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CMIL SIGNED

Crosstalk of Metabolism and Inflammation

Total Cost €

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EC-Contrib. €

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 Outcomes and results

 CMIL project word cloud

Explore the words cloud of the CMIL project. It provides you a very rough idea of what is the project "CMIL" about.

chronic    oxidative    local    cell    inflammation    mouse    metabolomics    create    man    crosstalk    perturbations    hotspot    reveal    edge    damage    signals    cancer    occurs    noxious    molecular    resolution    model    proteomics    networks    tissue    metabolite    shapes    profiling    disciplinary    appreciated    kinetics    deep    stimuli    metabolism    bile    genetic    secreted    immunomodulatory    mediating    virus    sequencing    initiates    models    systemic    explore    nodes    drives    cross    inflammatory    tightly    central    diseases    technologies    receiving    dimensional    interface    alterations    infections    culture    bear    repair    metabolic    hypothesise    metabolites    functional    pathological    hepatitis    candidates    bioinformatics    distributing    levels    roles    acids    disease    implications    fails    organ    virological    preliminary    autoimmunity    cutting    experiments    immunological    integration    chose    develops    orthogonal    viral    longitudinal    paired    liver    regulatory    cytokines    maps    pharmacological    quantitative    rheostat   

Project "CMIL" data sheet

The following table provides information about the project.

Coordinator		 CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Austria [AT]
 Project website https://cemm.at/research/funding/international-funding/erc-starting-grant-cmil/
 Total cost 1˙701˙011 €
 EC max contribution 1˙701˙011 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 1˙701˙011.00

Map

 Project objective

Inflammation is a response to noxious stimuli and initiates tissue repair. If resolution fails, however, chronic inflammation develops, which drives tissue damage in many diseases including autoimmunity, cancer and infections. Inflammatory processes are increasingly being appreciated as tightly integrated with metabolic pathways. The molecular crosstalk occurs on different levels including secreted metabolites and cytokines. I hypothesise that this interface of metabolism and inflammation represents a functional rheostat that shapes tissue damage and disease.

Here, I propose to analyse the metabolic and inflammatory processes in a mouse model of chronic viral hepatitis. I chose this model to explore the inflammatory rheostat because the liver is the central organ for metabolism and a hotspot for receiving, processing and distributing local and systemic signals. Cutting-edge technologies including deep sequencing, quantitative proteomics and metabolomics will let us create longitudinal multi-dimensional maps of virus-induced alterations. Paired with immunological, virological and pathological analyses, I expect to identify novel regulatory nodes between metabolism and inflammation. Within our systems-wide experiments and supported by preliminary results, we will specifically focus on the immunomodulatory roles of the metabolite bile acids and oxidative metabolism. These as well as other candidates will be investigated by genetic and pharmacological perturbations in cell culture and in mouse models. Bioinformatics integration of the orthogonal profiling kinetics is expected to reveal novel properties of the molecular networks mediating between metabolism and inflammation.

This proposed cross-disciplinary approach aims to improve our understanding of the crosstalk of metabolism and inflammation. The results of this project may be relevant to viral hepatitis in man and bear broader implications for other inflammatory diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
published pages: 1074-1087.e9, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.10.014 		Immunity 51/6 2020-02-19
2019 Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Anna Orlova, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin D. de Araujo, David A. Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Gregory M. Woods, Stefan Kubicek, Elizabeth P. Murchison, Keiryn L. Bennett, Richard Moriggl, Andreas Bergthaler
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
published pages: 125-139.e9, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.11.018 		Cancer Cell 35/1 2020-01-29
2019 Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler
CD8+ T cells induce cachexia during chronic viral infection
published pages: 701-710, ISSN: 1529-2908, DOI: 10.1038/s41590-019-0397-y 		Nature Immunology 20/6 2020-01-29

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The information about "CMIL" are provided by the European Opendata Portal: CORDIS opendata.

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