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GLINT SIGNED

GlucoCEST Imaging of Neoplastic Tumours

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GLINT project word cloud

Explore the words cloud of the GLINT project. It provides you a very rough idea of what is the project "GLINT" about.

examination image accounting combination metabolism analogues full pseudo world treating detected invasive native disruptive oxy tracers medical survival alternative methyl managed effect million shown 2008 glucocest devastating alpha tumour thereby unsolved glucose techniques cancer clinic saturation progression differentiation regrowth metabolisable treatment sensitivity nuclear tumours 3omg detect led diseases transfer technique recovery detection chemical sophistication potentially chances named medicine imaging usually deaths cheap combined exchange

Project "GLINT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.glint-project.eu
Total cost	6˙454˙612 €
EC max contribution	5˙797˙799 € (90%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙687˙712.00
2	TEL AVIV UNIVERSITY TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	848˙325.00
3	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	746˙912.00
4	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	739˙125.00
5	OLEA MEDICAL OLEA MEDICAL Organization address address: 93 AVENUE DES SORBIERS ZI ATHELIA IV city: LA CIOTAT postcode: 13600 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LA CIOTAT)	participant	731˙475.00
6	BRACCO IMAGING SPA BRACCO IMAGING SPA Organization address address: VIA EGIDIO FOLLI 50 city: MILAN postcode: 20134 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILAN)	participant	645˙250.00
7	EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Organization address address: NEUTORGASSE 9/2 city: WIEN postcode: 1010 website: www.eibir.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	399˙000.00
8	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	0.00

Map

Project objective

Cancer is one of the most devastating diseases the world is currently facing, accounting for 7.6 million deaths in 2008 (WHO). Cancer is usually detected through advanced medical imaging. Early detection is very important as it increases the chances of survival and the potential for full recovery. Further, The high level of sophistication in treating cancer has led to a new unsolved problem, the differentiation between treatment effect, regrowth or pseudo-progression of the tumour. Here, we aim to develop and bring to the clinic a potentially disruptive new technology to characterize and image glucose delivery, uptake and metabolism in cancer. Recently we managed to demonstrate the sensitivity of a technique, named glucose-based Chemical Exchange Saturation Transfer (glucoCEST), to detect native (α-D-glucose) glucose uptake in tumours. In addition, recent developments have shown glucose analogues, such as 3-oxy-methyl-D-glucose (3OMG) can be used as potential non-metabolisable tracers using the same technique. In this proposal, we aim to bring the combination of native D-glucose and 3-oxy-methyl-D-glucose as a combined examination to the clinic to assess cancer glucose uptake and metabolism, thereby providing a cheap, widely available, more comprehensive, non-invasive alternative to nuclear medicine techniques currently used for cancer assessment within Europe.

Deliverables

List of deliverables.
N-pool Bloch-McConnell simulation software	Other	2019-05-31 15:08:48
pK by combined CEST / 13C NMR spectroscopy	Documents, reports	2019-06-06 16:31:01
Assessment of GlucoCEST effect of 3OMG on a number of tumour models including from breast tumour cell lines DA3, 4T1, and MCF7 and brain metastases of the DA3 tumour cells.	Documents, reports	2019-06-06 16:31:07
Assessment of in vivo pH dependence of GlucoCEST contrast in mouse tumour models using CEST-based agents	Documents, reports	2019-06-06 16:31:00
Dependence of detection thresholds on administration ways	Documents, reports	2019-05-31 15:08:56
Assessment of intracellular energy substrate levels upon native and methylated glucose injections	Documents, reports	2019-05-31 15:08:46
Set up of website	Websites, patent fillings, videos etc.	2019-05-31 15:08:55
Development and implementation of optimized MR T2 and T1Ï techniques	Other	2019-06-06 16:37:05
Estimate of the coefficients of variation, signal- and contrast-to-noise of both sequences on volunteers	Documents, reports	2019-05-31 15:08:54
Up-to-date steady-state and dynamic MRI sequences for GlucoCEST	Demonstrators, pilots, prototypes	2019-05-31 15:08:58
Scanning of 1st adult patient for head-and-neck tumours and gliomas	Demonstrators, pilots, prototypes	2019-05-31 15:09:00
Assessment of in vitro magnetic field dependence properties	Documents, reports	2019-05-31 15:08:52
Technical validation of the GlucoCEST technique in human cancers	Documents, reports	2019-05-31 15:08:55
Development and implementation of optimized MRI CEST sequences based, e.g. on SSFP	Other	2019-06-06 16:31:08
Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)	Documents, reports	2019-05-31 15:08:48
Ethical approval for animal experiments, with personal licenses (incl. translation)	Documents, reports	2019-05-31 15:08:56
Assessing the intra-/extracellular localisation of 3OMG by measuring pH	Documents, reports	2019-05-31 15:08:46
Comparison of GlucoCEST contrast with [18F]FDG uptake	Documents, reports	2019-06-06 16:30:58
Ethics for scanning children and scanning of first paediatric lymphoma patient	Documents, reports	2019-04-30 20:38:12

