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VOXEL SIGNED

volumetric medical x-ray imaging at extremely low dose

Total Cost €

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EC-Contrib. €

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Project "VOXEL" data sheet

The following table provides information about the project.

Coordinator
ASSOCIACAO DO INSTITUTO SUPERIOR TECNICO PARA A INVESTIGACAO E DESENVOLVIMENTO 

Organization address
address: AVENIDA ROVISCO PAIS 1
city: LISBOA
postcode: 1049 001
website: www.ist-id.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.voxel-project.eu
 Total cost 3˙996˙875 €
 EC max contribution 3˙996˙875 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASSOCIACAO DO INSTITUTO SUPERIOR TECNICO PARA A INVESTIGACAO E DESENVOLVIMENTO PT (LISBOA) coordinator 762˙500.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 846˙250.00
3    IMAGINE OPTIC FR (ORSAY) participant 793˙125.00
4    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 510˙000.00
5    STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN NL (UTRECHT) participant 437˙500.00
6    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 376˙250.00
7    UNIVERSIDAD POLITECNICA DE MADRID ES (MADRID) participant 271˙250.00
8    STICHTING CENTRUM VOOR WISKUNDE EN INFORMATICA NL (AMSTERDAM) participant 0.00

Map

 Project objective

Computerized Tomography (CT) has been one of the greatest achievements in medical imaging, but at the cost of a high, potentially harmful, X-ray irradiation dose. The ultimate goal of VOXEL is to provide an alternative to tomography with a disruptive technology enabling 3D X-ray imaging at very low dose. VOXEL aims at prototyping new cameras that will combine the X-ray penetration and nanometre spatial resolution, easiness to use, afforded by avoiding the rotation of the source or the sample, and extremely low dose for maximum impact on medicine and biology. VOXEL relies on the integration of trans-disciplinary fields in medical imaging, optics, X-ray physics, applied mathematics and value to society through foreseeable commercialization. VOXEL aims at prototyping in parallel a soft X-ray “water window” microscope and a hard X-ray 3D camera for medical applications. While both cameras need groundbreaking development in the underlying physics, only hard X-ray camera has high technological risk (and high societal impact). VOXEL will benefit from the soft X-ray camera thanks to its Biological applications in nano-tomography but also as a test platform for our physical and mathematical models.. The VOXEL team members are leaders in X-ray metrology, wavefront sensing, atomic physic, mathematical computing and 3D medical imaging; with VOXEL we are uniquely positioned to succeed, and to raise the competitiveness of Europe. Doing so by basing the research lead in Portugal with a woman coordinator will be exemplary: beyond the scientific and technological success, thanks to our focus in science and its valorisation, VOXEL will be transformative for scientifically emerging countries.

 Deliverables

List of deliverables.
Data Management plan update Open Research Data Pilot 2020-02-26 11:29:37
Manufacturing hard X-ray light field prototypes Demonstrators, pilots, prototypes 2020-02-26 11:29:37
Report with the measured performances of the different X-ray optics Documents, reports 2020-02-26 11:29:34
Optics XUV test for integration in the prototype (matrix plus enhanced lens) Documents, reports 2020-02-26 11:29:34
Manufacturing soft X-ray light field prototypes Demonstrators, pilots, prototypes 2020-02-26 11:29:34
Optics X-Ray test for integration in the prototype (matrix plus enhanced lens) Documents, reports 2020-02-26 11:29:37
Report on plenoptic camera theory for X-rays Documents, reports 2020-02-26 11:29:34
Conceptual design reports for hard X-ray light field cameras Documents, reports 2020-02-26 11:29:33
Conceptual design reports for soft XUV light field cameras Documents, reports 2020-02-26 11:29:33
Website with open and secured sessions Websites, patent fillings, videos etc. 2020-02-26 11:29:34
Report with the measured performances of the different XUV optics Documents, reports 2020-02-26 11:29:34

