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Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments

Total Cost €


EC-Contrib. €






Project "MEDLEM" data sheet

The following table provides information about the project.


Organization address
city: NOVI SAD
postcode: 21000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Serbia [RS]
 Project website
 Total cost 333˙000 €
 EC max contribution 283˙500 € (85%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERZITET U NOVOM SADU RS (NOVI SAD) coordinator 166˙500.00
2    ELVESYS FR (PARIS) participant 45˙000.00
4    GENOCHEM FR (GRASSE) participant 31˙500.00


 Project objective

The project entitled: “Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments”, with acronym MEDLEM, has a general objective to foster exchanging knowledge and sharing different culture and approaches in reaching high level of excellence, in research and innovation, in the framework of this field.

The project is aimed at strengthening research collaboration through active networking, staff exchange and dissemination activities between 4 European organizations from Serbia, Germany and France as well as 2 non-European institutions from Thailand and Australia, in linking the fields of microfluidic electronic devices, optimal drug administration, fractional pharmacokinetics, and leukemia treatments. The project will exploit complementary competencies and synergies of the participants, and enable knowledge sharing via international/inter-sectoral mobility, based on secondments of research staff. The consortium offers a unique opportunity that creativity and entrepreneurship will flourish and will help exchanged personnel to turn creative ideas into innovative electronics products, reaching breakthroughs in modelling, drug administration and improvements in therapy protocols.

The main technical goals of the joint research programme are: - Development of fractional pharmacokinetic models and procedures for parameter identification within these models; - Design and fabrication of microfluidic device with in-built electronics for optimal drug delivery protocol; - Pharmacokinetics determination of the pharmaceuticals for leukemia treatments and its testing in vitro and in vivo systems; - Optimal control problem, its numerical solution and implementation.

The proposal will develop new research links and strengthen the current research links among the partners and will help build up long-term, world-class research in more successful leukemia treatments.


