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A-DIET SIGNED

Metabolomics based biomarkers of dietary intake- new tools for nutrition research

Total Cost €

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EC-Contrib. €

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Partnership

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Project "A-DIET" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://www.ucd.ie/nutrimarkers
 Total cost 1˙995˙548 €
 EC max contribution 1˙995˙548 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 1˙995˙548.00

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 Project objective

In todays advanced technological world, we can track the exact movement of individuals, analyse their genetic makeup and predict predisposition to certain diseases. However, we are unable to accurately assess an individual’s dietary intake. This is without a doubt one of the main stumbling blocks in assessing the link between diet and disease/health. The present proposal (A-DIET) will address this issue with the overarching objective to develop novel strategies for assessment of dietary intake. Using approaches to (1) identify biomarkers of specific foods (2) classify people into dietary patterns (nutritypes) and (3) develop a tool for integration of dietary and biomarker data, A-DIET has the potential to dramatically enhance our ability to accurately assess dietary intake. The ultimate output from A-DIET will be a dietary assessment tool which can be used to obtain an accurate assessment of dietary intake by combining dietary and biomarker data which in turn will allow investigations into relationships between diet, health and disease. New biomarkers of specific foods will be identified and validated using intervention studies and metabolomic analyses. Methods will be developed to classify individuals into dietary patterns based on biomarker/metabolomic profiles thus demonstrating the novel concept of nutritypes. Strategies for integration of dietary and biomarker data will be developed and translated into a tool that will be made available to the wider scientific community. Advances made in A-DIET will enable nutrition epidemiologist’s to properly examine the relationship between diet and disease and develop clear public health messages with regard to diet and health. Additionally results from A-DIET will allow researchers to accurately assess people’s diet and implement health promotion strategies and enable dieticians in a clinical environment to assess compliance to therapeutic diets such as adherence to a high fibre diet or a gluten free diet.

