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ProPlantStress SIGNED

Proteolytic processing in plant stress signal transduction and responses to abiotic stress and pathogen attack

Total Cost €


EC-Contrib. €






 ProPlantStress project word cloud

Explore the words cloud of the ProPlantStress project. It provides you a very rough idea of what is the project "ProPlantStress" about.

hundreds    insights    locations    site    plant    time    underlying    regulates    protease    co    modifications    domains    triggered    reveal    cleavage    bacterial    hypotheses    proteolytic    catalogue    serendipitously    few    functions    stress    mitigation    despite    hormonal    repertoires    unattainable    harvest    strategies    implicated    postdoctoral    generates    employ    proteins    thereby    termini    protection    mechanisms    testable    post    modification    signaling    function    acclimation    species    interactions    correlation    irreversible    signal    examined    recognition    800    systemic    combined    fundamental    host    translational    rarely    positional    retrograde    arabidopsis    linked    substrate    gt    largely    mapping    abiotic    plants    proplantstress    light    intensity    immune    substrates    protein    crop    merely    profiling    sites    phosphorylation    proteomics    processed    pathogen    quantitative    encoded    effector    resolved    chloroplast    transduction    subcellular    metabolic    identification    genomes    biotic    proteases   

Project "ProPlantStress" data sheet

The following table provides information about the project.


Organization address
city: JULICH
postcode: 52428

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 1˙804˙663 €
 EC max contribution 1˙804˙663 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙804˙663.00


 Project objective

Site-specific proteolytic processing is an irreversible post-translational protein modification that generates distinct protein species with new functions, interactions and subcellular locations. In plants, proteolytic processing regulates hormonal and stress signaling leading to adaptation of metabolic pathways and is implicated in plant-pathogen interactions. Despite their importance, proteolytic processes have largely been identified serendipitously, specific cleavage sites have rarely been identified and only a few of the hundreds of proteases encoded in plant genomes (>800 in Arabidopsis) have been linked to any substrates. Positional proteomics enables system-wide identification of proteolytic processing and protease substrate repertoires through quantitative determination of protein N- or C-termini. ProPlantStress will employ these approaches, which I co-developed during my postdoctoral research, to two linked abiotic and biotic stress conditions: i) Time-resolved mapping of chloroplast protein processing induced by high intensity light will reveal novel mechanisms of retrograde signal transduction, stress response and acclimation; ii) Profiling of protein processing triggered by pathogen recognition, combined with substrate identification for selected host and bacterial pathogen effector proteases will identify proteins with novel functions in plant immune responses and systemic signaling. Importantly, ProPlantStress will not merely catalogue termini and substrates: Mapping of cleavage sites to the protein domains and correlation with other modifications, such as phosphorylation, generates testable hypotheses on the function of processed protein species that will be examined in detail. ProPlantStress will thereby provide fundamental insights into proteolytic mechanisms underlying plant stress responses that are unattainable by other means. In the long term such knowledge is needed to develop new strategies for crop protection and mitigation of harvest loss.


year authors and title journal last update
List of publications.
2020 Wai Tuck Soh, Fatih Demir, Elfriede Dall, Andreas Perrar, Sven O. Dahms, Maithreyan Kuppusamy, Hans Brandstetter, Pitter F. Huesgen
ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease
published pages: 2961-2971, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b03604
Analytical Chemistry 92/4 2020-03-23
2020 Stefan Niedermaier, Trang Schneider, Marc-Oliver Bahl, Shizue Matsubara, Pitter F. Huesgen
Photoprotective Acclimation of the Arabidopsis thaliana Leaf Proteome to Fluctuating Light
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2020.00154
Frontiers in Genetics 11 2020-03-23
2019 Samuel SH Weng, Fatih Demir, Enes K. Ergin, Sabrina Dirnberger, Anuli Uzozie, Domenic Tuscher, Lorenz Nierves, Janice Tsui, Pitter F. Huesgen, Philipp F. Lange
Sensitive determination of proteolytic proteoforms in limited microscale proteome samples
published pages: mcp.TIR119.00156, ISSN: 1535-9476, DOI: 10.1074/mcp.TIR119.001560
Molecular & Cellular Proteomics 2020-01-24
2019 Catharina V Huber, Barbara D Jakobs, Laxmi S Mishra, Stefan Niedermaier, Marc Stift, Gudrun Winter, Iwona Adamska, Christiane Funk, Pitter F Huesgen, Dietmar Funck
DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erz294
Journal of Experimental Botany 2020-01-24
2017 Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. Völker, Eva-Maria Schurek, Julie Binz, Martin Höhne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton
published pages: 2867-2878, ISSN: 1046-6673, DOI: 10.1681/ASN.2016101119
Journal of the American Society of Nephrology 28/10 2020-01-24
2019 Johana C. Misas Villamil, André N. Mueller, Fatih Demir, Ute Meyer, Bilal Ökmen, Jan Schulze Hüynck, Marlen Breuer, Helen Dauben, Joe Win, Pitter F. Huesgen, Gunther Doehlemann
A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09472-8
Nature Communications 10/1 2020-01-24
2018 Fatih Demir, Stefan Niedermaier, Joji Grace Villamor, Pitter Florian Huesgen
Quantitative proteomics in plant protease substrate identification
published pages: 936-943, ISSN: 0028-646X, DOI: 10.1111/nph.14587
New Phytologist 218/3 2020-01-24
2019 Andreas Perrar, Nico Dissmeyer, Pitter F Huesgen
New beginnings and new ends – Methods for large-scale characterization of protein termini and their use in plant biology
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erz104
Journal of Experimental Botany 2020-01-24
2019 Fatih Demir, Andreas Perrar, Pitter F. Huesgen
Das maßgeschneiderte Proteom: Proteinmodifikation durch Proteolyse
published pages: 41-44, ISSN: 0947-0867, DOI: 10.1007/s12268-019-1003-4
BIOspektrum 25/1 2020-01-24
2018 Stefan Niedermaier, Pitter F. Huesgen
Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins
published pages: , ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2018.09.004
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2020-01-24

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