Explore the words cloud of the MMXVI project. It provides you a very rough idea of what is the project "MMXVI" about.
The following table provides information about the project.
UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-06-01 to 2019-05-31|
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|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||183˙454.00|
Viral diseases represent one of the world’s highest socio-economic burdens. Increased global trade and travel, climate change resulting in shifting viral vectors, and the emergence of new and often deadly viruses is inevitable. Therefore, detailed understanding of the complexity of virus particles and the development of new model systems to study them, will be essential to develop new research, diagnostic, and therapeutic tools. The structural changes that occur during the initial contact between a virus and its host remains one of the major challenges in infection biology. Until recently, the investigation of viral nano-architecture and dynamic changes that occur in virus particles during the infectious lifecycle was limited to methods, such as EM, with no capacity to capture dynamic events or define molecular specificity. The goal of the proposed project is to create a new minimal model of virus infection based on cell-derived membrane blebs. The model will be amenable to novel super-resolution microscopy (SRM) methods that allow the visualization of viral structures at resolutions of tens of nanometers. Recently developed analytical tools like single-virion averaging allows the generation of precise models from hundreds of events. This affords unprecedented insights into the biological and biophysical requirements of virus infection. Furthermore, we aim to investigate the dynamics of virus architectural changes during the first stages of infection, particularly at the membrane level, by combining single-molecule techniques with our new model-system. While initially aimed at investigating protein structure-function relationships within the prototypic poxvirus, vaccinia, the model system and imaging developments outlined will be broadly applicable to a wide range of biological systems including other viruses. Thereby, this proposal looks to advance the field of infection biology into the nanoscale.
|year||authors and title||journal||last update|
Alexander Balinovic, David Albrecht, Ulrike Endesfelder
Spectrally red-shifted fluorescent fiducial markers for optimal drift correction in localization microscopy
published pages: 204002, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0862
|Journal of Physics D: Applied Physics 52/20||2019-10-31|
Robert D. M. Gray, David Albrecht, Corina Beerli, Moona Huttunen, Gary H. Cohen, Ian J. White, Jemima J. Burden, Ricardo Henriques, Jason Mercer
Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion
published pages: N/A, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0488-4
|Nature Microbiology N/A||2019-10-31|
SiÃ¢n Culley, David Albrecht, Caron Jacobs, Pedro Matos Pereira, Christophe Leterrier, Jason Mercer, Ricardo Henriques
Quantitative mapping and minimization of super-resolution optical imaging artifacts
published pages: 263-266, ISSN: 1548-7091, DOI: 10.1038/nmeth.4605
|Nature Methods 15/4||2019-10-31|
Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin LindÃ¥s, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, SiÃ¢n Culley, Ricardo Henriques
NanoJ: a high-performance open-source super-resolution microscopy toolbox
published pages: 163001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0261
|Journal of Physics D: Applied Physics 52/16||2019-10-31|
Pedro M. Pereira, David Albrecht, SiÃ¢n Culley, Caron Jacobs, Mark Marsh, Jason Mercer, Ricardo Henriques
Fix Your Membrane Receptor Imaging: Actin Cytoskeleton and CD4 Membrane Organization Disruption by Chemical Fixation
published pages: 675, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00675
|Frontiers in Immunology 10||2019-10-31|
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