Take a look to the deliverables list in detail:  detailed list of VOXEL deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Samaan, Julien
Étude et applications de l\'imagerie sans lentille par diffraction cohérente
published pages: , ISSN: , DOI:
\"Optique [physics.optics]. Université Paris-Saclay, 2016. Français. ⟨NNT : 2016SACLS557⟩\" 2 2020-02-26
2017 Cassin, Rémy
Imagerie nanométrique ultra-rapide par diffraction cohérente de rayonnement XUV produit par génération d\'harmoniques d\'ordre élevés
published pages: , ISSN: , DOI:
https://tel.archives-ouvertes.fr/tel-01664520 2 2020-02-26
2018 Lorenzo Massimi, Francesco Brun, Michela Fratini, Inna Bukreeva, Alessia Cedola
An improved ring removal procedure for in-line x-ray phase contrast tomography
published pages: 45007, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaa706
Physics in Medicine & Biology 63/4 2020-02-26
2016 Schumaker, W.; Brown, S.; Curry, C.; Gauthier, M.; Gamboa, E.; Goede, S.; Fletcher, L.; Kim, J.; MacDonald, M.; Mishra, R.; Roedel, C.; Glenzer, S.; Fiuza, F.; Granados, E.; Nagler, B.; Zhou, Z.; MacKinnon, A.; Obst, L.; Ziel, K.; Pak, A.; Williams, G.; Fajardo, M.
Phase contrast imaging of high-intensity laser hole boring of solid-density wires at LCLS-MEC
published pages: , ISSN: , DOI:
2020-02-26
2019 Joana Duarte
Novel computational and experimental methods 2D and 3D soft X-ray lensless imaging
published pages: , ISSN: , DOI:
2020-02-26
2018 E. Longo
From X-ray tomography to the first X-ray plenoptic camera for nanoparticles bio-localization
published pages: , ISSN: , DOI:
2020-02-26
2019 Lorenzo Massimi, Inna Bukreeva, Giulia Santamaria, Michela Fratini, Alessandro Corbelli, Francesco Brun, Stefano Fumagalli, Laura Maugeri, Alexandra Pacureanu, Peter Cloetens, Nicola Pieroni, Fabio Fiordaliso, Gianluigi Forloni, Antonio Uccelli, Nicole Kerlero de Rosbo, Claudia Balducci, Alessia Cedola
Exploring Alzheimer\'s disease mouse brain through X-ray phase contrast tomography: From the cell to the organ
published pages: 490-495, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.09.044
NeuroImage 184 2020-02-26
2017 Hamed Merdji
Ultrafast nanoscale imaging using high order harmonic generation (Conference Presentation)
published pages: , ISSN: , DOI:
2020-02-26
2015 Merdji H.
Lensless Imaging using high order harmonic generation
published pages: , ISSN: , DOI:
2020-02-26
2018 Eduardo Oliva, Adrien Depresseux, Manuel Cotelo, Agustín Lifschitz, Fabien Tissandier, Julien Gautier, Gilles Maynard, Pedro Velarde, Stéphane Sebban
Hydrodynamic evolution of plasma waveguides for soft-x-ray amplifiers
published pages: , ISSN: 2470-0045, DOI: 10.1103/physreve.97.023203
Physical Review E 97/2 2020-02-26
2018 Philippe Zeitoun; Domenico Alj; Hugo Dacasa; Ombeline de La Rochefoucauld
Compact metrology beamline for EUV optic and test of adaptive optic
published pages: , ISSN: , DOI:
2020-02-26
2019 Gareth O. Williams, H.-K. Chung, S. Künzel, V. Hilbert, U. Zastrau, H. Scott, S. Daboussi, B. Iwan, A. I. Gonzalez, W. Boutu, H. J. Lee, B. Nagler, E. Granados, 8 E. Galtier, P. Heimann, B. Barbrel, R. W. Lee, B. I. Cho, P. Renaudin, H. Merdji, Ph. Zeitoun, M. Fajardo
The impact of free electron degeneracy on collisional rates in plasmas
published pages: , ISSN: , DOI:
2020-02-26
2019 Williams, Gareth O.; Chung, H. -K.; Künzel, S.; Hilbert, V.; Zastrau, U.; Scott, H.; Daboussi, S.; Iwan, B.; Gonzalez, A. I.; Boutu, W.; Lee, H. J.; Nagler, B.; Granados, E.; Galtier, 8 E.; Heimann, P.; Barbrel, B.; Lee, R. W.; Cho, B. I.; Renaudin, P.; Merdji, H.; Zeitoun, Ph.; Fajardo, M.
