Opendata, web and dolomites


An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

Total Cost €


EC-Contrib. €






 EU-ToxRisk project word cloud

Explore the words cloud of the EU-ToxRisk project. It provides you a very rough idea of what is the project "EU-ToxRisk" about.

drive    kidney    extensively    complexity    dose    mechanistic    liver    forms    phases    initio    disciplines    vivo    combined    vitro    microscopy    toxrisk    fit    validation    silico    read    service    optimization    ab    training    assays    toxicity    industry    regulators    algorithms    aop    sectors    systemic    ke    quantitative    background    repeated    throughput    aops    shift    extrapolation    speed    flexible    toxicology    technologies    risk    transcriptomics    incorporating    computational    solid    outcome    cosmetics    toxicokinetic    purpose    pragmatic    tiered    structured    tools    reproduction    developmental    animal    strategy    events    safety    adverse    underpinning    mechanism    toxicokinetics    activation    interference    human    unite    biological    broad    rna    nervous    lung    agro    strategies    pharma    continued    basis    free    paradigm    chemicals    stakeholders    spectrum    data    iterative    integrates    flagship    chemical    vision    regulatory    combines    balance    little    proof    plan    hazard   

Project "EU-ToxRisk" data sheet

The following table provides information about the project.


Organization address
address: RAPENBURG 70
city: LEIDEN
postcode: 2311 EZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 30˙122˙153 €
 EC max contribution 27˙798˙299 € (92%)
 Programme 1. H2020-EU.3.1.6. (Health care provision and integrated care)
 Code Call H2020-PHC-2015-single-stage_RTD
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT LEIDEN NL (LEIDEN) coordinator 4˙672˙069.00
2    UNIVERSITAT KONSTANZ DE (KONSTANZ) participant 1˙408˙187.00
3    ARTTIC FR (PARIS) participant 1˙395˙580.00
4    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 1˙295˙810.00
5    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 1˙282˙235.00
8    BioDetection Systems B.V. NL (Amsterdam) participant 960˙218.00
14    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 773˙260.00
15    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 767˙500.00
18    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 723˙190.00
19    STICHTING VU NL (AMSTERDAM) participant 720˙387.00
20    BASF SE DE (LUDWIGSHAFEN AM RHEIN) participant 695˙410.00
21    TISSUSE GMBH DE (BERLIN) participant 695˙065.00
22    CERTARA UK LIMITED UK (LONDON) participant 670˙765.00
25    UNIVERSITAT WIEN AT (WIEN) participant 594˙061.00
26    JOHNS HOPKINS UNIVERSITY US (BALTIMORE) participant 515˙762.00
28    LHASA LIMITED UK (LEEDS) participant 325˙000.00
30    The Danish Environmental Protection Agency DK (Copenhagen) participant 77˙750.00
32    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 64˙000.00
35    L'OREAL SA FR (PARIS) participant 14˙440.00
36    OPEN PHACTS FOUNDATION LBG UK (CAMBRIDGE) participant 11˙000.00
38    EDELWEISS CONNECT GMBH CH (BASEL) participant 0.00
39    F. HOFFMANN-LA ROCHE AG CH (BASEL) participant 0.00
40    INSPHERO AG CH (SCHLIEREN) participant 0.00


 Project objective

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.


List of deliverables.
Mapping ToxCast data to AOPs Documents, reports 2020-04-06 10:11:10
AOPs and key events for adverse effects Documents, reports 2020-04-06 10:11:10
Compound reference information resources Documents, reports 2020-04-06 10:11:09

Take a look to the deliverables list in detail:  detailed list of EU-ToxRisk deliverables.