year authors and title journal last update
List of publications.
2017 Somyot Chirasatitsin, Sanja Kojić, Goran Stojanović
published pages: , ISSN: , DOI:
Scientific conference ETIKUM’2017 December 6-8 2020-02-13
2018 Jelena Laketa, Tijana Kojić, Milan Radovanović, Sanja Kojić, Dajana Milićević, Goran Stojanović
Cost-effective microfluidic device for detection of psychoactive substances
published pages: , ISSN: , DOI:
International Symposium on Industrial Electronics, INDEL’2018 2020-02-13
2018 B. Stanimirov, K. Stankov, N. Pavlović, M. Đanić, S. Goločorbin Kon, M. Mikov
In vivo effects of ursodeoxycholic acid on doxorubicin-induced oxidative injury of hepatocyte
published pages: p.PO1-9-11, ISSN: , DOI:
18th World Congress of Basic and Clinical Pharmacology (WCP2018) 2020-02-13
2019 Jovana Jevremov, Ivana Podunavac, Jovana Lazarević, Sanja Kojić, Vasa Radonić, Goran Stojanović
Performances of Microfluidic Mixing Regulated using Active Pressure Controller
published pages: , ISSN: , DOI:
6th Int. Conf. on Electrical, Electronic and Computing Engineering (Ic)ETRAN 2020-02-13
2019 Mahdee Samae, Pawarit Ritmetee, Somyot Chirasatitsin, Sanja Kojić, Tijana Kojić, Jovana Jevremov, Goran Stojanović, Hani Al Salami
Precise Manufacturing and Performance Validation of Paper-Based Passive Microfluidic Micromixers
published pages: , ISSN: 2234-7593, DOI: 10.1007/s12541-019-00272-0
International Journal of Precision Engineering and Manufacturing 2020-01-14
2019 Maja Ðanić, Bojan Stanimirov, Nebojša Pavlović, Saša Vukmirović, Jelena Lazić, Hani Al-Salami, Momir Mikov
Transport and Biotransformation of Gliclazide and the Effect of Deoxycholic Acid in a Probiotic Bacteria Model
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2019.01083
Frontiers in Pharmacology 10 2019-12-17
2019 Slavica Lazarević, Maja Đanić, Svetlana Goločorbin-Kon, Hani Al-Salami, Momir Mikov
Semisynthetic bile acids: a new therapeutic option for metabolic syndrome
published pages: 104333, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2019.104333
Pharmacological Research 146 2019-11-26
2019 Ivana Rajsic, Nebojsa Pavlovic, Boris Milijasevic, Sasa Vukmirovic, Dragan Spasic, Miodrag Zigic, Nenad Grahovac, Svetlana Golocorbin-Kon, Momir Mikov
The increasing doses of methotrexate pharmacokinetics after intravenous administration in rats - model selection
published pages: 126-126, ISSN: 0042-8450, DOI: 10.2298/vsp190430126r
Vojnosanitetski pregled 0 2019-11-26
2019 Mitar Simić, Zdenka Babić, Vladimir Risojević, Goran M. Stojanović
Non-iterative parameter estimation of the 2R-1C model suitable for low-cost embedded hardware
published pages: 1-15, ISSN: 2095-9184, DOI: 10.1631/fitee.1900112
Frontiers of Information Technology & Electronic Engineering 2019-11-26
2019 Momir Mikov, Nebojša Pavlović, Bojan Stanimirov, Maja Đanić, Svetlana Goločorbin-Kon, Karmen Stankov, Hani Al-Salami
DPP-4 Inhibitors: Renoprotective Potential and Pharmacokinetics in Type 2 Diabetes Mellitus Patients with Renal Impairment
published pages: 1-14, ISSN: 0378-7966, DOI: 10.1007/s13318-019-00570-y
European Journal of Drug Metabolism and Pharmacokinetics 2019-11-26
2019 ijana Koji?, Goran M. Stojanovi?, Aleksandar Mileti?, Milan Radovanovi?, Hani Al-Salami, Fabiana Arduini
Testing and Characterization of Different Papers as Substrate Material for Printed Electronics and Application in Humidity Sensor
published pages: 2981, ISSN: 0914-4935, DOI: 10.18494/sam.2019.2473
Sensors and Materials 31/9 2019-11-26
2019 Armin Mooranian, Nassim Zamani, Giuseppe Luna, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic, Hani Al-Salami
Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in Type 1 diabetes development in a murine mode
published pages: 1-22, ISSN: 1083-7450, DOI: 10.1080/10837450.2019.1665069
Pharmaceutical Development and Technology 2019-11-26
2019 Goran Stojanović, Milica Pojić, Sanja Kojić, Aleksandra Mišan, Dragana Vasiljević
Mechanical properties of edible biofilm as a substrate for printed electronics
published pages: 576-583, ISSN: 0947-8396, DOI: 10.1007/s00339-019-2881-5
Applied Physics A 125/8 2019-11-26
2019 Goran Stojanović, Milan Radovanović, Dragana Vasiljević, Tijana Kojić, Bojana Pivaš, Tatjana Puškar, Sunil Kapadia, Reinhard Baumann
Comparison of Performances of Flexible Tailor-Made Force Sensing Resistors Fabricated Using Inkjet and Xurographic Techniques
published pages: 1-8, ISSN: 1687-725X, DOI: 10.1155/2019/9181492