The impact of free electron degeneracy on collisional rates in plasmas
published pages: , ISSN: , DOI:
3 2020-02-26
2019 Maddalena Mastrogiacomo, Gaetano Campi, Ranieri Cancedda, Alessia Cedola
Synchrotron radiation techniques boost the research in bone tissue engineering
published pages: 33-46, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.03.031
Acta Biomaterialia 89 2020-02-26
2018 Laura Maugeri, Mauro DiNuzzo, Marta Moraschi, Charles Nicaise, Inna Bukreeva, Fabio Mangini, Federico Giove, Alessia Cedola, Michela Fratini
Fractal Dimension Analysis of High-Resolution X-Ray Phase Contrast Micro-Tomography Images at Different Threshold Levels in a Mouse Spinal Cord
published pages: 48, ISSN: 2410-3896, DOI: 10.3390/condmat3040048
Condensed Matter 3/4 2020-02-26
2016 Merdji H.
2D and 3D nanoscale imaging using high order harmonic generation
published pages: , ISSN: , DOI:
2020-02-26
2017 Rémy Cassin
Ultrafast lensless imaging and applications 
published pages: , ISSN: , DOI:
2020-02-26
2018 Liping Shi, Rana Nicolas, Jose R. C. Andrade, Willem Boutu, Dominik Franz, Torsten Heidenblut, Carsten Reinhardt, Uwe Morgner, Hamed Merdji, Milutin Kovacev
Impact of Plasmon-Induced Atoms Migration in Harmonic Generation
published pages: 1208-1214, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.7b01560
ACS Photonics 5/4 2020-02-26
2019 Michele Natile
Pulse compression and CEP stabilization of Ytterbium fiber laser: application to high harmonic generation
published pages: , ISSN: , DOI:
2020-02-26
2017 S. Kunzel
Characterization, optimization and applications of coherent XUV sources
published pages: , ISSN: , DOI:
2020-02-26
2018 Nicola Viganò, Henri Der Sarkissian, Charlotte Herzog, Ombeline de la Rochefoucauld, Robert van Liere, Kees Joost Batenburg
Tomographic approach for the quantitative scene reconstruction from light field images
published pages: 22574, ISSN: 1094-4087, DOI: 10.1364/oe.26.022574
Optics Express 26/18 2020-02-26
2018 Q. Y. van den Berg, E. V. Fernandez-Tello, T. Burian, J. Chalupský, H.-K Chung, O. Ciricosta, G. L. Dakovski, V. Hájková, P. Hollebon, L. Juha, J. Krzywinski, R. W. Lee, M. P. Minitti, T. R. Preston, A. G. de la Varga, V. Vozda, U. Zastrau, J. S. Wark, P. Velarde, S. M. Vinko
Clocking Femtosecond Collisional Dynamics via Resonant X-Ray Spectroscopy
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.120.055002
Physical Review Letters 120/5 2020-02-26
2017 Merdji H
Nanoplasmonic amplification of laser harmonics
published pages: , ISSN: , DOI:
2020-02-26
2018 P. Estrela
X-Ray Optics
published pages: , ISSN: , DOI:
2020-02-26
2018 N. Viganò, W. Ludwig
Advances in 6d diffraction contrast tomography
published pages: C04017-C04017, ISSN: 1748-0221, DOI: 10.1088/1748-0221/13/04/C04017
Journal of Instrumentation 13/04 2020-02-26
2019 Ramona Corman
Table-top lensless imaging applications in biology
published pages: , ISSN: , DOI:
2020-02-26
2015 Gareth O. Williams, A. I. Gonzalez, S. Künzel, L. Li, M. Lozano, E. Oliva, B. Iwan, S. Daboussi, W. Boutu, H. Merdji, M. Fajardo, Ph. Zeitoun
Fourier transform holography with high harmonic spectra for attosecond imaging applications
published pages: 3205, ISSN: 0146-9592, DOI: 10.1364/ol.40.003205
Optics Letters 40/13 2020-02-26
2015 Boutu W
Imaging dynamics with (sub-)femtosecond and nanometer resolutions
published pages: , ISSN: , DOI:
