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HisMoDetect

An Antibody Microarray for Histone Modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HisMoDetect project word cloud

Explore the words cloud of the HisMoDetect project. It provides you a very rough idea of what is the project "HisMoDetect" about.

regulatory    levels    genomic    recognize    eukaryotic    suppressed    tissue    histone    post    structure    histones    active    protrude    dictate    vital    drugs    dna    indirect    programs    structural    drug    variety    companies    sumoylation    prognosis    fast    essentially    basic    epigentic    acetylation    blot    developmental    landscape    intensive    microarray    tails    core    compact    recruitment    polyribosylation    modifications    rendering    monitor    biological    h2a    procedure    consuming    local    cell    mechanisms    of    screening    h2b    euchromatic    chromatin    dozens    labour    heterochromatic    nucleosome    proteins    expression    simultaneously    phosphorylation    platform    binding    division    h4    methylation    antibody    time    epigenetic    believe    residues    suggest    gene    h3    western    copies    associate    diagnosis    translational    ubiquitination    form    decondensed    serve    subject    global    direct    silencing    multiple    cellular   

Project "HisMoDetect" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 150˙000.00

Map

 Project objective

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.

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The information about "HISMODETECT" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-05-15 7:38:12) correctly updated