Opendata, web and dolomites

HomeoBalanceExcInh SIGNED

Homeostatic balancing of excitation and inhibition in vivo

Total Cost €


EC-Contrib. €






 HomeoBalanceExcInh project word cloud

Explore the words cloud of the HomeoBalanceExcInh project. It provides you a very rough idea of what is the project "HomeoBalanceExcInh" about.

schizophrenia    linked    balance    candidate    homeostatic    progress    autism    depends    preparations    perturbations    little    genes    bounds    balancing    memory    tractable    mechanisms    diseases    sparse    enhances    circuit    maintaining    neuron    plasticity    powerful    elucidating    intact    normal    sophisticated    model    kenyon    adapt    perturbed    neural    first    projection    maintains    epilepsy    coding    kc    disruption    genetically    underlying    opportunity    kcs    adjusting    representations    apl    associative    indicates    responsiveness    neurons    cells    uncover    receive    gap    balanced    mediates    brain    establishing    despite    reducing    inhibition    preliminary    specificity    prolonged    single    breaking    drosophila    forces    levels    molecular    odour    time    reveal    tools    fundamental    genetic    feedback    excitation    function    regulated    pns    deviations    compensate    olfactory    cellular    ground    overlap    vivo    pn   

Project "HomeoBalanceExcInh" data sheet

The following table provides information about the project.


Organization address
postcode: S10 2TN

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 1˙500˙000.00


 Project objective

Balanced excitation and inhibition is a fundamental principle of neural circuit function, and perturbed excitation/inhibition (E/I) balance has been linked to diseases such as epilepsy, autism and schizophrenia. Maintaining E/I balance within normal bounds depends in part on homeostatic plasticity, in which neurons compensate for deviations in activity levels by adjusting their responsiveness to excitation and inhibition. Yet despite recent progress in elucidating molecular mechanisms underlying homeostatic plasticity in reduced preparations, little is known about such mechanisms in the intact brain.

I propose to address this gap using a simple and genetically tractable neural circuit that I recently characterized. In Drosophila, Kenyon cells (KCs), the neurons underlying olfactory associative memory, receive excitation from projection neurons (PNs) as well as feedback inhibition from a single identified neuron (‘APL’). The balance between these two forces maintains sparse odour coding in KCs, which enhances the odour-specificity of associative memory by reducing overlap between odour representations.

Preliminary evidence indicates that KCs adapt to prolonged disruption of E/I balance, providing a ground-breaking opportunity to use the powerful genetic tools of Drosophila to uncover the molecular mechanisms underlying homeostatic balancing of excitation and inhibition in vivo in a defined circuit that mediates a sophisticated behaviour.

Specific aims: 1. Characterize homeostatic plasticity in the PN-KC-APL circuit. 2. Identify genes up- and down-regulated in response to perturbations of E/I balance. 3. Determine role of candidate genes and cellular mechanisms in homeostatic plasticity.

Establishing the PN-KC-APL circuit as a novel model system for homeostatic plasticity will reveal for the first time the molecular mechanisms underlying homeostatic balancing of excitation and inhibition in the intact brain.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HOMEOBALANCEEXCINH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HOMEOBALANCEEXCINH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More  


The Mass Politics of Disintegration

Read More