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REGMAMKID SIGNED

How to regenerate the mammalian kidney

Total Cost €

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EC-Contrib. €

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Partnership

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 REGMAMKID project word cloud

Explore the words cloud of the REGMAMKID project. It provides you a very rough idea of what is the project "REGMAMKID" about.

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Project "REGMAMKID" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙499˙604 €
 EC max contribution 1˙499˙604 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 1˙499˙604.00

Map

 Project objective

Kidney non-endocrine functions are primarily performed by millions of individual integral units called nephrons. Although the adults of simple vertebrates (fish, amphibians and reptiles) have the ability to regenerate entire nephrons by a process called “nephron neogenesis”, this capacity is absent in birds and mammals. In this regard we have observed, for the first time, that the murine neonatal kidney is able to generate new nephrons after the resection of the 20 per cent of the kidney mass. In the same manner, our recent published data on the generation of human kidney organoids ex vivo from kidney disease derived induced pluripotent stem cells (iPS), demonstrates the suitability of iPS technology to establish an unprecedented platform for drug screening, disease modelling and kidney regeneration. Thus, with support from REGMAMKID we will carry out a dual strategy for kidney regeneration and therapy. For kidney regeneration, we will make use of our newly developed mouse model of neonatal kidney regeneration and identify the molecular and epigenetic drivers responsible for this process. For kidney therapy, we will generate specific kidney cell populations with therapeutic potential such as podocytes and tubular epithelial cells by combining emerging cutting-edge technologies from the fields of cellular reprogramming and pluripotent stem cells differentiation. Making use of the tools developed in REGMAMKID we will model two different genetic kidney disorders: one affecting the podocyte (Congenital Nephrotic Syndrome) and other leading to an excessive proliferation of tubular epithelial cells (Autosomal Dominant Polycistic Disease). These studies will significantly impact on our understanding of kidney disease and healing.

 Publications

year authors and title journal last update
List of publications.
2016 Elena Garreta, Lorena de Oñate, M. Eugenia Fernández-Santos, Roger Oria, Carolina Tarantino, Andreu M. Climent, Andrés Marco, Mireia Samitier, Elena Martínez, Maria Valls-Margarit, Rafael Matesanz, Doris A. Taylor, Francisco Fernández-Avilés, Juan Carlos Izpisua Belmonte, Nuria Montserrat
Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts
published pages: 64-78, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2016.04.003
Biomaterials 98 2020-03-17
2016 C. Eguizabal, L. Herrera, L. De Oñate, N. Montserrat, P. Hajkova, J. C. Izpisua Belmonte
Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming
published pages: 2418-2428, ISSN: 1066-5099, DOI: 10.1002/stem.2422
STEM CELLS 34/9 2020-03-17
2018 Elena Garreta, Federico González, Núria Montserrat
Studying Kidney Disease Using Tissue and Genome Engineering in Human Pluripotent Stem Cells
published pages: 48-59, ISSN: 1660-8151, DOI: 10.1159/000480710
Nephron 138/1 2020-03-17
2016 Elena Garreta, Andres Marco, Juan Carlos Izpisua Belmonte, Nuria Montserrat
Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease
published pages: 76-76, ISSN: 2313-0792, DOI: 10.21037/sci.2016.10.11
Stem Cell Investigation 3 2020-03-17
2016 Nuria Montserrat, Elena Garreta, Juan Carlos Izpisua Belmonte
Regenerative strategies for kidney engineering
published pages: 3303-3324, ISSN: 1742-464X, DOI: 10.1111/febs.13704
The FEBS Journal 283/18 2020-03-17
2017 Elena Garreta, Roger Oria, Carolina Tarantino, Mateu Pla-Roca, Patricia Prado, Francisco Fernández-Avilés, Josep Maria Campistol, Josep Samitier, Nuria Montserrat
Tissue engineering by decellularization and 3D bioprinting
published pages: , ISSN: 1369-7021, DOI: 10.1016/j.mattod.2016.12.005
Materials Today 2020-03-17
2018 Elena Garreta, Nuria Montserrat, Juan Carlos Izpisua Belmonte
Kidney organoids for disease modeling
published pages: 12552-12553, ISSN: 1949-2553, DOI: 10.18632/oncotarget.24438
Oncotarget 9/16 2020-03-17
2018 Elena Garreta, Sonia Sanchez, Jeronimo Lajara, Nuria Montserrat, Juan Carlos Izpisua Belmonte
Roadblocks in the Path of iPSC to the Clinic
published pages: 14-18, ISSN: 2196-3029, DOI: 10.1007/s40472-018-0177-x
Current Transplantation Reports 5/1 2020-03-17

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