Journal of Sensors 2019 2019-11-26
2017 Bojan Stanimirov, Karmen Stankov, Nebojša Pavlović, Maja Đanić, Svetlana Goločorbin-Kon, Velibor Vasović, Momir Mikov
Antioxidant effects of ursodeoxycholic acid in doxorubicin-induced oxidative hepatocyte injury
published pages: S309, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.08.031
Toxicology Letters 280 2019-11-26
2017 Bojan Stanimirov, Karmen Stankov, Nebojša Pavlović, Maja Đanić, Velibor Vasović, Momir Mikov
Ursodeoxycholic acid sensitizes human breast adenocarcinoma cells to doxorubicin-induced apoptosis
published pages: S317-S318, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.08.058
Toxicology Letters 280 2019-11-26
2018 Sanja Kojić, Dajana Milićević1, Jovana Lazarević1, Mihailo Drljača and Goran Stojanović
Design and Testing of Microfluidic Micromixer Fabricated Using Xurographic Technique
published pages: , ISSN: , DOI:
41st International Spring Seminar on Electronics Technology - ISSE 2018 2019-11-26
2018 Jovana Lazarević, Mihailo Drljača, Sanja Brdar, Bojan Petrović, Sanja Kojić, Goran Stojanović
Automating of Nanoindentation raw results processing with Python module
published pages: , ISSN: , DOI:
2018 Bojan Stanimirov
The influence of bile acids on cell and tissue penetration and pharmacodynamics of doxorubicin
published pages: , ISSN: , DOI:
2018 Jovana Trifunovic, Vladan Borcic, Sasa Vukmirovic, Momir Mikov
Pharmacokinetic Profiling of Some Carbohydrate Derivatives and Their Structure Activity Relationship Evaluation
published pages: 262-270, ISSN: 1573-4129, DOI: 10.2174/1573412913666170410133503
Current Pharmaceutical Analysis 14/3 2019-11-26
2018 Soracha Thamphiwatana, Tonghathai Phairatana, Somyot Chirasatitsin, Mahdee Samae, Guilhem Velvé Casquillas, Hani Al-Salami, Sanja Kojić, Goran Stojanović
A microfluidic micromixer fabricated using polydimethylsiloxane-based platform for biomedical applications
published pages: 173 – 179, ISSN: 0352-9045, DOI:
Informacije MIDEM - Journal of Microelectronics, Electronic Components and Materials Vol. 48, No. 3(2018) 2019-11-26
2018 L. Heinrich
Microsensor enhanced wound management systems
published pages: , ISSN: , DOI:
2019 Tanja Å arenac, Momir Mikov
Cervical Cancer, Different Treatments and Importance of Bile Acids as Therapeutic Agents in This Disease
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2019.00484
Frontiers in Pharmacology 10 2019-11-26
2018 Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Hani Al-Salami
Eudragit ® -based microcapsules of probucol with a gut-bacterial processed secondary bile acid
published pages: 811-821, ISSN: 2041-5990, DOI: 10.4155/tde-2018-0036
Therapeutic Delivery 9/11 2019-11-26
2018 Chun Y. Wong, Jorge Martinez, Hani Al-Salami, Crispin R. Dass
Quantification of BSA-loaded chitosan/oligonucleotide nanoparticles using reverse-phase high-performance liquid chromatography
published pages: 6991-7006, ISSN: 1618-2642, DOI: 10.1007/s00216-018-1319-9
Analytical and Bioanalytical Chemistry 410/27 2019-11-26
2018 Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
Recent advancements in oral administration of insulin-loaded liposomal drug delivery systems for diabetes mellitus
published pages: 201-217, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2018.07.041
International Journal of Pharmaceutics 549/1-2 2019-11-26
2019 Sanja Kojic, Goran Stojanovic, Vasa Radonic
Novel Cost-Effective Microfluidic Chip Based on Hybrid Fabrication and Its Comprehensive Characterization
published pages: , ISSN: 1424-8220, DOI: 10.3390/s19071719
Sensors, 19(7), 1719 2019-11-26
2019 Ahmed Gedawy, Hani Al-Salami, Crispin R. Dass
Development and validation of a new analytical HPLC method for simultaneous determination of the antidiabetic drugs, metformin and gliclazide
published pages: 315-322, ISSN: 1021-9498, DOI: 10.1016/j.jfda.2018.06.007
Journal of Food and Drug Analysis 27/1 2019-11-26
2019 Ana Tomas, Nebojša Stilinović, Ana Sabo, Zdenko Tomić
Use of microdialysis for the assessment of fluoroquinolone pharmacokinetics in the clinical practice
published pages: 230-242, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2019.02.032
European Journal of Pharmaceutical Sciences 131 2019-11-26
2019 Goran Stojanović, Tijana Kojić, Milan Radovanović, Dragana Vasiljević, Sanja Panić, Vladimir Srdić, Jelena Cvejić
Flexible sensors based on two conductive electrodes and MWCNTs coating for efficient pH value measurement
