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COMbAT

Commercialization of a novel tool for designing personalized nOvel MelAnoma Therapies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COMbAT project word cloud

Explore the words cloud of the COMbAT project. It provides you a very rough idea of what is the project "COMbAT" about.

treatment    investments    death    combat    chemotherapy    undergo    later    pharmaceutical    lack    molecular    combination    companies    strategies    mortality    alarming    screens    melanoma    types    mutations    threats    trials    personalized    lower    driver    clinical    realizing    costly    tool    combinatorial    designing    biotech    efficacy    industry    drug    patient    population    promise    innovative    economic    cells    pigment    urgent    start    holds    genes    enormous    cancer    manner    burden    located    timelines    toxicities    young    propensity    poc    drugs    skin    lethal    believe    aggressive    reactions    express    genetic    incidence    adverse    treatments    redefining    business    illustrates    psychological    healthcare    genome    preclinical    therapy    therapies    models    diseases    pressures    landscape    resistant    person    mutated    metastasis    creation    patent    caused    backlash    expirations    unnecessary    designed    serve    regulatory    physiological    systematic    patients    suffering    exact    tumours    significantly    candidates    eliminated   

Project "COMbAT" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 150˙000.00

Map

 Project objective

Melanoma tumours develop in the pigment cells located in the skin. It is the most aggressive and treatment-resistant type of skin cancer as well as the leading cause of death among skin diseases. Moreover, melanoma’s alarming increase in incidence, especially in the young population, in combination with its propensity for lethal metastasis, illustrates an urgent need for new treatment strategies. In this PoC project, we propose developing an innovative tool, called COMbAT, for designing highly personalized therapies for melanoma patients. Each therapy will be based on existing, already designed drugs and will specifically target the driver mutations present in a patient’s melanoma genome.

COMbAT involves the use of novel unique preclinical models designed to express patient-derived mutated genes in melanoma cells in a physiological manner. These models will undergo systematic combinatorial drug screens aiming to target the exact driver mutations present in patients. Such personalized targeting of the patient’s melanoma genetic landscape is key to a significantly improved mortality. Specifically, COMbAT can serve as a unique preclinical tool in the delivery of healthcare, from redefining clinical trials to targeted treatments of melanoma patients to start and a wide range of other cancer types later. Importantly, as COMbAT will allow the increased use of specific targeting of molecular drug targets, it will help to significantly lower the patient’s economic and psychological burden caused by unnecessary chemotherapy. COMbAT also holds the promise of realizing value from enormous past investments in drug candidates that were eliminated due to person-specific toxicities or lack of efficacy. We thus believe that COMbAT will enable the creation of new business models for the pharmaceutical industry which is suffering from patent expirations, threats from biotech companies, regulatory pressures, costly drug development timelines, and backlash from adverse drug reactions.

 Publications

year authors and title journal last update
List of publications.
2015 Rand Arafeh, Nouar Qutob, Rafi Emmanuel, Alona Keren-Paz, Jason Madore, Abdel Elkahloun, James S Wilmott, Jared J Gartner, Antonella Di Pizio, Sabina Winograd-Katz, Sivasish Sindiri, Ron Rotkopf, Ken Dutton-Regester, Peter Johansson, Antonia L Pritchard, Nicola Waddell, Victoria K Hill, Jimmy C Lin, Yael Hevroni, Steven A Rosenberg, Javed Khan, Shifra Ben-Dor, Masha Y Niv, Igor Ulitsky, Graham J Mann, Richard A Scolyer, Nicholas K Hayward, Yardena Samuels
Recurrent inactivating RASA2 mutations in melanoma
published pages: 1408-1410, ISSN: 1061-4036, DOI: 10.1038/ng.3427
Nature Genetics 47/12 2019-07-25

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