Explore the words cloud of the GliaInnateSensing project. It provides you a very rough idea of what is the project "GliaInnateSensing" about.
The following table provides information about the project.
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
|Coordinator Country||Portugal [PT]|
|Total cost||2˙270˙000 €|
|EC max contribution||2˙270˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
Take a look of project's partnership.
|1||FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD||PT (LISBOA)||coordinator||1˙144˙742.00|
|2||INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES||PT (LISBOA)||participant||1˙125˙257.00|
The interplay between intestinal microbes and immune cells ensures vital functions of the organism. However, inadequate host-microbe relationships lead to inflammatory diseases that are major public health concerns.
Innate lymphoid cells (ILC) are an emergent family of effectors abundantly present at mucosal sites. Group 3 ILC (ILC3) produce pro-inflammatory cytokines and regulate mucosal homeostasis, anti-microbial defence and adaptive immune responses.
ILC development and function have been widely perceived to be programmed. However, recent evidence indicates that ILC are also controlled by dietary signals. Nevertheless, how ILC3 perceive, integrate and respond to environmental cues remains utterly unexplored.
We hypothesise that ILC3 sense their environment and exert their function as part of a novel epithelial-glial-ILC unit orchestrated by neurotrophic factors. Thus, we propose to employ genetic, cellular and molecular approaches to decipher how this unconventional multi-cellular unit is controlled and how glial-derived factors set ILC3 function and intestinal homeostasis.
In order to achieve this, we will assess ILC3-autonomous functions of neurotrophic factor receptors. ILC3-specific loss and gain of function mutant mice for neuroregulatory receptors will be used to define the role of these molecules in ILC3 function, mucosal homeostasis, gut defence and microbial ecology. Sequentially we propose to decipher the anatomical and functional basis for the enteric epithelial-glial-ILC unit. To this end we will employ high-resolution imaging, genome-wide expression analysis and tissue-specific mutants for define target genes.
Our ground-breaking research will establish a novel sensing program by which ILC3 integrate environmental cues and will define a key multi-cellular unit at the core of intestinal homeostasis and defence. Finally, our work will reveal new pathways that may be targeted in inflammatory diseases that are major Public Health concerns.
|year||authors and title||journal||last update|
Sales Ibiza, Bethania GarcÃa-Cassani, HÃ©lder Ribeiro, TÃ¢nia Carvalho, LuÃs Almeida, Rute Marques, Ana M. Misic, Casey Bartow-McKenney, Denise M. Larson, William J. Pavan, GÃ©rard Eberl, Elizabeth A. Grice, Henrique Veiga-Fernandes
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
published pages: 440-443, ISSN: 0028-0836, DOI: 10.1038/nature18644
Marc Veldhoen, Henrique Veiga-Fernandes
Feeding immunity: skepticism, delicacies and delights
published pages: 215-219, ISSN: 1529-2908, DOI: 10.1038/ni.3100
|Nature Immunology 16/3||2020-01-29|
Henrique Veiga-Fernandes, David Artis
Neuronalâ€“immune system cross-talk in homeostasis
published pages: 1465-1466, ISSN: 0036-8075, DOI: 10.1126/science.aap9598
Henrique Veiga-Fernandes, Vassilis Pachnis
Neuroimmune regulation during intestinal development and homeostasis
published pages: 116-122, ISSN: 1529-2908, DOI: 10.1038/ni.3634
|Nature Immunology 18/2||2020-01-29|
