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RivRNAStructureDecay SIGNED

Investigating the role of in vivo RNA structure in RNA degradation

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EC-Contrib. €

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Project "RivRNAStructureDecay" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
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surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.jic.ac.uk/directory/yiliang-ding/
 Total cost 1˙499˙986 €
 EC max contribution 1˙499˙986 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 1˙499˙986.00

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 Project objective

RNA plays a central role in the regulation of gene expression. The basal levels of RNA in a cell depend on the ratio between RNA synthesis and RNA degradation. RNA degradation is an active and critical process that dictates RNA levels and in part controls the relative levels of gene expression. However, despite many years of research, important and perplexing questions remain about RNA stability. Even when comparable RNA degradation processes are involved individual RNAs can have distinct decay rates and the mechanisms that control such distinctive rates are unknown. RNA structure is likely to be intrinsic to our understanding of the RNA features that govern stability and until very recently our ability to measure the true in vivo RNA structure has been incredibly limited.

The aim of this proposal is to understand the role of RNA structure in the regulation of RNA degradation and determine the RNA structural features that regulate the degradation pathways. We propose an ambitious programme that will pursue the following objectives:

1. Globally investigate RNA structural features and compare these to RNA degradation in vivo. 2. Decipher the mechanism of no go decay (NGD) via identifying the role of the G-quadruplex. 3. Determine the role of RNA structure in the miRNA pathway for both miRNA precursor processing and miRNA-directed processing.

This proposed study will reveal the fundamental function of RNA structures in RNA degradation. Two novel in vivo RNA structural profiling platforms will be established. The combination of RNA structural profiling, with existing ribosome profiling and the RNA degradome will generate a global view of RNA structural features and their relationship with RNA degradation. This proposed study will fill a significant gap in our understanding of the mechanisms of RNA degradation in plants and this will likely impact RNA studies in all eukaryotes.

 Publications

year authors and title journal last update
List of publications.
2018 Xiaofei Yang, Minglei Yang, Hongjing Deng, Yiliang Ding
New Era of Studying RNA Secondary Structure and Its Influence on Gene Regulation in Plants
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2018.00671
Frontiers in Plant Science 9 2019-06-19
2018 Hongjing Deng, Jitender Cheema, Hang Zhang, Hugh Woolfenden, Matthew Norris, Zhenshan Liu, Qi Liu, Xiaofei Yang, Minglei Yang, Xian Deng, Xiaofeng Cao, Yiliang Ding
Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants
published pages: 607-622, ISSN: 1674-2052, DOI: 10.1016/j.molp.2018.01.008
Molecular Plant 11/4 2019-06-19
2018 Yiliang Ding, Chun Kit Kwok
Emergence of vascular plants
published pages: 325-326, ISSN: 2055-0278, DOI: 10.1038/s41477-018-0159-0
Nature Plants 4/6 2019-06-19

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The information about "RIVRNASTRUCTUREDECAY" are provided by the European Opendata Portal: CORDIS opendata.

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