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HEP-CAR SIGNED

Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.

Total Cost €

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EC-Contrib. €

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Project "HEP-CAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.hep-car.eu/
 Total cost 5˙698˙310 €
 EC max contribution 5˙698˙310 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 771˙550.00
2    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 1˙012˙755.00
3    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 828˙164.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 800˙000.00
5    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 600˙000.00
6    THE BABRAHAM INSTITUTE UK (CAMBRIDGE) participant 599˙380.00
7    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 500˙000.00
8    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 399˙375.00
9    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) participant 180˙000.00
10    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) participant 7˙085.00

Map

 Project objective

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and become per definition co-morbidities, such as nonalcoholic steatohepatitis (NASH) or hepatitis B and C virus infection. Most patients die within one year of diagnosis and treatment failure reflects the heterogeneous nature of this tumour, highlighting the need to identify common and co-morbidity specific disease pathways for individualized therapy. HEP-CAR will focus on three leading HCC associated co-morbidities, specifically NASH and hepatitis B and C infection. Non-biased genetic and lipidomic screens will define cellular pathways that are deregulated in HCC and the impact of co-morbidities and gender. Next to established patient cohorts, several in vitro and in vivo models are available to evaluate the role of co-morbidities as drivers of host oncogenic pathways and to provide much needed pre-clinical models for mechanistic studies and future drug screening. We will develop new approaches to study the impact of co-morbidities on HCC immunobiology, ranging from state-of-art tissue explant models to novel humanized mouse models. The aim of HEP-CAR is to define host pathways that impact HCC pathogenesis and to assess their role in different co-morbidities and treatment responses. The research and clinical excellence will be combined with the knowledge transfer and communication competence of leading organizations such as the European Association for the Study of the Liver (EASL) and the European Liver Patients Association (ELPA). Thus, HEP-CAR will generate tangible and sustained improvements in the understanding, prevention and management of HCC for all European citizens.

 Deliverables

List of deliverables.
Website development and management Websites, patent fillings, videos etc. 2019-05-30 12:48:36

Take a look to the deliverables list in detail:  detailed list of HEP-CAR deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Radiomics in hepatocellular carcinoma: a quantitative review
published pages: 546-559, ISSN: 1936-0533, DOI: 10.1007/s12072-019-09973-0
Hepatology International 13/5 2020-02-28
2019 Catrin Tauber, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack
Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.27146
Oncotarget 10/50 2020-02-28
2016 Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Hepatitis B virus receptors and molecular drug targets
published pages: 567-573, ISSN: 1936-0533, DOI: 10.1007/s12072-016-9718-5
Hepatology International 10/4 2020-02-28
2019 Robert Montal, Carmen Andreu-Oller, Laia Bassaganyas, Roger Esteban-Fabró, Sebastián Moran, Carla Montironi, Agrin Moeini, Roser Pinyol, Judit Peix, Laia Cabellos, Augusto Villanueva, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet
Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials
published pages: 340-343, ISSN: 0007-0920, DOI: 10.1038/s41416-019-0513-7
British Journal of Cancer 121/4 2020-02-28
2019 Antonio Saviano, Thomas F. Baumert
Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease
published pages: 307-310, ISSN: 2304-3881, DOI: 10.21037/hbsn.2019.01.21
HepatoBiliary Surgery and Nutrition 8/3 2020-02-28
2019 Emmanuel Thomas, Thomas F. Baumert
Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms
published pages: 301-314, ISSN: 0272-8087, DOI: 10.1055/s-0039-1685518
Seminars in Liver Disease 39/03 2020-02-28
2019 Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder
Platelets in chronic liver disease, from bench to bedside
published pages: 448-459, ISSN: 2589-5559, DOI: 10.1016/j.jhepr.2019.10.001
JHEP Reports 1/6 2020-02-28
2020 Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis
published pages: a037366, ISSN: 2157-1422, DOI: 10.1101/cshperspect.a037366
Cold Spring Harbor Perspectives in Medicine 10/1 2020-02-28
2016 Mirjam B. Zeisel, Thomas F. Baumert
Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma
published pages: 671-674, ISSN: 0270-9139, DOI: 10.1002/hep.28653
Hepatology 64/2 2020-02-28
2016 Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection
published pages: 261, ISSN: 1999-4915, DOI: 10.3390/v8090261
Viruses 8/9 2020-02-28
2019 Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Learning from a clinical cohort for HCV vaccine development
published pages: 9-11, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.03.030
Journal of Hepatology 71/1 2020-02-28
2019 Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
published pages: e201900355, ISSN: 2575-1077, DOI: 10.26508/lsa.201900355
Life Science Alliance 2/2 2020-02-28
2019 Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets
published pages: 158-167, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-317065
Gut 69/1 2020-02-28
2019 Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination
published pages: 998-1009, ISSN: 0021-9738, DOI: 10.1172/jci129642
Journal of Clinical Investigation 130/2 2020-02-28
2019 Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development
published pages: 537-551.e9, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.04.003
Gastroenterology 157/2 2020-02-28
2018 Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Oncogenic Signaling Induced by HCV Infection
published pages: 538, ISSN: 1999-4915, DOI: 10.3390/v10100538
Viruses 10/10 2020-02-28
2016 Mirjam B. Zeisel, Thomas F. Baumert
Hepatitis B virus: is a cure possible?
