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WideBrainImaging

Development of high-speed microscopes to study wide-scale neural activity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 WideBrainImaging project word cloud

Explore the words cloud of the WideBrainImaging project. It provides you a very rough idea of what is the project "WideBrainImaging" about.

cells    tool    consequently    enlarge    relies    intact    attempt    dynamic    penetrate    neurons    excitation    resolution    multiphoton       reduces    resonant    volume    enduring    uses    dynamics    tissue    powerful    observation    memory    microscope    hippocampus    limited    relatively    slow    1mm    cellular    imaging    scan    ultrafast    networks    fluorescence    faster    layers    generally    cell    limit    photon    eeg    thousands    neuroscience    suppresses    brains    transfer    sculpt    otherwise    individual    volumes    computation    regime    reveal    pixels    inserted    complementary    continue    deeper    controllably    electrodes    single    larger    fluorescent    wavelengths    spot    observe    longer    provides    25x    functional    scanning    completion    image    accessible    6mm    exceeding    cortex    microscopes    emerged    insights    focal    measured    opaque    multiple    few    retention    neural    opening    background    speed    temporal    once    achievable    patterns   

Project "WideBrainImaging" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH 

Organization address
address: CAMPUS-VIENNA-BIOCENTER 1
city: WIEN
postcode: 1030
website: www.imp.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://vaziria.com/
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH AT (WIEN) coordinator 178˙156.00

Map

 Project objective

The dynamic of neural computation is often studied in individual cells using inserted electrodes, or using low-resolution methods such as EEG. Functional fluorescent imaging has recently emerged as a powerful complementary tool that allows single-cell resolution of relatively large networks, opening a new regime to neuroscience. However, complex brains are generally opaque and can only be studied with scanning two-photon microscopes; with the achievable depth limited to ~0.6mm, and the volume limited by the relatively slow scan. This project will develop ultrafast scanning multiphoton microscopes to image neural activity at cellular resolution over large volumes, and at greater depth. Using these we will study patterns of activity in the hippocampus, and particularly attempt to observe the pathways involved in memory retention. To increase speed we will use temporal focusing to controllably sculpt the excitation volume and enlarge the focal spot. This reduces the number of measured pixels and allows faster scanning (or larger volume), at the cost of resolution. This will allow 25x faster imaging in a resonant scanning two-photon microscope; allowing observation of many thousands of cells at once, which could reveal the wide-scale characteristic activity. We will build a second microscope that uses three-photon excitation with temporal focusing. Three-photon imaging relies on longer wavelengths that penetrate deeper into tissue, and also suppresses background fluorescence which could otherwise limit depth. Consequently, this microscope will allow high-speed imaging at depth exceeding 1mm. This allows study of information transfer across multiple layers; or provides access to the hippocampus through the intact cortex. These studies could provide crucial insights to neuroscience that are currently accessible only for a few neurons. Following completion of this project these microscopes could have an enduring impact as they continue to be used to study neural dynamics.

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The information about "WIDEBRAINIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

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