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Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia

Total Cost €


EC-Contrib. €






Project "TREATMENT" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 3˙750˙898 €
 EC max contribution 3˙750˙898 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    UPPSALA UNIVERSITET SE (UPPSALA) participant 527˙318.00
7    NIMGENETICS, GENOMICA Y MEDICINA S.L. ES (MADRID) participant 247˙872.00
8    BNML BEHAVIORAL & MOLECULAR LAB PT (BRAGA) participant 238˙356.00
9    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 234˙997.00


 Project objective

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients require life-long medications that subsequently trigger metabolic diseases with a strong negative impact on their health and well-being. To achieve this, and improve adherence to treatments, we will evaluate how short-term antipsychotic drug responses impact long-term metabolic control to identify and validate biomarkers with clinically predictive value for targeting drug induced metabolic dysfunctions. This effort will have added commercial value by enabling the design of predictive marker kits for testing adverse secondary metabolic effects of drugs to be used in pharmacological and medical practice. TREATMENT will provide multidisciplinary knowledge, capabilities and tools to implement this ambitious strategy by the training of young scientists in a program that combines pharmacology, metabolism and mental health research with strategies for product and tool design and validation. Our ultimate goal is to empower the intersectorial and trans-national employability of young scientists across academic, public and private sectors to foster the development and implementation of personalized medicine tools that will provide effective treatment regimens for life long health-care interventions and decrease the risk for development of chronic metabolic diseases.


List of deliverables.
Dissemination report 1 Documents, reports 2020-02-25 14:39:42
Research Training schools/Meetings, and reports 3 Documents, reports 2020-02-25 14:39:42
Researchers Declarations Other 2020-02-25 14:39:42
Open Research Data Pilot Open Research Data Pilot 2020-02-25 14:39:42
Supervisory Board of the network Other 2020-02-25 14:39:42

Take a look to the deliverables list in detail:  detailed list of TREATMENT deliverables.


