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LeukoTheranostics SIGNED

Harnessing Targeted Nanotheranostics to Reprogram Activated Leukocytes in Inflammatory Bowel Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 LeukoTheranostics project word cloud

Explore the words cloud of the LeukoTheranostics project. It provides you a very rough idea of what is the project "LeukoTheranostics" about.

40    generating    rnai    combined    therapeutic    profiles    unregulated    implicated    imposes    tract    near    peak    foundation    a4b7    integrin    approximately    patients    ct    expressed    unknown    leukocytes    modality    cells    models    countries    crohn    europeans    group    micropet    dimensional    safety    diseases    rna    inflammation    colitis    small    primary    uc    gastrointestinal    therapeutics    health    first    trials    horse    landscape    molecular    activated    ibd    15    3b    chronic    indirect    persons    lay    gut    annual    vivo    utilizing    prevalence    prepare    modalities    refractory    treatments    age    care    medical    nanoparticles    reprogram    clinical    burden    urgent    conventional    onset    rodent    etiology    ulcerative    decade    strategy    disease    imaging    million    cd    pathogenesis    theranostic    immune    affinity    fate    conformation    time    community    inflammatory    bowel    trojan    interference    strategies    tsnps    efficacy    home    platform    meet    combination   

Project "LeukoTheranostics" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Project website https://www3.tau.ac.il/danpeer/index.php/eu-project
 Total cost 2˙703˙125 €
 EC max contribution 2˙703˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙527˙608.00
2    CHILDREN'S HOSPITAL CORPORATION US (BOSTON) participant 175˙517.00

Map

 Project objective

'Inflammatory bowel diseases (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn’s disease (CD) and Ulcerative Colitis (UC) that can impact both the large and small bowel. IBD affects approximately 3.7 million Europeans and its peak onset is in persons of 15 to 30 years of age. IBD imposes a significant burden on Europe with over €3B in annual health care costs and over €3B in indirect cost. The prevalence of IBD is expected to increase by more than 40% over the next decade in many European countries. Therefore, to meet the needs of IBD patients in the European community, we must prepare for the evolving landscape of IBD care in the near future. Although its etiology remains unknown, unregulated immune cells are implicated in the pathogenesis of IBD. As many IBD patients are refractory to conventional medical treatments, there is an urgent need to develop novel therapeutic modalities in combination with real-time imaging in order to manage the disease. I will achieve this goal by generating a 'Trojan horse' strategy of targeting activated leukocytes that home to the gut in IBD rodent models and reprogram their fate using RNA interference (RNAi) combined with molecular imaging. The primary objective of this proposal is to reprogram in vivo activated leukocytes involved in gut inflammation using advanced RNAi-based therapeutics combined with molecular imaging strategies as the first theranostic modality utilizing leukocytes. The following specific aims include: (i) To develop and characterize unique integrin-targeted nanoparticles (I-tsNPs) targeting a high-affinity (HA) conformation of a4b7 integrin expressed on gut leukocytes; (ii) To study I-tsNPs 3-dimensional (3-D) delivery in colitis models using microPET/CT imaging; (iii) To investigate efficacy and safety profiles using the HA I-tsNPs platform for IBD therapeutics and disease management that will lay the foundation for future clinical trials. '

 Publications

year authors and title journal last update
List of publications.
2018 Ranit Kedmi, Nuphar Veiga, Srinivas Ramishetti, Meir Goldsmith, Daniel Rosenblum, Niels Dammes, Inbal Hazan-Halevy, Limor Nahary, Shani Leviatan-Ben-Arye, Michael Harlev, Mark Behlke, Itai Benhar, Judy Lieberman, Dan Peer
A modular platform for targeted RNAi therapeutics
published pages: 214-219, ISSN: 1748-3387, DOI: 10.1038/s41565-017-0043-5
Nature Nanotechnology 13/3 2020-02-21
2018 Daniel Rosenblum, Nitin Joshi, Wei Tao, Jeffrey M. Karp, Dan Peer
Progress and challenges towards targeted delivery of cancer therapeutics
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03705-y
Nature Communications 9/1 2020-02-21
2018 Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas Ramishetti, Dan Peer
Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06936-1
Nature Communications 9/1 2020-02-21
2017 Shoshy Mizrahy, Inbal Hazan-Halevy, Niels Dammes, Dalit Landesman-Milo, Dan Peer
Current Progress in Non-viral RNAi-Based Delivery Strategies to Lymphocytes
published pages: , ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.03.001
Molecular Therapy 2020-02-21
2016 Inbal Hazan-Halevy, Dalit Landesman-Milo, Daniel Rosenblum, Shoshy Mizrahy, Brandon D. Ng, Dan Peer
Immunomodulation of hematological malignancies using oligonucleotides based-nanomedicines
published pages: 149-156, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2016.07.052
Journal of Controlled Release 244 2020-02-21

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