Opendata, web and dolomites


Slow-Fast Systems in Cellular Biology

Total Cost €


EC-Contrib. €






Project "SFSysCellBio" data sheet

The following table provides information about the project.


Organization address
address: KARLSPLATZ 13
city: WIEN
postcode: 1040

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-08-30   to  2019-08-29


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 178˙156.00


 Project objective

Mathematical modelling has emerged as an important tool to handle the structural complexity of cellular processes and to gain better understanding of their functioning and dynamics. We propose to develop methods for the mathematical analysis of ODE models arising in cell biology. We focus on models of great biomedical importance, i.e. cell division cycle, NF-kB signalling pathway, and the p53 system. Pertinent mathematical questions of biological interest are: existence and stability of equilibria, periodic oscillations, switching phenomena, and bifurcations. Often the analysis of such models relies heavily on computational approaches but qualitative analysis is also very important. Detailed models of individual pathways or the cell division cycle are too large for theoretical analysis. However, there is evidence from simulations that often only a small or moderate number of components of a large systems play essential roles, while other parts have almost negligible roles. This allows the systematic use of perturbation methods. In particular slow-fast dynamical systems, i.e. systems with solutions varying on very different timescales are abundant in biology in general and in cellular biology in particular.

The approach in this project relies strongly on novel dynamical systems methods for systems with multiple time scale dynamics, known as geometric singular perturbation theory (GSPT). Interestingly, the models under investigation do not have the standard form covered by the existing theory. Due to these difficulties GSPT has not been applied systematically in this area. An extended version of GSPT - using hierarchies of local approximations - will be developed for the specific models. The project will lead to better understanding of cell-cyle and signaling pathway models.

These issues and the methods to resolve them are of great importance also for other models in cellular biology and also for slow-fast dynamical systems in general.


year authors and title journal last update
List of publications.
2019 Amirkhanov, Aleksandr and Kosiuk, Ilona and Szmolyan, Peter and Amirkhanov, Artem and Mistelbauer, Gabriel and Gröller, Eduard and Raidou, Renata Georgia
ManyLands: A Journey Across 4D Phase Space of Trajectories
published pages: , ISSN: 1467-8659, DOI: 10.1111/cgf.13828
Computer Graphics Forum 38-Issue 7 2020-04-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SFSYSCELLBIO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SFSYSCELLBIO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

iRhomADAM (2020)

Uncovering the role of the iRhom2-ADAM17 interaction in inflammatory signalling

Read More  

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

COLEX (2019)

Coopetition and Legislation in the Spanish Netherlands (1598-1665)

Read More