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SyDAD SIGNED

Synaptic Dysfunction in Alzheimer Disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SyDAD" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 3˙846˙736 €
 EC max contribution 3˙846˙736 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙054˙637.00
2    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 788˙626.00
3    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 774˙183.00
4    DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DE (BONN) participant 747˙649.00
5    JANSSEN PHARMACEUTICA NV BE (BEERSE) participant 250˙560.00
6    AXON NEUROSCIENCE SE SK (BRATISLAVA) participant 231˙078.00
7    ALZECURE DISCOVERY SE (Huddinge) partner 0.00
8    ALZHEIMER EUROPE LU (LUXEMBOURG) partner 0.00
9    ASTRAZENECA AB SE (SODERTAELJE) partner 0.00
10    GOETEBORGS UNIVERSITET SE (GOETEBORG) partner 0.00
11    SERENDIPITY INNOVATIONS AB SE (STOCKHOLM) partner 0.00

Map

 Project objective

Given an overwhelming increase of dementia costs and an aging population, there is an urgent need for finding novel therapies for Alzheimer Disease (AD). We are, however, facing a large number of failed clinical trials and a retraction of the nervous system R&D programmes from several big pharmaceutical companies. Increased collaboration between academia and the private sector is required to overcome this challenge. The “Synaptic Dysfunction in Alzheimer Disease” (SyDAD) project will significantly contribute to this approach by training a new generation of researchers with experience and full understanding of the requirements of academia, pharmaceutical companies, the clinics and the society. The research programme will focus on synaptic dysfunction, the main connection point between pathology and cognitive decline in AD. Given the complementary expertise, SyDAD will have excellent opportunities to delineate the cross-talk between different pathways underlying synaptic dysfunction in AD and to identify novel pharmaceutical targets. For future implementation of the research findings into clinical trials, a drug discovery platform will be elaborated, utilising the industrial and clinical expertise in the network. The early-stage researchers (ESRs) will be trained in this environment and provided with a mind-set of future commercial and clinical utilisation of their research findings. Apart from the innovative and collaborative approach of the research programme, the ESRs will also be provided with a training programme where cutting-edge methodology, innovation and transferable skills are key components. The trained ESRs will have excellent intersectoral and interdisciplinary career opportunities and will, together with the SyDAD partners, provide a solid ground to tackle one of the major societal challenges of our century: Finding therapies to decrease the suffering and economic burden of AD patients.

 Deliverables

List of deliverables.
Publications Websites, patent fillings, videos etc. 2020-03-24 11:02:43
Half-time control reports and seminars by the ESRs Documents, reports 2020-03-24 11:02:32
Doctoral degrees Documents, reports 2020-03-24 11:02:27
Detailed plans for second years training and meetings Documents, reports 2020-03-24 11:02:43
Detailed plans for third years training and meetings Documents, reports 2020-03-24 11:02:15
Established website Websites, patent fillings, videos etc. 2019-10-01 10:07:09
Detailed plans for first years training and meetings Documents, reports 2019-10-01 10:07:09
ESRs recruited Documents, reports 2019-10-01 10:07:09
Public dissemination, including workshop with People living with dementia Documents, reports 2019-10-01 10:07:09

Take a look to the deliverables list in detail:  detailed list of SyDAD deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2019.00273
Frontiers in Aging Neuroscience 11 2020-01-28
2020 Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration
published pages: 104645, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2019.104645
Neurobiology of Disease 134 2020-01-28
2019 Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, Gaël Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman
The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease
published pages: mcp.RA119.001737, ISSN: 1535-9476, DOI: 10.1074/mcp.ra119.001737
Molecular & Cellular Proteomics 2020-01-28
2019 Una Smailovic, Vesna Jelic
Neurophysiological Markers of Alzheimer’s Disease: Quantitative EEG Approach
published pages: 37-55, ISSN: 2193-8253, DOI: 10.1007/s40120-019-00169-0
Neurology and Therapy 8/S2 2020-01-28
2019 Una Smailovic, Thomas Koenig, Erika J Laukka, Grégoria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic
EEG time signature in Alzheimer´s disease: Functional brain networks falling apart
published pages: 102046, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.102046
NeuroImage: Clinical 24 2020-01-28
2018 Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar Björkhem, Javier DeFelipe, Angel Cedazo-Minguez
27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons
published pages: 429-446, ISSN: 1047-3211, DOI: 10.1093/cercor/bhy274
Cerebral Cortex 29/1 2020-01-28
2018 Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito Calì, Paola Pizzo, Maria Ankarcrona
TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
published pages: 369-382.e6, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.12.047
Current Biology 28/3 2019-10-28
2019 Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera
The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40887-x
Scientific Reports 9/1 2019-10-28
2019 Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano
Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
published pages: e99558, ISSN: 0261-4189, DOI: 10.15252/embj.201899558
The EMBO Journal 38/6 2019-10-28
2019 Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca
Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena
published pages: 7136-7143, ISSN: 0893-7648, DOI: 10.1007/s12035-019-1583-5
Molecular Neurobiology 56/10 2019-10-28
2018 Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona
Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients
published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-018-0605-2
Acta Neuropathologica Communications 6/1 2019-10-28
2018 Kostoula Troulinaki, Sven Büttner, Anaïs Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano
WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans
published pages: , ISSN: 2058-7716, DOI: 10.1038/s41420-017-0005-6
Cell Death Discovery 4/1 2019-10-28
2017 Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka
Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research
published pages: , ISSN: 2161-0460, DOI: 10.4172/2161-0460.1000400
Journal of Alzheimer’s Disease & Parkinsonism 07/06 2019-10-28
2018 G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka
Inhibitory interneurons in Alzheimer’s disease
published pages: 205-209, ISSN: 1336-0345, DOI: 10.4149/bll_2018_038
Bratislava Medical Journal 119/04 2019-10-28
2018 Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06813-x
Nature Communications 9/1 2019-10-28
2019 Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Propagation of tau pathology: integrating insights from post mortem and in vivo studies
published pages: , ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.09.019
Biological Psychiatry 2019-10-28
2019 Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka
Intersection of pathological tau and microglia at the synapse
published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-019-0754-y
Acta Neuropathologica Communications 7/1 2019-10-28

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