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T2DSystems SIGNED

Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes

Total Cost €

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EC-Contrib. €

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Partnership

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 T2DSystems project word cloud

Explore the words cloud of the T2DSystems project. It provides you a very rough idea of what is the project "T2DSystems" about.

genotype    expand    pancreatic    ensues    functional    individual    t2dsystems    mechanisms    cohorts    translational    stratification    prevention    translate    bio    modifying    progressive    citizens    banks    tests    genetic    million    patients    seek    goals    care    diabetes    human    tiger    frameworks    operate    unprecedented    basis    islet    true    epigenetic    cell    underlying    mechanistic    probably    disease    biological    hyperglycaemia    environmental    metabolomics    diseased    diseases    personalized    patient    therapies    type    preventive    create    predictive    risk    treat    individualized    diagnostic    phenotypes    pathophysiology    health    tissue    tools    closely    integrating    biomedicine    beta    heterogeneous    55    group    packages    stratified    complexity    compile    resource    newly    pathogenic    individuals    interacting    public    subgroups    vivo    t2d    expression    events    probabilistic    therapeutics    medical    failing    molecular    taxonomy    data    perturbations    datasets   

Project "T2DSystems" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.t2dsystems.eu
 Total cost 5˙998˙602 €
 EC max contribution 5˙998˙602 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 1˙504˙957.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 633˙418.00
3    LUNDS UNIVERSITET SE (LUND) participant 589˙667.00
4    UNIVERSITA DI PISA IT (PISA) participant 517˙722.00
5    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 488˙492.00
6    INTOMICS AS DK (KGS LYNGBY) participant 471˙486.00
7    SIRION BIOTECH GMBH DE (PLANEGG MARTINSRIED) participant 454˙500.00
8    BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION ES (BARCELONA) participant 451˙961.00
9    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 402˙829.00
10    A2F ASSOCIATES LIMITED UK (NEWMARKET) participant 186˙150.00
11    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 179˙237.00
12    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 118˙179.00

Map

 Project objective

Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently available T2D therapies are not disease modifying: they treat hyperglycaemia without addressing its underlying cause, i.e. beta cell failure. In this proposal we seek to identify pathogenic molecular events that operate in the diseased tissue, i.e. the failing human beta cell, at their true level of complexity. T2DSystems will accomplish this ambitious goal by integrating human islet genetic and epigenetic data with disease-relevant environmental perturbations, metabolomics and functional studies, and use this knowledge to identify distinct human islet phenotypes in subgroups of patients. In closely interacting work packages, we will achieve the following goals: • Compile and expand existing European bio-banks and datasets to create the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), a T2D systems biomedicine resource of unprecedented scale; • Develop large-scale data analysis tools and both data driven and mechanistic probabilistic modelling frameworks to exploit TIGER towards system level biological insight; • Translate these findings to identify stratified beta cell phenotypes in human cohorts. This will provide understanding of beta cell pathophysiology in vivo and enable stratified prevention and therapeutics. T2DSystems will enable the development of personalized diagnostic tests, taking into account individual environmental and genetic risk factors. The newly identified molecular disease mechanisms will provide the basis for development of novel therapies and for patient stratification to test individualized therapies.

 Deliverables

List of deliverables.
Training workshops on the theoretical background and research tools for T2DSystems Other 2020-03-27 09:12:38
Publications (abstracts, full papers in peer-reviewed journals, electronic newsletters) Documents, reports 2020-03-06 14:57:09
Project website Other 2019-11-12 17:18:35

