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T2DSystems SIGNED

Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

T2DSystems project word cloud

Explore the words cloud of the T2DSystems project. It provides you a very rough idea of what is the project "T2DSystems" about.

disease diagnostic pancreatic unprecedented vivo bio create hyperglycaemia therapies basis heterogeneous data citizens public biological molecular diseased integrating subgroups goals modifying phenotypes tools true taxonomy interacting probabilistic tiger health operate stratification prevention seek islet frameworks pathophysiology treat metabolomics medical epigenetic ensues packages diseases mechanisms patients predictive diabetes therapeutics expression t2dsystems underlying mechanistic type newly cohorts genotype functional individualized datasets banks care individual tissue tests patient human translate genetic preventive biomedicine failing perturbations t2d events closely complexity individuals 55 probably environmental resource pathogenic progressive group compile million beta cell expand personalized risk stratified translational

Project "T2DSystems" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://www.t2dsystems.eu
Total cost	5˙998˙602 €
EC max contribution	5˙998˙602 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	coordinator	1˙504˙957.00
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	633˙418.00
3	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	589˙667.00
4	UNIVERSITA DI PISA UNIVERSITA DI PISA Organization address address: LUNGARNO PACINOTTI 43/44 city: PISA postcode: 56126 website: www.unipi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	participant	517˙722.00
5	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	488˙492.00
6	INTOMICS AS INTOMICS AS Organization address address: LOTTENBORGVEJ 26 city: KGS LYNGBY postcode: 2800 website: www.intomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	471˙486.00
7	SIRION BIOTECH GMBH SIRION BIOTECH GMBH Organization address address: AM KLOPFERSPITZ 19 city: PLANEGG MARTINSRIED postcode: 82152 website: www.sirion-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (PLANEGG MARTINSRIED)	participant	454˙500.00
8	BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION Organization address address: Calle Jordi Girona 31 city: BARCELONA postcode: 8034 website: www.bsc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	451˙961.00
9	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	402˙829.00
10	A2F ASSOCIATES LIMITED A2F ASSOCIATES LIMITED Organization address address: 7 LAUREATE PADDOCKS city: NEWMARKET postcode: CB8 0AP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWMARKET)	participant	186˙150.00
11	FUNDACIO CENTRE DE REGULACIO GENOMICA FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	179˙237.00
12	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	118˙179.00

Map

Project objective

Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently available T2D therapies are not disease modifying: they treat hyperglycaemia without addressing its underlying cause, i.e. beta cell failure. In this proposal we seek to identify pathogenic molecular events that operate in the diseased tissue, i.e. the failing human beta cell, at their true level of complexity. T2DSystems will accomplish this ambitious goal by integrating human islet genetic and epigenetic data with disease-relevant environmental perturbations, metabolomics and functional studies, and use this knowledge to identify distinct human islet phenotypes in subgroups of patients. In closely interacting work packages, we will achieve the following goals: • Compile and expand existing European bio-banks and datasets to create the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), a T2D systems biomedicine resource of unprecedented scale; • Develop large-scale data analysis tools and both data driven and mechanistic probabilistic modelling frameworks to exploit TIGER towards system level biological insight; • Translate these findings to identify stratified beta cell phenotypes in human cohorts. This will provide understanding of beta cell pathophysiology in vivo and enable stratified prevention and therapeutics. T2DSystems will enable the development of personalized diagnostic tests, taking into account individual environmental and genetic risk factors. The newly identified molecular disease mechanisms will provide the basis for development of novel therapies and for patient stratification to test individualized therapies.

Deliverables

List of deliverables.
Training workshops on the theoretical background and research tools for T2DSystems	Other	2020-03-27 09:12:38
Publications (abstracts, full papers in peer-reviewed journals, electronic newsletters)	Documents, reports	2020-03-06 14:57:09
Project website	Other	2019-11-12 17:18:35

