Explore the words cloud of the METALS project. It provides you a very rough idea of what is the project "METALS" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||1˙798˙750 €|
|EC max contribution||1˙798˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2021-02-28|
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|1||SYDDANSK UNIVERSITET||DK (ODENSE M)||coordinator||1˙798˙750.00|
The chemistry of metals is rich and viewed in a biological context its diversity is crucial for a multitude of molecular functions in the living cell. Many of these reactions are very attractive to both academia and industry. In this proposal, I plan to develop novel applications of metal compounds to solve immediate challenges in mass spectrometry-based proteome research, but also will assess the potential risks of using nano-sized metals in our society. First, it is important to develop an efficient enzyme-independent method to synthesize large amounts of biologically relevant C-terminal amidated peptides. Presently, C-terminal peptide amidation poses a challenge in pharmaceutical production due to limitations of the two enzymes used for this purpose. The suggested approach in METALS will examine the specific binding of uranyl to artificially phosphorylated recombinant peptides. Data reveal that subsequent UV irradiation produces C-terminal amidated peptides. I will attempt to minimize the bias inherent in current phosphopeptide analysis, which comes from inefficient inhibition of phosphatases during cell lysis. Application of a recently developed gallium complex during cell lysis should limit the extent of this bias by binding phosphorylated proteins. The neutral conditions involved with the gallium complex reaction should also facilitate the possibility of enrichment of acid labile phospho-histidine peptides of which only a handful have been characterized. Finally, humans are now exposed to increasing amounts of artificially nano-metals applied via consumer products, food packages, and cosmetics. I will investigate this problem using advanced mass spectrometry, confocal microscopy, and biochemical assays of the response of human neural cells to nano-metal particles. The particular focus area will be to elucidate whether the action of nanoparticles in human neural cells may shed new light on understanding of diseases like Parkinson´s disease.
|year||authors and title||journal||last update|
Anja M. Billing, Kristina B. Knudsen, Andrew J. Chetwynd, Laura-Jayne A. Ellis, Selina V.Y. Tang, Trine Berthing, HÃ¥kan Wallin, Iseult Lynch, Ulla Vogel, Frank Kjeldsen
Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.9b08818
Julia A. Bubis, Daria S. Spasskaya, Vladimir A. Gorshkov, Frank Kjeldsen, Aleksandra M. Kofanova, Dmitry S. Lekanov, Mikhail V. Gorshkov, Vadim L. Karpov, Irina A. Tarasova, Dmitry S. Karpov
Rpn4 and proteasome-mediated yeast resistance to ethanol includes regulation of autophagy
published pages: , ISSN: 0175-7598, DOI: 10.1007/s00253-020-10518-x
|Applied Microbiology and Biotechnology||2020-03-24|
Mark V. Ivanov, Julia A. Bubis, Vladimir Gorshkov, Irina A. Tarasova, Lev I. Levitsky, Anna A. Lobas, Elizaveta M. Solovyeva, Marina L. Pridatchenko, Frank Kjeldsen, Mikhail V. Gorshkov
DirectMS1: MS/MS-Free Identification of 1000 Proteins of Cellular Proteomes in 5 Minutes
published pages: , ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b05095
Asif Manzoor Khan, Barbara Korzeniowska, Vladimir Gorshkov, Muhammad Tahir, Henrik SchrÃ¸der, Lilian Skytte, Kaare Lund Rasmussen, Surabhi Khandige, Jakob MÃ¸ller-Jensen, Frank Kjeldsen
Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model
published pages: 221-239, ISSN: 1743-5390, DOI: 10.1080/17435390.2018.1540728
Roberto Gonzalez-Pizarro, Graziella Parrotta, Rodrigo Vera, Elena SÃ¡nchez-LÃ³pez, Ruth Galindo, Frank Kjeldsen, Josefa Badia, Laura Baldoma, Marta Espina, MarÃa L GarcÃa
Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
published pages: 3089-3104, ISSN: 1743-5889, DOI: 10.2217/nnm-2019-0201
Vladimir Gorshkov, Julia A. Bubis, Elizaveta M. Solovyeva, Mikhail V. Gorshkov, Frank Kjeldsen
Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution
published pages: 1089-1098, ISSN: 2051-8153, DOI: 10.1039/c8en01054d
|Environmental Science: Nano 6/4||2020-03-11|
Diana Paola GÃ³mez-Mendoza, FÃºlvia Dias Marques, Marcella Nunes Melo-Braga, Richard R. Sprenger, RubÃ©n Dario Sinisterra, Frank Kjeldsen, Robson Augusto Santos, Thiago Verano-Braga
Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4
published pages: 103486, ISSN: 1874-3919, DOI: 10.1016/j.jprot.2019.103486
|Journal of Proteomics 208||2020-03-11|
Lucas Rodrigues-Ribeiro, Marcella Nunes Melo-Braga, Frank Kjeldsen, Diana Paola GÃ³mez-Mendoza, Thiago Verano-Braga
Assessment of protein extraction and digestion efficiency of well-established shotgun protocols for heart proteomics
published pages: 51-59, ISSN: 0003-2697, DOI: 10.1016/j.ab.2019.05.006
|Analytical Biochemistry 578||2020-03-11|
Vladimir Gorshkov, StÃ©phanie Yuki Kolbeck Hotta, Thiago Verano-Braga, Frank Kjeldsen
Peptide de novo sequencing of mixture tandem mass spectra
published pages: 2470-2479, ISSN: 1615-9853, DOI: 10.1002/pmic.201500549
Rasmus Linde Bang Elnegaard, Niels Erik MÃ¸llegaard, Qiang Zhang, Frank Kjeldsen, Thomas J.D. JÃ¸rgensen
Uranyl photocleavage of phosphopeptides yields truncated C-terminally amidated peptide products
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201700103
Irina A Tarasova, Alesya V Tereshkova, Anna A Lobas, Elizaveta M Solovyeva, Alena S Sidorenko, Vladimir Gorshkov, Frank Kjeldsen, Julia A Bubis, Mark V Ivanov, Irina Y Ilina, Sergei A Moshkovskii, Peter M Chumakov, Mikhail V Gorshkov
Comparative proteomics as a tool for identifying specific alterations within interferon response pathways in human glioblastoma multiforme cells
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.22751
Renata Rank Miranda, Arandi Ginane Bezerra Jr, Ciro Alberto Oliveira Ribeiro, Marco AntÃ´nio Ferreira Randi, Carmen LÃºcia Voigt, Lilian Skytte, Kaare Lund Rasmussen, Frank Kjeldsen, Francisco Filipak Neto
Toxicological interactions of silver nanoparticles and non-essential metals in human hepatocarcinoma cell line
published pages: 134-143, ISSN: 0887-2333, DOI: 10.1016/j.tiv.2017.01.003
|Toxicology in Vitro 40||2019-05-30|
Renata Rank Miranda, Vladimir Gorshkov, Barbara Korzeniowska, Stefan J. Kempf, Francisco Filipak Neto, Frank Kjeldsen
Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells
published pages: 781-795, ISSN: 1743-5390, DOI: 10.1080/17435390.2018.1489987
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