published pages: 1129-1130, ISSN: 1751-2433, DOI: 10.1080/17512433.2016.1206466
Expert Review of Clinical Pharmacology 9/9 2020-02-28
2016 Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, Jörg Schüttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, François Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert
Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin
published pages: 1495-1506, ISSN: 0270-9139, DOI: 10.1002/hep.28767
Hepatology 64/5 2020-02-28
2019 Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection
published pages: 136-141, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.018
Antiviral Research 162 2020-02-27
2019 Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan
Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial
published pages: 1065-1075, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316408
Gut 68/6 2020-02-27
2019 Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion
published pages: 118-129, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.019
Antiviral Research 162 2020-02-27
2019 Roser Pinyol, Daniela Sia, Josep M. Llovet
Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC
published pages: 2021-2023, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-18-3778
Clinical Cancer Research 25/7 2020-02-27
2019 Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-Sánchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, Verónica Miguela, María Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri
β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma
published pages: 1124-1141, ISSN: 2159-8274, DOI: 10.1158/2159-8290.cd-19-0074
Cancer Discovery 9/8 2020-02-27
2019 Jianming Hu, Ulrike Protzer, Aleem Siddiqui
Revisiting Hepatitis B Virus: Challenges of Curative Therapies
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.01032-19
Journal of Virology 93/20 2020-02-27
2019 Natascha Roehlen, Thomas F. Baumert
Uncovering the mechanism of action of aspirin in HCC chemoprevention
published pages: 21-22, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2019.07.047
EBioMedicine 46 2020-02-27
2017 Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Toward novel immunocompetent animal models for hepatitis B virus infection
published pages: 691-693, ISSN: 0270-9139, DOI: 10.1002/hep.29249
Hepatology 66/3 2020-02-27
2019 Josep M. Llovet, Robert Montal, Augusto Villanueva
Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival
published pages: 1262-1277, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.01.028
Journal of Hepatology 70/6 2020-02-27
2019 Agrin Moeini, Sara Torrecilla, Victoria Tovar, Carla Montironi, Carmen Andreu-Oller, Judit Peix, Mónica Higuera, Dominik Pfister, Pierluigi Ramadori, Roser Pinyol, Manel Solé, Mathias Heikenwälder, Scott L. Friedman, Daniela Sia, Josep M. Llovet
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents
published pages: 1383-1397.e11, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.07.028
Gastroenterology 157/5 2020-02-27
2019 Karim Majzoub, Florian Wrensch, Thomas F. Baumert
The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans
published pages: 758, ISSN: 1999-4915, DOI: 10.3390/v11080758
Viruses 11/8 2020-02-27
2019 Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
The circadian clock and liver function in health and disease
published pages: 200-211, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.03.020
Journal of Hepatology 71/1 2020-02-27
2019 Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
published pages: 641-655, ISSN: 1078-8956, DOI: 10.1038/s41591-019-0379-5
Nature Medicine 25/4 2020-02-27
2019 Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer
A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection
published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.01440-19
Antimicrobial Agents and Chemotherapy 64/1 2020-02-27
2019 Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma
published pages: , ISSN: 2161-2617, DOI: 10.1002/cpmo.62
Current Protocols in Mouse Biology 9/2 2020-02-20
2016 Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies
published pages: 1535-1544, ISSN: 1476-0584, DOI: 10.1080/14760584.2016.1194759
Expert Review of Vaccines 15/12 2020-02-20
2017 Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Zooming in on liver zonation
published pages: 784-787, ISSN: 0270-9139, DOI: 10.1002/hep.29554
Hepatology 67/2 2020-02-20
2019 Josep M. Llovet, Robert Montal, Augusto Villanueva
Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival
published pages: 1262-1277, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.01.028
Journal of Hepatology 70/6 2020-02-20
2020 Benjamin Goeppert, Trine Folseraas, Stephanie Roessler, Matthias Kloor, Anna‐Lena Volckmar, Volker Endris, Ivo Buchhalter, Albrecht Stenzinger, Krzysztof Grzyb, Marit M. Grimsrud, Barbara Gornicka, Erik von Seth, Gary M. Reynolds, Andre Franke, Daniel N. Gotthardt, Arianeb Mehrabi, Angela Cheung, Joanne Verheij, Johanna Arola, Heikki Mäkisalo, Tor J. Eide, Sören Weidemann, John C. Cheville, Gi
Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities
published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.31110
Hepatology 2020-02-20
2016 Che C. Colpitts, Thomas F. Baumert
Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals
published pages: 741-748, ISSN: 1936-0533, DOI: 10.1007/s12072-016-9724-7
Hepatology International 10/5 2020-02-20
2018 Steven K. H. Foung, Thomas F. Baumert
Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02577
Frontiers in Immunology 9 2020-02-20
2019 Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-Sánchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, Verónica Miguela, María Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri
β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma
published pages: 1124-1141, ISSN: 2159-8274, DOI: 10.1158/2159-8290.cd-19-0074
Cancer Discovery 9/8 2020-02-20
2019 Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response
published pages: 2313-2329.e7, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.02.038
Gastroenterology 156/8 2020-02-20
2016 Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma
published pages: 99-105, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2016.09.010
Current Opinion in Virology 20 2020-02-20
2019 Valentina D’Arienzo, Andrea Magri, James M. Harris, Peter A. C. Wing, Chunkyu Ko, Claudia Orbegozo Rubio, Peter A. Revill, Ulrike Protzer, Peter Balfe, Jane A. McKeating
A PCR assay to quantify patterns of HBV transcription
published pages: , ISSN: 0022-1317, DOI: 10.1099/jgv.0.001373
Journal of General Virology 2020-02-20
2019 Thomas F. Baumert, Yujin Hoshida
Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma
published pages: 441, ISSN: 1999-4915, DOI: 10.3390/v11050441
Viruses 11/5 2020-02-20
2019 Adam J. Gehring, Ulrike Protzer
Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection
published pages: 325-337, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.10.032
Gastroenterology 156/2 2020-02-20
2017 Daniel Gonçalves-Carneiro, Jane A. McKeating, Dalan Bailey
The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis
published pages: e02255-16, ISSN: 0022-538X, DOI: 10.1128/JVI.02255-16
Journal of Virology 91/7 2019-07-02
2017 Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux
published pages: 896-907, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2015-311289
Gut 66/5 2019-07-02
2017 Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features
published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.06.007
Gastroenterology pii: S0016-5085(17)35741-4 2019-07-02
2018 Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges
published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.10.024
Gastroenterology 2019-07-02
2017 Victoria Tovar, Helena Cornella, Agrin Moeini, Samuel Vidal, Yujin Hoshida, Daniela Sia, Judit Peix, Laia Cabellos, Clara Alsinet, Sara Torrecilla, Iris Martinez-Quetglas, Juan José Lozano, Christèle Desbois-Mouthon, Manel Solé, Josep Domingo-Domenech, Augusto Villanueva, Josep M Llovet
Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma
published pages: 530-540, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2015-309501
Gut 66/3 2019-07-02
2016 Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice
published pages: 35230, ISSN: 2045-2322, DOI: 10.1038/srep35230
Scientific Reports 6/1 2019-07-02
2017 Agrin Moeini, Daniela Sia, Zhongyang Zhang, Genis Camprecios, Ashley Stueck, Hui Dong, Robert Montal, Laura Torrens, Iris Martinez-Quetglas, M. Isabel Fiel, Ke Hao, Augusto Villanueva, Swan N. Thung, Myron E. Schwartz, Josep M. Llovet
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity
published pages: 952-961, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.01.010
Journal of Hepatology 66/5 2019-07-02
2017 Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet
Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis
published pages: 745-761, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.11.048
