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EvolutioNeuroCircuit SIGNED

Cellular and genetic bases of neural circuits evolution

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EvolutioNeuroCircuit project word cloud

Explore the words cloud of the EvolutioNeuroCircuit project. It provides you a very rough idea of what is the project "EvolutioNeuroCircuit" about.

electron    appropriate    throughput    divergent    neurogenetics    melanogaster    biology    transcriptomic    neural    genetic    profiling    species    characterised    specialisation    behaviours    diverged    unprecedented    genetics    bases    model    larva    conserved    sensory    functionally    questions    tackling    causality    serial    guided    probe    evolve    calcium    evolutionary    brain    shape    fly    technological    differentially    evoked    central    circuit    deep    valences    fundamental    resolution    forces    question    pioneered    rewiring    underlying    developmental    ideal    genome    imaging    candidates    odour    encode    assays    molecular    expressed    drosophila    microscopy    sensitivity    re    multidisciplinary    dependent    interrogation    optogenetics    population    biological    integration    ecological    editing    arise    context    switched    shaped    evolution    circuits    advancements    tools    combining    larval    put    little    stage    genes    world    progress    olfactory    behavioural    reconstruction   

Project "EvolutioNeuroCircuit" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙312˙500 €
 EC max contribution 1˙312˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 1˙312˙500.00

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 Project objective

Sensory systems encode the world around us to produce context-dependent appropriate behaviours. However, we know little about the way new sensory evoked behaviours arise as neural circuits are re-shaped during evolution. Tackling this question requires a deep understanding of the circuits underlying specific behaviours and integration of this knowledge with tools from other fields, including evolutionary and developmental biology. Recent technological advancements on neural circuit interrogation and genome editing have put progress on this fundamental biological question within reach. The olfactory system of the larval stage of the fly Drosophila melanogaster and related species is an ideal model for investigating these questions because (i) D. melanogaster has pioneered both the fields of population genetics and neurogenetics and (ii) its olfactory system is one of the best-characterised neural circuits. We will address the question of how olfactory circuits evolve by studying four species with divergent odour-guided behaviours through the following multidisciplinary aims: 1. Which olfactory pathways are targeted in the evolution of ecological specialisation? – Combining high-throughput behavioural assays, optogenetics and calcium imaging in the larva of all four species we will determine whether/which olfactory pathways have switched valences or sensitivity. 2. How have central neural circuits diverged? – We will address this question at unprecedented resolution through whole-brain calcium imaging and serial electron microscopy reconstruction. 3. What are the molecular and genetic bases of neural circuits rewiring during evolution? – Using transcriptomic profiling we will identify differentially expressed genes in conserved and divergent circuits across species, and functionally probe selected candidates to establish causality. 4. How do evolutionary forces shape olfactory circuits? – We will investigate this question using field studies and population genetics

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