Take a look to the deliverables list in detail: detailed list of T2DSystems deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	StÃ©phane Demine, Andrea Alex Schiavo, Sandra MarÃn-CaÃ±as, Piero Marchetti, Miriam Cnop, Decio L. Eizirik Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-019-1523-3	Stem Cell Research & Therapy 11/1	2020-03-05
2018	Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop Inflammatory stress in islet Î²-cells: therapeutic implications for type 2 diabetes? published pages: 40-45, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.002	Current Opinion in Pharmacology 43	2020-03-05
2019	Gianmarco Ferri, Luca Digiacomo, Zeno Lavagnino, Margherita Occhipinti, Marco Bugliani, Valentina Cappello, Giulio Caracciolo, Piero Marchetti, David W. Piston, Francesco Cardarelli Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living Î²-cells published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-39329-5	Scientific Reports 9/1	2020-03-05
2019	Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic Î²-Cell Failure published pages: 1262-1274, ISSN: 1945-7170, DOI: 10.1210/en.2019-00098	Endocrinology 160/5	2020-03-05
2019	Maria Lytrivi, Anne-Laure Castell, Vincent Poitout, Miriam Cnop Recent Insights Into Mechanisms of Î²-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2019.09.016	Journal of Molecular Biology	2020-03-05
2019	Peter SpÃ©gel, Hindrik Mulder Metabolomics Analysis of Nutrient Metabolism in Î²-Cells published pages: , ISSN: 0022-2836, DOI: 10.1016/j.jmb.2019.07.020	Journal of Molecular Biology	2020-03-05
2019	MaikelÂ L. Colli, FlaviaÂ M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, DecioÂ L. Eizirik, Anne OpÂ deÂ beeck Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic Î² Cells published pages: 375-390, ISSN: 1662-811X, DOI: 10.1159/000496034	Journal of Innate Immunity 11/4	2020-03-05
2018	Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.31977	eLife 7	2020-03-05
2019	Anne-Sophie Azzi, Cristina Cosentino, JÃ©sabelle Kibanda, FranÃ§oise FÃ©ry, Miriam Cnop OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia published pages: 161-166, ISSN: 2328-9503, DOI: 10.1002/acn3.686	Annals of Clinical and Translational Neurology 6/1	2020-03-05
2018	Cristina Cosentino, Sanna Toivonen, Esteban DiazÂ Villamil, Mohamed Atta, Jean-Luc Ravanat, StÃ©phane Demine, AndreaÂ Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, DÃ©cio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve Pancreatic Î²-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes published pages: 10302-10318, ISSN: 0305-1048, DOI: 10.1093/nar/gky839	Nucleic Acids Research 46/19	2020-03-05
2020	Agata Wesolowska-Andersen, Rikke Rejnholdt Jensen, Marta PÃ©rez AlcÃ¡ntara, Nicola L. Beer, Claire Duff, Vibe Nylander, Matthew Gosden, Lorna Witty, Rory Bowden, Mark I. McCarthy, Mattias Hansson, Anna L. Gloyn, Christian Honore Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation published pages: 138-153, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.11.010	Stem Cell Reports 14/1	2020-03-05
2019	Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L. Beer, Antje Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J. Payne, Daniela Moralli, Soren K. Thomsen, Philipp Kramer, Ioannis Spili Loss of ZnT8 function protects against diabetes by enhanced insulin secretion published pages: 1596-1606, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0513-9	Nature Genetics 51/11	2020-03-05
2018	Jonathan L. S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson MicroRNAs in islet hormone secretion published pages: 11-19, ISSN: 1462-8902, DOI: 10.1111/dom.13382	Diabetes, Obesity and Metabolism 20	2020-03-05
2019	ViÃ±uela, A., Varshney A., van de Bunt M., Prasad R.B., Asplund O., Bennett A., Boehnke M, Brown A, Erdos M.R., Fadista J., Hansson O, Hatem G, Howald C, Iyengar A.K., Johnson P., Krus U, MacDonald P.E., Mahajan A, Manning Fox J., Narisu J., Nylander N., Orchard P., Oskolkov N., Panousis N.I., Payne A., Stitzel M.L., Vadlamudi S., Welch R., Collins F.S., Mohlke K.L., Gloyn AL, Scott L.E, Dermitzak Influence of genetic variants on gene expression in human pancreatic islets â€“ implications for type 2 diabetes published pages: , ISSN: , DOI: 10.1101/655670	bioRxiv	2020-03-05
2020	Anna Wendt, Lena Eliasson Pancreatic Î±-cells â€“ The unsung heroes in islet function published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2020.01.006	Seminars in Cell & Developmental Biology	2020-03-05
2020	Chiara Saponaro, Markus MÃ¼hlemann, Ana Acosta-Montalvo, Anthony Piron, Valery Gmyr, Nathalie Delalleau, Ericka Moerman, Julien ThÃ©venet, Gianni Pasquetti, Anais Coddeville, Miriam Cnop, Julie Kerr-Conte, Bart Staels, FranÃ§ois Pattou, Caroline Bonner Inter-Individual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets published pages: db190888, ISSN: 0012-1797, DOI: 10.2337/db19-0888	Diabetes	2020-03-05
