Opendata, web and dolomites

IDentIFY SIGNED

Improving Diagnosis by Fast Field-Cycling MRI

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IDentIFY project word cloud

Explore the words cloud of the IDentIFY project. It provides you a very rough idea of what is the project "IDentIFY" about.

scanners    inadequately    unmet    scans    banks    teams    cancer    molecular    adoption    contributes    generate    magnetic    tissues    coils    stability    agents    pulse    chemistry    switch    obtaining    sequences    vitro    world    scanning    correction    samples    paradigm    acquisition    mechanisms    monitor    consolidates    supply    sustainability    diagnosis    contrast    sarcopenia    examples    patients    many    diagnosed    osteoarthritis    ffc    treatment    monitoring    sensitivity    radiofrequency    standard    disease    understand    theory    fast    surgery    solutions    diseases    engineering    solution    informing    magnetometers    solved    extend    tissue    diagnostic    cycling    physics    ultra    models    shifting    mri    biomarkers    power    environmental    thromboembolic    lower    stabilise    magnet    create    healthcare    signals    demonstrated    clinical    relaxation    arise    imaging    patient    invisible    uses    decisions    correct    quantitative    proof    innovations   

Project "IDentIFY" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.identify-project.eu
 Total cost 6˙597˙377 €
 EC max contribution 6˙597˙377 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 1˙479˙853.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 1˙173˙041.00
3    STELAR SRL IT (MEDE) participant 902˙750.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 633˙625.00
5    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 584˙750.00
6    TECHNISCHE UNIVERSITAET ILMENAU DE (ILMENAU) participant 442˙250.00
7    OY INTERNATIONAL ELECTRIC COMPANY FI (HELSINKI) participant 437˙081.00
8    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 367˙560.00
9    UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE PL (OLSZTYN) participant 321˙000.00
10    INTERNATIONAL ELECTRIC COMPANY OY FI (HELSINKI) participant 255˙466.00

Map

 Project objective

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption. Objectives: Understand the mechanisms determining FFC signals in tissues; Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields; Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging; Improve FFC technology, in order to extend its range of clinical applications; Test FFC-MRI on tissue samples and on patients. Achieved by: Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers; Developing magnetometers for FFC-MRI, and environmental-field correction; Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity; Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences; Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients. FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal consolidates the EU lead in FFC technology and uses new concepts from world-leading teams to deliver solutions based on innovations in theory, modelling, physics, chemistry and engineering.

 Deliverables

List of deliverables.
Amplifier stability measurement techniques Demonstrators, pilots, prototypes 2019-05-31 11:39:11
Upgraded FFC-NMR relaxometers Demonstrators, pilots, prototypes 2019-05-31 11:39:08
Analytical models of environmental magnetic fields Documents, reports 2019-05-31 11:39:12
Low‐field correction coils Demonstrators, pilots, prototypes 2019-05-31 11:39:12
Currently-approved contrast agents for FFC-MRI Documents, reports 2019-05-31 11:39:12
Theory of relaxation processes Demonstrators, pilots, prototypes 2019-05-31 11:39:10
Array RF coils and receivers for FFC-MRI Demonstrators, pilots, prototypes 2019-05-31 11:39:12
FFC-NMR and FFC-MRI protocols Documents, reports 2019-05-31 11:39:14
Speed-up of FFC-MRI Demonstrators, pilots, prototypes 2019-05-31 11:39:12
First study subject approvals package Documents, reports 2019-05-31 11:39:11
Surface RF coil for relaxometer Demonstrators, pilots, prototypes 2019-05-30 13:16:19
Magnetic field mapping and correction with existing coils Documents, reports 2019-05-30 13:16:23
Numerical tool for non-exponential relaxation analysis Demonstrators, pilots, prototypes 2019-05-30 13:16:22
Magnetic field sensor survey Documents, reports 2019-05-30 13:16:22

