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MMXVI

Minimal Model for Pox-Virus Infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MMXVI project word cloud

Explore the words cloud of the MMXVI project. It provides you a very rough idea of what is the project "MMXVI" about.

therapeutic    deadly    resolution    host    structures    imaging    nano    structure    em    global    biological    specificity    emergence    viruses    until    molecular    techniques    biophysical    architecture    lifecycle    infection    prototypic    nanoscale    vectors    amenable    function    climate    unprecedented    generation    capacity    model    limited    stages    burdens    initial    cell    insights    relationships    microscopy    virus    trade    membrane    hundreds    investigation    shifting    tools    outlined    combining    diagnostic    looks    nanometers    poxvirus    infectious    single    structural    resolutions    world    contact    travel    socio    first    molecule    dynamics    models    ing    tens    averaging    virion    economic    inevitable    protein    dynamic    capture    initially    affords    complexity    minimal    highest    events    biology    blebs    visualization    super    particles    broadly    thereby    diseases    analytical    create    precise    architectural    viral    applicable    vaccinia    srm   

Project "MMXVI" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ucl.ac.uk/lmcb/users/david-albrecht-0
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Viral diseases represent one of the world’s highest socio-economic burdens. Increased global trade and travel, climate change resulting in shifting viral vectors, and the emergence of new and often deadly viruses is inevitable. Therefore, detailed understanding of the complexity of virus particles and the development of new model systems to study them, will be essential to develop new research, diagnostic, and therapeutic tools. The structural changes that occur during the initial contact between a virus and its host remains one of the major challenges in infection biology. Until recently, the investigation of viral nano-architecture and dynamic changes that occur in virus particles during the infectious lifecycle was limited to methods, such as EM, with no capacity to capture dynamic events or define molecular specificity. The goal of the proposed project is to create a new minimal model of virus infection based on cell-derived membrane blebs. The model will be amenable to novel super-resolution microscopy (SRM) methods that allow the visualization of viral structures at resolutions of tens of nanometers. Recently developed analytical tools like single-virion averaging allows the generation of precise models from hundreds of events. This affords unprecedented insights into the biological and biophysical requirements of virus infection. Furthermore, we aim to investigate the dynamics of virus architectural changes during the first stages of infection, particularly at the membrane level, by combining single-molecule techniques with our new model-system. While initially aimed at investigating protein structure-function relationships within the prototypic poxvirus, vaccinia, the model system and imaging developments outlined will be broadly applicable to a wide range of biological systems including other viruses. Thereby, this proposal looks to advance the field of infection biology into the nanoscale.

 Publications

year authors and title journal last update
List of publications.
2019 Alexander Balinovic, David Albrecht, Ulrike Endesfelder
Spectrally red-shifted fluorescent fiducial markers for optimal drift correction in localization microscopy
published pages: 204002, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0862
Journal of Physics D: Applied Physics 52/20 2019-10-31
2019 Robert D. M. Gray, David Albrecht, Corina Beerli, Moona Huttunen, Gary H. Cohen, Ian J. White, Jemima J. Burden, Ricardo Henriques, Jason Mercer
Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion
published pages: N/A, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0488-4
Nature Microbiology N/A 2019-10-31
2018 Siân Culley, David Albrecht, Caron Jacobs, Pedro Matos Pereira, Christophe Leterrier, Jason Mercer, Ricardo Henriques
Quantitative mapping and minimization of super-resolution optical imaging artifacts
published pages: 263-266, ISSN: 1548-7091, DOI: 10.1038/nmeth.4605
Nature Methods 15/4 2019-10-31
2019 Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin Lindås, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, Siân Culley, Ricardo Henriques
NanoJ: a high-performance open-source super-resolution microscopy toolbox
published pages: 163001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0261
Journal of Physics D: Applied Physics 52/16 2019-10-31
2019 Pedro M. Pereira, David Albrecht, Siân Culley, Caron Jacobs, Mark Marsh, Jason Mercer, Ricardo Henriques
Fix Your Membrane Receptor Imaging: Actin Cytoskeleton and CD4 Membrane Organization Disruption by Chemical Fixation
published pages: 675, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00675
Frontiers in Immunology 10 2019-10-31

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