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Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses

Total Cost €


EC-Contrib. €






 SATBIOFUN project word cloud

Explore the words cloud of the SATBIOFUN project. It provides you a very rough idea of what is the project "SATBIOFUN" about.

protein    trained    satellites    quantitative    coupling    dense    base    ciliopathies    position    time    mutations    granules    disease    maturity    skills    group    alongside    independent    proteins    computational    central    centre    morphometric    serves    organizing    biogenesis    cilium    normal    resolution    edge    overarching    centrosome    genes    composition    secondment    follow    delineate    professional    cellular    microscopy    receives    cell    centriolar    systematically    dna    function    encoding    lie    external    shows    termed    dissect    mechanisms    molecular    satellite    stimuli    outgoing    techniques    regulation    microtubule    data    scientific    electron    acquire    structure    establishing    primary    assembly    industry    etiology    complementary    super    content    teaching    cytoplasmic    biotech    underpinning    qualifications    demonstrating    cells    first    editing    training    stress    return    thereby    whilst    little    career    genome    antenna    trafficking    transfer    perform    encompasses    automated    cutting    manipulation    imaging    courses    fellow   

Project "SATBIOFUN" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 233˙555 €
 EC max contribution 233˙555 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 233˙555.00
2    Mount Sinai Hospital CA (TORONTO) partner 0.00


 Project objective

The centrosome is the major microtubule-organizing centre of a cell. It also serves as the base for the primary cilium, an antenna-like structure that allows cells to respond to external stimuli. Around the centrosome lie a number of electron dense cytoplasmic granules, termed centriolar satellites. These are involved in protein trafficking and are crucial for normal centrosome and cilium assembly and function. However, little is known about satellite composition, biogenesis or regulation. Mutations in a number of genes encoding satellite proteins cause ciliopathies, demonstrating their importance in the etiology of disease. Emerging data also shows that satellites contribute to the cellular stress response. The central scientific goal of this proposal is to systematically dissect, for the first time, the molecular mechanisms underpinning centriolar satellite biogenesis and function. Coupling genome-editing and cutting-edge imaging techniques we will perform morphometric quantitative analysis of satellite proteins to delineate their specific role in the cellular response to stress. This project encompasses an Outgoing Phase during which the Fellow will be trained in advanced, high-content, automated, and super-resolution microscopy, and computational analysis to study satellite biogenesis and function. Within this phase a secondment to the biotech sector will occur during which the Fellow will learn cutting-edge DNA manipulation methods. The Return Phase allows the transfer of this knowledge to Europe whilst the Fellow receives training in the analysis of stress responses. Alongside this the Fellow will follow a program of courses to acquire a range of complementary skills, including industry-related skills and teaching qualifications. Together, this will accomplish the overarching objective of developing the Fellow’s career to a position of professional maturity, thereby facilitating her long-term goal of establishing her own independent research group in Europe.

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The information about "SATBIOFUN" are provided by the European Opendata Portal: CORDIS opendata.

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