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BetaCellTherapy SIGNED

Beta Cell Generation by Stem Cell-Derived Implants in Diabetes

Total Cost €


EC-Contrib. €






 BetaCellTherapy project word cloud

Explore the words cloud of the BetaCellTherapy project. It provides you a very rough idea of what is the project "BetaCellTherapy" about.

clinically    society    joins    stem    influence    implants    prepared    es    preclinical    pancreatic    collected    pluripotent    efficacy    laboratory    depletion    insulin    device    caused    implant    pilot    innate    grafts    academic    treatment    homeostatic    metabolic    mass    ipsc    patients    maturation    clinical    models    generate    search    forms    protocols    serious    monitor    manufactured    status    health    risks    proof    despite    understand    innovating    heavy    basis    recipient    modifications    transition    examine    guide    indicate    chronic    reactivity    therapeutic    shown    subcutaneous    metabolically    endodermal    data    diabetes    markers    biology    pancreases    hu    immune    cells    minds    helps    progress    outcome    explore    embryonic    cure    beta    functional    industry    burden    improvement    restoration    encapsulated    human    host    combination    source    auto    biologic    disease    combined    cell    expert    life   

Project "BetaCellTherapy" data sheet

The following table provides information about the project.


Organization address
address: PLEINLAAN 2
postcode: 1050

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website
 Total cost 6˙800˙000 €
 EC max contribution 6˙200˙000 € (91%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-single-stage_RTD
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) coordinator 3˙100˙000.00
2    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 1˙200˙000.00
3    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 600˙000.00
5    VIACYTE, INC CORPORATION US (SAN DIEGO CA) participant 600˙000.00
7    NESTEC SA CH (LAUSANNE) participant 0.00
8    NESTEC SA CH (VEVEY) participant 0.00


 Project objective

Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases have shown proof-of-principle but also the need for developing a large-scale source for therapeutic cells. Our objective is to generate a functional beta cell mass by stem cell-derived implants in diabetes patients. A combined preclinical and clinical project will search recipient and implant conditions for formation and maturation of beta cells in subcutaneous implants of device-encapsulated pancreatic endodermal cells that are derived from human embryonic stem cells (hu-ES) and manufactured for clinical studies. We collected preclinical evidence for the therapeutic potential of this implant from comparison with clinically used human beta cell grafts. State-of-the art methods and markers have been developed to investigate the biology of implants and to monitor host immune and innate reactivity. This approach helps understand the basis for metabolic outcome and identify targets for improvement. Pilot studies examine the influence of the (auto)immune status of the patients. Data will determine transition to clinical efficacy studies, or indicate the need for further laboratory development. Implants in preclinical models will guide modifications in clinical protocols, and explore the biologic properties of grafts derived from human induced pluripotent stem cell (iPSc) as can also be prepared from diabetes patients. Our consortium joins innovating cells, methods, markers and minds in a unique combination of expert clinical, academic and industry activities that need each other to make progress in an ambitious program.


List of deliverables.
Human beta cell grafts with QC data for start transplants in subgroup of type 1 diabetes recipients of VCTM implant Demonstrators, pilots, prototypes 2020-03-11 13:03:37
Human beta cell preparations with QC data for comparative assessment of human iPS-derived implants in preclinical model and their use in screening assay Demonstrators, pilots, prototypes 2020-03-11 13:03:57
Production of biodegradable microparticles for local release of VEGF, NGF and exenatide Demonstrators, pilots, prototypes 2019-09-13 11:09:19
Time-table for public information on program Other 2019-09-13 11:09:19
Communication network operational Other 2019-09-13 11:09:19

Take a look to the deliverables list in detail:  detailed list of BetaCellTherapy deliverables.


