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HisMoDetect

An Antibody Microarray for Histone Modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HisMoDetect project word cloud

Explore the words cloud of the HisMoDetect project. It provides you a very rough idea of what is the project "HisMoDetect" about.

post    eukaryotic    methylation    serve    translational    tails    recognize    local    developmental    labour    chromatin    h2a    heterochromatic    diagnosis    tissue    time    copies    antibody    nucleosome    recruitment    genomic    platform    modifications    basic    multiple    silencing    division    dna    programs    landscape    cell    indirect    regulatory    core    dictate    structural    prognosis    global    associate    h3    believe    dozens    epigentic    simultaneously    ubiquitination    h2b    mechanisms    screening    polyribosylation    western    rendering    subject    active    procedure    fast    variety    binding    biological    gene    expression    epigenetic    acetylation    direct    suppressed    intensive    decondensed    blot    phosphorylation    histone    drug    residues    microarray    suggest    of    consuming    drugs    euchromatic    protrude    structure    levels    essentially    cellular    compact    histones    h4    proteins    vital    sumoylation    companies    monitor    form   

Project "HisMoDetect" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 150˙000.00

Map

 Project objective

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.

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The information about "HISMODETECT" are provided by the European Opendata Portal: CORDIS opendata.

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