolyse
published pages: 41-44, ISSN: 0947-0867, DOI: 10.1007/s12268-019-1003-4
BIOspektrum 25/1 2020-01-24
2018 Stefan Niedermaier, Pitter F. Huesgen
Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins
published pages: , ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2018.09.004
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2020-01-24

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