Opendata, web and dolomites

MMXVI

Minimal Model for Pox-Virus Infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MMXVI project word cloud

Explore the words cloud of the MMXVI project. It provides you a very rough idea of what is the project "MMXVI" about.

em    combining    looks    vectors    structures    molecular    single    until    visualization    poxvirus    resolution    viral    viruses    thereby    cell    molecule    resolutions    architectural    srm    tools    shifting    create    global    tens    particles    complexity    techniques    broadly    initially    investigation    architecture    virus    prototypic    dynamics    super    emergence    relationships    models    nanoscale    analytical    protein    biology    events    limited    minimal    amenable    specificity    nanometers    inevitable    affords    economic    highest    therapeutic    unprecedented    stages    burdens    world    initial    hundreds    function    infectious    lifecycle    infection    capture    generation    diseases    biophysical    outlined    first    averaging    membrane    dynamic    climate    socio    applicable    diagnostic    insights    ing    virion    deadly    microscopy    capacity    model    structural    vaccinia    structure    nano    trade    precise    blebs    contact    travel    host    biological    imaging   

Project "MMXVI" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ucl.ac.uk/lmcb/users/david-albrecht-0
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Viral diseases represent one of the world’s highest socio-economic burdens. Increased global trade and travel, climate change resulting in shifting viral vectors, and the emergence of new and often deadly viruses is inevitable. Therefore, detailed understanding of the complexity of virus particles and the development of new model systems to study them, will be essential to develop new research, diagnostic, and therapeutic tools. The structural changes that occur during the initial contact between a virus and its host remains one of the major challenges in infection biology. Until recently, the investigation of viral nano-architecture and dynamic changes that occur in virus particles during the infectious lifecycle was limited to methods, such as EM, with no capacity to capture dynamic events or define molecular specificity. The goal of the proposed project is to create a new minimal model of virus infection based on cell-derived membrane blebs. The model will be amenable to novel super-resolution microscopy (SRM) methods that allow the visualization of viral structures at resolutions of tens of nanometers. Recently developed analytical tools like single-virion averaging allows the generation of precise models from hundreds of events. This affords unprecedented insights into the biological and biophysical requirements of virus infection. Furthermore, we aim to investigate the dynamics of virus architectural changes during the first stages of infection, particularly at the membrane level, by combining single-molecule techniques with our new model-system. While initially aimed at investigating protein structure-function relationships within the prototypic poxvirus, vaccinia, the model system and imaging developments outlined will be broadly applicable to a wide range of biological systems including other viruses. Thereby, this proposal looks to advance the field of infection biology into the nanoscale.

 Publications

year authors and title journal last update
List of publications.
2019 Alexander Balinovic, David Albrecht, Ulrike Endesfelder
Spectrally red-shifted fluorescent fiducial markers for optimal drift correction in localization microscopy
published pages: 204002, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0862
Journal of Physics D: Applied Physics 52/20 2019-10-31
2019 Robert D. M. Gray, David Albrecht, Corina Beerli, Moona Huttunen, Gary H. Cohen, Ian J. White, Jemima J. Burden, Ricardo Henriques, Jason Mercer
Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion
published pages: N/A, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0488-4
Nature Microbiology N/A 2019-10-31
2018 Siân Culley, David Albrecht, Caron Jacobs, Pedro Matos Pereira, Christophe Leterrier, Jason Mercer, Ricardo Henriques
Quantitative mapping and minimization of super-resolution optical imaging artifacts
published pages: 263-266, ISSN: 1548-7091, DOI: 10.1038/nmeth.4605
Nature Methods 15/4 2019-10-31
2019 Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert D M Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin Lindås, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, Siân Culley, Ricardo Henriques
NanoJ: a high-performance open-source super-resolution microscopy toolbox
published pages: 163001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/ab0261
Journal of Physics D: Applied Physics 52/16 2019-10-31
2019 Pedro M. Pereira, David Albrecht, Siân Culley, Caron Jacobs, Mark Marsh, Jason Mercer, Ricardo Henriques
Fix Your Membrane Receptor Imaging: Actin Cytoskeleton and CD4 Membrane Organization Disruption by Chemical Fixation
published pages: 675, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00675
Frontiers in Immunology 10 2019-10-31

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MMXVI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MMXVI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

GW (2019)

Analysing the heavy element factories of the Universe : photometric and spectroscopic sample study of kilonovae

Read More