Wei Xu, RitaÂ G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, HÃ©lder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, VÃ©ronique Braud, Barbara Kee, Hugh Brady, MarkÂ C. Coles, Christian Vosshenrich, Masato Kubo, JamesÂ P. DiÂ Santo, Henrique Veiga-Fernandes
NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors
published pages: 2043-2054, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.02.057
|Cell Reports 10/12||2020-01-29|
Julie ChesnÃ©, VÃ¢nia Cardoso, Henrique Veiga-Fernandes
Neuro-immune regulation of mucosal physiology
published pages: , ISSN: 1933-0219, DOI: 10.1038/s41385-018-0063-y
Henrique Veiga-Fernandes, AntÃ³nio A. Freitas
The S(c)ensory Immune System Theory
published pages: 777-788, ISSN: 1471-4906, DOI: 10.1016/j.it.2017.02.007
|Trends in Immunology 38/10||2020-01-29|
Walter K. Mowel, Sam J. McCright, Jonathan J. Kotzin, Magalie A. Collet, Asli Uyar, Xin Chen, Alexandra DeLaney, Sean P. Spencer, Anthony T. Virtue, EnJun Yang, Alejandro Villarino, Makoto Kurachi, Margaret C. Dunagin, Gretchen Harms Pritchard, Judith Stein, Cynthia Hughes, Diogo Fonseca-Pereira, Henrique Veiga-Fernandes, Arjun Raj, Taku Kambayashi, Igor E. Brodsky, John J. Oâ€™Shea, E. John Wherry, Loyal A. Goff, John L. Rinn, Adam Williams, Richard A. Flavell, Jorge Henao-Mejia
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA
published pages: 435-449.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.08.012
VÃ¢nia Cardoso, Julie ChesnÃ©, HÃ©lder Ribeiro, Bethania GarcÃa-Cassani, TÃ¢nia Carvalho, Tiffany Bouchery, Kathleen Shah, Nuno L. Barbosa-Morais, Nicola Harris, Henrique Veiga-Fernandes
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
published pages: 277-281, ISSN: 0028-0836, DOI: 10.1038/nature23469
S M Fernandes, A R Pires, P Matoso, C Ferreira, H Nunes-CabaÃ§o, L Correia, E Valadas, J PoÃ§as, P Pacheco, H Veiga-Fernandes, R B Foxall, A E Sousa
HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication
published pages: 236-248, ISSN: 1933-0219, DOI: 10.1038/mi.2017.44
|Mucosal Immunology 11/1||2020-01-29|
Johanna EmgÃ¥rd, Hana Kammoun, Bethania GarcÃa-Cassani, Julie ChesnÃ©, Sara M. Parigi, Jean-Marie Jacob, Hung-Wei Cheng, Elza Evren, Srustidhar Das, Paulo Czarnewski, Natalie Sleiers, Felipe Melo-Gonzalez, Egle Kvedaraite, Mattias Svensson, Elke Scandella, Matthew R. Hepworth, Samuel Huber, Burkhard Ludewig, Lucie Peduto, Eduardo J. Villablanca, Henrique Veiga-Fernandes, JoÃ£o P. Pereira, Richard A. Flavell, Tim Willinger
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
published pages: 120-132.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.11.020
Gera Goverse, Carlos Labao-Almeida, Manuela Ferreira, Rosalie Molenaar, Sigrid Wahlen, Tanja Konijn, Jasper Koning, Henrique Veiga-Fernandes, Reina E. Mebius
Vitamin A Controls the Presence of RORÎ³ + Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine
published pages: 5148-5155, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1501106
|The Journal of Immunology 196/12||2020-01-29|
Julien Ettersperger, Nicolas Montcuquet, Georgia Malamut, Nicolas Guegan, Silvia Lopez-Lastra, SÃ©golÃ¨ne Gayraud, Christian Reimann, Elodie Vidal, Nicolas Cagnard, Patrick Villarese, Isabelle Andre-Schmutz, Rita GomesÂ Domingues, Cristina Godinho-Silva, Henrique Veiga-Fernandes, Ludovic Lhermitte, Vahid Asnafi, Elizabeth Macintyre, Christophe Cellier, Kheira Beldjord, JamesÂ P. DiÂ Santo, Nadine Cerf-Bensussan, Bertrand Meresse
Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease
published pages: 610-625, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.07.018
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