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EpimiRTherapy SIGNED

Using human tissue to translate microRNA-based therapies for epilepsy

Total Cost €


EC-Contrib. €






 EpimiRTherapy project word cloud

Explore the words cloud of the EpimiRTherapy project. It provides you a very rough idea of what is the project "EpimiRTherapy" about.

levels    unmet    rnas    human    coding    surgically    seizure    rcsi    transcriptional    lobectomies    landscapes    anti    antagomir    rodents    biophysical    expertise    transfer    clinical    temporal    translational    collaborations    mechanism    first    epimirtherapy    complemented    position    microrna    edge    cell    acquired    brain    antagomirs    treat    resolution    therapy    launchpad    myself    neuron    protein    certain    gap    treatments    lab    modifying    intersectoral    slices    imaging    tested    training    resected    neurological    single    reaching    limited    icl    disease    antisense    time    tissue    fellowship    combination    humans    fills    cutting    secondment    never    elucidate    electrophysiology    ant    network    134    serve    urgent    interdisciplinary    micrornas    maturity    techniques    collaborators    treatment    whilst    meet    professional    molecular    host    core    regulate    molecules    epilepsy    independence    knockdown   

Project "EpimiRTherapy" data sheet

The following table provides information about the project.


Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The overall research aim of EpimiRTherapy is to elucidate the mechanism of a novel disease-modifying therapy for epilepsy at single cell resolution in the human brain. MicroRNAs are short non-coding RNAs which regulate protein levels in the brain. Certain microRNAs are strongly associated with epilepsy and their knockdown, using antisense molecules called ‘antagomirs’, has anti-seizure effects in rodents. Antagomir targeting microRNA-134 (ant-134) is a particularly promising disease-modifying treatment for epilepsy, which could meet an urgent clinical need. However, antagomirs to treat neurological disease have never been tested in humans due to limited translational evidence. EpimiRTherapy, for the first time, fills this gap: I will use state-of-the-art techniques to produce human brain slices from tissue surgically resected during temporal lobectomies for epilepsy. I will use a combination of molecular techniques (acquired at the host lab in RCSI and through secondment to ICL) and electrophysiology, my core expertise, to determine the impact of ant-134 on the biophysical and transcriptional landscapes of human tissue and a network and single neuron level. This will be complemented with cutting edge systems modelling and imaging techniques acquired through collaborations. This fellowship, through advanced interdisciplinary and intersectoral training, will serve as a launchpad for reaching a position of professional independence and maturity, whilst at the same time facilitating a transfer of knowledge between myself, the host and the collaborators, by bringing cutting edge electrophysiology and human tissue processing techniques to RCSI and addressing an urgent and unmet clinical need for novel epilepsy treatments.

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The information about "EPIMIRTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

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