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EvolutioNeuroCircuit SIGNED

Cellular and genetic bases of neural circuits evolution

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EvolutioNeuroCircuit project word cloud

Explore the words cloud of the EvolutioNeuroCircuit project. It provides you a very rough idea of what is the project "EvolutioNeuroCircuit" about.

biological    question    fly    brain    genome    forces    melanogaster    odour    electron    molecular    imaging    integration    candidates    behaviours    transcriptomic    olfactory    genetic    profiling    deep    underlying    tools    put    model    ecological    drosophila    resolution    little    rewiring    pioneered    specialisation    larva    questions    advancements    neurogenetics    arise    sensory    switched    combining    sensitivity    expressed    appropriate    biology    world    causality    calcium    technological    encode    ideal    multidisciplinary    unprecedented    characterised    probe    neural    evoked    evolve    context    progress    circuits    differentially    valences    interrogation    editing    throughput    shaped    genetics    microscopy    guided    assays    developmental    serial    evolutionary    evolution    optogenetics    population    fundamental    functionally    central    species    shape    re    divergent    diverged    larval    reconstruction    tackling    conserved    bases    behavioural    stage    genes    dependent    circuit   

Project "EvolutioNeuroCircuit" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙312˙500 €
 EC max contribution 1˙312˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 1˙312˙500.00

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 Project objective

Sensory systems encode the world around us to produce context-dependent appropriate behaviours. However, we know little about the way new sensory evoked behaviours arise as neural circuits are re-shaped during evolution. Tackling this question requires a deep understanding of the circuits underlying specific behaviours and integration of this knowledge with tools from other fields, including evolutionary and developmental biology. Recent technological advancements on neural circuit interrogation and genome editing have put progress on this fundamental biological question within reach. The olfactory system of the larval stage of the fly Drosophila melanogaster and related species is an ideal model for investigating these questions because (i) D. melanogaster has pioneered both the fields of population genetics and neurogenetics and (ii) its olfactory system is one of the best-characterised neural circuits. We will address the question of how olfactory circuits evolve by studying four species with divergent odour-guided behaviours through the following multidisciplinary aims: 1. Which olfactory pathways are targeted in the evolution of ecological specialisation? – Combining high-throughput behavioural assays, optogenetics and calcium imaging in the larva of all four species we will determine whether/which olfactory pathways have switched valences or sensitivity. 2. How have central neural circuits diverged? – We will address this question at unprecedented resolution through whole-brain calcium imaging and serial electron microscopy reconstruction. 3. What are the molecular and genetic bases of neural circuits rewiring during evolution? – Using transcriptomic profiling we will identify differentially expressed genes in conserved and divergent circuits across species, and functionally probe selected candidates to establish causality. 4. How do evolutionary forces shape olfactory circuits? – We will investigate this question using field studies and population genetics

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The information about "EVOLUTIONEUROCIRCUIT" are provided by the European Opendata Portal: CORDIS opendata.

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