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WideBrainImaging

Development of high-speed microscopes to study wide-scale neural activity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 WideBrainImaging project word cloud

Explore the words cloud of the WideBrainImaging project. It provides you a very rough idea of what is the project "WideBrainImaging" about.

networks    observe    scanning    memory    thousands    controllably    attempt    retention    eeg    6mm    measured    insights    regime    deeper    imaging    cell    1mm    wavelengths    volumes    resolution    penetrate    multiphoton    focal    suppresses    cortex    sculpt    multiple    reduces    opaque    25x    enlarge    computation    complementary    otherwise    longer    microscope    patterns    tool    provides    limit    temporal    reveal    hippocampus    single    photon    speed    volume    neural    slow    larger    consequently    fluorescence    powerful    intact    exceeding    completion    relatively    uses    electrodes    pixels    emerged    dynamic    microscopes    layers    spot    achievable    neuroscience    once    background    functional    few    accessible    faster    scan    transfer    limited    observation    ultrafast    enduring       individual    relies    cells    brains    opening    image    resonant    fluorescent    generally    continue    dynamics    cellular    inserted    neurons    tissue    excitation   

Project "WideBrainImaging" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH 

Organization address
address: CAMPUS-VIENNA-BIOCENTER 1
city: WIEN
postcode: 1030
website: www.imp.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://vaziria.com/
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH AT (WIEN) coordinator 178˙156.00

Map

 Project objective

The dynamic of neural computation is often studied in individual cells using inserted electrodes, or using low-resolution methods such as EEG. Functional fluorescent imaging has recently emerged as a powerful complementary tool that allows single-cell resolution of relatively large networks, opening a new regime to neuroscience. However, complex brains are generally opaque and can only be studied with scanning two-photon microscopes; with the achievable depth limited to ~0.6mm, and the volume limited by the relatively slow scan. This project will develop ultrafast scanning multiphoton microscopes to image neural activity at cellular resolution over large volumes, and at greater depth. Using these we will study patterns of activity in the hippocampus, and particularly attempt to observe the pathways involved in memory retention. To increase speed we will use temporal focusing to controllably sculpt the excitation volume and enlarge the focal spot. This reduces the number of measured pixels and allows faster scanning (or larger volume), at the cost of resolution. This will allow 25x faster imaging in a resonant scanning two-photon microscope; allowing observation of many thousands of cells at once, which could reveal the wide-scale characteristic activity. We will build a second microscope that uses three-photon excitation with temporal focusing. Three-photon imaging relies on longer wavelengths that penetrate deeper into tissue, and also suppresses background fluorescence which could otherwise limit depth. Consequently, this microscope will allow high-speed imaging at depth exceeding 1mm. This allows study of information transfer across multiple layers; or provides access to the hippocampus through the intact cortex. These studies could provide crucial insights to neuroscience that are currently accessible only for a few neurons. Following completion of this project these microscopes could have an enduring impact as they continue to be used to study neural dynamics.

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The information about "WIDEBRAINIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

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