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CMIL SIGNED

Crosstalk of Metabolism and Inflammation

Total Cost €

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EC-Contrib. €

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Partnership

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 CMIL project word cloud

Explore the words cloud of the CMIL project. It provides you a very rough idea of what is the project "CMIL" about.

tissue    cell    candidates    networks    man    liver    systemic    integration    experiments    disciplinary    metabolite    central    cutting    proteomics    appreciated    cytokines    immunological    shapes    functional    signals    molecular    chose    perturbations    cross    hotspot    technologies    chronic    roles    mouse    hypothesise    nodes    inflammation    metabolic    models    oxidative    alterations    immunomodulatory    quantitative    genetic    reveal    metabolomics    virological    longitudinal    fails    diseases    noxious    repair    dimensional    interface    occurs    distributing    maps    damage    tightly    cancer    edge    stimuli    develops    orthogonal    pharmacological    crosstalk    disease    kinetics    model    initiates    bile    implications    secreted    resolution    preliminary    metabolism    bioinformatics    regulatory    hepatitis    organ    bear    sequencing    drives    profiling    acids    pathological    viral    virus    culture    paired    rheostat    infections    autoimmunity    deep    local    explore    levels    receiving    metabolites    inflammatory    create    mediating   

Project "CMIL" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://cemm.at/research/funding/international-funding/erc-starting-grant-cmil/
 Total cost 1˙701˙011 €
 EC max contribution 1˙701˙011 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 1˙701˙011.00

Map

 Project objective

Inflammation is a response to noxious stimuli and initiates tissue repair. If resolution fails, however, chronic inflammation develops, which drives tissue damage in many diseases including autoimmunity, cancer and infections. Inflammatory processes are increasingly being appreciated as tightly integrated with metabolic pathways. The molecular crosstalk occurs on different levels including secreted metabolites and cytokines. I hypothesise that this interface of metabolism and inflammation represents a functional rheostat that shapes tissue damage and disease.

Here, I propose to analyse the metabolic and inflammatory processes in a mouse model of chronic viral hepatitis. I chose this model to explore the inflammatory rheostat because the liver is the central organ for metabolism and a hotspot for receiving, processing and distributing local and systemic signals. Cutting-edge technologies including deep sequencing, quantitative proteomics and metabolomics will let us create longitudinal multi-dimensional maps of virus-induced alterations. Paired with immunological, virological and pathological analyses, I expect to identify novel regulatory nodes between metabolism and inflammation. Within our systems-wide experiments and supported by preliminary results, we will specifically focus on the immunomodulatory roles of the metabolite bile acids and oxidative metabolism. These as well as other candidates will be investigated by genetic and pharmacological perturbations in cell culture and in mouse models. Bioinformatics integration of the orthogonal profiling kinetics is expected to reveal novel properties of the molecular networks mediating between metabolism and inflammation.

This proposed cross-disciplinary approach aims to improve our understanding of the crosstalk of metabolism and inflammation. The results of this project may be relevant to viral hepatitis in man and bear broader implications for other inflammatory diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
published pages: 1074-1087.e9, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.10.014
Immunity 51/6 2020-02-19
2019 Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Anna Orlova, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin D. de Araujo, David A. Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Gregory M. Woods, Stefan Kubicek, Elizabeth P. Murchison, Keiryn L. Bennett, Richard Moriggl, Andreas Bergthaler
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
published pages: 125-139.e9, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.11.018
Cancer Cell 35/1 2020-01-29
2019 Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler
CD8+ T cells induce cachexia during chronic viral infection
published pages: 701-710, ISSN: 1529-2908, DOI: 10.1038/s41590-019-0397-y
Nature Immunology 20/6 2020-01-29

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