Opendata, web and dolomites

HisMoDetect

An Antibody Microarray for Histone Modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HisMoDetect project word cloud

Explore the words cloud of the HisMoDetect project. It provides you a very rough idea of what is the project "HisMoDetect" about.

mechanisms    dictate    copies    tails    histone    developmental    division    western    decondensed    drug    genomic    nucleosome    global    euchromatic    dozens    protrude    cellular    associate    serve    phosphorylation    drugs    heterochromatic    expression    of    structural    recognize    consuming    vital    suppressed    blot    microarray    believe    ubiquitination    rendering    structure    recruitment    silencing    core    modifications    dna    acetylation    h3    tissue    methylation    post    variety    h4    polyribosylation    cell    platform    prognosis    direct    companies    fast    essentially    chromatin    local    landscape    translational    residues    h2a    intensive    epigentic    biological    epigenetic    labour    subject    suggest    monitor    eukaryotic    multiple    form    procedure    sumoylation    proteins    antibody    basic    histones    simultaneously    programs    diagnosis    screening    regulatory    levels    h2b    indirect    compact    time    binding    active    gene   

Project "HisMoDetect" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 150˙000.00

Map

 Project objective

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HISMODETECT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HISMODETECT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ChromoSOMe (2020)

Canonical and Non-canonical modes of Chromosome Segregation in Oocyte Meiosis

Read More  

Mereodao (2020)

Mereological Reconstruction of the Metaphysical System in the Daodejing

Read More  

IGOC (2019)

Interactions between Groups, Orbits, and Cartans

Read More