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AFib-TrainNet

EU Training Network on Novel Targets and Methods in Atrial Fibrillation

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AFib-TrainNet" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://afib.ku.dk/
 Total cost 4˙101˙221 €
 EC max contribution 4˙101˙221 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 870˙245.00
2    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 747˙649.00
3    ACESION PHARMA APS DK (KOBENHAVN) participant 580˙163.00
4    SIMULA RESEARCH LABORATORY AS NO (FORNEBU) participant 572˙550.00
5    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 546˙575.00
6    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 510˙748.00
7    CLYDE BIOSCIENCES LIMITED UK (MOTHERWELL LANARKSHIRE) participant 273˙287.00
8    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) partner 0.00
9    Fondazione Cardiocentro Ticino CH (Lugano) partner 0.00
10    OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN AT (WIEN) partner 0.00
11    XENTION CAMBRIDGE UK (CAMBRIDGE) partner 0.00

Map

 Project objective

The AFib-TrainNet consortium will enable promising young scientists to become excellent research leaders of the future, capable of fighting the challenges that Atrial Fibrillation (AF) presents to the European population. AF is the most common sustained cardiac arrhythmia, occurring in between 1-2% of the general population. More than 6 million Europeans suffer from this arrhythmia and its prevalence is expected to increase by more than two-fold during the next 40 years due to increased life expectancy. Thus, AF is said to assume epidemic proportions. Current options for pharmacological therapy are limited by both low efficacy and side effects, including life‐threatening ventricular arrhythmias and severe extra-cardiac toxicities. A very limited number of novel AF drug therapies have been introduced in the last 20 years. This imbalance reflects a gap in understanding in both how AF develops and how it can be treated, which thereby limits the development of new medicines. Our ambition with the AFib-TrainNet is to fill this gap by producing new knowledge, leading to critical insight into origins and mechanisms of sustenance of atrial fibrillation. We will accomplish this by developing novel experimental and computational models recapitulating human AF, and employing these models on two very promising atrial biological targets. Experimental models will be instrumental in improving the understanding AF’s underlying mechanisms, and will, along with clinical data, inform state-of-the-art computational models of human atrial electrophysiology. These new tools will permit fresh insight into the molecular, cellular and electrical mechanisms involved in the progression of healthy atria into an AF state. Our endeavor will deliver results which can be leveraged by the pharmaceutical industry to target AF drug development, and the work accomplished in AFib-TrainNet will thus constitute a beacon in the search for new AF medicine.

 Deliverables

List of deliverables.
Periodical Scientific Reports (2) Documents, reports 2020-02-28 08:16:54
Report on CDE activities (2) Documents, reports 2020-02-28 08:16:54
Periodic report Documents, reports 2020-02-28 08:16:54
Final report on training activities Documents, reports 2020-02-28 08:16:54
Synergy meeting Other 2020-02-28 08:16:54
Periodical training activities report (2) Documents, reports 2020-02-28 08:16:54
CDE plan (3) Documents, reports 2020-02-28 08:16:54
Career and Industry Day Other 2020-02-28 08:16:54
15 PhD theses Documents, reports 2020-02-28 08:16:54
Periodical training activities report (3) Documents, reports 2020-02-28 08:16:54
Periodical Scientific Reports (3) Documents, reports 2020-02-28 08:16:54
Open Research Data Pilot Open Research Data Pilot 2020-02-28 08:16:54
Website Websites, patent fillings, videos etc. 2020-02-28 08:16:53
Progress report Documents, reports 2020-02-28 08:16:53
CDE plan (2) Documents, reports 2020-02-28 08:16:53
List of recruited ESRs Documents, reports 2020-02-28 08:16:53
Periodical training activities report (1) Documents, reports 2020-02-28 08:16:53
Periodical Scientific Reports (1) Documents, reports 2020-02-28 08:16:53
Report on CDE activities (1) Documents, reports 2020-02-28 08:16:53
CDE plan (1) Documents, reports 2020-02-28 08:16:53

Take a look to the deliverables list in detail:  detailed list of AFib-TrainNet deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 L. Soattin; A. Lubberding; BH. Bentzen; T. Jespersen
Adenosine 1 receptor activation plays a proarrhythmic role in rat atrium
published pages: ii219-ii220, ISSN: , DOI:
Poster session abstract / EHRA EUROPACE - CARDIOSTIM 2017 Abstract supplement June 18-21, 2020-02-28
2019 Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2019.00668
Frontiers in Pharmacology 10 2020-02-28
2019 Marta Lemme, Ingke Braren, Maksymilian Prondzynski, Bülent Aksehirlioglu, Bärbel M Ulmer, Mirja L Schulze, Djemail Ismaili, Christian Meyer, Arne Hansen, Torsten Christ, Marc D Lemoine, Thomas Eschenhagen
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvz245
Cardiovascular Research 2020-02-28
2019 Giommi A, Gurgel AR, Saxena P, Smith GL, Workman AJ
An investigation of small conductance Ca2+-activated K+ current (ISK) in rabbit and human atrial cardiomyocytes
published pages: 299-300, ISSN: , DOI:
Abstract / Proc Physiol Soc 43 (2019) PC041 2020-02-28
2018 Marta Lemme, Bärbel M. Ulmer, Marc D. Lemoine, Antonia T.L. Zech, Frederik Flenner, Ursula Ravens, Hermann Reichenspurner, Miriam Rol-Garcia, Godfrey Smith, Arne Hansen, Torsten Christ, Thomas Eschenhagen
Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium
published pages: 1378-1390, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.10.008
Stem Cell Reports 11/6 2020-02-28
2018 András Horváth, Marc D. Lemoine, Alexandra Löser, Ingra Mannhardt, Frederik Flenner, Ahmet Umur Uzun, Christiane Neuber, Kaja Breckwoldt, Arne Hansen, Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes
published pages: 822-833, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.012
Stem Cell Reports 10/3 2020-02-28
2018 Márcia Vagos, Ilsbeth G. M. van Herck, Joakim Sundnes, Hermenegild J. Arevalo, Andrew G. Edwards, Jussi T. Koivumäki
Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01221
Frontiers in Physiology 9 2020-02-28
2018 Arne van Hunnik, Stef Zeemering, Piotr Podziemski, Jorik Simons, Giulia Gatta, Laura Hannink, Bart Maesen, Marion Kuiper, Sander Verheule, Ulrich Schotten
Stationary Atrial Fibrillation Properties in the Goat Do Not Entail Stable or Recurrent Conduction Patterns
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00947
Frontiers in Physiology 9 2020-02-28
2018 Rafel Simó-Vicens, Sofia H. Bomholtz, Ulrik S. Sørensen, Bo H. Bentzen
2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01409
Frontiers in Pharmacology 9 2020-02-28
2018 Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, Bjørg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen
Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters
published pages: 1410-1419, ISSN: 0891-6640, DOI: 10.1111/jvim.15137
Journal of Veterinary Internal Medicine 32/4 2020-02-28

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