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VERTICAL CITY SIGNED

Versatility of scaffold complexes in vivo to control synaptic plasticity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VERTICAL CITY project word cloud

Explore the words cloud of the VERTICAL CITY project. It provides you a very rough idea of what is the project "VERTICAL CITY" about.

scaffold    recording    strategy    cognitive    animals    structures    first    conclude    correlations    memory    time    oligomer    space    physiological    functions    opportunity    interactions    signaling    techniques    therapeutically    tuning    encoding    composition    sciences    avoiding    neurological    stable    events    dynamics    proteins    complexes    performance    treatment    significance    relatively    community    remodeling    provides    individual    modify    modifying    imaging    receptor    link    biding    biological    technologies    behaving    exchange    proposes    cellular    fine    synaptic    scope    ranging    manner    exclusively    protein    brain    altered    restore    undesired    transmission    powerful    monitor    scaffolds    life    adaptor    function    receptors    ligand    broad    cellulo    molecular    specificity    receptosome    instead    disorders    pocket    speed    neuronal    bret    functional    live    regulated    plasticity    interfering    innovative    deficiencies    vivo    versatility    therapeutic   

Project "VERTICAL CITY" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙964˙199 €
 EC max contribution 1˙964˙199 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙964˙199.00

Map

 Project objective

Receptors and associated scaffolds, together called receptosome, are relatively stable structures, but exchange of individual adaptor proteins can occur on a short time scale and in a highly regulated manner, which provides fine-tuning, speed, and specificity to the receptor signaling. Therefore, understanding how receptor function is affected by the composition and dynamics of complexes is an essential biological concern that will offer the opportunity to target exclusively the therapeutically relevant signaling pathway of a given receptor. We propose that in the brain, receptosome dynamics is involved in fine-tuning synaptic transmission and plasticity, which might be crucial for cognitive functions. First, we will establish the link between molecular events, neuronal signaling and memory performance. More than correlations, this project proposes live recording of molecular events and cellular signaling during memory encoding. Second, new specific therapeutic targets will be proposed for the treatment of cognitive deficiencies: instead of interfering with the ligand-biding pocket of the receptor, we propose to target specific scaffold interactions. This strategy will only modify a specific altered function of a receptor without modifying other functions (thus, avoiding undesired side effects). Third, within the scope of this proposal, we will develop innovative, powerful techniques that will be of high interest for a broad community of researchers in life sciences. These technologies will enable to monitor the versatility of protein-protein interactions in space and time ranging from in cellulo to in vivo BRET imaging in freely behaving animals. To conclude, we will establish the functional significance of oligomer remodeling in the physiological synaptic plasticity and try to restore it in neurological disorders.

 Publications

year authors and title journal last update
List of publications.
2016 Elise Goyet, Nathalie Bouquier, Vincent Ollendorff, Julie Perroy
Fast and high resolution single-cell BRET imaging
published pages: 28231, ISSN: 2045-2322, DOI: 10.1038/srep28231
Scientific Reports 6 2019-09-02
2017 Laura Ceolin, Nathalie Bouquier, Jihane Vitre-Boubaker, Stéphanie Rialle, Dany Severac, Emmanuel Valjent, Julie Perroy, Emma Puighermanal
Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00340
Frontiers in Molecular Neuroscience 10 2019-09-02
2018 Yan Chastagnier, Enora Moutin, Anne-Laure Hemonnot, Julie Perroy
Image Processing for Bioluminescence Resonance Energy Transfer Measurement—BRET-Analyzer
published pages: , ISSN: 1662-5188, DOI: 10.3389/fncom.2017.00118
Frontiers in Computational Neuroscience 11 2019-09-02
2015 Weirui Guo, Laura Ceolin, Katie A. Collins, Julie Perroy, Kimberly M. Huber
Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model
published pages: , ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.11.013
Cell reports 2019-09-02
2016 A. A. Pradhan, J. Perroy, W. M. Walwyn, M. L. Smith, A. Vicente-Sanchez, L. Segura, A. Bana, B. L. Kieffer, C. J. Evans
Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function
published pages: 3541-3551, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.4124-15.2016
Journal of Neuroscience 36/12 2019-09-02
2017 Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding
published pages: , ISSN: , DOI: 10.1007/7355_2017_2
2019-09-02

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