Gastroenterology 152/4 2019-07-02
2017 Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis
published pages: gutjnl-2016-3122, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312270
Gut pii: gutjnl-2016-312270 2019-07-02
2017 Che C. Colpitts, Thomas F. Baumert
SMAD About Hepatitis C Virus Cell Entry and Liver Disease
published pages: 21-23, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.11.029
Gastroenterology 152/1 2019-07-02
2017 Marc Ringehan, Jane A. McKeating, Ulrike Protzer
Viral hepatitis and liver cancer
published pages: 20160274, ISSN: 0962-8436, DOI: 10.1098/rstb.2016.0274
Philosophical Transactions of the Royal Society B: Biological Sciences 372/1732 2019-07-02
2017 Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Plasmodium P36 determines host cell receptor usage during sporozoite invasion
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25903
eLife 6 2019-07-02
2017 Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results
published pages: , ISSN: 0938-7994, DOI: 10.1007/s00330-017-4844-6
European Radiology 2019-07-02
2016 Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis
published pages: 7298-7300, ISSN: 0027-8424, DOI: 10.1073/pnas.1607732113
Proceedings of the National Academy of Sciences 113/27 2019-07-02
2016 Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis
published pages: 6387-6400, ISSN: 0022-538X, DOI: 10.1128/JVI.00619-16
Journal of Virology 90/14 2019-07-02
2016 Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, Sara Torrecilla, Victoria Tovar, Agrin Moeini, Clara Alsinet, Anna Portela, Leonardo Rodriguez-Carunchio, Manel Solé, Amaia Lujambio, Augusto Villanueva, Swan Thung, Manel Esteller, Lars Zender, Josep M. Llovet
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models
published pages: 1192-1205, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.09.001
Gastroenterology 151/6 2019-07-02
2016 Josep M. Llovet, Jessica Zucman-Rossi, Eli Pikarsky, Bruno Sangro, Myron Schwartz, Morris Sherman, Gregory Gores
Hepatocellular carcinoma
published pages: 16018, ISSN: 2056-676X, DOI: 10.1038/nrdp.2016.18
Nature Reviews Disease Primers 2 2019-07-02
2017 Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape
published pages: gutjnl-2016-3125, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312577
Gut pii: gutjnl-2016-312577 2019-07-02
2017 Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Advancing hepatitis B virus entry inhibitors
published pages: 677-679, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2016.11.028
Journal of Hepatology 66/4 2019-07-02
2017 Michelle J. Farquhar, Isla S. Humphreys, Simon A. Rudge, Garrick K. Wilson, Bishnupriya Bhattacharya, Maria Ciaccia, Ke Hu, Qifeng Zhang, Laurent Mailly, Gary M. Reynolds, Margaret Ashcroft, Peter Balfe, Thomas F. Baumert, Stephanie Roessler, Michael J.O. Wakelam, Jane A. McKeating
Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication
published pages: 919-929, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.01.009
Journal of Hepatology 66/5 2019-07-02
2017 Che C. Colpitts, Thomas F. Baumert
SCARB1 variants and HCV infection: Host susceptibility is lost in translation
published pages: 211-213, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.04.013
Journal of Hepatology 67(2) 2019-07-02
2017 Julien Bollard, Verónica Miguela, Marina Ruiz de Galarreta, Anu Venkatesh, C Billie Bian, Mark P Roberto, Victoria Tovar, Daniela Sia, Pedro Molina-Sánchez, Christie B Nguyen, Shigeki Nakagawa, Josep M Llovet, Yujin Hoshida, Amaia Lujambio
Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma
published pages: 1286-1296, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312268
Gut 66/7 2019-07-02
2017 Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0815-7
BMC Medicine 15/1 2019-07-02
2017 Riccardo Lencioni, Robert Montal, Ferran Torres, Joong-Won Park, Thomas Decaens, Jean-Luc Raoul, Masatoshi Kudo, Charissa Chang, José Ríos, Valerie Boige, Eric Assenat, Yoon-Koo Kang, Ho-Yeong Lim, Ian Walters, Josep M. Llovet
Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC
published pages: 1166-1172, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.01.012
Journal of Hepatology 66/6 2019-07-02
2016 Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes
published pages: 1357-1368, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.09.084
Cell Reports 17/5 2019-07-02
2017 Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy
published pages: 129-137, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.01.001
Antiviral Research 139 2019-07-02
2017 Monique D. Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A. McKeating, Stan F. J. van de Graaf
N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection
published pages: e0170419, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0170419
PLOS ONE 12/1 2019-07-02
2016 A. Moeini, D. Sia, N. Bardeesy, V. Mazzaferro, J. M. Llovet
Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma
published pages: 291-300, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-14-3296
Clinical Cancer Research 22/2 2019-07-02
2018 Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
Single cell polarity in liquid phase facilitates tumour metastasis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03139-6
Nature Communications 9/1 2019-05-20
2018 Marc Ringelhan, Dominik Pfister, Tracy O’Connor, Eli Pikarsky, Mathias Heikenwalder
The immunology of hepatocellular carcinoma
published pages: 222-232, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0044-z
Nature Immunology 19/3 2019-05-20
2019 Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Jane A. McKeating
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08299-7
Nature Communications 10/1 2019-05-20
2018 Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G.J. Surewaard, Dominik Rath, Sheikh Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patrick Helbling, César Nombela-Arrieta, Anahita Rafiei, Martina Steurer, Marcel Rall, Florian Baku, Caroline L. Wilson, Jack Leslie, Tracy O`Connor, Christopher C. Weston, David H. Adams, Lozan Sheriff, Ana Teijeiro, Marco Prinz, Ruzhica Bogeska, Natasha Anstee, Malte Bongers, Mike Notohamiprodjo, Tobias Geisler, Dominic J. Withers, Jerry Ware, Derek A. Mann, Hellmut Augustin, Alexandros Vegiopoulos, Michael Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Roser Pinyol, Frank Tacke, Roland Rad, Nabil Djouder, Paul Kubes, Percy A. Knolle, Kristian Unger, Lars Zender, Bernhard Nieswandt, Meinrad Gawaz, Achim Weber and Mathias Heikenwalder
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
published pages: in press, ISSN: 1078-8956, DOI:
Nature Medicine 2019-05-20
2018 Xiaodong Zhuang, Alvina G. Lai, Jane A. McKeating, Ian Rowe, Peter Balfe
Daytime variation in hepatitis C virus replication kinetics following liver transplant
published pages: 96, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14696.2
Wellcome Open Research 3 2019-05-20
2018 Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating
Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen
published pages: 126, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14839.1
Wellcome Open Research 3 2019-05-20
2018 Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D\'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, Joaquín Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, Jesús Gil
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
published pages: 85-102.e9, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.06.007
Cancer Cell 34/1 2019-05-20
2017 Joe Grove, Ke Hu, Michelle J. Farquhar, Margaret Goodall, Lucas Walker, Mohammed Jamshad, Heidi E. Drummer, Roslyn M. Bill, Peter Balfe, Jane A. McKeating
A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81
published pages: 82, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.12058.1
Wellcome Open Research 2 2019-05-20
2018 Lucia Cardo, Isabel Nawroth, Peter J. Cail, Jane A. McKeating, Michael J. Hannon
Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo
published pages: 13342, ISSN: 2045-2322, DOI: 10.1038/s41598-018-31513-3
Scientific Reports 8/1 2019-05-20
2017 Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G. Lai, Jane A. McKeating
Interplay between circadian clock and viral infection
published pages: 1283-1289, ISSN: 0946-2716, DOI: 10.1007/s00109-017-1592-7
Journal of Molecular Medicine 95/12 2019-05-20
2019 Anna L. McNaughton, Valentina D’Arienzo, M. Azim Ansari, Sheila F. Lumley, Margaret Littlejohn, Peter Revill, Jane A. McKeating, Philippa C. Matthews
Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood
published pages: 384-399, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.07.058
Gastroenterology 156/2 2019-05-20
2018 Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson
Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure
published pages: [Epub ahead of p, ISSN: 0300-0664, DOI: 10.1111/cen.13924
Clinical Endocrinology 2019-05-20