year authors and title journal last update
List of publications.
2017 Alla P. Toropova, Andrey A. Toropov
Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles
published pages: 57-66, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.03.023
Toxicology Letters 275 2020-04-06
2017 Liudmila Efremova, Petra Chovancova, Martina Adam, Simon Gutbier, Stefan Schildknecht, Marcel Leist
Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation
published pages: 231-246, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1702-2
Archives of Toxicology 91/1 2020-04-06
2016 Isoude A. Kuijper, Huan Yang, Bob Van De Water, Joost B. Beltman
Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling
published pages: 5-17, ISSN: 1742-5255, DOI: 10.1080/17425255.2017.1234607
Expert Opinion on Drug Metabolism & Toxicology 13/1 2020-04-06
2016 Olivier Taboureau
Human Environmental Disease Network: A computational model to assess toxicology of contaminants
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1607201
ALTEX 2020-04-06
2017 Tanja Waldmann, Marianna Grinberg, André König, Eugen Rempel, Stefan Schildknecht, Margit Henry, Anna-Katharina Holzer, Nadine Dreser, Vaibhav Shinde, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Marcel Leist
Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity
published pages: 905-922, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.6b00259
Chemical Research in Toxicology 30/4 2020-04-06
2016 Thomas Luechtefeld
Analysis of publically available skin sensitization data from REACH registrations 2008-2014
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510055
ALTEX 2020-04-06
2016 Fabiola Pizzo, Anna Lombardo, Alberto Manganaro, Emilio Benfenati
A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2016.00442
Frontiers in Pharmacology 7 2020-04-06
2017 João V. Sá, Susanne Kleiderman, Catarina Brito, Ursula Sonnewald, Marcel Leist, Ana P. Teixeira, Paula M. Alves
Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis
published pages: 244-253, ISSN: 0364-3190, DOI: 10.1007/s11064-016-1907-z
Neurochemical Research 42/1 2020-04-06
2016 Thomas Luechtefeld
Analysis of public oral toxicity data from REACH registrations 2008-2014
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510054
ALTEX 2020-04-06
2017 Alejandro Aguayo-Orozco, Karine Audouze, Soren Brunak, Olivier Taboureau
In Silico Systems Pharmacology to Assess Drug\'s Therapeutic and Toxic Effects
published pages: 6895-6902, ISSN: 1381-6128, DOI: 10.2174/1381612822666160907093215
Current Pharmaceutical Design 22/46 2020-04-06
2017 Steven Wink, Steven Hiemstra, Bram Herpers, Bob van de Water
High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities
published pages: 1367-1383, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1781-0
Archives of Toxicology 91/3 2020-04-06
2017 Béla Z. Schmidt, Martin Lehmann, Simon Gutbier, Erastus Nembo, Sabrina Noel, Lena Smirnova, Anna Forsby, Jürgen Hescheler, Hasan X. Avci, Thomas Hartung, Marcel Leist, Julianna Kobolák, András Dinnyés
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
published pages: 1-33, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1805-9
Archives of Toxicology 91/1 2020-04-06
2016 Hao Zhu
Supporting read-across using biological data
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1601252
ALTEX 2020-04-06
2017 Andrey A. Toropov, Alla P. Toropova
The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models?
published pages: 31-37, ISSN: 1383-5718, DOI: 10.1016/j.mrgentox.2017.05.008
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 819 2020-04-06
2016 David Pamies
Good Cell Culture Practice for stem cells and stem-cell-derived models
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1607121
ALTEX 2020-04-06
2017 Alla P. Toropova, Andrey A. Toropov
The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability?
published pages: 466-472, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2017.01.198
Science of The Total Environment 586 2020-04-06
2016 Vaibhav Shinde, Sureshkumar Perumal Srinivasan, Margit Henry, Tamara Rotshteyn, Jürgen Hescheler, Jörg Rahnenführer, Marianna Grinberg, Johannes Meisig, Nils Blüthgen, Tanja Waldmann, Marcel Leist, Jan Georg Hengstler, Agapios Sachinidis
Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells
published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-016-0449-2
Stem Cell Research & Therapy 7/1 2020-04-06
2017 Vaibhav Shinde, Lisa Hoelting, Sureshkumar Perumal Srinivasan, Johannes Meisig, Kesavan Meganathan, Smita Jagtap, Marianna Grinberg, Julia Liebing, Nils Bluethgen, Jörg Rahnenführer, Eugen Rempel, Regina Stoeber, Stefan Schildknecht, Sunniva Förster, Patricio Godoy, Christoph van Thriel, John Antonydas Gaspar, Jürgen Hescheler, Tanja Waldmann, Jan G. Hengstler, Marcel Leist, Agapios Sachinidis
Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests
published pages: 839-864, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1741-8
Archives of Toxicology 91/2 2020-04-06
2016 Johanna Nyffeler
Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1605031
ALTEX 2020-04-06
2016 Lisa Hoelting, Stefanie Klima, Christiaan Karreman, Marianna Grinberg, Johannes Meisig, Margit Henry, Tamara Rotshteyn, Jörg Rahnenführer, Nils Blüthgen, Agapios Sachinidis, Tanja Waldmann, Marcel Leist
Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants
published pages: 476-487, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0108
STEM CELLS Translational Medicine 5/4 2020-04-06
2016 J. Meiser, S. Delcambre, A. Wegner, C. Jäger, J. Ghelfi, A. Fouquier d\'Herouel, X. Dong, D. Weindl, C. Stautner, Y. Nonnenmacher, A. Michelucci, O. Popp, F. Giesert, S. Schildknecht, L. Krämer, J.G. Schneider, D. Woitalla, W. Wurst, A. Skupin, D.M. Vogt Weisenhorn, R. Krüger, M. Leist, K. Hiller
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism
published pages: 112-125, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.01.019
Neurobiology of Disease 89 2020-04-06
2017 Alla P. Toropova, Andrey A. Toropov
CORAL: Binary classifications (active/inactive) for drug-induced liver injury
published pages: 51-57, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.01.011
Toxicology Letters 268 2020-04-06
2017 Christopher Goldring, Daniel J. Antoine, Frank Bonner, Jonathan Crozier, Chris Denning, Robert J. Fontana, Neil A. Hanley, David C. Hay, Magnus Ingelman-Sundberg, Satu Juhila, Neil Kitteringham, Beatriz Silva-Lima, Alan Norris, Chris Pridgeon, James A. Ross, Rowena Sison Young, Danilo Tagle, Belen Tornesi, Bob van de Water, Richard J. Weaver, Fang Zhang, B. Kevin Park
Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury
published pages: 710-721, ISSN: 0270-9139, DOI: 10.1002/hep.28886
Hepatology 65/2 2020-04-06
2016 Thomas Luechtefeld
Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510052
ALTEX 2020-04-06
2017 Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Antonio F Hernandez‐Jerez, Marcel Leist, Alberto Mantovani, Pablo Menendez, Olavi Pelkonen, Anna Price, Barbara Viviani, Arianna Chiusolo, Federica Ruffo, Andrea Terron, Susanne Hougaard Bennekou
Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson\'s disease and childhood leukaemia†
published pages: , ISSN: 1831-4732, DOI: 10.2903/j.efsa.2017.4691
EFSA Journal 15/3 2020-04-06
2016 Nicholas Ball
Toward Good Read-Across Practice (GRAP) guidance
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1601251
ALTEX 2020-04-06
2016 Thomas Luechtefeld
Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510053
ALTEX 2020-04-06
2017 Cordula Hirsch, Britta Striegl, Stephanie Mathes, Christian Adlhart, Michael Edelmann, Epifania Bono, Sabyasachi Gaan, Khalifah A. Salmeia, Lisa Hoelting, Alice Krebs, Johanna Nyffeler, Regina Pape, Alexander Bürkle, Marcel Leist, Peter Wick, Stefan Schildknecht
Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants
published pages: 407-425, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1680-4
Archives of Toxicology 91/1 2020-04-06
2017 Peter L.M. Jansen, Ahmed Ghallab, Nachiket Vartak, Raymond Reif, Frank G. Schaap, Jochen Hampe, Jan G. Hengstler
The ascending pathophysiology of cholestatic liver disease
published pages: 722-738, ISSN: 0270-9139, DOI: 10.1002/hep.28965
Hepatology 65/2 2020-04-06
2016 Mardas Daneshian, Hennicke Kamp, Jan Hengstler, Marcel Leist, Bob van de Water
Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk
published pages: 1021-1024, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1698-7
Archives of Toxicology 90/5 2020-04-06