published pages: , ISSN: 0925-8388, DOI: 10.1016/j.jallcom.2019.04.243
Journal of Alloys and Compounds 2019-11-26
2019 Ivana Vranić, Ivona Vranić, Boris Antić, Goran Stojanović, Hani Al-Salami
Influence of the Main Filter on QRS-amplitude and Duration in Human Electrocardiogram
published pages: 29-34, ISSN: 1335-8871, DOI: 10.2478/msr-2019-0005
Measurement Science Review 19/1 2019-11-26
2018 Nebojša Pavlović, Svetlana Goločorbin-Kon, Maja Ðanić, Bojan Stanimirov, Hani Al-Salami, Karmen Stankov, Momir Mikov
Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01283
Frontiers in Pharmacology 9 2019-11-26
2018 Đanić M, Stanimirov B, Pavlović N, Goločorbin-Kon S, Al-Salami H, Stankov K, Mikov M
Pharmacological applications of bile acids and their derivatives in the treatment of metabolic syndrome
published pages: , ISSN: 1663-9812, DOI:
Frontiers in Pharmacology 2019-11-26
2018 Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Hani Al-Salami
Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses
published pages: 1-7, ISSN: 2169-1401, DOI: 10.1080/21691401.2018.1511571
Artificial Cells, Nanomedicine, and Biotechnology 2019-11-26
2019 Stojanović, Paroški, Samardžić, Radovanović, Krstić
Microfluidics-Based Four Fundamental Electronic Circuit Elements Resistor, Inductor, Capacitor and Memristor
published pages: 960, ISSN: 2079-9292, DOI: 10.3390/electronics8090960
Electronics 8/9 2019-11-26
2016 D.T. Spasic, N.M. Grahovac, M.M. Žigic, J. Kolarevic, S. Goločorbin-Kon and M. Mikov
On optimal high dose methotrexate administration in consolidation phase of acute lymphoblastic leukaemia in children
published pages: , ISSN: , DOI:
International Conference on Fractional Differentiation and its Applications, ICFDA’2016 2019-11-26
2017 L. Heinrich, O. Korzhenko, L. Baus, K. Borrmann, B. Greve, I. A. Kurzina
Development of Dressings for Chronic Wounds
published pages: , ISSN: , DOI:
\"Workshop \"\"Smart Materials and Technologies\"\"\" 2019-11-26
2017 L. Heinrich, O. Korzhenko, L. Baus, K. Borrmann, B. Greve, I. A. Kurzina
Stabilization of antioxidative drugs against premature oxidation
published pages: , ISSN: , DOI:
XIV International Conference „Development perspectives of the fundamental sciences“ 2019-11-26
2016 E. Mauchauffée, C. Poinsard, E, Borde, M. Mikov, S. Golocorbin-Kon, D. T. Spasic
Evaluation of Dried Blood Spot technology in preclinical and clinical development
published pages: , ISSN: , DOI:
Nov 14 - 16 2019-11-26
2017 Tsveta Stoyanova, Iglika Lessigiarska, Momir Mikov, Ilza Pajeva, Stanislav Yanev
Xanthates As Useful Probes for Testing the Active Sites of Cytochromes P450 4A11 and 2E1
published pages: 672-681, ISSN: 1663-9812, DOI: 10.3389/fphar.2017.00672
Frontiers in Pharmacology 8 2019-11-26
2017 Svetlana Golocorbin-Kon, Jelena Calasan, Boris Milijasevic, Sasa Vukmirovic, Mladena Lalic-Popovic, Momir Mikov, Hani Al-Salami
High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect
published pages: , ISSN: 0378-7966, DOI: 10.1007/s13318-017-0415-0
European Journal of Drug Metabolism and Pharmacokinetics 2019-11-26
2016 B. Pajaziti, K. Borrmann, B. Greve, U. Haverkamp, Irina A. Kurzina, L. Heinrich
Investigations on vitamin E caused radiation protection of healthy cells
published pages: , ISSN: , DOI:
\"XIII International Conference of Students and Young Scientists \"\"Prospects of Fundamental Sciences Development“, April 26-29th\" 2019-11-26
2016 S. Goločorbin-Kon, N. Pavlović, B. Stanimirov, S. Vumirović, B Milijašević, H. Al-Salami, M. Mikov
Methotrexate – an old drug with new pharmaceutical formulations and new indications
published pages: 69 - 70, ISSN: 1409-8695, DOI:
Macedonian pharmaceutical bulletin 62 (suppl) 2019-11-26
2017 Momir Mikov, Maja Đanić, Nebojša Pavlović, Bojan Stanimirov, Svetlana Goločorbin-Kon, Karmen Stankov, Hani Al-Salami
Potential Applications of Gliclazide in Treating Type 1 Diabetes Mellitus: Formulation with Bile Acids and Probiotics
published pages: 1-12, ISSN: 0378-7966, DOI: 10.1007/s13318-017-0441-y
European Journal of Drug Metabolism and Pharmacokinetics Oct 16 2019-11-26
2017 Jelena Laketa, Milan Radovanović, Tijana Kojić, Goran Stojanović, Saša Vukmirović, Momir Mikov, Zoran Stamenković
Determination of electrical parameters of dried blood spot samples with different concentration of methotrexate
published pages: , ISSN: , DOI:
2017 Momir Mikov, Maja Đanić, Nebojša Pavlović, Bojan Stanimirov, Svetlana Goločorbin-Kon, Karmen Stankov, Hani Al-Salami
