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Virus-X: Viral Metagenomics for Innovation Value

Total Cost €


EC-Contrib. €






Project "Virus-X" data sheet

The following table provides information about the project.


Organization address
address: VINLANDSLEID 12
postcode: 113

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Iceland [IS]
 Project website
 Total cost 7˙964˙214 €
 EC max contribution 7˙964˙092 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-LEIT-BIO-2015-1
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MATIS OHF IS (REYKJAVIK) coordinator 1˙356˙025.00
2    UNIVERSITY OF DURHAM UK (DURHAM) participant 665˙000.00
3    UNIVERSITAET BIELEFELD DE (BIELEFELD) participant 641˙875.00
4    UNIWERSYTET GDANSKI PL (GDANSK) participant 610˙000.00
5    LUNDS UNIVERSITET SE (LUND) participant 599˙782.00
6    SAROMICS BIOSTRUCTURES AB SE (Lund) participant 558˙175.00
8    UNIVERSITAET STUTTGART DE (STUTTGART) participant 505˙653.00
9    UNIVERSITETET I BERGEN NO (BERGEN) participant 496˙250.00
10    ArcticZymes AS NO (Tromsø) participant 468˙331.00
11    BIO-PRODICT BV NL (NIJMEGEN) participant 458˙750.00
12    A&A BIOTECHNOLOGY SC PL (GDYNIA) participant 322˙500.00
13    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 297˙500.00
15    PROKAZYME EHF. IS (REYKJAVIK) participant 173˙500.00


 Project objective

Biological sequence diversity in nowhere as apparent as in the vast sequence space of viral genomes. The Virus-X project will specifically explore the outer realms of this diversity by targeting the virosphere of selected microbial ecosystems and investigate the encoded functional variety of viral gene products. The project is driven by the expected large innovation value and unique properties of viral proteins, previously demonstrated by the many virally-derived DNA and RNA processing enzymes used in biotechnology. Concomitantly, the project will advance our understanding of important aspects of ecology in terms of viral diversity, ecosystem dynamics and virus-host interplay. Last but not least, due to the inherent challenges in gene annotation, functional assignments and other virus-specific technical obstacles of viral metagenomics, the Virus-X project specifically addresses these challenges using innovative measures in all parts of the discovery and analysis pipeline, from sampling difficult extreme biotopes, through sequencing and innovative bioinformatics to efficient production of enzymes for molecular biotechnology. Virus-X will advance the metagenomic tool-box significantly and our capabilities for future exploitation of viral biological diversity, the largest unexplored genetic reservoir on Earth.


List of deliverables.
WP3 - Scientific publications, patents or congress contribution and outreach Documents, reports 2019-07-22 17:09:00
WP1 - Scientific publications, patents or congress contribution and outreach Documents, reports 2019-05-09 18:31:12
Project website built and online Websites, patent fillings, videos etc. 2019-05-24 18:53:51

Take a look to the deliverables list in detail:  detailed list of Virus-X deliverables.


year authors and title journal last update
List of publications.
2019 Roux , Simon; Adriaenssens , Evelien; Dutilh , Bas ,; Koonin , Eugene; Kropinski , Andrew; Krupovic , Mart; Kuhn , Jens; Lavigne , Rob; Brister , J Rodney; Varsani , Arvind; Amid , Clara; Aziz , Ramy; Bordenstein , Seth; Bork , Peer; Breitbart , Mya; Cochrane , Guy; Daly , Rebecca; Desnues , Christelle; Duhaime , Melissa; Emerson , Joanne; Enault , François; Fuhrman , Jed; Hingamp , Pascal; Hugen
Minimum Information about an Uncultivated Virus Genome (MIUViG)
published pages: , ISSN: 1087-0156, DOI: 10.3929/ethz-b-000315358 10 2019-08-05
2018 10. Krupovic M, Cvirkaite-Krupovic V, Iranzo J, Prangishvili D, Koonin E.
Viruses of archaea: Structural, functional, environmental and evolutionary genomics
published pages: , ISSN: 1872-7492, DOI:
Virus research 2019-08-05
2017 Clovis Galiez, Matthias Siebert, François Enault, Jonathan Vincent, Johannes Söding
WIsH: who is the host? Predicting prokaryotic hosts from metagenomic phage contigs
published pages: 3113-3114, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btx383
Bioinformatics 33/19 2019-08-05
2018 17. Sandaa, R.A, Bratbak, G.
Is a virus important? And some other questions
published pages: , ISSN: 1999-4915, DOI:
Viruses 2019-08-05
2018 Yuchen Wang, Beibei Chen, Mengzhuo Cao, Linshan Sima, David Prangishvili, Xiangdong Chen, Mart Krupovic
Rolling-circle replication initiation protein of haloarchaeal sphaerolipovirus SNJ1 is homologous to bacterial transposases of the IS91 family insertion sequences
published pages: 416-421, ISSN: 0022-1317, DOI: 10.1099/jgv.0.001009
Journal of General Virology 99/3 2019-08-05
2017 Denis Ptchelkine, Ashley Gillum, Tomohiro Mochizuki, Soizick Lucas-Staat, Ying Liu, Mart Krupovic, Simon E. V. Phillips, David Prangishvili, Juha T. Huiskonen
Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01668-0
Nature Communications 8/1 2019-08-05
2019 Magdalena Plotka, Enea Sancho-Vaello, Sebastian Dorawa, Anna-Karina Kaczorowska, Lukasz P. Kozlowski, Tadeusz Kaczorowski, Kornelius Zeth
Structure and function of the Ts2631 endolysin of Thermus scotoductus phage vB_Tsc2631 with unique N-terminal extension used for peptidoglycan binding
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37417-6
Scientific Reports 9/1 2019-06-06
2018 Mirdita, M., Steinegger, M., and Soeding, J
MMseqs2 desktop and local web server app for fast, interactive sequence searches.
published pages: 419895, ISSN: , DOI: 10.1101/419895
bioRxiv 2019-05-09
2017 Martin Steinegger, Johannes Söding
MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets
published pages: 1026–1028, ISSN: 1087-0156, DOI: 10.1038/nbt.3988
Nature Biotechnology 35 2019-06-18
2018 Martin Steinegger and Johannes Soeding
Clustering huge protein sequence sets in linear time.
published pages: 2542, ISSN: , DOI: 10.1101/104034
Nature Communications 9(1) 2019-06-18
2018 Steinegger, M., Mirdita, M., and S ̈oding, J.
Protein-level assembly increases protein sequence recovery from metagenomic samples manyfold.
published pages: 386110, ISSN: , DOI: 10.1101/386110
bioRxiv 2019-06-18
2017 Milot Mirdita, Lars von den Driesch, Clovis Galiez, Maria J. Martin, Johannes Söding, Martin Steinegger
Uniclust databases of clustered and deeply annotated protein sequences and alignments
published pages: D170-D176, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1081
Nucleic Acids Research 45/D1 2019-06-18

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