Explore the words cloud of the StressNetAdapt project. It provides you a very rough idea of what is the project "StressNetAdapt" about.
The following table provides information about the project.
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
|Coordinator Country||Germany [DE]|
|Total cost||1˙996˙750 €|
|EC max contribution||1˙996˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
Take a look of project's partnership.
|1||HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH||DE (NEUHERBERG)||coordinator||1˙437˙046.00|
|2||TECHNISCHE UNIVERSITAET MUENCHEN||DE (MUENCHEN)||participant||559˙703.00|
Abiotic stresses, such as drought or salt stress, affect plant growth and threaten the capacity to feed a growing world population. Understanding and altering how plants deal with stress will be critical for society’s adaptation to a changed climate. I propose a novel systems-biology based approach to identify biotechnological targets based on comparison of interaction and signalling networks of evolutionary related species that show differential abiotic stress tolerance. Similar to most crops, Arabidopsis thaliana is an abiotic-stress sensitive glycophyte whereas several close relatives are stress tolerant. This constitutes an opportunity to understand how plant stress-signalling networks are modified by evolutionary processes to adapt to novel environmental conditions. Biological processes are mediated by physically and functionally interacting proteins. Especially stress response networks are rewired when plants adapt to new environmental conditions. I aim to experimentally map the abiotic stress networks of four closely related brassicaceae: A. thaliana, A. lyrata, A. halleri and E. salsugineum. Novel conceptual advances in interactome mapping and a state-of-the art interactome mapping pipeline will be exploited to ensure direct alignability of the resulting reference networks. In addition the dynamic signalling events under drought stress will be analysed. Using a combination of network alignment, graph theoretical and statistical analyses, data integration, and literature-informed criteria a ranked candidate list of stress response regulators will be assembled. These will be genetically and biotechnologically validated. First level candidates will be tested in Arabidopsis thaliana and evaluated with respect to stress tolerance and overall biomass production. The most promising targets will then be transferred to Brassica napus to evaluate the performance in a commercially relevant crop.
|year||authors and title||journal||last update|
Junshi Yazaki, Mary Galli, Alice Y. Kim, Kazumasa Nito, Fernando Aleman, Katherine N. Chang, Anne-Ruxandra Carvunis, Rosa Quan, Hien Nguyen, Liang Song, JosÃ© M. Alvarez, Shao-shan Carol Huang, Huaming Chen, Niroshan Ramachandran, Stefan Altmann, Rodrigo A. GutiÃ©rrez, David E. Hill, Julian I. Schroeder, Joanne Chory, Joshua LaBaer, Marc Vidal, Pascal Braun, Joseph R. Ecker
Mapping transcription factor interactome networks using HaloTag protein arrays
published pages: E4238-E4247, ISSN: 0027-8424, DOI: 10.1073/pnas.1603229113
|Proceedings of the National Academy of Sciences 113/29||2019-06-06|
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