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Development of high-speed microscopes to study wide-scale neural activity

Total Cost €


EC-Contrib. €






 WideBrainImaging project word cloud

Explore the words cloud of the WideBrainImaging project. It provides you a very rough idea of what is the project "WideBrainImaging" about.

cells    volume    penetrate    dynamic    6mm    memory    electrodes    otherwise    networks    few    reduces    regime    multiphoton    continue    transfer    sculpt    dynamics    wavelengths    individual    opening    faster    neurons    intact    generally    relatively    slow    functional    reveal    inserted    tissue    uses    insights    opaque    spot    1mm    suppresses    layers    scanning    brains    background    speed    accessible    retention    enduring    ultrafast    once    temporal    photon    single    consequently    multiple    controllably    cortex    resolution    complementary    powerful    longer    neural    achievable    larger    eeg    completion    observe    exceeding    provides    emerged    limited    imaging    tool    relies    computation    cellular    cell    scan    deeper    thousands    observation    attempt    excitation    measured    resonant    25x    focal    patterns    neuroscience    microscopes    hippocampus    microscope    limit    pixels    volumes    fluorescent    enlarge    fluorescence       image   

Project "WideBrainImaging" data sheet

The following table provides information about the project.


Organization address
city: WIEN
postcode: 1030

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The dynamic of neural computation is often studied in individual cells using inserted electrodes, or using low-resolution methods such as EEG. Functional fluorescent imaging has recently emerged as a powerful complementary tool that allows single-cell resolution of relatively large networks, opening a new regime to neuroscience. However, complex brains are generally opaque and can only be studied with scanning two-photon microscopes; with the achievable depth limited to ~0.6mm, and the volume limited by the relatively slow scan. This project will develop ultrafast scanning multiphoton microscopes to image neural activity at cellular resolution over large volumes, and at greater depth. Using these we will study patterns of activity in the hippocampus, and particularly attempt to observe the pathways involved in memory retention. To increase speed we will use temporal focusing to controllably sculpt the excitation volume and enlarge the focal spot. This reduces the number of measured pixels and allows faster scanning (or larger volume), at the cost of resolution. This will allow 25x faster imaging in a resonant scanning two-photon microscope; allowing observation of many thousands of cells at once, which could reveal the wide-scale characteristic activity. We will build a second microscope that uses three-photon excitation with temporal focusing. Three-photon imaging relies on longer wavelengths that penetrate deeper into tissue, and also suppresses background fluorescence which could otherwise limit depth. Consequently, this microscope will allow high-speed imaging at depth exceeding 1mm. This allows study of information transfer across multiple layers; or provides access to the hippocampus through the intact cortex. These studies could provide crucial insights to neuroscience that are currently accessible only for a few neurons. Following completion of this project these microscopes could have an enduring impact as they continue to be used to study neural dynamics.

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The information about "WIDEBRAINIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

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