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The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe

Total Cost €


EC-Contrib. €






 HYPERDIAMOND project word cloud

Explore the words cloud of the HYPERDIAMOND project. It provides you a very rough idea of what is the project "HYPERDIAMOND" about.

hyperpolarizes    technological    probe    first    sensitivity    introduce    commercialization    invasively    vivo    revolutionize    exhibit    patients    improves    minutes    quantum    extremely    positron    magnetic    diagnostics    tomography    feasible    conventional    diamond    breakthroughs       sensitive    revolution    pyruvate    exhibiting    breakthrough    limiting    hyperpolarizer    times    enormous    hyperpolarized    solution    centres    pet    previously    cumbersome    producing    viability    primary    hyperpolarization    molecular    clinically    nv    human    layouts    metabolic    emission    gap    clinical    probes    prostate    mri    nd    expensive    socioeconomic    non    nano    imaging    image    hour    innovation    diamonds    diseases    easily    defects    dosage    unseen    monitoring    nitrogen    undergoing    hyperdiamond    demonstrated    small    resonance    time    fold    nanotechnology    bridge    diagnosis    technologies    vacancy    cancer    proved    treatment    fits    gt   

Project "HYPERDIAMOND" data sheet

The following table provides information about the project.


Organization address
city: ULM
postcode: 89081

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 5˙073˙550 €
 EC max contribution 4˙866˙050 € (96%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET ULM DE (ULM) coordinator 1˙233˙863.00
2    NVISION IMAGING TECHNOLOGIES GMBH DE (ULM) participant 685˙625.00
3    UNIVERSITE DE TOURS FR (TOURS) participant 627˙382.00
8    ARTTIC FR (PARIS) participant 282˙580.00
9    KANFIT LTD IL (MIGDAL HA-EMEK) participant 272˙805.00
11    LM VAN MOPPES AND SONS SA CH (CAROUGE GE) participant 0.00


 Project objective

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous potential for socioeconomic relevant diseases. E.g. pyruvate-based hyperpolarized imaging was clinically demonstrated to be effective for prostate cancer diagnostics in human patients. However, the current state-of-the-art hyperpolarization methods are expensive and cumbersome, limiting the access to hyperpolarization technology, and require long hyperpolarization times of 60-90 minutes per dosage; hyperpolarization probes exhibit short hyperpolarization duration (1-5 minutes), limiting the usage of hyperpolarization to metabolic imaging. A quantum technological breakthrough, Nitrogen-Vacancy defects (NV centres) in diamonds, is set to revolutionize the field of hyperpolarization for both hyperpolarizer and probes. The primary objective of HYPERDIAMOND is the development and commercialization of two new molecular imaging technologies for sensitive diagnosis and treatment monitoring, based on NV centres: The Diamond Hyperpolarizer will offer a cost- and time-effective solution for hyperpolarization that easily fits current MRI layouts, hyperpolarizes within 5 minutes, and improves clinical viability. The Nano-diamond (ND) Probe will introduce the first targeted MRI probe capable of achieving comparable molecular sensitivity to positron emission tomography (PET) with MRI systems, exhibiting extremely long hyperpolarization duration (~1 hour), and enabling non-metabolic hyperpolarized imaging. HYPERDIAMOND will bridge the gap between novel quantum and nanotechnology and their applications in hyperpolarized imaging, producing innovation not feasible with current technology.


List of deliverables.
Report on ND-probe hyperpolarization system Documents, reports 2020-02-07 10:14:37
HYPERDIAMOND Public website Websites, patent fillings, videos etc. 2020-02-07 10:14:37

Take a look to the deliverables list in detail:  detailed list of HYPERDIAMOND deliverables.


