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MetamorphChip SIGNED

Dynamic Microfluidic Structures for Analysis of Single Cell Systems

Total Cost €

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EC-Contrib. €

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Project "MetamorphChip" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://www.microfluidic-technologies.com/erc-metamorph
 Total cost 1˙744˙056 €
 EC max contribution 1˙744˙056 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 1˙744˙056.00

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 Project objective

The interaction and communication between individual cells plays a central role in virtually all fields of biology, from the cooperative work of cells in the immune system, through the differentiation of stem cells, and to the proliferation of cancer cells. In recent years it has been shown that these processes are fundamentally coupled to cell-to-cell heterogeneity and variability. Despite the fact that studying cellular ensembles obscures these fundamental biological processes, most current studies consider cell populations, largely due to technological limitations in the ability to dynamically compartmentalize, manipulate, and analyze single cells.

We propose to develop and demonstrate a new concept for a single-cell-level bioanalytical workspace that is dynamically configurable in real time. Making use of electrokinetically driven surface deformations, a physical mechanism recently invented in my lab, the MetamorphChip will be able to dynamically modify its own microfluidic structure, thus allowing complete freedom in the manipulation of individual cells and their environment, in real time.

The project is divided into 5 aims: 1. Deepening our physical understanding of electrokinetically driven surface deformations, and using it to create a “library” of fundamental dynamic elements. 2. Designing, building, and testing the first prototype MetamorphChip. 3. Demonstrating the ability of the MetamorphChip to manipulate single cells and their microenvironment. 4. Performing advanced biochemical analysis on single cells using the chip. 5. Demonstrating the use of the MetamorphChip for experimental study of immune cell interaction.

I strongly believe that successful implementation of this project would fundamentally change the way in which single-cell experiments are conceived and performed.

 Publications

year authors and title journal last update
List of publications.
2018 Evgeniy Boyko, Ran Eshel, Khaled Gommed, Amir D. Gat, and Moran Bercovici
Elastohydrodynamics of a pre-stretched finite elastic sheet lubricated by a thin viscous film with application to microfluidic soft actuators
published pages: , ISSN: 0022-1120, DOI:
Journal of Fluid Mechanics 2019-04-18
2017 Evgeniy Boyko, Moran Bercovici, Amir D. Gat
Viscous-elastic dynamics of power-law fluids within an elastic cylinder
published pages: 1-19, ISSN: 2469-990X, DOI: 10.1103/physrevfluids.2.073301
Physical Review Fluids 2/7 2019-06-19
2017 Shimon Rubin, Arie Tulchinsky, Amir D. Gat, Moran Bercovici
Elastic deformations driven by non-uniform lubrication flows
published pages: 841-865, ISSN: 0022-1120, DOI: 10.1017/jfm.2016.830
Journal of Fluid Mechanics 812 2019-06-19
2016 Evgeniy Boyko, Moran Bercovici, Amir D. Gat
Flow of power-law liquids in a Hele-Shaw cell driven by non-uniform electro-osmotic slip in the case of strong depletion
published pages: 235-257, ISSN: 0022-1120, DOI: 10.1017/jfm.2016.622
Journal of Fluid Mechanics 807 2019-06-19

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "METAMORPHCHIP" project.

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The information about "METAMORPHCHIP" are provided by the European Opendata Portal: CORDIS opendata.

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