2017 Johanna Nyffeler, Xenia Dolde, Alice Krebs, Kevin Pinto-Gil, Manuel Pastor, Mamta Behl, Tanja Waldmann, Marcel Leist
Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library
published pages: , ISSN: 0340-5761, DOI: 10.1007/s00204-017-1977-y
Archives of Toxicology 2020-04-06
2016 Michael Aschner
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1604201
ALTEX 2020-04-06
2016 Abinaya Chandrasekaran, Hasan X. Avci, Marcel Leist, Julianna Kobolák, Andras Dinnyés
Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2016.00215
Frontiers in Cellular Neuroscience 10 2020-04-06
2017 Alla P. Toropova, Andrey A. Toropov, Marco Marzo, Sylvia E. Escher, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models
published pages: , ISSN: 0278-6915, DOI: 10.1016/j.fct.2017.03.060
Food and Chemical Toxicology 2020-04-06
2018 Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung
Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility
published pages: 198-212, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfy152
Toxicological Sciences 165/1 2020-04-06
2018 Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati
A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications
published pages: , ISSN: 1758-2946, DOI: 10.1186/s13321-018-0315-6
Journal of Cheminformatics 10/1 2020-04-06
2018 Domenico Gadaleta, Serena Manganelli, Alessandra Roncaglioni, Cosimo Toma, Emilio Benfenati, Enrico Mombelli
QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis
published pages: 1501-1517, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.8b00297
Journal of Chemical Information and Modeling 58/8 2020-04-06
2018 Simon Gutbier, Patrick May, Sylvie Berthelot, Abhimanyu Krishna, Timo Trefzer, Mehri Behbehani, Liudmila Efremova, Johannes Delp, Gerhard Gstraunthaler, Tanja Waldmann, Marcel Leist
Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
published pages: 3487-3503, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2326-5
Archives of Toxicology 92/12 2020-04-06
2018 Charles Laroche, Manoj Aggarwal, Hans Bender, Paul Benndorf, Barbara Birk, Jonathan Crozier, Gianni Dal Negro, Federica De Gaetano, Christian Desaintes, Iain Gardner, Bruno Hubesch, Amaia Irizar, David John, Vikas Kumar, Alfonso Lostia, Irene Manou, Mario Monshouwer, Boris P. Müller, Alicia Paini, Kirsty Reid, Timothy Rowan, Magdalini Sachana, Katrin Schutte, Catrina Stirling, Rob Taalman, Leon van Aerts, Renate Weissenhorn, Ursula G. Sauer
Finding synergies for 3Rs – Toxicokinetics and read-across: Report from an EPAA partners\' Forum
published pages: 5-21, ISSN: 0273-2300, DOI: 10.1016/j.yrtph.2018.08.006
Regulatory Toxicology and Pharmacology 99 2020-04-06
2018 Alejandro Aguayo-Orozco, Frederic Yves Bois, Søren Brunak, Olivier Taboureau
Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00396
Frontiers in Genetics 9 2020-04-06
2018 Johannes Delp
A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays
published pages: 235-253, ISSN: 1868-596X, DOI: 10.14573/altex.1712182
ALTEX 2020-04-06
2018 Steven Wink, Steven W. Hiemstra, Suzanne Huppelschoten, Janna E. Klip, Bob van de Water
Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury
published pages: 1797-1814, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2178-z
Archives of Toxicology 92/5 2020-04-06
2018 Xiaolong Gu, Wiebke Albrecht, Karolina Edlund, Franziska Kappenberg, Jörg Rahnenführer, Marcel Leist, Wolfgang Moritz, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Tim Brecklinghaus, Laia Tolosa Pardo, José V. Castell, Iain Gardner, Bo Han, Jan G. Hengstler, Regina Stoeber
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
published pages: 3505-3515, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2302-0
Archives of Toxicology 92/12 2020-04-06
2018 Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknecht
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
published pages: 41-82, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2133-4
Archives of Toxicology 92/1 2020-04-06
2018 Georgina Harris, Melanie Eschment, Sebastian Perez Orozco, J. Michael McCaffery, Richard Maclennan, Daniel Severin, Marcel Leist, Andre Kleensang, David Pamies, Alexandra Maertens, Helena T. Hogberg, Dana Freeman, Alfredo Kirkwood, Thomas Hartung, Lena Smirnova
Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone
published pages: 2587-2606, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2250-8
Archives of Toxicology 92/8 2020-04-06
2019 Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
published pages: 385-399, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2354-1
Archives of Toxicology 93/2 2020-04-06
2018 Johanna Nyffeler, Petra Chovancova, Xenia Dolde, Anna-Katharina Holzer, Vladimir Purvanov, Ilona Kindinger, Anna Kerins, David Higton, Steve Silvester, Barbara M. A. van Vugt-Lussenburg, Enrico Glaab, Bart van der Burg, Richard Maclennan, Daniel F. Legler, Marcel Leist
A structure–activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins
published pages: 1225-1247, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2125-4
Archives of Toxicology 92/3 2020-04-06
2018 Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Current EU research activities on combined exposure to multiple chemicals
published pages: 544-562, ISSN: 0160-4120, DOI: 10.1016/j.envint.2018.07.037
Environment International 120 2020-04-06
2018 Alice Limonciel, Gamze Ates, Giada Carta, Anja Wilmes, Manfred Watzele, Peter J. Shepard, Harper C. VanSteenhouse, Bruce Seligmann, Joanne M. Yeakley, Bob van de Water, Mathieu Vinken, Paul Jennings
Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq
published pages: 2517-2531, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2256-2
Archives of Toxicology 92/8 2020-04-06
2017 Giorgia Pallocca, Johanna Nyffeler, Xenia Dolde, Marianna Grinberg, Gerhard Gstraunthaler, Tanja Waldmann, Jörg Rahnenführer, Agapios Sachinidis, Marcel Leist
Impairment of human neural crest cell migration by prolonged exposure to interferon-beta
published pages: 3385-3402, ISSN: 0340-5761, DOI: 10.1007/s00204-017-1966-1
Archives of Toxicology 91/10 2020-04-06
2019 Luc J. M. Bischoff, Isoude A. Kuijper, Johannes P. Schimming, Liesanne Wolters, Bas ter Braak, Jan P. Langenberg, Daan Noort, Joost B. Beltman, Bob van de Water
A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure
published pages: 435-451, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2353-2
Archives of Toxicology 93/2 2020-04-06
2018 Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings
Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00429
Frontiers in Genetics 9 2020-04-06
2019 Jaffar Kisitu
Chemical concentrations in cell culture compartments (C5) – concentration definitions
published pages: 154-160, ISSN: 1868-596X, DOI: 10.14573/altex.1901031
ALTEX 36/1 2020-04-06
2018 Niemeijer M, Hiemstra S, Wink S, den Hollander W, ter Braak B, van de Water B
Systems microscopy approaches in unravelling and predicting drug-induced liver injury (DILI)
published pages: 611-625, ISSN: , DOI:
Methods in Pharmacology and Toxicology 2020-04-06
2018 Domenico Gadaleta, Serena Manganelli, Alessandra Roncaglioni, Cosimo Toma, Emilio Benfenati, Enrico Mombelli
QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis
published pages: 1501-1517, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.8b00297
Journal of Chemical Information and Modeling 58/8 2020-04-06
2018 Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung
Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility
published pages: 198-212, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfy152
Toxicological Sciences 165/1 2020-04-06
2018 Alice Krebs
Normalization of data for viability and relative cell function curves
published pages: 268-271, ISSN: 1868-596X, DOI: 10.14573/1803231
ALTEX 2020-04-06
2018 Alice Limonciel, Simone G. van Breda, Xiaoqi Jiang, Gregory D. Tredwell, Anja Wilmes, Lydia Aschauer, Alexandros P. Siskos, Agapios Sachinidis, Hector C. Keun, Annette Kopp-Schneider, Theo M. de Kok, Jos C. S. Kleinjans, Paul Jennings
Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00558
Frontiers in Genetics 9 2020-04-06
2018 Mar Coll, Luis Perea, Ruben Boon, Sofia B. Leite, Julia Vallverdú, Inge Mannaerts, Ayla Smout, Adil El Taghdouini, Delia Blaya, Daniel Rodrigo-Torres, Isabel Graupera, Beatriz Aguilar-Bravo, Christophe Chesne, Mustapha Najimi, Etienne Sokal, Juan José Lozano, Leo A. van Grunsven, Catherine M. Verfaillie, Pau Sancho-Bru
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis
