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MMXVI

Minimal Model for Pox-Virus Infection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MMXVI project word cloud

Explore the words cloud of the MMXVI project. It provides you a very rough idea of what is the project "MMXVI" about.

first virus averaging em membrane highest tens capacity insights lifecycle burdens socio affords resolutions super particles hundreds outlined resolution prototypic molecule until initial blebs ing investigation unprecedented relationships vectors contact poxvirus diseases climate infectious broadly specificity structure limited techniques microscopy architecture infection trade nanoscale structures biophysical complexity events biological srm function economic viral world dynamic nano therapeutic precise structural travel single applicable combining deadly visualization analytical molecular minimal protein shifting viruses vaccinia nanometers models stages diagnostic thereby model initially inevitable emergence architectural tools virion host imaging capture cell generation looks biology amenable dynamics global create

Project "MMXVI" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.ucl.ac.uk/lmcb/users/david-albrecht-0
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

Viral diseases represent one of the world’s highest socio-economic burdens. Increased global trade and travel, climate change resulting in shifting viral vectors, and the emergence of new and often deadly viruses is inevitable. Therefore, detailed understanding of the complexity of virus particles and the development of new model systems to study them, will be essential to develop new research, diagnostic, and therapeutic tools. The structural changes that occur during the initial contact between a virus and its host remains one of the major challenges in infection biology. Until recently, the investigation of viral nano-architecture and dynamic changes that occur in virus particles during the infectious lifecycle was limited to methods, such as EM, with no capacity to capture dynamic events or define molecular specificity. The goal of the proposed project is to create a new minimal model of virus infection based on cell-derived membrane blebs. The model will be amenable to novel super-resolution microscopy (SRM) methods that allow the visualization of viral structures at resolutions of tens of nanometers. Recently developed analytical tools like single-virion averaging allows the generation of precise models from hundreds of events. This affords unprecedented insights into the biological and biophysical requirements of virus infection. Furthermore, we aim to investigate the dynamics of virus architectural changes during the first stages of infection, particularly at the membrane level, by combining single-molecule techniques with our new model-system. While initially aimed at investigating protein structure-function relationships within the prototypic poxvirus, vaccinia, the model system and imaging developments outlined will be broadly applicable to a wide range of biological systems including other viruses. Thereby, this proposal looks to advance the field of infection biology into the nanoscale.

Publications

List of publications.
year	authors and title	journal	last update
2019	Alexander Balinovic, David Albrecht, Ulrike Endesfelder Spectrally red-shifted fluorescent fiducial markers for optimal drift correction in localization microscopy published pages: 204002, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0862	Journal of Physics D: Applied Physics 52/20	2019-10-31
2019	Robert D. M. Gray, David Albrecht, Corina Beerli, Moona Huttunen, Gary H. Cohen, Ian J. White, Jemima J. Burden, Ricardo Henriques, Jason Mercer Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion published pages: N/A, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0488-4	Nature Microbiology N/A	2019-10-31
2018	SiÃ¢n Culley, David Albrecht, Caron Jacobs, Pedro Matos Pereira, Christophe Leterrier, Jason Mercer, Ricardo Henriques Quantitative mapping and minimization of super-resolution optical imaging artifacts published pages: 263-266, ISSN: 1548-7091, DOI: 10.1038/nmeth.4605	Nature Methods 15/4	2019-10-31
2019	Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin LindÃ¥s, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, SiÃ¢n Culley, Ricardo Henriques NanoJ: a high-performance open-source super-resolution microscopy toolbox published pages: 163001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0261	Journal of Physics D: Applied Physics 52/16	2019-10-31
2019	Pedro M. Pereira, David Albrecht, SiÃ¢n Culley, Caron Jacobs, Mark Marsh, Jason Mercer, Ricardo Henriques Fix Your Membrane Receptor Imaging: Actin Cytoskeleton and CD4 Membrane Organization Disruption by Chemical Fixation published pages: 675, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00675	Frontiers in Immunology 10	2019-10-31

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