2018	Piero Marchetti, Mara Suleiman, Lorella Marselli Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource published pages: 770-774, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4546-x	Diabetologia 61/4	2020-03-05
2020	Masaya Oshima, SÃ©verine Pechberty, Lara Bellini, Sven O. GÃ¶pel, MÃ©lanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, HervÃ© Le Stunff, RaphaÃ«l Scharfmann Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity published pages: 395-409, ISSN: 0012-186X, DOI: 10.1007/s00125-019-05046-x	Diabetologia 63/2	2020-03-05
2019	Roel Bijkerk, Jonathan L.S. Esguerra, Johanne H. Ellenbroek, Yu Wah Au, Maaike A.J. Hanegraaf, Eelco J. de Koning, Lena Eliasson, Anton Jan van Zonneveld In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion published pages: 67-72, ISSN: 2159-3337, DOI: 10.1089/nat.2018.0763	Nucleic Acid Therapeutics 29/2	2020-03-05
2019	Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, DÃ©cio L Eizirik The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells published pages: 139-149, ISSN: 0952-5041, DOI: 10.1530/jme-19-0066	Journal of Molecular Endocrinology 63/2	2020-03-05
2018	Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, ChloÃ© Sarnowski, Reedik MÃ¤gi, Jana Nano, Christian Gieger, Stella Trompet, CÃ©cile Lecoeur, Michael H. Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jenni Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps published pages: 1505-1513, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0241-6	Nature Genetics 50/11	2020-03-05
2019	Jihua Sun, Christian Theil Have, Mette Hollensted, Niels Grarup, Allan Linneberg, Oluf Pedersen, Jens Steen Nielsen, JÃ¸rgen Rungby, Cramer Christensen, Ivan Brandslund, Karsten Kristiansen, Wang Jun, Torben Hansen, Anette P. Gjesing Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants published pages: e0220805, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0220805	PLOS ONE 14/8	2020-03-05
2018	Anna Wendt, Jonathan LS Esguerra, Lena Eliasson Islet microRNAs in health and type-2 diabetes published pages: 46-52, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.003	Current Opinion in Pharmacology 43	2020-03-05
2018	SÃlvia BonÃ s-Guarch, Marta Guindo-MartÃnez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman SÃ¡nchez, MercÃ¨ Planas-FÃ¨lix, Paula Cortes-SÃ¡nchez, Santi GonzÃ¡lez, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. GonzÃ¡lez, Montserrat Puiggros, Jonathan MartÃ, Ehm A. Andersson, Carlos DÃaz, Rosa M. Badia, Miriam Udler, Aaron Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02380-9	Nature Communications 9/1	2020-03-05
2020	Mariana Igoillo-Esteve, Ana F. Oliveira, Cristina Cosentino, Federica Fantuzzi, CÃ©line Demarez, Sanna Toivonen, AmÃ©lie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, DÃ©cio L. Eizirik, Miriam Cnop Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.134221	JCI Insight 5/2	2020-03-05
2019	Mireia Ramos-RodrÃguez, Helena Raurell-Vila, Maikel L. Colli, Maria InÃªs Alvelos, Marc Subirana-GranÃ©s, JonÃ s Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, DÃ©cio L. Eizirik, Lorenzo Pasquali The impact of proinflammatory cytokines on the Î²-cell regulatory landscape provides insights into the genetics of type 1 diabetes published pages: 1588-1595, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0524-6	Nature Genetics 51/11	2020-03-05
2018	Soren K. Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J. Payne, Mahesh M. Umapathysivam, Aliya F. Spigelman, Amy Barrett, Christopher J. Groves, Nicola L. Beer, Jocelyn E. Manning Fox, Mark I. McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E. MacDonald, Anna L. Gloyn Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic Î²-cells published pages: 1122-1131, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0173-1	Nature Genetics 50/8	2020-03-05
2019	Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena Fostering improved human islet research: a European perspective published pages: 1514-1516, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4911-4	Diabetologia 62/8	2020-03-05
2020	Agata Wesolowska-Andersen, Grace Zhuo Yu, Vibe Nylander, Fernando Abaitua, Matthias Thurner, Jason M Torres, Anubha Mahajan, Anna L Gloyn, Mark I McCarthy Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.51503	eLife 9	2020-03-05
2019	Sara Althari, Laeya A. Najmi, Amanda J. Bennett, Ingvild Aukrust, Jana K. Rundle, Kevin Colclough, Janne Molnes, Alba Kaci, Sameena Nawaz, Timme van der Lugt, Neelam Hassanali, Anders Molven, Sian Ellard, Mark I. McCarthy, Lise Bjorkhaug, Pal Rasmus Njolstad, Anna L Gloyn Unsupervised clustering of missense variants in the HNF1A gene using multidimensional functional data aids clinical interpretation published pages: , ISSN: , DOI: 10.1101/19010900	medRxiv	2020-03-05
2020	Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, Joao Fadista, Hitoshi Sugihara, Leif Groop, Lena Eliasson Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA published pages: 160-167, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2019.12.012	Molecular Metabolism 32	2020-03-05
