Explore the words cloud of the HyGlio project. It provides you a very rough idea of what is the project "HyGlio" about.
The following table provides information about the project.
POLITECNICO DI TORINO
|Coordinator Country||Italy [IT]|
|Total cost||244˙269 €|
|EC max contribution||244˙269 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-09-30 to 2019-09-29|
Take a look of project's partnership.
|1||POLITECNICO DI TORINO||IT (TORINO)||coordinator||244˙269.00|
|2||THE METHODIST HOSPITAL RESEARCH INSTITUTE||US (HOUSTON TX)||partner||0.00|
Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults and is characterized by invariably fatal prognosis. Although the incidence of GBM is less than 10 to 100,000, the median survival of approximate 1 year from diagnosis makes it a considerable socio-economic burden. The presence of biological barriers for effective drug transport to the brain, the strong migrating-ability of the tumor and its rapid evolution into more aggressive and treatment-resistant variants, make GBM extremely hard to treat with traditional systemic chemotherapy. The HyGlio project proposes an ambitious bottom-up approach to build a multifunctional tool for long-term imaging and treatment of GBM, combining multiple treatment strategies, patient-specificity, and BBB bypassing in an all-in-one system. The system combines the advantages of: (i) Intracranial treatment, which maximizes efficacy while minimizing side effects; (ii) mild gelling conditions of the hydrogel, which reduce potential damages to the healthy tissue; (iii) increased drug penetration and selectivity due to the use of targeted polymer nanoparticles; (iv) Inhibition of molecular mechanisms involved in GBM spreading and aggressiveness; (iv) theranostic potential, due to the presence of magnetic resonance imaging, agents for rapid therapy adjustment according to patient’s needs. The HyGlio project is expected to introduce innovative concepts and methodologies for the treatment of GBM, by providing advanced and promising tools for more efficient therapy and increased patient outcome.
|year||authors and title||journal||last update|
G. Brachi, F. Bussolino, G. Ciardelli, C. Mattu
NANOMEDICINE FOR IMAGING AND THERAPY OF PANCREATIC ADENOCARCINOMA
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00307
|Frontiers in Bioengineering and Biotechnology||2020-04-07|
Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono
MicroRNA delivery through nanoparticles
published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.10.007
|Journal of Controlled Release||2020-04-07|
C. Mattu, G. Brachi, L. Menichetti, A. Flori, P. Armanetti, E. Ranzato, S. Martinotti, S. Nizzero, M. Ferrari, G. Ciardelli
Alternating block copolymer-based nanoparticles as tools to modulate the loading of multiple chemotherapeutics and imaging probes
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.09.021
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The information about "HYGLIO" are provided by the European Opendata Portal: CORDIS opendata.