Take a look to the deliverables list in detail:  detailed list of IDentIFY deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Danuta Kruk, Elzbieta Masiewicz, Milosz Wojciechowski, Malgorzata Florek-Wojciechowska, Lionel M. Broche, David J. Lurie
Slow dynamics of solid proteins - Nuclear Magnetic Resonance relaxometry versus Dielectric Spectroscopy
published pages: 106721, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2020.106721
Journal of Magnetic Resonance 2020-04-15
2020 Hassan Abbas, Lionel M. Broche, Aiarpi Ezdoglian, Dmitriy Li, Raif Yuecel, P. James Ross, Lesley Cheyne, Heather M. Wilson, David J. Lurie, Dana K. Dawson
Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept
published pages: 106722, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2020.106722
Journal of Magnetic Resonance 313 2020-04-15
2020 Simona Baroni, Maria Rosaria Ruggiero, Valeria Bitonto, Lionel M. Broche, David J. Lurie, Silvio Aime, Simonetta Geninatti Crich
In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles
published pages: 119805, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2020.119805
Biomaterials 236 2020-02-13
2019 Danuta Kruk, Elzbieta Masiewicz, Anna M. Borkowska, Pawel Rochowski, Pascal H. Fries, Lionel M. Broche, David J. Lurie
Dynamics of Solid Proteins by Means of Nuclear Magnetic Resonance Relaxometry
published pages: 652, ISSN: 2218-273X, DOI: 10.3390/biom9110652
Biomolecules 9/11 2020-01-29
2019 Danuta Kruk, Pawel Rochowski, Elzbieta Masiewicz, Slawomir Wilczynski, Milosz Wojciechowski, Lionel M. Broche, David J. Lurie
Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry
published pages: 2816-2822, ISSN: 1439-4235, DOI: 10.1002/cphc.201900761
ChemPhysChem 20/21 2020-01-29
2019 Maria Ruggiero, Diego Alberti, Valeria Bitonto, Simonetta Geninatti Crich
Ferritin: A Platform for MRI Contrast Agents Delivery
published pages: 33, ISSN: 2304-6740, DOI: 10.3390/inorganics7030033
Inorganics 7/3 2020-01-30
2019 Simona Baroni, Maria Rosaria Ruggiero, Silvio Aime, Simonetta Geninatti Crich
Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent
published pages: 845-851, ISSN: 0749-1581, DOI: 10.1002/mrc.4837
Magnetic Resonance in Chemistry 57/10 2020-01-29
2019 Enza Di Gregorio, Giuseppe Ferrauto, Stefania Lanzardo, Eliana Gianolio, Silvio Aime
Use of FCC-NMRD relaxometry for early detection and characterization of ex-vivo murine breast cancer
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41154-9
Scientific Reports 9/1 2020-01-29
2018 Giuseppe Ferrauto, Enza Di Gregorio, Stefania Lanzardo, Laura Ciolli, Manuela Iezzi, Silvio Aime
Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28926-5
Scientific Reports 8/1 2019-10-08
2019 Lionel M. Broche, P. James Ross, Gareth R. Davies, Mary-Joan MacLeod, David J. Lurie
A whole-body Fast Field-Cycling scanner for clinical molecular imaging studies
published pages: 10402, ISSN: 2045-2322, DOI: 10.1038/s41598-019-46648-0
Scientific Reports 9/1 2019-08-29
2018 Maria Rosaria Ruggiero, Simona Baroni, Silvio Aime, Simonetta Geninatti Crich
Relaxometric investigations addressing the determination of intracellular water lifetime: a novel tumour biomarker of general applicability
published pages: 1-7, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1527045
Molecular Physics 2019-04-30
2018 Pascal H. Fries, Elie Belorizky
Theory of fast field-cycling NMR relaxometry of liquid systems undergoing chemical exchange
published pages: 1-12, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1538539
Molecular Physics 2019-04-30
2019 Markus Bödenler, Ludovic de Rochefort, P. James Ross, Nicolas Chanet, Geneviève Guillot, Gareth R. Davies, Christian Gösweiner, Hermann Scharfetter, David J. Lurie, Lionel M. Broche
Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives
published pages: 1-17, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1557349
Molecular Physics 2019-04-30
2017 G. Galuppini, C. Toffanin, D.M. Raimondo, A. Provera, Y. Xia, R. Rolfi, G. Ferrante, L. Magni
Towards a Model-Based Field-Frequency Lock for NMR
published pages: 13020-13025, ISSN: 2405-8963, DOI: 10.1016/j.ifacol.2017.08.1999
IFAC-PapersOnLine 50/1 2019-04-30
2018 Oleg V. Petrov, Siegfried Stapf
Multicomponent analysis of T 1 relaxation in bovine articular cartilage at low magnetic fields
published pages: , ISSN: 0740-3194, DOI: 10.1002/mrm.27624
Magnetic Resonance in Medicine 2019-04-30
2018 Juan Carlos Cutrin, Diego Alberti, Caterina Bernacchioni, Silvia Ciambellotti, Paola Turano, Claudio Luchinat, Simonetta Geninatti Crich, Silvio Aime
Cancer cell death induced by ferritins and the peculiar role of their labile iron pool
published pages: 27974-27984, ISSN: 1949-2553, DOI: 10.18632/oncotarget.25416
Oncotarget 9/46 2019-04-30
2018 Maria Rosaria Ruggiero, Simona Baroni, Stefania Pezzana, Gianni Ferrante, Simonetta Geninatti Crich, Silvio Aime
Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry
published pages: 7468-7472, ISSN: 1433-7851, DOI: 10.1002/anie.201713318
Angewandte Chemie International Edition 57/25 2019-04-30

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IDENTIFY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IDENTIFY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.3.)

PanCareFollowUp (2019)

PanCareFollowUp: Novel, patient-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for survivors and caregivers

Read More  

ENDOSCAPE (2019)

ENDOSCAPE, a clinically applicable non-viral gene delivery technology

Read More  

LEGACy (2019)

CeLac and European consortium for a personalized medicine approach to Gastric Cancer

Read More