2019	Irene Miguel-Escalada, Silvia BonÃ s-Guarch, IneÌ‚s Cebola, Joan Ponsa-Cobas, Julen Mendieta-Esteban, Goutham Atla, Biola M. Javierre, Delphine M. Y. Rolando, Irene Farabella, Claire C. Morgan, Javier GarciÌa-Hurtado, Anthony Beucher, Ignasi MorÃ¡n, Lorenzo Pasquali, Mireia Ramos-RodrÃguez, Emil V. R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philip Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes published pages: 1137-1148, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0457-0	Nature Genetics 51/7	2020-03-05
2017	Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena StanÄÃ¡kovÃ¡, Thomas W. Laver, Kevin Colclough, Matthew B. Johnson, Marc Abramowicz, Leif Groop, PÃ¤ivi J. Miettinen, Maggie H. Shepherd, Sarah E. Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T. Hattersley, Tiinamaija Tuomi, Miriam Cnop, Michael N. Weedon Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00895-9	Nature Communications 8/1	2019-11-12
2017	Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence LadriÃ¨re, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, DÃ©cio L. Eizirik, Miriam Cnop Pancreatic Î²-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF) published pages: 14977-14988, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.769877	Journal of Biological Chemistry 292/36	2019-11-12
2018	Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik Exercise training protects human and rodent Î² cells against endoplasmic reticulum stress and apoptosis published pages: 1524-1536, ISSN: 0892-6638, DOI: 10.1096/fj.201700710R	The FASEB Journal 32/3	2019-11-12
2017	Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea Endoplasmic reticulum stress and eIF2Î± phosphorylation: The Achilles heel of pancreatic Î² cells published pages: 1024-1039, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.06.001	Molecular Metabolism 6/9	2019-11-12
2017	Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, RÃ©my Burcelin, Mischa van Eimeren Europe has to step up its efforts to produce innovative and safe diabetes technology published pages: 2532-2533, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4455-4	Diabetologia 60/12	2019-11-12
2017	Federica Ciregia, Marco Bugliani, Maurizio Ronci, Laura Giusti, Claudia Boldrini, Maria R Mazzoni, Sandra Mossuto, Francesca Grano, Miriam Cnop, Lorella Marselli, Gino Giannaccini, Andrea Urbani, Antonio Lucacchini, Piero Marchetti Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal Î² cells and human pancreatic islets published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13908-w	Scientific Reports 7/1	2019-11-12
2018	BenoÃ®t Hastoy, Mahdieh Godazgar, Anne Clark, Vibe Nylander, Ioannis Spiliotis, Martijn van de Bunt, Margarita V. Chibalina, Amy Barrett, Carla Burrows, Andrei I. Tarasov, Raphael Scharfmann, Anna L. Gloyn, Patrik Rorsman Electrophysiological properties of human beta-cell lines EndoC-Î²H1 and -Î²H2 conform with human beta-cells published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34743-7	Scientific Reports 8/1	2019-11-12
2018	RubÃ©n Cereijo, Aleix GavaldÃ -Navarro, Montserrat CairÃ³, Tania Quesada-LÃ³pez, Joan Villarroya, Samantha MorÃ³n-Ros, David SÃ¡nchez-Infantes, Marion Peyrou, Roser Iglesias, Teresa Mampel, Jean-Valery Turatsinze, DÃ©cio L. Eizirik, Marta Giralt, Francesc Villarroya CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation published pages: , ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.07.015	Cell Metabolism	2019-11-12
2018	Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. JÃ¸rgensen, Kristine FÃ¦rch, Daniel R. Witte, Jens J. Holst, Torben JÃ¸rgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, JÃ¸rgen K. Kanters, Torben Hansen Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses published pages: , ISSN: 1471-2156, DOI: 10.1186/s12863-018-0602-2	BMC Genetics 19/1	2019-11-12
2017	Sun, Jiangming; Jain, Ruchi; Andersson, Lotta E.; Medina, Anya; Storm, Petter; Spegel, Peter; Mulder, Hindrik Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes published pages: , ISSN: , DOI: 10.1101/212548	bioRxiv - biorxiv;212548v1 8	2019-11-12
2018	Fernandez-Tajes, Juan; Gaulton, Kyle J; van de Bunt, Martijn; Torres, Jason; Turner, Mathias; Mahajan, Anubha; Gloyn, Anna L; Lage, Kasper; McCarthy, Mark I Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data published pages: , ISSN: , DOI: 10.1101/350181	bioRxiv - biorxiv;350181v2 7	2019-11-12
2019	M. Bugliani, S. Mossuto, F. Grano, M. Suleiman, L. Marselli, U. Boggi, P. De Simone, D. L. Eizirik, M. Cnop, P. Marchetti, V. De Tata Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2019.00052	Frontiers in Endocrinology 10	2019-11-12

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "T2DSYSTEMS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "T2DSYSTEMS" are provided by the European Opendata Portal: CORDIS opendata.