Take a look to the deliverables list in detail: detailed list of GLINT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	L.Mancini, S. Casagranda, F. Torrealdea, M.Rega, E. De Vita, B. Lopez, S. Brandner, B. Schmitt, P. Liebig, E. Sanverdi, X. Golay, S. Bisdas Glioma staging with CEST asymmetry curves and amides/amines ratio published pages: , ISSN: , DOI:	ISRM 2020	2020-03-05
2019	Mina Kim, Francisco Torrealdea, Sola Adeleke, Marilena Rega, Vincent Evans, Teresita Beeston, Katerina Soteriou, Stefanie Thust, Aaron Kujawa, Sachi Okuchi, Elizabeth Isaac, Wivijin Piga, Jonathan R. Lambert, Asim Afaq, Eleni Demetriou, Pratik Choudhary, King Kenneth Cheung, Sarita Naik, David Atkinson, Shonit Punwani, Xavier Golay Challenges in glucoCEST MR body imaging at 3 Tesla published pages: 1628-1640, ISSN: 2223-4292, DOI: 10.21037/qims.2019.10.05	Quantitative Imaging in Medicine and Surgery 9/10	2020-03-05
2019	Mina Kim , Marco Battiston , Eleni Demetriou , Aaron Kujawa , Torben Schneider , Vincent Evans , Sachi Okuchi , David Atkinson , Claudia Wheeler-Kingshott , Xavier Golay Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner published pages: , ISSN: , DOI:	ISMRM 2019	2020-03-05
2020	S. Casagranda, L. Mancini, G. Gautier, P. Peter, B. Lopez, S. Brandner, E. De Vita, X. Golay, and S. Bisdas Fluid suppression in CEST imaging affects predominantly IDH-mutant 1p/19q retained gliomas with T2-FLAIR mismatch published pages: , ISSN: , DOI:	ISMRM 2020	2020-03-05
2019	Aaron Kujawa , Eleni Demetriou , Mina Kim , Moritz Zaiss , Xavier Golay Bayesian fitting of Chemical Exchange Saturation Transfer (CEST) imaging data with an analytical model for multiple CEST pools published pages: , ISSN: , DOI:	ISMRM 2019	2020-03-05
2019	Aaron Kujawa, Mina Kim, Eleni Demetriou, Annasofia Anemone, Dario Livio Longo, Moritz Zaiss, Xavier Golay Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging published pages: 120-134, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.01.006	Journal of Magnetic Resonance 300	2020-03-05
2017	Michal Rivlin, Gil Navon CEST MRI of 3-O-methyl-D-glucose on different breast cancer models published pages: , ISSN: 0740-3194, DOI: 10.1002/mrm.26752	Magnetic Resonance in Medicine	2019-07-02
2018	Moritz Zaiss, Goran Angelovski, Eleni Demetriou, Michael T. McMahon, Xavier Golay, Klaus Scheffler QUESP and QUEST revisited - fast and accurate quantitative CEST experiments published pages: 1708-1721, ISSN: 0740-3194, DOI: 10.1002/mrm.26813	Magnetic Resonance in Medicine 79/3	2019-07-02
2017	Annasofia Anemone, Lorena Consolino, Laura Conti, Francesca Reineri, Federica Cavallo, Silvio Aime, Dario Longo In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging published pages: , ISSN: 1019-6439, DOI: 10.3892/ijo.2017.4029	International Journal of Oncology	2019-07-02
2018	Francesca Arena, Pietro Irrera, Lorena Consolino, Sonia Colombo Serra, Moritz Zaiss, Dario Livio Longo Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging published pages: 1-9, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.12.007	Journal of Magnetic Resonance 287	2019-04-30
2019	Moritz Zaiss, Kai Herz, Anagha Deshmane, Mina Kim, Xavier Golay, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler Possible artifacts in dynamic CEST MRI due to motion and field alterations published pages: 16-22, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.11.002	Journal of Magnetic Resonance 298	2019-04-30
2018	Michal Rivlin, Gil Navon 3-O-Methyl-d-glucose mutarotation and proton exchange rates assessed by 13C, 1H NMR and by chemical exchange saturation transfer and spin lock measurements published pages: 93-103, ISSN: 0925-2738, DOI: 10.1007/s10858-018-0209-y	Journal of Biomolecular NMR 72/1-2	2019-04-30
2018	Ferrauto, Giuseppe; Di Gregorio, Enza; Lanzardo, Stefania; Ciolli, Laura; Iezzi, Manuela; Aime, Silvio Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28926-5	Scientific Reports	2019-04-30
2017	Longo, Dario Livio; Moustaghfir, Fatima Zzahra; Zerbo, Alexandre; Consolino, Lorena; Anemone, Annasofia; Bracesco, Martina; Aime, Silvio EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging published pages: , ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2017.04.040	International Journal of Pharmaceutics	2019-04-30
2018	Casagranda, Stefano; Pizzolato, Marco; Torrealdea, Francisco; Golay, Xavier; Boutelier, TimothÃ© Principal Process Analysis of dynamic GlucoCEST MRI data published pages: , ISSN: , DOI:	ISMRM 2018 1	2019-04-30

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