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HyGlio SIGNED

Theranostic Injectable Hydrogel for Glioblastoma

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "HyGlio" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.dimeas.polito.it/la_ricerca/gruppi/materiali_per_le_bionanotecnologie_e_laboratorio_biomedico
 Total cost 244˙269 €
 EC max contribution 244˙269 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-30   to  2019-09-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 244˙269.00
2    THE METHODIST HOSPITAL RESEARCH INSTITUTE US (HOUSTON TX) partner 0.00

Map

 Project objective

Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults and is characterized by invariably fatal prognosis. Although the incidence of GBM is less than 10 to 100,000, the median survival of approximate 1 year from diagnosis makes it a considerable socio-economic burden. The presence of biological barriers for effective drug transport to the brain, the strong migrating-ability of the tumor and its rapid evolution into more aggressive and treatment-resistant variants, make GBM extremely hard to treat with traditional systemic chemotherapy. The HyGlio project proposes an ambitious bottom-up approach to build a multifunctional tool for long-term imaging and treatment of GBM, combining multiple treatment strategies, patient-specificity, and BBB bypassing in an all-in-one system. The system combines the advantages of: (i) Intracranial treatment, which maximizes efficacy while minimizing side effects; (ii) mild gelling conditions of the hydrogel, which reduce potential damages to the healthy tissue; (iii) increased drug penetration and selectivity due to the use of targeted polymer nanoparticles; (iv) Inhibition of molecular mechanisms involved in GBM spreading and aggressiveness; (iv) theranostic potential, due to the presence of magnetic resonance imaging, agents for rapid therapy adjustment according to patient’s needs. The HyGlio project is expected to introduce innovative concepts and methodologies for the treatment of GBM, by providing advanced and promising tools for more efficient therapy and increased patient outcome.

 Publications

year authors and title journal last update
List of publications.
2019 G. Brachi, F. Bussolino, G. Ciardelli, C. Mattu
NANOMEDICINE FOR IMAGING AND THERAPY OF PANCREATIC ADENOCARCINOMA
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00307
Frontiers in Bioengineering and Biotechnology 2020-04-07
2019 Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono
MicroRNA delivery through nanoparticles
published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.10.007
Journal of Controlled Release 2020-04-07
2018 C. Mattu, G. Brachi, L. Menichetti, A. Flori, P. Armanetti, E. Ranzato, S. Martinotti, S. Nizzero, M. Ferrari, G. Ciardelli
Alternating block copolymer-based nanoparticles as tools to modulate the loading of multiple chemotherapeutics and imaging probes
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.09.021
Acta Biomaterialia 2020-04-07

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The information about "HYGLIO" are provided by the European Opendata Portal: CORDIS opendata.

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