year authors and title journal last update
List of publications.
2020 Lujuan Xu, Marco Raabe, Maksymilian Marek Zegota, Joao Nogueira, Vijay Chudasama, Seah Ling Kuan, Tanja Weil
Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation
published pages: , ISSN: 1477-0520, DOI: 10.1039/c9ob02687h
Organic & Biomolecular Chemistry 2020-02-07
2019 Jonas Friebel, Christopher P. Ender, Markus Mezger, Jasper Michels, Manfred Wagner, Kenneth B. Wagener, Tanja Weil
Synthesis of Precision Poly(1,3-adamantylene alkylene)s via Acyclic Diene Metathesis Polycondensation
published pages: 4483-4491, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.9b00294
Macromolecules 52/12 2020-02-07
2019 Pierpaolo Moscariello, Marco Raabe, Weina Liu, Sandra Bernhardt, Haoyuan Qi, Ute Kaiser, Yuzhou Wu, Tanja Weil, Heiko J. Luhmann, Jana Hedrich
Unraveling In Vivo Brain Transport of Protein‐Coated Fluorescent Nanodiamonds
published pages: 1902992, ISSN: 1613-6810, DOI: 10.1002/smll.201902992
Small 2020-02-07
2019 Shen Han, Marco Raabe, Lorna Hodgson, Judith Mantell, Paul Verkade, Theo Lasser, Katharina Landfester, Tanja Weil, Ingo Lieberwirth
High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis
published pages: 2178-2185, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b00752
Nano Letters 19/3 2020-02-07
2019 Genov, Genko T.; Aharon, Nati; Jelezko, Fedor; Retzker, Alex
Mixed Dynamical Decoupling
published pages: , ISSN: , DOI:
Quantum Physics 1 2020-02-07
2018 Unden, Thomas; Tomek, Nikolas; Weggler, Timo; Frank, Florian; London, Paz; Zopes, Jonathan; Degen, Christian; Raatz, Nicole; Meijer, Jan; Watanabe, Hideyuki; Itoh, Kohei M.; Plenio, Martin B.; Naydenov, Boris; Jelezko, Fedor
Coherent control of solid state nuclear spin nano-ensembles
published pages: , ISSN: , DOI:
1 2020-02-07
2017 Alexander Stark, Nati Aharon, Thomas Unden, Daniel Louzon, Alexander Huck, Alex Retzker, Ulrik L. Andersen, Fedor Jelezko
Narrow-bandwidth sensing of high-frequency fields with continuous dynamical decoupling
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01159-2
Nature Communications 8/1 2020-02-07
2017 N Aharon, M Drewsen, A Retzker
Enhanced quantum sensing with multi-level structures of trapped ions
published pages: 34006, ISSN: 2058-9565, DOI: 10.1088/2058-9565/aa771a
Quantum Science and Technology 2/3 2020-02-07
2017 Rotem, Amit; Gefen, Tuvia; Schmitt, Simon; McGuiness, Liam; Jelezko, Fedor; Retzker, Alex
Limits on spectral resolution measurements by quantum probes
published pages: , ISSN: , DOI:
1 2020-02-07
2018 Pierpaolo Moscariello, David Y. W. Ng, Malin Jansen, Tanja Weil, Heiko J. Luhmann, Jana Hedrich
Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates
published pages: 1700897, ISSN: 2198-3844, DOI: 10.1002/advs.201700897
Advanced Science 2020-02-07
2016 N Aharon, I Cohen, F Jelezko, A Retzker
Fully robust qubit in atomic and molecular three-level systems
published pages: 123012, ISSN: 1367-2630, DOI: 10.1088/1367-2630/aa4fd3
New Journal of Physics 18/12 2020-02-07
2017 Bikram Keshari Agrawalla, Tao Wang, Andreas Riegger, Matthias P. Domogalla, Kerstin Steinbrink, Thilo Dörfler, Xi Chen, Felix Boldt, Markus Lamla, Jens Michaelis, Seah Ling Kuan, Tanja Weil
Chemoselective Dual Labeling of Native and Recombinant Proteins
published pages: 29-34, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00675
Bioconjugate Chemistry 29/1 2020-02-07
2017 David Y. W. Ng, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener, Tanja Weil
Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02020-2
Nature Communications 8/1 2020-02-07
2017 Cohen, Itsik; Unden, Thomas; Jelezko, Fedor; Retzker, Alex
Protecting a nuclear spin from a noisy electron spin in diamond
published pages: , ISSN: , DOI:
1 2020-02-07
2018 Seah Ling Kuan, Stephan Fischer, Susanne Hafner, Tao Wang, Tatiana Syrovets, Weina Liu, Yu Tokura, David Yuen Wah Ng, Andreas Riegger, Christina Förtsch, Daniela Jäger, Thomas F. E. Barth, Thomas Simmet, Holger Barth, Tanja Weil
Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins
published pages: 1701036, ISSN: 2198-3844, DOI: 10.1002/advs.201701036
Advanced Science 5/8 2020-02-07

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