Opendata, web and dolomites

BROADimmune SIGNED

Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "BROADimmune" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE PER L ISTITUTO DI RICERCA IN BIOMEDICINA 

Organization address
address: VIA VINCENZO VELA 6
city: BELLINZONA
postcode: 6500
website: http://www.irb.usi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website https://www.irb.usi.ch/structural-genetic-and-functional-analyses-broadly-neutralizing-antibodies-against-human-pathogens
 Total cost 1˙867˙500 €
 EC max contribution 1˙867˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE PER L ISTITUTO DI RICERCA IN BIOMEDICINA CH (BELLINZONA) coordinator 1˙867˙500.00

Map

 Project objective

The overall goal of this project is to understand the molecular mechanisms that lead to the generation of potent and broadly neutralizing antibodies against medically relevant pathogens, and to identify the factors that limit their production in response to infection or vaccination with current vaccines. We will use high-throughput cellular screens to isolate from immune donors clonally related antibodies to different sites of influenza hemagglutinin, which will be fully characterized and sequenced in order to reconstruct their developmental pathways. Using this approach, we will ask fundamental questions with regards to the role of somatic mutations in affinity maturation and intraclonal diversification, which in some cases may lead to the generation of autoantibodies. We will combine crystallography and long time-scale molecular dynamics simulation to understand how mutations can increase affinity and broaden antibody specificity. By mapping the B and T cell response to all sites and conformations of influenza hemagglutinin, we will uncover the factors, such as insufficient T cell help or the instability of the pre-fusion hemagglutinin, that may limit the generation of broadly neutralizing antibodies. We will also perform a broad analysis of the antibody response to erythrocytes infected by P. falciparum to identify conserved epitopes on the parasite and to unravel the role of an enigmatic V gene that appears to be involved in response to blood-stage parasites. The hypotheses tested are strongly supported by preliminary observations from our own laboratory. While these studies will contribute to our understanding of B cell biology, the results obtained will also have translational implications for the development of potent and broad-spectrum antibodies, for the definition of correlates of protection, and for improving vaccine design.

 Publications

year authors and title journal last update
List of publications.
2016 Antonio Lanzavecchia, Alexander Frühwirth, Laurent Perez, Davide Corti
Antibody-guided vaccine design: identification of protective epitopes
published pages: 62-67, ISSN: 0952-7915, DOI: 10.1016/j.coi.2016.06.001
Current Opinion in Immunology 41 2019-08-30
2018 Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli, Sonia Barbieri, Mathilde Foglierini, Chiara Silacci Fregni, Jessica Marcandalli, Said Jongo, Salim Abdulla, Laurent Perez, Giampietro Corradin, Luca Varani, Federica Sallusto, Betty Kim Lee Sim, Stephen L Hoffman, Stefan H I Kappe, Claudia Daubenberger, Ian A Wilson, Antonio Lanzavecchia
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
published pages: 401-407, ISSN: 1078-8956, DOI: 10.1038/nm.4513
Nature Medicine 24/4 2019-08-30
2017 Kathrin Pieper, Joshua Tan, Luca Piccoli, Mathilde Foglierini, Sonia Barbieri, Yiwei Chen, Chiara Silacci-Fregni, Tobias Wolf, David Jarrossay, Marica Anderle, Abdirahman Abdi, Francis M. Ndungu, Ogobara K. Doumbo, Boubacar Traore, Tuan M. Tran, Said Jongo, Isabelle Zenklusen, Peter D. Crompton, Claudia Daubenberger, Peter C. Bull, Federica Sallusto, Antonio Lanzavecchia
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities
published pages: 597-601, ISSN: 0028-0836, DOI: 10.1038/nature23670
Nature 548/7669 2019-08-30
2018 Antonio Lanzavecchia
Dissecting human antibody responses: useful, basic and surprising findings
published pages: e8879, ISSN: 1757-4676, DOI: 10.15252/emmm.201808879
EMBO Molecular Medicine 10/3 2019-08-30

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BROADIMMUNE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BROADIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More