published pages: 101-113.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.05.027
Cell Stem Cell 23/1 2020-04-06
2018 David Pamies
Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
published pages: 353-378, ISSN: 1868-596X, DOI: 10.14573/altex.1710081
ALTEX 2020-04-06
2018 C. Fisher, S. Siméon, M. Jamei, I. Gardner, Y.F. Bois
VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays
published pages: , ISSN: 0887-2333, DOI: 10.1016/j.tiv.2018.12.017
Toxicology in Vitro 2020-04-06
2018 C.P. Fisher, O. Hatley, B. van Vugt, F. Bois, S. Escher, I. Gardner
In Vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approach
published pages: S246, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.1015
Toxicology Letters 295 2020-04-06
2017 Ugis Sarkans, Mikhail Gostev, Awais Athar, Ehsan Behrangi, Olga Melnichuk, Ahmed Ali, Jasmine Minguet, Juan Camillo Rada, Catherine Snow, Andrew Tikhonov, Alvis Brazma, Johanna McEntyre
The BioStudies database—one stop shop for all data supporting a life sciences study
published pages: D1266-D1270, ISSN: 0305-1048, DOI: 10.1093/nar/gkx965
Nucleic Acids Research 46/D1 2020-04-06
2018 Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L. Krüger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P. Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Water, Christopher E. Goldring, B. Kevin Park, Jens Timmer, Ursula Klingmüller
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
published pages: , ISSN: 2056-7189, DOI: 10.1038/s41540-018-0058-z
npj Systems Biology and Applications 4/1 2020-04-06
2018 Megan Chesnut
Regulatory acceptance of read-across
published pages: 413-419, ISSN: 1868-596X, DOI: 10.14573/altex.1805081
ALTEX 2020-04-06
2018 M. Pastor, G.J.P. Westen, J.C. Gómez-Tamayo, B.E. Lenselink, C.-C. Lam, B. Water, U. Norinder, S. Manganelli, D. Gadaleta, A. Roncaglioni
Development and validation of computational models for predicting oxidative stress responses using comprehensive series of drug-like compounds
published pages: S62-S63, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.062
Toxicology Letters 295 2020-04-06
2018 Johannes Delp, Simon Gutbier, Martin Cerff, Christin Zasada, Sebastian Niedenführ, Liang Zhao, Lena Smirnova, Thomas Hartung, Hanna Borlinghaus, Falk Schreiber, Jörg Bergemann, Jochem Gätgens, Martin Beyss, Salah Azzouzi, Tanja Waldmann, Stefan Kempa, Katharina Nöh, Marcel Leist
Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity
published pages: 64-80, ISSN: 0041-008X, DOI: 10.1016/j.taap.2017.12.013
Toxicology and Applied Pharmacology 354 2020-04-06
2019 Cosimo Toma, Domenico Gadaleta, Alessandra Roncaglioni, Andrey Toropov, Alla Toropova, Marco Marzo, Emilio Benfenati
QSAR Development for Plasma Protein Binding: Influence of the Ionization State
published pages: , ISSN: 0724-8741, DOI: 10.1007/s11095-018-2561-8
Pharmaceutical Research 36/2 2020-04-06
2018 Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati
A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications
published pages: , ISSN: 1758-2946, DOI: 10.1186/s13321-018-0315-6
Journal of Cheminformatics 10/1 2020-04-06
2018 Anna Bal-Price
Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
published pages: 306-352, ISSN: 1868-596X, DOI: 10.14573/altex.1712081
ALTEX 2020-04-06
2018 Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo, Egon L. Willighagen
Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00661
Frontiers in Genetics 9 2020-04-06
2018 C. Mahony, R. Currie, G. Daston, N. Kleinstreuer, B. van de Water
Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable summary
published pages: 1015-1020, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2145-0
Archives of Toxicology 92/2 2020-04-06
2018 Marcel Leist
Essential components of methods papers
published pages: 429-432, ISSN: 1868-596X, DOI: 10.14573/altex.1807031
ALTEX 2020-04-06
2018 Simon Gutbier, Anna-Sophie Spreng, Johannes Delp, Stefan Schildknecht, Christiaan Karreman, Ilinca Suciu, Thomas Brunner, Marcus Groettrup, Marcel Leist
Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress
published pages: 2101-2117, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0229-x
Cell Death & Differentiation 25/12 2020-04-06

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