year authors and title journal last update
List of publications.
2020 Ignacio Prieto, Carmen Rubio Alarcón, Raquel García-Gómez, Rebeca Berdún, Tamara Urgel, Manuel Portero, Reinald Pamplona, Antonio Martínez-Ruiz, José Ignacio Ruiz-Sanz, M. Begoña Ruiz-Larrea, Mariona Jove, Sebastián Cerdán, María Monsalve
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
published pages: 101396, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101396
Redox Biology 29 2020-03-06
2019 Ignacio Prieto, Alberto Zambrano, Javier Laso, Ana Aranda, Enrique Samper, María Monsalve
Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
published pages: 23-32, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.04.015
Free Radical Biology and Medicine 138 2020-03-06
2019 Dora Koller, Pablo Zubiaur, Miriam Saiz-Rodríguez, Francisco Abad-Santos, Aneta Wojnicz
Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation
published pages: 159-168, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2019.01.112
Talanta 198 2020-03-06
2020 Akram Obiedat, Yoav Charpak-Amikam, Julie Tai-Schmiedel, Einat Seidel, Mohamed Mahameed, Tony Avril, Noam Stern-Ginossar, Lorraine Springuel, Jennifer Bolsée, David E. Gilham, Priya Dipta, Miriam Shmuel, Eric Chevet, Ofer Mandelboim, Boaz Tirosh
The integrated stress response promotes B7H6 expression
published pages: 135-148, ISSN: 0946-2716, DOI: 10.1007/s00109-019-01859-w
Journal of Molecular Medicine 98/1 2020-03-06
2019 Anja Šoštarič, Barbara Jenko, Nada Rotovnik Kozjek, Darja Ovijač, Dušan Šuput, Irina Milisav, Vita Dolžan
Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention
published pages: 1184-1194, ISSN: 1734-1922, DOI: 10.5114/aoms.2019.87462
Archives of Medical Science 15/5 2020-02-25
2020 Vitor Ferreira, Diana Grajales, Ángela M. Valverde
Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view
published pages: 158534, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2019.158534
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865/2 2020-02-25
2019 Izak Patrik Miller, Ivan Pavlović, Borut Poljšak, Dušan Šuput, Irina Milisav
Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival
published pages: 434, ISSN: 2076-3921, DOI: 10.3390/antiox8100434
Antioxidants 8/10 2020-02-25
2019 Diana Grajales, Vitor Ferreira, Ángela M. Valverde
Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain
published pages: 1336, ISSN: 2073-4409, DOI: 10.3390/cells8111336
Cells 8/11 2020-02-25
2018 M.C. Ovejero-Benito, P. Sánchez-Jiménez, M. Saiz-Rodríguez, S. Martín-Vilchez, T. Cabaleiro, M. Román, D. Ochoa, F. Abad-Santos, A. Reolid, E. Muñoz-Aceituno, M. Llamas-Velasco, E. Daudén, F. Abad-Santos
Histone modifications associated with nonconventional systemic drug response in moderate-to-severe psoriasis.
published pages: , ISSN: 2531-0151, DOI: 10.24217/2531-0151.18v1s1.00007
IBJ Plus 2020-02-25
2018 M. Pilar Valdecantos, Laura Ruiz, Virginia Pardo, Luis Castro-Sanchez, Carmelo García-Monzón, Borja Lanzón, Javier Rupérez, Coral Barbas, Jaqueline Naylor, James L. Trevaskis, Joseph Grimsby, Cristina M. Rondinone, Ángela M. Valverde
Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33949-z
Scientific Reports 8/1 2020-02-25
2019 Alessandra Stacchiotti, Ilaria Grossi, Raquel García-Gómez, Gaurangkumar Arvindbhai Patel, Alessandro Salvi, Antonio Lavazza, Giuseppina De Petro, Maria Monsalve, Rita Rezzani
Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy
published pages: 1053, ISSN: 2073-4409, DOI: 10.3390/cells8091053
Cells 8/9 2020-02-25
2018 Miriam Saiz-Rodríguez, Dolores Ochoa, Coral Herrador, Carmen Belmonte, Manuel Román, Enrique Alday, Dora Koller, Pablo Zubiaur, Gina Mejía, María Hernández-Martínez, Francisco Abad-Santos
Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects
published pages: , ISSN: 1742-7835, DOI: 10.1111/bcpt.13141
Basic & Clinical Pharmacology & Toxicology 2020-02-25
2018 Catía Marques, Assel Sarsenbayeva, Gretha Boersma, Maria João Pereira, Jan Eriksson, Angela Valverde, Angela Valverde, Eugénia Carvalho
Effects of olanzapine and aripiprazole on glucose uptake in healthy human subcutaneous adipocytes during short incubations.
published pages: , ISSN: 2531-0151, DOI: 10.24217/2531-0151.18v1s1.00008
IBJ Plus 2020-02-25
2018 Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Maria Monsalve, Luigi Rodella, Rita Rezzani
Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney
published pages: 689, ISSN: 2072-6643, DOI: 10.3390/nu10060689
Nutrients 10/6 2020-02-25
2018 Miriam Saiz-Rodríguez, Daniel Romero-Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo Bárcena, María Talegón, Francisco Abad-Santos
Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure
published pages: , ISSN: 0009-9236, DOI: 10.1002/cpt.1067
Clinical Pharmacology & Therapeutics 2020-02-25
2019 Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury
published pages: dmm038810, ISSN: 1754-8403, DOI: 10.1242/dmm.038810
Disease Models & Mechanisms 12/7 2020-02-25
2019 Assel Sarsenbayeva, Cátia M. Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E. Almby, Martin Lundqvist, Jan W. Eriksson, Maria J. Pereira
Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism
published pages: 104445, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2019.104445
Psychoneuroendocrinology 2020-02-25
2018 Elena Alcalde-Estévez, Ana I. Arroba, Elena M. Sánchez-Fernández, Carmen Ortiz Mellet, Jose M. García Fernández, Laura Masgrau, Ángela M. Valverde
The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5 N ,6 O -oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants
published pages: 454-466, ISSN: 0278-6915, DOI: 10.1016/j.fct.2017.11.050
Food and Chemical Toxicology 111 2020-02-25
2018 Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos
Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects
published pages: 1212-1222, ISSN: 0269-8811, DOI: 10.1177/0269881118798605
Journal of Psychopharmacology 32/11 2020-02-25
2017 M Morais, P Patrício, A Mateus-Pinheiro, N D Alves, A R Machado-Santos, J S Correia, J Pereira, L Pinto, N Sousa, J M Bessa
The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression
published pages: e1146, ISSN: 2158-3188, DOI: 10.1038/tp.2017.120
Translational Psychiatry 7/6 2020-02-25
2019 Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde
Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases
published pages: 101263, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101263
Redox Biology 26 2020-02-25
2018 Ana I. Arroba, Antonio Campos-Caro, Manuel Aguilar-Diosdado, Ángela M. Valverde
IGF-1, Inflammation and Retinal Degeneration: A Close Network
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2018.00203
Frontiers in Aging Neuroscience 10 2020-02-25
2018 Miriam Saiz-Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina Mejía, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos
Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants
published pages: 474-485, ISSN: 1742-7835, DOI: 10.1111/bcpt.13031
Basic & Clinical Pharmacology & Toxicology 123/4 2020-02-25
2018 Marina Mojena, María Pimentel-Santillana, Adrián Povo-Retana, Victoria Fernández-García, Silvia González-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma Martín-Sanz, Angela M. Valverde, Lisardo Boscá
Protection against gamma-radiation injury by protein tyrosine phosphatase 1B
published pages: 213-223, ISSN: 2213-2317, DOI: 10.1016/j.redox.2018.04.018
Redox Biology 17 2020-02-25
2019 Martin H. Lundqvist, Kristina Almby, Niclas Abrahamsson, Jan W. Eriksson
Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00457
Frontiers in Physiology 10 2020-02-25
2019 Špela Šalamon, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, Irina Milisav
Medical and Dietary Uses of N-Acetylcysteine
published pages: 111, ISSN: 2076-3921, DOI: 10.3390/antiox8050111
Antioxidants 8/5 2020-02-25
2018 Águeda González-Rodríguez, M. Pilar Valdecantos, Patricia Rada, Annalisa Addante, Inés Barahona, Esther Rey, Virginia Pardo, Laura Ruiz, Laura M. Laiglesia, María J. Moreno-Aliaga, Carmelo García-Monzón, Aránzazu Sánchez, Ángela M. Valverde
Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis
published pages: 132-146, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.10.008
Molecular Metabolism 7 2020-02-25

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