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CMIL SIGNED

Crosstalk of Metabolism and Inflammation

Total Cost €

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EC-Contrib. €

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 Outcomes and results

 CMIL project word cloud

Explore the words cloud of the CMIL project. It provides you a very rough idea of what is the project "CMIL" about.

drives    hypothesise    acids    regulatory    profiling    chronic    chose    networks    metabolites    bile    metabolism    occurs    experiments    tightly    autoimmunity    fails    create    virus    technologies    viral    damage    tissue    paired    inflammatory    virological    disease    organ    initiates    systemic    oxidative    interface    metabolomics    mouse    pharmacological    cytokines    receiving    diseases    nodes    rheostat    explore    integration    signals    levels    preliminary    immunomodulatory    crosstalk    sequencing    cross    secreted    resolution    noxious    develops    metabolite    shapes    cutting    alterations    cell    quantitative    functional    dimensional    inflammation    kinetics    perturbations    longitudinal    implications    bioinformatics    disciplinary    edge    cancer    candidates    hotspot    stimuli    pathological    central    orthogonal    maps    genetic    molecular    models    hepatitis    roles    culture    mediating    deep    man    proteomics    metabolic    distributing    model    repair    immunological    bear    local    appreciated    infections    reveal    liver   

Project "CMIL" data sheet

The following table provides information about the project.

Coordinator		 CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Austria [AT]
 Project website https://cemm.at/research/funding/international-funding/erc-starting-grant-cmil/
 Total cost 1˙701˙011 €
 EC max contribution 1˙701˙011 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 1˙701˙011.00

Map

 Project objective

Inflammation is a response to noxious stimuli and initiates tissue repair. If resolution fails, however, chronic inflammation develops, which drives tissue damage in many diseases including autoimmunity, cancer and infections. Inflammatory processes are increasingly being appreciated as tightly integrated with metabolic pathways. The molecular crosstalk occurs on different levels including secreted metabolites and cytokines. I hypothesise that this interface of metabolism and inflammation represents a functional rheostat that shapes tissue damage and disease.

Here, I propose to analyse the metabolic and inflammatory processes in a mouse model of chronic viral hepatitis. I chose this model to explore the inflammatory rheostat because the liver is the central organ for metabolism and a hotspot for receiving, processing and distributing local and systemic signals. Cutting-edge technologies including deep sequencing, quantitative proteomics and metabolomics will let us create longitudinal multi-dimensional maps of virus-induced alterations. Paired with immunological, virological and pathological analyses, I expect to identify novel regulatory nodes between metabolism and inflammation. Within our systems-wide experiments and supported by preliminary results, we will specifically focus on the immunomodulatory roles of the metabolite bile acids and oxidative metabolism. These as well as other candidates will be investigated by genetic and pharmacological perturbations in cell culture and in mouse models. Bioinformatics integration of the orthogonal profiling kinetics is expected to reveal novel properties of the molecular networks mediating between metabolism and inflammation.

This proposed cross-disciplinary approach aims to improve our understanding of the crosstalk of metabolism and inflammation. The results of this project may be relevant to viral hepatitis in man and bear broader implications for other inflammatory diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
published pages: 1074-1087.e9, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.10.014 		Immunity 51/6 2020-02-19
2019 Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Anna Orlova, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin D. de Araujo, David A. Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Gregory M. Woods, Stefan Kubicek, Elizabeth P. Murchison, Keiryn L. Bennett, Richard Moriggl, Andreas Bergthaler
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
published pages: 125-139.e9, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.11.018 		Cancer Cell 35/1 2020-01-29
2019 Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler
CD8+ T cells induce cachexia during chronic viral infection
published pages: 701-710, ISSN: 1529-2908, DOI: 10.1038/s41590-019-0397-y 		Nature Immunology 20/6 2020-01-29

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The information about "CMIL" are provided by the European Opendata Portal: CORDIS opendata.

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