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Deep non-invasive imaging via scattered-light acoustically-mediated computational microscopy

Total Cost €


EC-Contrib. €






 DYNA-MIC project word cloud

Explore the words cloud of the DYNA-MIC project. It provides you a very rough idea of what is the project "DYNA-MIC" about.

possess    made    structure    intrinsic    data    governing    struggling    limits    permit    harnessing    micron    opaque    persist    optical    radiation    amounts    hidden    lost    sampling    deeper    microscopy    digital    nanoscopy    deep    fraction    formed    light    diffraction    dynamics    employing    randomness    drastically    algorithms    insights    discovery    breakthrough    scattering    signal    breaks    correlations    complementary    media    extracting    millimeter    sub    limit    biomedical    scattered    assumption    tissue    diseases    nonlinear    peer    back    modulation    patterns    visually    tool    resolution    samples    paradigm    vast    surpass    ultrasonic    probing    contained    clinical    microscopic    cellular    digitally    mediated    platform    investigations    transform    investigation    ultrasound    microscope    combining    image    diagnostics    inside    inferior    techniques    fight    accurate    diagnosis    structures    stochastic    noninvasively    penetration    compressive    ionizing    physics    cancer    perhaps    random    imaging   

Project "DYNA-MIC" data sheet

The following table provides information about the project.


Organization address
postcode: 91904

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Optical microscopy, perhaps the most important tool in biomedical investigation and clinical diagnostics, is currently held back by the assumption that it is not possible to noninvasively image microscopic structures more than a fraction of a millimeter deep inside tissue. The governing paradigm is that high-resolution information carried by light is lost due to random scattering in complex samples such as tissue. While non-optical imaging techniques, employing non-ionizing radiation such as ultrasound, allow deeper investigations, they possess drastically inferior resolution and do not permit microscopic studies of cellular structures, crucial for accurate diagnosis of cancer and other diseases. I propose a new kind of microscope, one that can peer deep inside visually opaque samples, combining the sub-micron resolution of light with the penetration depth of ultrasound. My novel approach is based on our discovery that information on microscopic structures is contained in random scattered-light patterns. It breaks current limits by exploiting the randomness of scattered light rather than struggling to fight it. We will transform this concept into a breakthrough imaging platform by combining ultrasonic probing and modulation of light with advanced digital signal processing algorithms, extracting the hidden microscopic structure by two complementary approaches: 1) By exploiting the stochastic dynamics of scattered light using methods developed to surpass the diffraction limit in optical nanoscopy and for compressive sampling, harnessing nonlinear effects. 2) Through the analysis of intrinsic correlations in scattered light that persist deep inside scattering tissue. This proposal is formed by bringing together novel insights on the physics of light in complex media, advanced microscopy techniques, and ultrasound-mediated imaging. It is made possible by the new ability to digitally process vast amounts of scattering data, and has the potential to impact many fields.


year authors and title journal last update
List of publications.
2019 Galya Stern, Ori Katz
Noninvasive focusing through scattering layers using speckle correlations
published pages: 143, ISSN: 0146-9592, DOI: 10.1364/ol.44.000143
Optics Letters 44/1 2019-10-29
2019 Ori Katz, François Ramaz, Sylvain Gigan, Mathias Fink
Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08583-6
Nature Communications 10/1 2019-10-09
2018 Daniel Doktofsky, Moriya Rosenfeld, Ori Katz
Acousto-optic tomography beyond the acoustic diffraction-limit using speckle decorrelation
published pages: , ISSN: , DOI: arXiv:1812.00400 2019-10-09
2016 Viktor Tsvirkun, Siddharth Sivankutty, Géraud Bouwmans, Ori Katz, Esben Ravn Andresen, Hervé Rigneault
Widefield lensless endoscopy with a multicore fiber
published pages: 4771, ISSN: 0146-9592, DOI: 10.1364/ol.41.004771
Optics Letters 41/20 2019-09-02
2019 Jeremy Boger-Lombard, Ori Katz
Passive optical time-of-flight for Non line-of-sight localization
published pages: , ISSN: , DOI: 2019-09-02
2016 Amir Porat, Esben Ravn Andresen, Hervé Rigneault, Dan Oron, Sylvain Gigan, Ori Katz
Widefield lensless imaging through a fiber bundle via speckle correlations
published pages: 16835, ISSN: 1094-4087, DOI: 10.1364/oe.24.016835
Optics Express 24/15 2019-06-19
2017 Eliel Hojman, Thomas Chaigne, Oren Solomon, Sylvain Gigan, Emmanuel Bossy, Yonina C. Eldar, Ori Katz
Photoacoustic imaging beyond the acoustic diffraction-limit with dynamic speckle illumination and sparse joint support recovery
published pages: 4875, ISSN: 1094-4087, DOI: 10.1364/oe.25.004875
Optics Express 25/5 2019-06-19
2016 Tengfei Wu, Ori Katz, Xiaopeng Shao, Sylvain Gigan
Single-shot diffraction-limited imaging through scattering layers via bispectrum analysis
published pages: 5003, ISSN: 0146-9592, DOI: 10.1364/ol.41.005003
Optics Letters 41/21 2019-06-19
2017 Thomas Chaigne, Bastien Arnal, Sergey Vilov, Emmanuel Bossy, Ori Katz
Super-resolution photoacoustic imaging via flow-induced absorption fluctuations
published pages: 1397, ISSN: 2334-2536, DOI: 10.1364/optica.4.001397
Optica 4/11 2019-06-19

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