Explore the words cloud of the VERTICAL CITY project. It provides you a very rough idea of what is the project "VERTICAL CITY" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||1˙964˙199 €|
|EC max contribution||1˙964˙199 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2021-05-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||1˙964˙199.00|
Receptors and associated scaffolds, together called receptosome, are relatively stable structures, but exchange of individual adaptor proteins can occur on a short time scale and in a highly regulated manner, which provides fine-tuning, speed, and specificity to the receptor signaling. Therefore, understanding how receptor function is affected by the composition and dynamics of complexes is an essential biological concern that will offer the opportunity to target exclusively the therapeutically relevant signaling pathway of a given receptor. We propose that in the brain, receptosome dynamics is involved in fine-tuning synaptic transmission and plasticity, which might be crucial for cognitive functions. First, we will establish the link between molecular events, neuronal signaling and memory performance. More than correlations, this project proposes live recording of molecular events and cellular signaling during memory encoding. Second, new specific therapeutic targets will be proposed for the treatment of cognitive deficiencies: instead of interfering with the ligand-biding pocket of the receptor, we propose to target specific scaffold interactions. This strategy will only modify a specific altered function of a receptor without modifying other functions (thus, avoiding undesired side effects). Third, within the scope of this proposal, we will develop innovative, powerful techniques that will be of high interest for a broad community of researchers in life sciences. These technologies will enable to monitor the versatility of protein-protein interactions in space and time ranging from in cellulo to in vivo BRET imaging in freely behaving animals. To conclude, we will establish the functional significance of oligomer remodeling in the physiological synaptic plasticity and try to restore it in neurological disorders.
|year||authors and title||journal||last update|
Elise Goyet, Nathalie Bouquier, Vincent Ollendorff, Julie Perroy
Fast and high resolution single-cell BRET imaging
published pages: 28231, ISSN: 2045-2322, DOI: 10.1038/srep28231
|Scientific Reports 6||2019-09-02|
Laura Ceolin, Nathalie Bouquier, Jihane Vitre-Boubaker, StÃ©phanie Rialle, Dany Severac, Emmanuel Valjent, Julie Perroy, Emma Puighermanal
Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00340
|Frontiers in Molecular Neuroscience 10||2019-09-02|
Yan Chastagnier, Enora Moutin, Anne-Laure Hemonnot, Julie Perroy
Image Processing for Bioluminescence Resonance Energy Transfer Measurementâ€”BRET-Analyzer
published pages: , ISSN: 1662-5188, DOI: 10.3389/fncom.2017.00118
|Frontiers in Computational Neuroscience 11||2019-09-02|
Weirui Guo, Laura Ceolin, Katie A. Collins, Julie Perroy, Kimberly M. Huber
Elevated CaMKIIÎ± and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model
published pages: , ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.11.013
A. A. Pradhan, J. Perroy, W. M. Walwyn, M. L. Smith, A. Vicente-Sanchez, L. Segura, A. Bana, B. L. Kieffer, C. J. Evans
Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function
published pages: 3541-3551, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.4124-15.2016
|Journal of Neuroscience 36/12||2019-09-02|
Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding
published pages: , ISSN: , DOI: 10.1007/7355_2017_2
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