2018 Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Julia Hasreiter, Jochen M. Wettengel, Daniela Stadler, Romina Bester, Theresa Asen, Ke Zhang, Karin Wisskirchen, Jane A. McKeating, Wang-Shick Ryu, Ulrike Protzer
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels
published pages: 1231-1241, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.08.012
Journal of Hepatology 69/6 2019-05-20
2018 Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas
Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)
published pages: 369-379, ISSN: 1527-6465, DOI: 10.1002/lt.24977
Liver Transplantation 24/3 2019-05-20
2019 Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler
Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma
published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30493
Hepatology 2019-05-20
2018 Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01194
Frontiers in Immunology 9 2019-05-20
2017 Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer
Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro
published pages: 1-12, ISSN: 2314-8861, DOI: 10.1155/2017/4828936
Journal of Immunology Research 2017 2019-05-20
2017 Sara Torrecilla, Daniela Sia, Andrew N. Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N. Thung, Augusto Villanueva, Sander Florman, Myron E. Schwartz, Josep M. Llovet
Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma
published pages: 1222-1231, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.08.013
Journal of Hepatology 67/6 2019-05-20
2017 Che C. Colpitts, Thomas F. Baumert
Claudins in viral infection: from entry to spread
published pages: 27-34, ISSN: 0031-6768, DOI: 10.1007/s00424-016-1908-4
Pflügers Archiv - European Journal of Physiology 469/1 2019-05-20
2018 Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling
published pages: 564-566, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.05.033
Journal of Hepatology 69/3 2019-05-20
2018 Gesa von Olshausen, Maria Quasdorff, Romina Bester, Silke Arzberger, Chunkyu Ko, Maarten van de Klundert, Ke Zhang, Margarete Odenthal, Marc Ringelhan, Carien M. Niessen, Ulrike Protzer
\"Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion\"
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.26103
Oncotarget 9/74 2019-05-20
2018 Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Viral manipulation of STAT3: Evade, exploit, and injure
published pages: e1006839, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006839
PLOS Pathogens 14/3 2019-05-20
2017 Ulrike Protzer
Viral hepatitis: The bumpy road to animal models for HBV infection
published pages: 327-328, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.44
Nature Reviews Gastroenterology & Hepatology 14/6 2019-05-20
2018 Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan N Thung, Augusto Villanueva, Carol Pena, Gerold Meinhardt, Jordi Bruix, Josep M Llovet
Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial
published pages: gutjnl-2018-3164, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316408
Gut 2019-05-20
2017 Daniela Sia, Josep M. Llovet
Liver cancer: Translating \'–omics\' results into precision medicine for hepatocellular carcinoma
published pages: , ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.103
Nature Reviews Gastroenterology & Hepatology 2019-05-20
2018 Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Host-targeting therapies for hepatitis C virus infection: current developments and future applications
published pages: 175628481875948, ISSN: 1756-2848, DOI: 10.1177/1756284818759483
Therapeutic Advances in Gastroenterology 11 2019-05-20
2018 Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Tight junction proteins in gastrointestinal and liver disease
published pages: gutjnl-2018-3169, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316906
Gut 2019-05-20
2018 Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes
published pages: 1695-1709, ISSN: 0270-9139, DOI: 10.1002/hep.30054
Hepatology 68/5 2019-05-20
2018 Christin Elßner, Benjamin Goeppert, Thomas Longerich, Anna-Lena Scherr, Jan Stindt, Lahiri Kanth Nanduri, Christian Rupp, Jakob Nikolas Kather, Nathalie Schmitt, Nicole Kautz, Kai Breuhahn, Lars Ismail, Danijela Heide, Jenny Hetzer, María García-Beccaria, Nadine Hövelmeyer, Ari Waisman, Toni Urbanik, Sebastian Mueller, Georg Gdynia, Jesus M. Banales, Stephanie Roessler, Peter Schirmacher, Dirk Jäger, Sebastian Schölch, Verena Keitel, Mathias Heikenwalder, Henning Schulze-Bergkamen, Bruno Christian Köhler
Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice
published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.11.018
Gastroenterology 2019-05-20
2018 A Vogel, A Cervantes, I Chau, B Daniele, J Llovet, T Meyer, J -C Nault, U Neumann, J Ricke, B Sangro, P Schirmacher, C Verslype, C J Zech, D Arnold, E Martinelli
Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
published pages: iv238-iv255, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy308
Annals of Oncology 29/Supplement_4 2019-05-20
2018 Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness
published pages: 1842-1856, ISSN: 0270-9139, DOI: 10.1002/hep.29669
Hepatology 67/5 2019-05-20
2017 Yong Li, Yuchen Xia, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning
IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13082-z
Scientific Reports 7/1 2019-05-20
2018 Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses
published pages: 3895-3905, ISSN: 1420-682X, DOI: 10.1007/s00018-018-2892-y
Cellular and Molecular Life Sciences 75/21 2019-05-20
2019 Gaetan Ligat, Catherine Schuster, Thomas F. Baumert
Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma
published pages: 5-8, ISSN: 0270-9139, DOI: 10.1002/hep.30231
Hepatology 69/1 2019-05-20
2018 Josep M. Llovet, Robert Montal, Daniela Sia, Richard S. Finn
Molecular therapies and precision medicine for hepatocellular carcinoma
published pages: 599-616, ISSN: 1759-4774, DOI: 10.1038/s41571-018-0073-4
Nature Reviews Clinical Oncology 15/10 2019-05-20
2018 Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01436
Frontiers in Immunology 9 2019-05-20
2017 David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection
published pages: 648-663.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.09.006
Immunity 47/4 2019-05-20
2017 Yuchen Xia, Ulrike Protzer
Control of Hepatitis B Virus by Cytokines
published pages: 18, ISSN: 1999-4915, DOI: 10.3390/v9010018
Viruses 9/1 2019-05-20
2017 Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Protein kinase D at the Golgi controls NLRP3 inflammasome activation
published pages: 2671-2693, ISSN: 0022-1007, DOI: 10.1084/jem.20162040
The Journal of Experimental Medicine 214/9 2019-05-20
2017 Marianna Hösel, Maria Quasdorff, Marc Ringelhan, Hamid Kashkar, Svenja Debey-Pascher, Martin F. Sprinzl, Jan-Hendrik Bockmann, Silke Arzberger, Dennis Webb, Gesa von Olshausen, Achim Weber, Joachim L. Schultze, Hildegard Büning, Mathias Heikenwalder, Ulrike Protzer
Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication
published pages: 339-363, ISSN: 2352-345X, DOI: 10.1016/j.jcmgh.2017.07.003
Cellular and Molecular Gastroenterology and Hepatology 4/3 2019-05-20
2017 Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation
published pages: 620-623, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.7b00091
ACS Infectious Diseases 3/9 2019-05-20
2017 Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Signalome-wide assessment of host cell response to hepatitis C virus
published pages: 15158, ISSN: 2041-1723, DOI: 10.1038/ncomms15158
Nature Communications 8 2019-05-20
2018 Peter R. Galle, Alejandro Forner, Josep M. Llovet, Vincenzo Mazzaferro, Fabio Piscaglia, Jean-Luc Raoul, Peter Schirmacher, Valérie Vilgrain
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
published pages: 182-236, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.03.019
Journal of Hepatology 69/1 2019-05-20
2017 Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo
published pages: 53-64, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.10.015
Antiviral Research 148 2019-05-20
2018 Ismail Labgaa, Carlos Villacorta-Martin, Delia D’Avola, Amanda J. Craig, Johann von Felden, Sebastiao N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, M. Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N. Thung, Celina Ang, Scott L. Friedman, Josep M. Llovet, Myron Schwartz, Augusto Villanueva
A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma
published pages: 3740-3752, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0206-3
Oncogene 37/27 2019-05-20
2018 Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Oncogenic Signaling Induced by HCV Infection
published pages: 538, ISSN: 1999-4915, DOI: 10.3390/v10100538
Viruses 10/10 2019-05-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HEP-CAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HEP-CAR" are provided by the European Opendata Portal: CORDIS opendata.

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