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dynamicmodifications SIGNED

Complexity and dynamics of nucleic acids modifications in vivo

Total Cost €

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EC-Contrib. €

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Partnership

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 dynamicmodifications project word cloud

Explore the words cloud of the dynamicmodifications project. It provides you a very rough idea of what is the project "dynamicmodifications" about.

reprogramming    cells    lost    advantage    embryonic    chromatin    germ    challenged    memory    capacity    epigenetic    naturally    teams    lc    sensitive    subsequent    ie    inherited    dna    interactions    paradigm    rna    acquired    containing    organisms    ms    onset    efforts    components    zygote    dynamics    wound    intense    development    additionally    generate    pluripotent    decisions    enigmatic    nuclear    models    give    layer    hundreds    mechanisms    events    organism    combination    genome    character    stable    mouse    molecular    divisions    fundamental    series    characterised    differentiation    fate    periods    regeneration    takes    modifications    primordial    toti    fertilised    developmental    totipotent    de    genomics    starts    implicated    lower    transdifferentiation    dictates    types    interplay    laid    transfer    healing    unidirectional    cellular    insights    ultra    understand    cell    progressively    stem    despite    specialised    erasure    underlie    progress    methylation   

Project "dynamicmodifications" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://lms.mrc.ac.uk/research-group/reprogramming-and-chromatin/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 2˙000˙000.00

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 Project objective

Development of any organism starts with a totipotent cell (zygote). Through series of cell divisions and differentiation processes this cell will eventually give rise to the whole organism containing hundreds of specialised cell. While the cells at the onset of development have the capacity to generate all cell types (ie are toti-or pluripotent), this developmental capacity is progressively lost as the cells undertake cell fate decisions. At the molecular level, the memory of these events is laid down in a complex layer of epigenetic modifications at both the DNA and the chromatin level. Unidirectional character of the developmental progress dictates that the key acquired epigenetic modifications are stable and inherited through subsequent cell divisions. This paradigm is, however, challenged during cellular reprogramming that requires de-differentiation (nuclear transfer, induced pluripotent stem cells, wound healing and regeneration in lower organisms) or a change in cell fate (transdifferentiation). Despite intense efforts of numerous research teams, the molecular mechanisms of these processes remain enigmatic. In order to understand cellular reprogramming at the molecular level, this proposal takes advantage of epigenetic reprogramming processes that occur naturally during mouse development. By using mouse fertilised zygote and mouse developing primordial germ cells we will investigate novel molecular components implicated in the genome-wide erasure of DNA methylation. Additionally, by using a unique combination of the developmental models with the state of the art ultra-sensitive LC/MS and genomics approaches we propose to investigate the dynamics and the interplay between DNA and RNA modifications during these key periods of embryonic development characterised by genome-wide epigenetic changes . Our work will thus provide new fundamental insights into a complex dynamics and interactions between epigenetic modifications that underlie epigenetic reprogramming

 Publications

year authors and title journal last update
List of publications.
2018 Harry G. Leitch, Petra Hajkova
Eggs sense high-fat diet
published pages: , ISSN: 1061-4036, DOI: 10.1038/s41588-018-0068-1
Nature Genetics 2019-06-07
2017 Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, Guillaume Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, Rachel Amouroux, Naoshi Dohmae, Takehiro Suzuki, Guillaume J. Filion, Wen Deng, Maud de Dieuleveult, Lauriane Fritsch, Srikanth Kudithipudi, Albert Jeltsch, Heinrich Leonhardt, Petra Hajkova, Jarrod A. Marto, Kyohei Arita, Yoichi Shinkai, Pierre-Antoine Defossez
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation
published pages: 550-565.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.07.012
Molecular Cell 67/4 2019-06-07
2018 Silvana Rošić, Rachel Amouroux, Cristina E. Requena, Ana Gomes, Max Emperle, Toni Beltran, Jayant K. Rane, Sarah Linnett, Murray E. Selkirk, Philipp H. Schiffer, Allison J. Bancroft, Richard K. Grencis, Albert Jeltsch, Petra Hajkova, Peter Sarkies
Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity
published pages: , ISSN: 1061-4036, DOI: 10.1038/s41588-018-0061-8
Nature Genetics 2019-06-07
2017 Annalisa Izzo, Céline Ziegler-Birling, Peter W.S. Hill, Lydia Brondani, Petra Hajkova, Maria-Elena Torres-Padilla, Robert Schneider
Dynamic changes in H1 subtype composition during epigenetic reprogramming
published pages: 3017-3028, ISSN: 0021-9525, DOI: 10.1083/jcb.201611012
The Journal of Cell Biology 216/10 2019-06-07
2016 Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter W. S. Hill, Zelpha D’Souza, Manabu Nakayama, Masashi Matsuda, Aleksandra Turp, Elodie Ndjetehe, Vesela Encheva, Nobuaki R. Kudo, Haruhiko Koseki, Hiroyuki Sasaki, Petra Hajkova
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
published pages: 225-233, ISSN: 1465-7392, DOI: 10.1038/ncb3296
Nature Cell Biology 18/2 2019-06-07
2018 Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan, Petra Hajkova
Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte
published pages: 392-396, ISSN: 0028-0836, DOI: 10.1038/nature25964
Nature 555/7696 2019-06-07
2016 Harry G. Leitch, M. Azim Surani, Petra Hajkova
DNA (De)Methylation: The Passive Route to Naïvety?
published pages: 592-595, ISSN: 0168-9525, DOI: 10.1016/j.tig.2016.08.005
Trends in Genetics 32/10 2019-06-07

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