Explore the words cloud of the ProPlantStress project. It provides you a very rough idea of what is the project "ProPlantStress" about.
The following table provides information about the project.
FORSCHUNGSZENTRUM JULICH GMBH
|Coordinator Country||Germany [DE]|
|Total cost||1˙804˙663 €|
|EC max contribution||1˙804˙663 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2020-11-30|
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|1||FORSCHUNGSZENTRUM JULICH GMBH||DE (JULICH)||coordinator||1˙804˙663.00|
Site-specific proteolytic processing is an irreversible post-translational protein modification that generates distinct protein species with new functions, interactions and subcellular locations. In plants, proteolytic processing regulates hormonal and stress signaling leading to adaptation of metabolic pathways and is implicated in plant-pathogen interactions. Despite their importance, proteolytic processes have largely been identified serendipitously, specific cleavage sites have rarely been identified and only a few of the hundreds of proteases encoded in plant genomes (>800 in Arabidopsis) have been linked to any substrates. Positional proteomics enables system-wide identification of proteolytic processing and protease substrate repertoires through quantitative determination of protein N- or C-termini. ProPlantStress will employ these approaches, which I co-developed during my postdoctoral research, to two linked abiotic and biotic stress conditions: i) Time-resolved mapping of chloroplast protein processing induced by high intensity light will reveal novel mechanisms of retrograde signal transduction, stress response and acclimation; ii) Profiling of protein processing triggered by pathogen recognition, combined with substrate identification for selected host and bacterial pathogen effector proteases will identify proteins with novel functions in plant immune responses and systemic signaling. Importantly, ProPlantStress will not merely catalogue termini and substrates: Mapping of cleavage sites to the protein domains and correlation with other modifications, such as phosphorylation, generates testable hypotheses on the function of processed protein species that will be examined in detail. ProPlantStress will thereby provide fundamental insights into proteolytic mechanisms underlying plant stress responses that are unattainable by other means. In the long term such knowledge is needed to develop new strategies for crop protection and mitigation of harvest loss.
|year||authors and title||journal||last update|
Wai Tuck Soh, Fatih Demir, Elfriede Dall, Andreas Perrar, Sven O. Dahms, Maithreyan Kuppusamy, Hans Brandstetter, Pitter F. Huesgen
ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease
published pages: 2961-2971, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b03604
|Analytical Chemistry 92/4||2020-03-23|
Stefan Niedermaier, Trang Schneider, Marc-Oliver Bahl, Shizue Matsubara, Pitter F. Huesgen
Photoprotective Acclimation of the Arabidopsis thaliana Leaf Proteome to Fluctuating Light
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2020.00154
|Frontiers in Genetics 11||2020-03-23|
Samuel SH Weng, Fatih Demir, Enes K. Ergin, Sabrina Dirnberger, Anuli Uzozie, Domenic Tuscher, Lorenz Nierves, Janice Tsui, Pitter F. Huesgen, Philipp F. Lange
Sensitive determination of proteolytic proteoforms in limited microscale proteome samples
published pages: mcp.TIR119.00156, ISSN: 1535-9476, DOI: 10.1074/mcp.TIR119.001560
|Molecular & Cellular Proteomics||2020-01-24|
Catharina V Huber, Barbara D Jakobs, Laxmi S Mishra, Stefan Niedermaier, Marc Stift, Gudrun Winter, Iwona Adamska, Christiane Funk, Pitter F Huesgen, Dietmar Funck
DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erz294
|Journal of Experimental Botany||2020-01-24|
Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. VÃ¶lker, Eva-Maria Schurek, Julie Binz, Martin HÃ¶hne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton
published pages: 2867-2878, ISSN: 1046-6673, DOI: 10.1681/ASN.2016101119
|Journal of the American Society of Nephrology 28/10||2020-01-24|
Johana C. Misas Villamil, AndrÃ© N. Mueller, Fatih Demir, Ute Meyer, Bilal Ã–kmen, Jan Schulze HÃ¼ynck, Marlen Breuer, Helen Dauben, Joe Win, Pitter F. Huesgen, Gunther Doehlemann
A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09472-8
|Nature Communications 10/1||2020-01-24|
Fatih Demir, Stefan Niedermaier, Joji Grace Villamor, Pitter Florian Huesgen
Quantitative proteomics in plant protease substrate identification
published pages: 936-943, ISSN: 0028-646X, DOI: 10.1111/nph.14587
|New Phytologist 218/3||2020-01-24|
Andreas Perrar, Nico Dissmeyer, Pitter F Huesgen
New beginnings and new ends â€“ Methods for large-scale characterization of protein termini and their use in plant biology
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erz104
|Journal of Experimental Botany||2020-01-24|
Fatih Demir, Andreas Perrar, Pitter F. Huesgen
Das maÃŸgeschneiderte Proteom: Proteinmodifikation durch Proteolyse
published pages: 41-44, ISSN: 0947-0867, DOI: 10.1007/s12268-019-1003-4
Stefan Niedermaier, Pitter F. Huesgen
Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins
published pages: , ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2018.09.004
|Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics||2020-01-24|
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