Take a look to the deliverables list in detail:  detailed list of T2DSystems deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-019-1523-3
Stem Cell Research & Therapy 11/1 2020-03-05
2018 Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?
published pages: 40-45, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.002
Current Opinion in Pharmacology 43 2020-03-05
2019 Gianmarco Ferri, Luca Digiacomo, Zeno Lavagnino, Margherita Occhipinti, Marco Bugliani, Valentina Cappello, Giulio Caracciolo, Piero Marchetti, David W. Piston, Francesco Cardarelli
Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-39329-5
Scientific Reports 9/1 2020-03-05
2019 Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure
published pages: 1262-1274, ISSN: 1945-7170, DOI: 10.1210/en.2019-00098
Endocrinology 160/5 2020-03-05
2019 Maria Lytrivi, Anne-Laure Castell, Vincent Poitout, Miriam Cnop
Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes
published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2019.09.016
Journal of Molecular Biology 2020-03-05
2019 Peter Spégel, Hindrik Mulder
Metabolomics Analysis of Nutrient Metabolism in β-Cells
published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2019.07.020
Journal of Molecular Biology 2020-03-05
2019 Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
published pages: 375-390, ISSN: 1662-811X, DOI: 10.1159/000496034
Journal of Innate Immunity 11/4 2020-03-05
2018 Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.31977
eLife 7 2020-03-05
2019 Anne-Sophie Azzi, Cristina Cosentino, Jésabelle Kibanda, Françoise Féry, Miriam Cnop
OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia
published pages: 161-166, ISSN: 2328-9503, DOI: 10.1002/acn3.686
Annals of Clinical and Translational Neurology 6/1 2020-03-05
2018 Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes
published pages: 10302-10318, ISSN: 0305-1048, DOI: 10.1093/nar/gky839
Nucleic Acids Research 46/19 2020-03-05
2020 Agata Wesolowska-Andersen, Rikke Rejnholdt Jensen, Marta Pérez Alcántara, Nicola L. Beer, Claire Duff, Vibe Nylander, Matthew Gosden, Lorna Witty, Rory Bowden, Mark I. McCarthy, Mattias Hansson, Anna L. Gloyn, Christian Honore
Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation
published pages: 138-153, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.11.010
Stem Cell Reports 14/1 2020-03-05
2019 Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L. Beer, Antje Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J. Payne, Daniela Moralli, Soren K. Thomsen, Philipp Kramer, Ioannis Spili
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
published pages: 1596-1606, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0513-9
Nature Genetics 51/11 2020-03-05
2018 Jonathan L. S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson
MicroRNAs in islet hormone secretion
published pages: 11-19, ISSN: 1462-8902, DOI: 10.1111/dom.13382
Diabetes, Obesity and Metabolism 20 2020-03-05
2019 Viñuela, A., Varshney A., van de Bunt M., Prasad R.B., Asplund O., Bennett A., Boehnke M, Brown A, Erdos M.R., Fadista J., Hansson O, Hatem G, Howald C, Iyengar A.K., Johnson P., Krus U, MacDonald P.E., Mahajan A, Manning Fox J., Narisu J., Nylander N., Orchard P., Oskolkov N., Panousis N.I., Payne A., Stitzel M.L., Vadlamudi S., Welch R., Collins F.S., Mohlke K.L., Gloyn AL, Scott L.E, Dermitzak
Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes
published pages: , ISSN: , DOI: 10.1101/655670
bioRxiv 2020-03-05
2020 Anna Wendt, Lena Eliasson
Pancreatic α-cells – The unsung heroes in islet function
published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2020.01.006
Seminars in Cell & Developmental Biology 2020-03-05
2020 Chiara Saponaro, Markus Mühlemann, Ana Acosta-Montalvo, Anthony Piron, Valery Gmyr, Nathalie Delalleau, Ericka Moerman, Julien Thévenet, Gianni Pasquetti, Anais Coddeville, Miriam Cnop, Julie Kerr-Conte, Bart Staels, François Pattou, Caroline Bonner
Inter-Individual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets
published pages: db190888, ISSN: 0012-1797, DOI: 10.2337/db19-0888
Diabetes 2020-03-05
2018 Piero Marchetti, Mara Suleiman, Lorella Marselli
Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource
published pages: 770-774, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4546-x
Diabetologia 61/4 2020-03-05
2020 Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
published pages: 395-409, ISSN: 0012-186X, DOI: 10.1007/s00125-019-05046-x
Diabetologia 63/2 2020-03-05
2019 Roel Bijkerk, Jonathan L.S. Esguerra, Johanne H. Ellenbroek, Yu Wah Au, Maaike A.J. Hanegraaf, Eelco J. de Koning, Lena Eliasson, Anton Jan van Zonneveld
In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion
published pages: 67-72, ISSN: 2159-3337, DOI: 10.1089/nat.2018.0763
Nucleic Acid Therapeutics 29/2 2020-03-05
2019 Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio L Eizirik
The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells
published pages: 139-149, ISSN: 0952-5041, DOI: 10.1530/jme-19-0066
Journal of Molecular Endocrinology 63/2 2020-03-05
2018 Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H. Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jenni
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
published pages: 1505-1513, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0241-6
Nature Genetics 50/11 2020-03-05
2019 Jihua Sun, Christian Theil Have, Mette Hollensted, Niels Grarup, Allan Linneberg, Oluf Pedersen, Jens Steen Nielsen, Jørgen Rungby, Cramer Christensen, Ivan Brandslund, Karsten Kristiansen, Wang Jun, Torben Hansen, Anette P. Gjesing
Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants
published pages: e0220805, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0220805
PLOS ONE 14/8 2020-03-05
2018 Anna Wendt, Jonathan LS Esguerra, Lena Eliasson
Islet microRNAs in health and type-2 diabetes
published pages: 46-52, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.003
Current Opinion in Pharmacology 43 2020-03-05
2018 Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02380-9
Nature Communications 9/1 2020-03-05
2020 Mariana Igoillo-Esteve, Ana F. Oliveira, Cristina Cosentino, Federica Fantuzzi, Céline Demarez, Sanna Toivonen, Amélie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, Décio L. Eizirik, Miriam Cnop
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.134221
JCI Insight 5/2 2020-03-05
2019 Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
published pages: 1588-1595, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0524-6
Nature Genetics 51/11 2020-03-05
2018 Soren K. Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J. Payne, Mahesh M. Umapathysivam, Aliya F. Spigelman, Amy Barrett, Christopher J. Groves, Nicola L. Beer, Jocelyn E. Manning Fox, Mark I. McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E. MacDonald, Anna L. Gloyn
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
published pages: 1122-1131, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0173-1
Nature Genetics 50/8 2020-03-05
2019 Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Fostering improved human islet research: a European perspective
published pages: 1514-1516, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4911-4
Diabetologia 62/8 2020-03-05
2020 Agata Wesolowska-Andersen, Grace Zhuo Yu, Vibe Nylander, Fernando Abaitua, Matthias Thurner, Jason M Torres, Anubha Mahajan, Anna L Gloyn, Mark I McCarthy
Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.51503
eLife 9 2020-03-05
2019 Sara Althari, Laeya A. Najmi, Amanda J. Bennett, Ingvild Aukrust, Jana K. Rundle, Kevin Colclough, Janne Molnes, Alba Kaci, Sameena Nawaz, Timme van der Lugt, Neelam Hassanali, Anders Molven, Sian Ellard, Mark I. McCarthy, Lise Bjorkhaug, Pal Rasmus Njolstad, Anna L Gloyn
Unsupervised clustering of missense variants in the HNF1A gene using multidimensional functional data aids clinical interpretation
published pages: , ISSN: , DOI: 10.1101/19010900
medRxiv 2020-03-05
2020 Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, Joao Fadista, Hitoshi Sugihara, Leif Groop, Lena Eliasson
Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
published pages: 160-167, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2019.12.012
Molecular Metabolism 32 2020-03-05
