Opendata, web and dolomites

GliaInnateSensing SIGNED

Glia-derived factors in innate lymphoid cell sensing and intestinal defence

Total Cost €


EC-Contrib. €






Project "GliaInnateSensing" data sheet

The following table provides information about the project.


Organization address
city: LISBOA
postcode: 1400-038

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website
 Total cost 2˙270˙000 €
 EC max contribution 2˙270˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The interplay between intestinal microbes and immune cells ensures vital functions of the organism. However, inadequate host-microbe relationships lead to inflammatory diseases that are major public health concerns.

Innate lymphoid cells (ILC) are an emergent family of effectors abundantly present at mucosal sites. Group 3 ILC (ILC3) produce pro-inflammatory cytokines and regulate mucosal homeostasis, anti-microbial defence and adaptive immune responses.

ILC development and function have been widely perceived to be programmed. However, recent evidence indicates that ILC are also controlled by dietary signals. Nevertheless, how ILC3 perceive, integrate and respond to environmental cues remains utterly unexplored.

We hypothesise that ILC3 sense their environment and exert their function as part of a novel epithelial-glial-ILC unit orchestrated by neurotrophic factors. Thus, we propose to employ genetic, cellular and molecular approaches to decipher how this unconventional multi-cellular unit is controlled and how glial-derived factors set ILC3 function and intestinal homeostasis.

In order to achieve this, we will assess ILC3-autonomous functions of neurotrophic factor receptors. ILC3-specific loss and gain of function mutant mice for neuroregulatory receptors will be used to define the role of these molecules in ILC3 function, mucosal homeostasis, gut defence and microbial ecology. Sequentially we propose to decipher the anatomical and functional basis for the enteric epithelial-glial-ILC unit. To this end we will employ high-resolution imaging, genome-wide expression analysis and tissue-specific mutants for define target genes.

Our ground-breaking research will establish a novel sensing program by which ILC3 integrate environmental cues and will define a key multi-cellular unit at the core of intestinal homeostasis and defence. Finally, our work will reveal new pathways that may be targeted in inflammatory diseases that are major Public Health concerns.


year authors and title journal last update
List of publications.
2016 Sales Ibiza, Bethania García-Cassani, Hélder Ribeiro, Tânia Carvalho, Luís Almeida, Rute Marques, Ana M. Misic, Casey Bartow-McKenney, Denise M. Larson, William J. Pavan, Gérard Eberl, Elizabeth A. Grice, Henrique Veiga-Fernandes
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
published pages: 440-443, ISSN: 0028-0836, DOI: 10.1038/nature18644
Nature 535/7612 2020-01-29
2015 Marc Veldhoen, Henrique Veiga-Fernandes
Feeding immunity: skepticism, delicacies and delights
published pages: 215-219, ISSN: 1529-2908, DOI: 10.1038/ni.3100
Nature Immunology 16/3 2020-01-29
2018 Henrique Veiga-Fernandes, David Artis
Neuronal–immune system cross-talk in homeostasis
published pages: 1465-1466, ISSN: 0036-8075, DOI: 10.1126/science.aap9598
Science 359/6383 2020-01-29
2017 Henrique Veiga-Fernandes, Vassilis Pachnis
Neuroimmune regulation during intestinal development and homeostasis
published pages: 116-122, ISSN: 1529-2908, DOI: 10.1038/ni.3634
Nature Immunology 18/2 2020-01-29
2015 Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors
published pages: 2043-2054, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.02.057
Cell Reports 10/12 2020-01-29
2018 Julie Chesné, Vânia Cardoso, Henrique Veiga-Fernandes
Neuro-immune regulation of mucosal physiology
published pages: , ISSN: 1933-0219, DOI: 10.1038/s41385-018-0063-y
Mucosal Immunology 2020-01-29
2017 Henrique Veiga-Fernandes, António A. Freitas
The S(c)ensory Immune System Theory
published pages: 777-788, ISSN: 1471-4906, DOI: 10.1016/
Trends in Immunology 38/10 2020-01-29
2017 Walter K. Mowel, Sam J. McCright, Jonathan J. Kotzin, Magalie A. Collet, Asli Uyar, Xin Chen, Alexandra DeLaney, Sean P. Spencer, Anthony T. Virtue, EnJun Yang, Alejandro Villarino, Makoto Kurachi, Margaret C. Dunagin, Gretchen Harms Pritchard, Judith Stein, Cynthia Hughes, Diogo Fonseca-Pereira, Henrique Veiga-Fernandes, Arjun Raj, Taku Kambayashi, Igor E. Brodsky, John J. O’Shea, E. John Wherry, Loyal A. Goff, John L. Rinn, Adam Williams, Richard A. Flavell, Jorge Henao-Mejia
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA
published pages: 435-449.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.08.012
Immunity 47/3 2020-01-29
2017 Vânia Cardoso, Julie Chesné, Hélder Ribeiro, Bethania García-Cassani, Tânia Carvalho, Tiffany Bouchery, Kathleen Shah, Nuno L. Barbosa-Morais, Nicola Harris, Henrique Veiga-Fernandes
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
published pages: 277-281, ISSN: 0028-0836, DOI: 10.1038/nature23469
Nature 549/7671 2020-01-29
2017 S M Fernandes, A R Pires, P Matoso, C Ferreira, H Nunes-Cabaço, L Correia, E Valadas, J Poças, P Pacheco, H Veiga-Fernandes, R B Foxall, A E Sousa
HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication
published pages: 236-248, ISSN: 1933-0219, DOI: 10.1038/mi.2017.44
Mucosal Immunology 11/1 2020-01-29
2018 Johanna Emgård, Hana Kammoun, Bethania García-Cassani, Julie Chesné, Sara M. Parigi, Jean-Marie Jacob, Hung-Wei Cheng, Elza Evren, Srustidhar Das, Paulo Czarnewski, Natalie Sleiers, Felipe Melo-Gonzalez, Egle Kvedaraite, Mattias Svensson, Elke Scandella, Matthew R. Hepworth, Samuel Huber, Burkhard Ludewig, Lucie Peduto, Eduardo J. Villablanca, Henrique Veiga-Fernandes, João P. Pereira, Richard A. Flavell, Tim Willinger
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
published pages: 120-132.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.11.020
Immunity 48/1 2020-01-29
2016 Gera Goverse, Carlos Labao-Almeida, Manuela Ferreira, Rosalie Molenaar, Sigrid Wahlen, Tanja Konijn, Jasper Koning, Henrique Veiga-Fernandes, Reina E. Mebius
Vitamin A Controls the Presence of RORγ + Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine
published pages: 5148-5155, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1501106
The Journal of Immunology 196/12 2020-01-29
2016 Julien Ettersperger, Nicolas Montcuquet, Georgia Malamut, Nicolas Guegan, Silvia Lopez-Lastra, Ségolène Gayraud, Christian Reimann, Elodie Vidal, Nicolas Cagnard, Patrick Villarese, Isabelle Andre-Schmutz, Rita Gomes Domingues, Cristina Godinho-Silva, Henrique Veiga-Fernandes, Ludovic Lhermitte, Vahid Asnafi, Elizabeth Macintyre, Christophe Cellier, Kheira Beldjord, James P. Di Santo, Nadine Cerf-Bensussan, Bertrand Meresse
Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease
published pages: 610-625, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.07.018
Immunity 45/3 2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLIAINNATESENSING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLIAINNATESENSING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

sociOlfa (2020)

Learning from social scents: from territory to identity

Read More  

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

CN Identity (2019)

Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasks

Read More