year authors and title journal last update
List of publications.
2018 Else M. Balke, Eric V. Balti, Bart Van der Auwera, Ilse Weets, Olivier Costa, Simke Demeester, Pascale Abrams, Kristina Casteels, Marina Coeckelberghs, Sylvie Tenoutasse, Bart Keymeulen, Daniel G. Pipeleers, Frans K. Gorus
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody–Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles
published pages: 1076-1083, ISSN: 0149-5992, DOI: 10.2337/dc17-2462
Diabetes Care 41/5 2019-10-29
2018 Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi
Pluripotent stem cell replacement approaches to treat type 1 diabetes
published pages: 20-26, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.07.007
Current Opinion in Pharmacology 43 2019-10-09
2018 Sarah Roels, Olivier R Costa, Sarah A Tersey, Geert Stangé, Dieter De Smet, Eric V Balti, Pieter Gillard, Bart Keymeulen, Zhidong Ling, Daniel G Pipeleers, Frans K Gorus, Raghavendra G Mirmira, Geert A Martens
Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D
published pages: 451-460, ISSN: 0021-972X, DOI: 10.1210/jc.2017-02520
The Journal of Clinical Endocrinology & Metabolism 104/2 2019-10-09
2019 Sarah Akbib, Jordy Stichelmans, Geert Stangé, Zhidong Ling, Zerihun Assefa, Karine H. Hellemans
Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially
published pages: e0212210, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212210
PLOS ONE 14/2 2019-10-09
2018 Olivier R. Costa, Katrijn Verhaeghen, Sarah Roels, Geert Stangé, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens
An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65
published pages: e0193670, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193670
PLOS ONE 13/3 2019-10-09
2018 Else M. Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J. Van der Auwera, Zhidong Ling, Bart O. Roep, Daniël G. Pipeleers, Bart Keymeulen, Frans K. Gorus
SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients
published pages: 1623-1632, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4609-z
Diabetologia 61/7 2019-10-09
2015 Zhidong Ling, Pieter De Pauw, Daniel Jacobs-Tulleneers-Thevissen, Rui Mao, Pieter Gillard, Christiane S. Hampe, Geert A. Martens, Peter In\'t Veld, Ã…ke Lernmark, Bart Keymeulen, Frans Gorus, Daniel Pipeleers
Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients
published pages: 2314-2321, ISSN: 0021-972X, DOI: 10.1210/jc.2015-1216
The Journal of Clinical Endocrinology & Metabolism 100/6 2019-10-09
2018 Ines De Mesmaeker, Thomas Robert, Krista G. Suenens, Geert M. Stangé, Freya Van Hulle, Zhidong Ling, Peter Tomme, Daniel Jacobs-Tulleneers-Thevissen, Bart Keymeulen, Daniel G. Pipeleers
Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells
published pages: 2640-2649, ISSN: 0012-1797, DOI: 10.2337/db18-0709
Diabetes 67/12 2019-10-09
2015 Silvia Pellegrini, Federica Ungaro, Alessia Mercalli, Raffaella Melzi, Guido Sebastiani, Francesco Dotta, Vania Broccoli, Lorenzo Piemonti, Valeria Sordi
Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo
published pages: 1025-1035, ISSN: 0940-5429, DOI: 10.1007/s00592-015-0726-z
Acta Diabetologica 52/6 2019-09-13
2016 Daniel Pipeleers, Thomas Robert, Ines De Mesmaeker, Zhidong Ling
Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes
published pages: 1338-1344, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0187
STEM CELLS Translational Medicine 5/10 2019-09-13
2016 Cornelis R. van der Torren, Annemarie A. Verrijn Stuart, DaHae Lee, Jenny Meerding, Ursule van de Velde, Daniel Pipeleers, Pieter Gillard, Bart Keymeulen, Wilco de Jager, Bart O. Roep
Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes
published pages: e0146649, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0146649
PLOS ONE 11/1 2019-09-13
2017 Cornelis R. van der Torren, Arnaud Zaldumbide, Gaby Duinkerken, Simone H. Brand-Schaaf, Mark Peakman, Geert Stangé, Laura Martinson, Evert Kroon, Eugene P. Brandon, Daniel Pipeleers, Bart O. Roep
Immunogenicity of human embryonic stem cell-derived beta cells
published pages: 126-133, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4125-y
Diabetologia 60/1 2019-09-13
2016 Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K. Gorus
Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio
published pages: e0166702, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0166702
PLOS ONE 11/12 2019-09-13
2017 Guido Sebastiani, Marco Valentini, Giuseppina Emanuela Grieco, Giuliana Ventriglia, Laura Nigi, Francesca Mancarella, Silvia Pellegrini, Gianvito Martino, Valeria Sordi, Lorenzo Piemonti, Francesco Dotta
MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells
published pages: 265-281, ISSN: 0940-5429, DOI: 10.1007/s00592-016-0955-9
Acta Diabetologica 54/3 2019-09-13
2017 Maria J L Kracht, Menno van Lummel, Tatjana Nikolic, Antoinette M Joosten, Sandra Laban, Arno R van der Slik, Peter A van Veelen, Françoise Carlotti, Eelco J P de Koning, Rob C Hoeben, Arnaud Zaldumbide, Bart O Roep
Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
published pages: 501-507, ISSN: 1078-8956, DOI: 10.1038/nm.4289
Nature Medicine 23/4 2019-09-13
2015 Gregory L. Szot, Mahesh Yadav, Jiena Lang, Evert Kroon, Justin Kerr, Kuniko Kadoya, Eugene P. Brandon, Emmanuel E. Baetge, Hélène Bour-Jordan, Jeffrey A. Bluestone
Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm
published pages: 148-157, ISSN: 1934-5909, DOI: 10.1016/j.stem.2014.12.001
Cell Stem Cell 16/2 2019-09-13
2015 Olivier R. Costa, Geert Stangé, Katrijn Verhaeghen, Benedicte Brackeva, Ellen Nonneman, Christiane S. Hampe, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens
Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death
published pages: 4755-4760, ISSN: 0013-7227, DOI: 10.1210/en.2015-1636
Endocrinology 156/12 2019-09-13
2017 Frans K. Gorus, Eric V. Balti, Anissa Messaaoui, Simke Demeester, Annelien Van Dalem, Olivier Costa, Harry Dorchy, Chantal Mathieu, Luc Van Gaal, Bart Keymeulen, Daniël G. Pipeleers, Ilse Weets
Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes
published pages: 1065-1072, ISSN: 0149-5992, DOI: 10.2337/dc16-2228
Diabetes Care 40/8 2019-09-13
2016 Zerihun Assefa, Sarah Akbib, Astrid Lavens, Geert Stangé, Zhidong Ling, Karine H. Hellemans, Daniel Pipeleers
Direct effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation
published pages: E698-E705, ISSN: 0193-1849, DOI: 10.1152/ajpendo.00070.2016
American Journal of Physiology - Endocrinology And Metabolism 311/4 2019-09-13
2018 Thomas Robert, Ines De Mesmaeker, Geert M. Stangé, Krista G. Suenens, Zhidong Ling, Evert J. Kroon, Daniel G. Pipeleers
Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control
published pages: 739-750, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.040
Stem Cell Reports 10/3 2019-09-13
2016 Simke Demeester, Else M. Balke, Bart J. Van der Auwera, Pieter Gillard, Robert Hilbrands, DaHae Lee, Ursule Van de Velde, Zhidong Ling, Bart O. Roep, Daniel G. Pipeleers, Frans K. Gorus, Bart Keymeulen
HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft
published pages: 1060-1064, ISSN: 0149-5992, DOI: 10.2337/dc15-2768
Diabetes Care 39/6 2019-09-13
2017 Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K. Gorus
Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio
published pages: e0179108, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179108
PLOS ONE 12/6 2019-09-13
2017 Elisa Cantarelli, Antonio Citro, Silvia Pellegrini, Alessia Mercalli, Raffaella Melzi, Erica Dugnani, Tatiana Jofra, Georgia Fousteri, Anna Mondino, Lorenzo Piemonti
Transplant Site Influences the Immune Response After Islet Transplantation
published pages: 1046-1055, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001462
Transplantation 101/5 2019-09-13
2018 Silvia Pellegrini, Fabio Manenti, Raniero Chimienti, Rita Nano, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Philippe Ravassard, Lorenzo Piemonti, Valeria Sordi
Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line
published pages: 1548-1560, ISSN: 0963-6897, DOI: 10.1177/0963689718798564
Cell Transplantation 27/10 2019-09-13
2017 A. Citro, E. Cantarelli, S. Pellegrini, E. Dugnani, L. Piemonti
Antiinflammatory strategies in intrahepatic islet transplantation
published pages: 1, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001925
Transplantation 2019-09-13
2017 Daniel Pipeleers, Ines De Mesmaeker, Thomas Robert, Freya Van Hulle
Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants
published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-017-0925-9
Current Diabetes Reports 17/10 2019-09-13
2017 Valeria Sordi, Silvia Pellegrini, Lorenzo Piemonti
Immunological Issues After Stem Cell-Based β Cell Replacement
published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-017-0901-4
Current Diabetes Reports 17/9 2019-09-13
2017 V. Sordi, S. Pellegrini, M. Krampera, P. Marchetti, A. Pessina, G. Ciardelli, G. Fadini, C. Pintus, G. Pantè, L. Piemonti
Stem cells to restore insulin production and cure diabetes
published pages: 583-600, ISSN: 0939-4753, DOI: 10.1016/j.numecd.2017.02.004
Nutrition, Metabolism and Cardiovascular Diseases 27/7 2019-09-13
2018 Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi
The potential and challenges of alternative sources of β cells for the cure of type 1 diabetes
published pages: R114-R125, ISSN: 2049-3614, DOI: 10.1530/EC-18-0012
Endocrine Connections 7/3 2019-09-13
2017 Dae Hae Lee, Bart Keymeulen, Robert Hilbrands, Zhidong Ling, Ursule Van de Velde, Daniel Jacobs-Tulleneers-Thevissen, Geert Maleux, Bruno Lapauw, Laurent Crenier, Christophe De Block, Chantal Mathieu, Daniel Pipeleers, Pieter Gillard
Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression
published pages: 2218-2227, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001543
Transplantation 101/9 2019-09-13

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