2020-02-26
2019 Domingo García-Senz, Pedro Velarde, Francisco Suzuki-Vidal, Chantal Stehlé, Manuel Cotelo, David Portillo, Tomasz Plewa, Arthur Pak
Interaction of Hemispherical Blast Waves with Inhomogeneous Spheres: Probing the Collision of a Supernova Ejecta with a Nearby Companion Star in the Laboratory
published pages: 177, ISSN: 1538-4357, DOI: 10.3847/1538-4357/aaf894
The Astrophysical Journal 871/2 2020-02-26
2018 Marta Fajardo, Richard Dendy
44th European physical society conference on plasma physics
published pages: 10101, ISSN: 0741-3335, DOI: 10.1088/1361-6587/aa9775
Plasma Physics and Controlled Fusion 60/1 2020-02-26
2015 Merdji H.
3D nanoscale lensless imaging using high harmonic generation
published pages: , ISSN: , DOI:
2020-02-26
2017 Merdji H.
Nanoscale single view 3D imaging based on hybrid phase retrieval and in-line holography imaging
published pages: , ISSN: , DOI:
2020-02-26
2019 J. Duarte, R. Cassin, J. Huijts, B. Iwan, F. Fortuna, L. Delbecq, H. Chapman, M. Fajardo, M. Kovacev, W. Boutu, H. Merdji
Computed stereo lensless X-ray imaging
published pages: 449-453, ISSN: 1749-4885, DOI: 10.1038/s41566-019-0419-1
Nature Photonics 13/7 2020-02-26
2017 Cassin, Rémy
Imagerie nanométrique ultra-rapide par diffraction cohérente de rayonnement XUV produit par génération d\'harmoniques d\'ordre élevés
published pages: , ISSN: , DOI:
\"Physique des Hautes Energies - Expérience [hep-ex]. Université Paris-Saclay, 2017. Français. 〈NNT : 2017SACLS591〉\" 2 2020-02-26
2016 Julien Samaan
Prototyping a lenless microscope 
published pages: , ISSN: , DOI:
2020-02-26
2018 G. Williams
X-ray based plasma diagnostics
published pages: , ISSN: , DOI:
2020-02-26
2018 J. Koliyadu
Spatio-temporal characterization of high harmonic generation for plasma diagnostics
published pages: , ISSN: , DOI:
2020-02-26
2018 E. Stefanutti, A. Sierra, P. Miocchi, L. Massimi, F. Brun, L. Maugeri, I. Bukreeva, A. Nurmi, G. Begani Provinciali, G. Tromba, O. Gröhn, F. Giove, A. Cedola, M. Fratini
Assessment of the effects of different sample perfusion procedures on phase-contrast tomographic images of mouse spinal cord
published pages: C03027-C03027, ISSN: 1748-0221, DOI: 10.1088/1748-0221/13/03/C03027
Journal of Instrumentation 13/03 2020-02-26
2015 Boutu W, Ducousso M, Hergott JF, Merdji H
HHG high flux sources
published pages: , ISSN: , DOI:
Optical Technologies for Extreme-Ultraviolet and Soft X-ray Coherent Sources 2020-02-26
2018 G. Williams, M. Fajardo
The impact of free electron degeneracy on collisional rates in plasmas
published pages: , ISSN: , DOI:
2020-02-26
2018 Julius Huijts
Attosecond lensless imaging
published pages: , ISSN: , DOI:
2020-02-26
2019 Nicola Viganò, Pablo Martínez Gil, Charlotte Herzog, Ombeline de la Rochefoucauld, Robert van Liere, Kees Joost Batenburg
Advanced light-field refocusing through tomographic modeling of the photographed scene
published pages: 7834, ISSN: 1094-4087, DOI: 10.1364/oe.27.007834
Optics Express 27/6 2020-02-26
2016 I. Bukreeva, A. Mittone, A. Bravin, G. Festa, M. Alessandrelli, P. Coan, V. Formoso, R. G. Agostino, M. Giocondo, F. Ciuchi, M. Fratini, L. Massimi, A. Lamarra, C. Andreani, R. Bartolino, G. Gigli, G. Ranocchia, A. Cedola
Virtual unrolling and deciphering of Herculaneum papyri by X-ray phase-contrast tomography
published pages: 27227, ISSN: 2045-2322, DOI: 10.1038/srep27227
Scientific Reports 6 2020-02-26

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