2019 Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Joan Ponsa-Cobas, Julen Mendieta-Esteban, Goutham Atla, Biola M. Javierre, Delphine M. Y. Rolando, Irene Farabella, Claire C. Morgan, Javier García-Hurtado, Anthony Beucher, Ignasi Morán, Lorenzo Pasquali, Mireia Ramos-Rodríguez, Emil V. R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philip
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
published pages: 1137-1148, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0457-0
Nature Genetics 51/7 2020-03-05
2017 Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, Kevin Colclough, Matthew B. Johnson, Marc Abramowicz, Leif Groop, Päivi J. Miettinen, Maggie H. Shepherd, Sarah E. Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T. Hattersley, Tiinamaija Tuomi, Miriam Cnop, Michael N. Weedon
Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00895-9
Nature Communications 8/1 2019-11-12
2017 Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
published pages: 14977-14988, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.769877
Journal of Biological Chemistry 292/36 2019-11-12
2018 Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
published pages: 1524-1536, ISSN: 0892-6638, DOI: 10.1096/fj.201700710R
The FASEB Journal 32/3 2019-11-12
2017 Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
published pages: 1024-1039, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.06.001
Molecular Metabolism 6/9 2019-11-12
2017 Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Europe has to step up its efforts to produce innovative and safe diabetes technology
published pages: 2532-2533, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4455-4
Diabetologia 60/12 2019-11-12
2017 Federica Ciregia, Marco Bugliani, Maurizio Ronci, Laura Giusti, Claudia Boldrini, Maria R Mazzoni, Sandra Mossuto, Francesca Grano, Miriam Cnop, Lorella Marselli, Gino Giannaccini, Andrea Urbani, Antonio Lucacchini, Piero Marchetti
Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13908-w
Scientific Reports 7/1 2019-11-12
2018 Benoît Hastoy, Mahdieh Godazgar, Anne Clark, Vibe Nylander, Ioannis Spiliotis, Martijn van de Bunt, Margarita V. Chibalina, Amy Barrett, Carla Burrows, Andrei I. Tarasov, Raphael Scharfmann, Anna L. Gloyn, Patrik Rorsman
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34743-7
Scientific Reports 8/1 2019-11-12
2018 Rubén Cereijo, Aleix Gavaldà-Navarro, Montserrat Cairó, Tania Quesada-López, Joan Villarroya, Samantha Morón-Ros, David Sánchez-Infantes, Marion Peyrou, Roser Iglesias, Teresa Mampel, Jean-Valery Turatsinze, Décio L. Eizirik, Marta Giralt, Francesc Villarroya
CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation
published pages: , ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.07.015
Cell Metabolism 2019-11-12
2018 Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters, Torben Hansen
Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
published pages: , ISSN: 1471-2156, DOI: 10.1186/s12863-018-0602-2
BMC Genetics 19/1 2019-11-12
2017 Sun, Jiangming; Jain, Ruchi; Andersson, Lotta E.; Medina, Anya; Storm, Petter; Spegel, Peter; Mulder, Hindrik
Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes
published pages: , ISSN: , DOI: 10.1101/212548
bioRxiv - biorxiv;212548v1 8 2019-11-12
2018 Fernandez-Tajes, Juan; Gaulton, Kyle J; van de Bunt, Martijn; Torres, Jason; Turner, Mathias; Mahajan, Anubha; Gloyn, Anna L; Lage, Kasper; McCarthy, Mark I
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data
published pages: , ISSN: , DOI: 10.1101/350181
bioRxiv - biorxiv;350181v2 7 2019-11-12
2019 M. Bugliani, S. Mossuto, F. Grano, M. Suleiman, L. Marselli, U. Boggi, P. De Simone, D. L. Eizirik, M. Cnop, P. Marchetti, V. De Tata
Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes
published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2019.00052
Frontiers in Endocrinology 10 2019-11-12

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BIND (2020)

Brain Involvement iN Dystrophinopathies

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UNITI (2020)

Unification of treatments and Interventions for Tinnitus patients

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