Opendata, web and dolomites

BOOSTB4 SIGNED

Boost Brittle Bones Before Birth

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "BOOSTB4" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://boostb4.eu/
 Total cost 8˙378˙755 €
 EC max contribution 6˙608˙754 € (79%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-single-stage_RTD
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙827˙061.00
2    GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST UK (LONDON) participant 1˙410˙493.00
3    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 703˙132.00
4    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 648˙543.00
5    CELLPROTECT NORDIC PHARMACEUTICALS AB SE (Huddinge) participant 549˙781.00
6    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 408˙395.00
7    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 262˙097.00
8    LUNDS UNIVERSITET SE (LUND) participant 241˙156.00
9    A2F ASSOCIATES LIMITED UK (NEWMARKET) participant 203˙725.00
10    MEDSCINET AB SE (Stockholm) participant 121˙093.00
11    NORDIC HEALTH ECONOMICS AB SE (GOTEBORG) participant 106˙000.00
12    EURAM LIMITED UK (LINCOLN) participant 77˙275.00
13    UNIVERSITY OF LEICESTER UK (LEICESTER) participant 50˙000.00

Map

 Project objective

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal mesenchymal stem cells (MSC) is a promising approach for treatment of OI. We receive regular requests for MSC transplantation from patients and their physicians; patient organisations support our approach. The principal objective of the BOOSTB4 project is to conduct a Phase I/II clinical trial of the safety and efficacy of pre- and/or postnatal MSC transplantation in the severest forms of OI (type III, severe type IV). Transplantation before birth at the onset of disease should lead to greater efficacy and engraftment with less rejection than transplantation after birth. Postnatal transplantation will be evaluated in cases where prenatal diagnosis was not made. The trial’s primary outcome is safety; secondary outcomes relate to efficacy (fracture frequency, growth, bone mineral density and quality of life). All patients will undergo molecular diagnosis to confirm OI before inclusion in the trial. Non-invasive prenatal diagnosis will be developed and validated. The BOOSTB4 consortium is led by experts in MSC, prenatal therapy and OI at the Karolinska Institutet (KI), which will also lead the international multicentre trial; five additional EU centres of excellence are included. Ethical and regulatory applications are underway to conduct this clinical trial. These are facilitated by the ethical and regulatory approvals for prenatal MSC transplantation in 10 cases of OI that have already been granted at KI. Successful prenatal transplantation represents a major step forward in the management of patients with severe OI, and beyond, to a range of other inherited birth defects.

 Deliverables

List of deliverables.
Project website Websites, patent fillings, videos etc. 2020-04-14 21:13:20

Take a look to the deliverables list in detail:  detailed list of BOOSTB4 deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Jennifer Couzin-Frankel
Ailing fetuses to be treated with stem cells
published pages: , ISSN: 0036-8075, DOI: 10.1126/science.aaf9912
Science 2020-04-14
2016 www.horizon2020projects.com
Boosting bones
published pages: 166-167, ISSN: 2054-2631, DOI:
Horizon 2020 Projects: Portal January 2016, Quarterly 2020-04-14
2018 Natalie Chandler, Sunayna Best, Jane Hayward, Francesca Faravelli, Sahar Mansour, Emma Kivuva, Dagmar Tapon, Alison Male, Catherine DeVile, Lyn S Chitty
Rapid prenatal diagnosis using targeted exome sequencing: a cohort study to assess feasibility and potential impact on prenatal counseling and pregnancy management
published pages: 1430-1437, ISSN: 1098-3600, DOI: 10.1038/gim.2018.30
Genetics in Medicine 20/11 2020-04-14
2018 Melissa Hill, Celine Lewis, Megan Riddington, Belinda Crowe, Catherine DeVile, Cecilia Götherström, Lyn Chitty
Exploring the impact of Osteogenesis Imperfecta on families: A mixed-methods systematic review
published pages: , ISSN: 1936-6574, DOI: 10.1016/j.dhjo.2018.12.003
Disability and Health Journal 2020-04-14
2017 Jane Hayward, Lyn Chitty, Lucy Jenkins, Fiona McKay, Natalie Chandler, Helena Ahlfors and Sunayna Best
Oral Abstracts of the ISPD 21 st International Conference on Prenatal Diagnosis and Therapy, San Diego, California, USA, 9-12 July 2017
published pages: 3-20, ISSN: 0197-3851, DOI: 10.1002/pd.5084
Prenatal Diagnosis 37 2020-04-14
2019 Mats Johansson, Göran Hermerén, Nils-Eric Sahlin
Paternal consent in prenatal research: ethical aspects
published pages: , ISSN: 1386-7423, DOI: 10.1007/s11019-019-09919-1
Medicine, Health Care and Philosophy 2020-04-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BOOSTB4" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BOOSTB4" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.3.)

PanCareFollowUp (2019)

PanCareFollowUp: Novel, patient-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for survivors and caregivers

Read More  

GACD (2019)

Global Alliance for Chronic Diseases Secretariat

Read More  

LEGACy (2019)

CeLac and European consortium for a personalized medicine approach to Gastric Cancer

Read More