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cureCD SIGNED

Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis

Total Cost €

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EC-Contrib. €

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Partnership

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 cureCD project word cloud

Explore the words cloud of the cureCD project. It provides you a very rough idea of what is the project "cureCD" about.

central    prospective    disorders    colitis    guide    suppress    renewal    explore    cellular    treatment    six    regarding    off    pathogenesis    relative    ulcer    expand    expression    functions    disease    ibd    dysregulation    deleterious    attempts    bowel    outcomes    mucosal    mediating    therapeutic    interactions    crohn    critical    iuml    human    ulcerative    interaction    regulate    tissue    co    mechanistic    gut    individuals    immune    million    hallmark    collected    conserved    nodes    diverse    microbiome    biopsies    exploration    prospectively    experimental    exhibit    minimal    strategies    granulocytes    healing    genes    plan    microbiota    model    uc    epithelial    pediatric    ulcers    rnaseq    culture    carful    mrnaseq    rnas    inflammatory    contexts    intervention    importently    failed    worldwide    tissues    utilize    cells    opposing    chronic    carries    na    ileum    informatics    diseases    limited    correlations    lncrna    intestinal    cd    relapsing    protein    epithelia    coding    half    lab    function    understand    ve    core    patients    profiles   

Project "cureCD" data sheet

The following table provides information about the project.

Coordinator
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER 

Organization address
address: TEL HASHOMER SHEBA MEDICAL CENTER
city: RAMAT GAN
postcode: 52621
website: http://www.sheba.co.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER IL (RAMAT GAN) coordinator 1˙500˙000.00

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 Project objective

The Inflammatory Bowel Diseases (IBD), Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic/relapsing disorders that affect over six million individuals worldwide. Mucosal ulcers, the hallmark of CD, are the result of a complex interaction between microbiota, immune cells, and gut epithelia. Healing of mucosal ulcers is associated with better outcomes, but is achieved in less than half of cases. Past attempts to suppress central and conserved nodes of the immune system failed due to opposing off-target deleterious effects on epithelial renewal. Therefore, there is a critical need to identify more tissue specific targets that lead to mucosal healing and to improved outcomes.

Using mRNAseq of intestinal biopsies, we identified a widespread dysregulation of long non-coding RNAs (lncRNA) in the ileum of treatment naïve pediatric CD patients. Importently, we identified significant correlations between lncRNA and mucosal ulcers. CD lncRNA, after carful mechanistic exploration, are highly promising targets for potential future intervention as they regulate diverse cellular functions and exhibit a more tissue specific expression in comparison to protein coding genes. The core goal of this proposal is to understand the role of CD lncRNA in ulcer pathogenesis focusing on granulocytes and epithelial functions in the contexts of their interactions with the microbiota.

I plan to utilize state of the art informatics, RNAseq and microbiome profiles together with advanced and novel experimental lab model and co-culture systems, patients-derived prospectively collected tissues, and gut microbiota to explore the role of CD lncRNA function in mediating healing of mucosal ulcers. This work carries the potential to guide new novel therapeutic strategies for mucosal healing with minimal off-targets effects. In a broader prospective, this work will expand our relative limited understanding regarding the role of lncRNA in mediating human diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-He
Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis
published pages: 491-502, ISSN: 1933-0219, DOI: 10.1038/s41385-018-0114-4
Mucosal Immunology 12/2 2020-02-13
2019 Nurit Loberman-Nachum, Katya Sosnovski, Ayelet Di Segni, Gilat Efroni, Tzipi Braun, Marina BenShoshan, Lait Anafi, Camila Avivi, Iris Barshack, Dror S. Shouval, Lee A. Denson, Amnon Amir, Ron Unger, Batia Weiss, Yael Haberman
Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-52733-1
Scientific Reports 9/1 2020-02-13

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