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COMbAT

Commercialization of a novel tool for designing personalized nOvel MelAnoma Therapies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COMbAT project word cloud

Explore the words cloud of the COMbAT project. It provides you a very rough idea of what is the project "COMbAT" about.

later    biotech    costly    combination    propensity    lower    located    trials    population    genetic    models    resistant    companies    combat    holds    drugs    eliminated    timelines    strategies    tumours    pressures    melanoma    poc    urgent    aggressive    cancer    expirations    suffering    serve    industry    undergo    screens    therapy    personalized    toxicities    combinatorial    drug    mutations    psychological    enormous    reactions    regulatory    start    types    redefining    death    driver    business    treatments    patent    pigment    efficacy    genome    caused    economic    unnecessary    treatment    candidates    therapies    promise    creation    mutated    illustrates    investments    healthcare    physiological    express    alarming    manner    molecular    burden    systematic    tool    cells    preclinical    significantly    backlash    pharmaceutical    exact    adverse    believe    metastasis    mortality    young    lethal    person    skin    patient    chemotherapy    incidence    realizing    designing    lack    threats    innovative    diseases    designed    patients    landscape    genes    clinical   

Project "COMbAT" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 150˙000.00

Map

 Project objective

Melanoma tumours develop in the pigment cells located in the skin. It is the most aggressive and treatment-resistant type of skin cancer as well as the leading cause of death among skin diseases. Moreover, melanoma’s alarming increase in incidence, especially in the young population, in combination with its propensity for lethal metastasis, illustrates an urgent need for new treatment strategies. In this PoC project, we propose developing an innovative tool, called COMbAT, for designing highly personalized therapies for melanoma patients. Each therapy will be based on existing, already designed drugs and will specifically target the driver mutations present in a patient’s melanoma genome.

COMbAT involves the use of novel unique preclinical models designed to express patient-derived mutated genes in melanoma cells in a physiological manner. These models will undergo systematic combinatorial drug screens aiming to target the exact driver mutations present in patients. Such personalized targeting of the patient’s melanoma genetic landscape is key to a significantly improved mortality. Specifically, COMbAT can serve as a unique preclinical tool in the delivery of healthcare, from redefining clinical trials to targeted treatments of melanoma patients to start and a wide range of other cancer types later. Importantly, as COMbAT will allow the increased use of specific targeting of molecular drug targets, it will help to significantly lower the patient’s economic and psychological burden caused by unnecessary chemotherapy. COMbAT also holds the promise of realizing value from enormous past investments in drug candidates that were eliminated due to person-specific toxicities or lack of efficacy. We thus believe that COMbAT will enable the creation of new business models for the pharmaceutical industry which is suffering from patent expirations, threats from biotech companies, regulatory pressures, costly drug development timelines, and backlash from adverse drug reactions.

 Publications

year authors and title journal last update
List of publications.
2015 Rand Arafeh, Nouar Qutob, Rafi Emmanuel, Alona Keren-Paz, Jason Madore, Abdel Elkahloun, James S Wilmott, Jared J Gartner, Antonella Di Pizio, Sabina Winograd-Katz, Sivasish Sindiri, Ron Rotkopf, Ken Dutton-Regester, Peter Johansson, Antonia L Pritchard, Nicola Waddell, Victoria K Hill, Jimmy C Lin, Yael Hevroni, Steven A Rosenberg, Javed Khan, Shifra Ben-Dor, Masha Y Niv, Igor Ulitsky, Graham J Mann, Richard A Scolyer, Nicholas K Hayward, Yardena Samuels
Recurrent inactivating RASA2 mutations in melanoma
published pages: 1408-1410, ISSN: 1061-4036, DOI: 10.1038/ng.3427
Nature Genetics 47/12 2019-07-25

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