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CRADLE SIGNED

Cancer treatment during pregnancy: from fetal safety to maternal efficacy

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CRADLE" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.cancerinpregnancy.org
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙709˙375.00
2    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 290˙625.00

Map

 Project objective

The evolution in drug regulation of the last 50 years has left pregnant women and their fetuses orphaned. This is particularly problematic for cancer during pregnancy, which raises a difficult and conflicting medical ethical decision process and which has recently become increasingly frequent. In 2012 we published the first prospective study indicating that antenatal exposure to cancer treatment can overall be considered safe. Building on this proof of concept, the current proposal wants to take a groundbreaking step towards developing a standard of care for cancer during pregnancy by addressing –in an integrated fashion- the challenges at the level of the fetus, the mother and the fetomaternal barrier. At the core of this proposal lies an international registry of pregnant women with cancer, along with a registry of their children, and biobanks of maternal, placental, cord blood and tumoral tissues. Research track ‘child’ aims to deliver robust evidence of fetal safety. Research track ‘mother’ aims to address the emerging concerns in the oncological management of the mother, and specifically, the possible distinct biology of pregnancy-associated breast cancer, the most frequent cancer type in pregnancy. The research approach includes large-scale clinical follow-up studies along with laboratory studies on patient biomaterials, including pharmacological investigations and RNA-sequencing studies. Complementary to these studies is research track ‘placenta’ in which cutting-edge models of human placental research are used to address the poorly understood physiological basis of the placental barrier function in this specific situation. This ambitious program will rely on a multidisciplinary team of experts. Not only may the scientific deliverables of this proposal constitute a major step forward to the well-being of both mother and fetus in a pregnancy complicated by cancer, the methodological approach may also provide critical impetus to further research in this field.

 Publications

year authors and title journal last update
List of publications.
2018 M. Verheecke, A. Cortès Calabuig, J. Finalet Ferreiro, V. Brys, R. Van Bree, G. Verbist, T. Everaert, L. Leemans, M.M. Gziri, I. Boere, M.J. Halaska, J. Vanhoudt, F. Amant, K. Van Calsteren
Genetic and microscopic assessment of the human chemotherapy-exposed placenta reveals possible pathways contributive to fetal growth restriction
published pages: 61-70, ISSN: 0143-4004, DOI: 10.1016/j.placenta.2018.03.002
Placenta 64 2020-04-14
2018 Sileny N. Han, Frédéric Amant, Katrijn Michielsen, Frederik De Keyzer, Steffen Fieuws, Kristel Van Calsteren, Raphaëla C. Dresen, Mina Mhallem Gziri, Vincent Vandecaveye
Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study
published pages: 1862-1874, ISSN: 0938-7994, DOI: 10.1007/s00330-017-5126-z
European Radiology 28/5 2020-04-14
2017 Sigrid Conings, Frédéric Amant, Pieter Annaert, Kristel Van Calsteren
Integration and validation of the ex vivo human placenta perfusion model
published pages: 25-31, ISSN: 1056-8719, DOI: 10.1016/j.vascn.2017.05.002
Journal of Pharmacological and Toxicological Methods 88 2020-04-14
2018 Magali Verheecke, Els Hermans, Sandra Tuyaerts, Erika Souche, Rita Van Bree, Godelieve Verbist, Tina Everaert, Jeroen Van Houdt, Kristel Van Calsteren, Frederic Amant
Acute Drug Effects on the Human Placental Tissue: The Development of a Placental Murine Xenograft Model
published pages: 193371911875677, ISSN: 1933-7191, DOI: 10.1177/1933719118756771
Reproductive Sciences 2020-04-14
2016 Tineke Vandenbroucke, Sileny N. Han, Kristel Van Calsteren, Tom F. Wilderjans, Bea R.H. Van den Bergh, Laurence Claes, Frédéric Amant
Psychological distress and cognitive coping in pregnant women diagnosed with cancer and their partners
published pages: 1215-1221, ISSN: 1057-9249, DOI: 10.1002/pon.4301
Psycho-Oncology vol. 26, issue 8 2020-04-14
2018 Jorine de Haan, Magali Verheecke, Kristel Van Calsteren, Ben Van Calster, Roman G Shmakov, Mina Mhallem Gziri, Michael J Halaska, Robert Fruscio, Christianne A R Lok, Ingrid A Boere, Paolo Zola, Petronella B Ottevanger, Christianne J M de Groot, Fedro A Peccatori, Karina Dahl Steffensen, Elyce H Cardonick, Evgeniya Polushkina, Lukas Rob, Lorenzo Ceppi, Gennady T Sukhikh, Sileny N Han, Frédéric Amant
Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients
published pages: 337-346, ISSN: 1470-2045, DOI: 10.1016/S1470-2045(18)30059-7
The Lancet Oncology 19/3 2020-04-14
2017 Tineke Vandenbroucke, Magali Verheecke, Monica Fumagalli, Christianne Lok, Frédéric Amant
Effects of cancer treatment during pregnancy on fetal and child development
published pages: 302-310, ISSN: 2352-4642, DOI: 10.1016/S2352-4642(17)30091-3
The Lancet Child & Adolescent Health 1/4 2020-04-14

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