The Role of Drug Metabolites in the Inhibition of Cytochrome P450 Enzymes
published pages: , ISSN: 0378-7966, DOI: 10.1007/s13318-017-0417-y
European Journal of Drug Metabolism and Pharmacokinetics 2019-11-26
2016 J. Kolarevic, M.M. Žigic, , N.M. Grahovac, M. Mikov and D.T. Spasic
On fractional methotrexate deposition/restoring model in the presence of pleural effusion
published pages: , ISSN: , DOI:
International Conference on Fractional Differentiation and its Applications, ICFDA\'2016 2019-11-26
2016 L. Heinrich, H. Ahrens, M. Wahrenburg, I. A. Kurzina
Bearing materials for joint replacement and endoprosthetic reconstruction - material performance, risks of failures and biofilm forming
published pages: , ISSN: , DOI:
\"IV International Conference \"\"New technologies of development and application bioceramics in regenerative medicine\"\"\" 2019-11-26
2017 Dragana Vasiljević, Danka Brajković, Damir Krklješ, Boris Obrenović, Goran M. Stojanović
Testing and Characterization of Multilayer Force Sensing Resistors Fabricated on Flexible Substrate
published pages: 40 – 48, ISSN: 0352-9045, DOI:
Informacije MIDEM - Journal of Microelectronics, Electronic Components and Materials Vol. 47, No. 1 2019-11-26
2016 B. Stanimirov, K. Stankov, N. Pavlovic N, M. Djanic, V. Kojic, I. Barjaktarovic, M. Mikov
The effects of usodeoxycholic acid on cytotoxic activity and proapoptotic potential of doxorubicin in MCF-7 cell line
published pages: pp. 560, ISSN: , DOI:
7th European Congress of Pharmacology (EPHAR) June 26-30, 2019-11-26
2016 Mladena Lalic-Popovic, Jovana Paunkovic, Zorica Grujic, Svetlana Golocorbin-Kon, Velibor Vasovic, Hani Al-Salami, Momir Mikov
The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine
published pages: 144-150, ISSN: 0143-4004, DOI: 10.1016/j.placenta.2016.11.001
Placenta 48 2019-11-26
A Novel Non-Iterative Method for Real-Time Parameter Estimation of the Fricke-Morse Model
published pages: 57-62, ISSN: 1582-7445, DOI: 10.4316/AECE.2016.04009
Advances in Electrical and Computer Engineering 16/4 2019-11-26
2017 M. Radovanović, S. Kojić, D. Vasiljević, N. Samardžić, F. Crespo, S. Cargou, G. V. Casquillas, S. Chirasatitsin, G. Stojanović
published pages: T1‐1.2, ISSN: , DOI:
8th PSU-UNS International conference, June 8-10 6120 2019-11-26
2016 Akhil Chandran M.K., Goran Stojanovic, Vladimir Srdic, Lothar Heinrich
Modeling and application of tin oxide sensors for detection of different pathogens
published pages: , ISSN: , DOI:
Annual conference of the German Society for Biomaterials 2016 2019-11-26
2017 Svetlana Golocorbin-Kon, Momir Mikov, Jelena Cvejic-Hogervorst, Hani Al-Salami, Vladimir Maksimovic
Dried blood spot: Utilizing dry blood for pharmacokinetic investigations - an old method with great future for therapeutic drug monitoring
published pages: 46-46, ISSN: 0042-8450, DOI: 10.2298/VSP170130046G
Vojnosanitetski pregled 0 2019-11-26
2016 S. Goločorbin-Kon, N. Pavlović, M. Lalić-Popović, B. Milijašević, B. Stanimirov, S. Vukmirović, M. Mikov
Microvesicle formulation containing sodium 3α,7α-dihydroxy-12-keto-5β-cholanate enhances oral absorption of cefotaxime
published pages: , ISSN: , DOI:
11th Central European Symposium on Pharmaceutical Technology September 22-24 2019-11-26
2016 N. Samardžić, G. Stojanović, D. Damjanović, H. Hofmann, M. Mionić-Ebersold
Fabrication and characterization of ink-jet printed TiO2 based memristors
published pages: , ISSN: , DOI:
FEMS Junior Euromat conference 2016 2019-11-26
2017 Mitar Simić, Zdenka Babić, Vladimir Risojević, Goran Stojanović
A novel approach for parameter estimation of Fricke-Morse model using Differential Impedance Analysis
published pages: 487-494, ISSN: , DOI: 10.1007/978-981-10-4166-2_75
Proc. of the Int. Conf. on Medical and Biological Engineering 2017 2017 2019-11-26
2016 M. Mikov, S. Goločorbin-Kon, N.M. Grahovac, M.M. Žigic, and D.T. Spasic
On the influence of 12-monoketocholic acid on methotrexate oral absorption in the rat by means of fractional calculus
published pages: , ISSN: , DOI:
International Conference on Fractional Differentiation and its Applications, ICFDA\'2016 2019-11-26
An Ink-Jet Printed Capacitive Sensor for Angular Position/Velocity Measurements
published pages: 77-82, ISSN: 1582-7445, DOI: 10.4316/AECE.2016.04012
Advances in Electrical and Computer Engineering 16/4 2019-11-26

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