 Publications

year authors and title journal last update
List of publications.
2018 L. O. Dragsted, Q. Gao, A. Scalbert, G. Vergères, M. Kolehmainen, C. Manach, L. Brennan, L. A. Afman, D. S. Wishart, C. Andres Lacueva, M. Garcia-Aloy, H. Verhagen, E. J. M. Feskens, G. Praticò
Validation of biomarkers of food intake—critical assessment of candidate biomarkers
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-018-0603-9
Genes & Nutrition 13/1 2020-02-28
2019 Silvia D\'Angelo, Isobel Claire Gormley, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Lorraine Brennan
Combining biomarker and food intake data: calibration equations for citrus intake
published pages: 977-983, ISSN: 0002-9165, DOI: 10.1093/ajcn/nqz168
The American Journal of Clinical Nutrition 110/4 2020-02-13
2018 Pedapati S.C. Sri Harsha, Roshaida Abdul Wahab, Catalina Cuparencu, Lars Dragsted, Lorraine Brennan
A Metabolomics Approach to the Identification of Urinary Biomarkers of Pea Intake
published pages: 1911, ISSN: 2072-6643, DOI: 10.3390/nu10121911
Nutrients 10/12 2020-02-13
2019 Cassandra Collins, Aoife E. McNamara, Lorraine Brennan
Role of metabolomics in identification of biomarkers related to food intake
published pages: 189-196, ISSN: 0029-6651, DOI: 10.1017/s002966511900048x
Proceedings of the Nutrition Society 78/02 2020-02-13
2019 Elaine Hillesheim, Lorraine Brennan
Metabotyping and its role in nutrition research
published pages: 1-10, ISSN: 0954-4224, DOI: 10.1017/s0954422419000179
Nutrition Research Reviews 2020-02-13
2019 Lorraine Brennan, Frank B. Hu
Metabolomics-Based Dietary Biomarkers in Nutritional Epidemiology-Current Status and Future Opportunities
published pages: 1701064, ISSN: 1613-4125, DOI: 10.1002/mnfr.201701064
Molecular Nutrition & Food Research 63/1 2020-02-13
2018 Victoria O’Sullivan, Francisco Madrid-Gambin, Taciane Alegra, Helena Gibbons, Lorraine Brennan
Impact of Sample Storage on the NMR Fecal Water Metabolome
published pages: 16585-16590, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01761
ACS Omega 3/12 2020-02-13
2019 Diana González-Peña, Lorraine Brennan
Recent Advances in the Application of Metabolomics for Nutrition and Health
published pages: 479-519, ISSN: 1941-1413, DOI: 10.1146/annurev-food-032818-121715
Annual Review of Food Science and Technology 10/1 2020-02-13
2020 Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A. McNulty, Anne P. Nugent, Janette Walton, Albert Flynn, Lorraine Brennan
The Relationship between Fish Intake and Urinary Trimethylamine‐ N ‐Oxide
published pages: 1900799, ISSN: 1613-4125, DOI: 10.1002/mnfr.201900799
Molecular Nutrition & Food Research 64/3 2020-02-13
2019 Lorraine Brennan, Helena Gibbons
Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions
published pages: 1-5, ISSN: 0029-6651, DOI: 10.1017/s002966511900106x
Proceedings of the Nutrition Society 2020-02-13
2019 Isobel Claire Gormley, Yuxin Bai, Lorraine Brennan
Combining biomarker and self-reported dietary intake data: A review of the state of the art and an exposition of concepts
published pages: 96228021983769, ISSN: 0962-2802, DOI: 10.1177/0962280219837698
Statistical Methods in Medical Research 2020-01-14
2017 Qian Gao, Giulia Praticò, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Lydia A. Afman, David S. Wishart, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens, Lars O. Dragsted
A scheme for a flexible classification of dietary and health biomarkers
published pages: , ISSN: 1555-8932, DOI: 10.1186/s12263-017-0587-x
Genes & Nutrition 12/1 2020-01-14
2019 Francisco Madrid-Gambin, Melanie Föcking, Sophie Sabherwal, Meike Heurich, Jane A. English, Aoife O’Gorman, Tommi Suvitaival, Linda Ahonen, Mary Cannon, Glyn Lewis, Ismo Mattila, Caitriona Scaife, Sean Madden, Tuulia Hyötyläinen, Matej Orešič, Stanley Zammit, Gerard Cagney, David R. Cotter, Lorraine Brennan
Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children
published pages: 25-34, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.01.018
Biological Psychiatry 86/1 2020-01-14
2017 L Brennan
Use of metabotyping for optimal nutrition
published pages: 35-38, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2016.10.008
Curr Opin Biotechnol 44 2019-06-06
2017 Jennifer Davison, Aoife O\'Gorman, Lorraine Brennan, David R. Cotter
A systematic review of metabolite biomarkers of schizophrenia
published pages: , ISSN: 0920-9964, DOI: 10.1016/j.schres.2017.09.021
Schizophrenia Research 2019-06-06
2017 Helena Gibbons, Lorraine Brennan
Metabolomics as a tool in the identification of dietary biomarkers
published pages: 42-53, ISSN: 0029-6651, DOI: 10.1017/S002966511600032X
Proceedings of the Nutrition Society 76/01 2019-06-06
2017 A O\'Gorman, T Suvitaival, L Ahonen, M Cannon, S Zammit, G Lewis, H M Roche, I Mattila, T Hyotylainen, M Oresic, L Brennan, D R Cotter
Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
published pages: e1240, ISSN: 2158-3188, DOI: 10.1038/tp.2017.211
Translational Psychiatry 7/9 2019-06-06
2016 Curran, Aoife M.; Gibney, Eileen R.; Drummond, Elaine; Brennan, Lorraine; Roche, Helen M.; Ryan, Miriam F.; Gibney, Michael J.
Uncovering Factors Related to Pancreatic Beta-Cell Function
published pages: , ISSN: 1932-6203, DOI: 10.1371/journal.pone.0161350
PLoS ONE 1 2019-06-06
2017 A. O\'Gorman, L. Brennan
The role of metabolomics in determination of new dietary biomarkers
published pages: 295-302, ISSN: 0029-6651, DOI: 10.1017/S0029665116002974
Proceedings of the Nutrition Society 76/03 2019-06-06
2017 Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Lorraine Brennan
Estimation of Chicken Intake by Adults Using Metabolomics-Derived Markers
published pages: 1850-1857, ISSN: 0022-3166, DOI: 10.3945/jn.117.252197
The Journal of Nutrition 147/10 2019-06-06
2017 Helena Gibbons, Charlotte J. R. Michielsen, Milena Rundle, Gary Frost, Breige A. McNulty, Anne P. Nugent, Janette Walton, Albert Flynn, Michael J. Gibney, Lorraine Brennan
Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example
published pages: 1700037, ISSN: 1613-4125, DOI: 10.1002/mnfr.201700037
Molecular Nutrition & Food Research 61/10 2019-06-06
2017 Helena Gibbons, Eibhlin Carr, Breige A. McNulty, Anne P. Nugent, Janette Walton, Albert Flynn, Michael J. Gibney, Lorraine Brennan
Metabolomic-based identification of clusters that reflect dietary patterns
published pages: 1601050, ISSN: 1613-4125, DOI: 10.1002/mnfr.201601050
Molecular Nutrition & Food Research 61/10 2019-06-06
2016 L. Brennan
Metabolomics in nutrition research-a powerful window into nutritional metabolism
published pages: 451-458, ISSN: 0071-1365, DOI: 10.1042/EBC20160029
Essays In Biochemistry 60/5 2019-06-06
2017 Baukje de Roos, Lorraine Brennan
Personalised Interventions—A Precision Approach for the Next Generation of Dietary Intervention Studies
published pages: 847, ISSN: 2072-6643, DOI: 10.3390/nu9080847
Nutrients 9/8 2019-06-06

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