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SmartNanoTox SIGNED

Smart Tools for Gauging Nano Hazards

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SmartNanoTox" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://www.smartnanotox.eu
 Total cost 8˙147˙304 €
 EC max contribution 7˙996˙124 € (98%)
 Programme 1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
 Code Call H2020-NMP-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 1˙695˙517.00
2    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 1˙058˙870.00
3    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 857˙548.00
4    INSTITUT JOZEF STEFAN SI (LJUBLJANA) participant 825˙250.00
5    DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DK (KOBENHAVN) participant 799˙820.00
6    INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE POUR LA PREVENTION DES ACCIDENTS DU TRAVAIL ET DES MALADIES PROFESSIONNELLES ASSOCIATION FR (PARIS) participant 799˙327.00
7    UNIVERSITE DE LORRAINE FR (NANCY CEDEX) participant 710˙793.00
8    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 666˙625.00
9    VITROCELL SYSTEMS GMBH DE (WALDKIRCH) participant 320˙348.00
10    TYOTERVEYSLAITOS FI (HELSINKI) participant 203˙273.00
11    DASSAULT SYSTEMES BIOVIA LIMITED UK (CAMBRIDGE) participant 58˙750.00
12    STATENS ARBEIDSMILJOINSTITUTT NO (OSLO) participant 0.00

Map

 Project objective

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

 Deliverables

List of deliverables.
Position paper on predictive in vitro models Documents, reports 2020-02-25 11:41:07
Establishment of a stakeholder advisory board Websites, patent fillings, videos etc. 2020-02-25 11:41:06
List of NMs Documents, reports 2020-02-25 11:41:06
Research data management plan Open Research Data Pilot 2020-02-25 11:41:07
Labelled NPs for tracking within cells and tissues Documents, reports 2020-02-25 11:41:06
List of nanomaterials and respective doses to be tested as TP benchmark Documents, reports 2020-02-25 11:41:06
Development of the data portal Websites, patent fillings, videos etc. 2020-02-25 11:41:06
PMFs and binding free energies for interaction of NM with building blocks of biomolecules Documents, reports 2020-02-25 11:41:06
Isolation and archiving of biological samples for subsequent analysis Documents, reports 2020-02-25 11:41:06
In vivo samples for transcriptomics studies (instillation) Documents, reports 2020-02-25 11:41:06
Identify and score the pathological outcome of the in vivo exposures Documents, reports 2020-02-25 11:41:06
Report of end-localization of NPs within relevant cells Documents, reports 2020-02-25 11:41:06

Take a look to the deliverables list in detail:  detailed list of SmartNanoTox deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Hana Majaron, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Manel Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Izto
From the roundabout of molecular events to nanomaterial-induced chronic inflammation prediction
published pages: , ISSN: 1943-0264, DOI: 10.1101/2020.02.27.966036
BioRxiv 2020-04-24
2020 Martin Thomas Horsch, Christoph Niethammer, Gianluca Boccardo, Paola Carbone, Silvia Chiacchiera, Mara Chiricotto, Joshua D. Elliott, Vladimir Lobaskin, Philipp Neumann, Peter Schiffels, Michael A. Seaton, Ilian T. Todorov, Jadran Vrabec, Welchy Leite Cavalcanti
Semantic Interoperability and Characterization of Data Provenance in Computational Molecular Engineering
published pages: 1313-1329, ISSN: 0021-9568, DOI: 10.1021/acs.jced.9b00739
Journal of Chemical & Engineering Data 65/3 2020-04-24
2020 Niels Hadrup, Vadim Zhernovkov, Nicklas Raun Jacobsen, Carola Voss, Maximilian Strunz, Meshal Ansari, Herbert B. Schiller, Sabina Halappanavar, Sarah S. Poulsen, Boris Kholodenko, Tobias Stoeger, Anne Thoustrup Saber, Ulla Vogel
Acute Phase Response as a Biological Mechanism-of-Action of (Nano)particle-Induced Cardiovascular Disease
published pages: 1907476, ISSN: 1613-6810, DOI: 10.1002/smll.201907476
Small 2020-04-24
2020 Fernando Luís Barroso da Silva, Paolo Carloni, David Cheung, Grazia Cottone, Serena Donnini, E. Allen Foegeding, Muhammad Gulzar, Jean Christophe Jacquier, Vladimir Lobaskin, Donal MacKernan, Zeynab Mohammad Hosseini Naveh, Ravi Radhakrishnan, Erik E. Santiso
Understanding and Controlling Food Protein Structure and Function in Foods: Perspectives from Experiments and Computer Simulations
published pages: 365-387, ISSN: 1941-1413, DOI: 10.1146/annurev-food-032519-051640
Annual Review of Food Science and Technology 11/1 2020-04-24
2019 Doumandji Zahra, Safar Ramia, Lovera-Leroux Mélanie, Nahle Sara, Cassidy Hilary, Matallanas David, Rihn Bertrand, Ferrari Luc, Joubert Olivier
Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles
published pages: , ISSN: 0742-2091, DOI: 10.1007/s10565-019-09484-6
Cell Biology and Toxicology 2020-02-25
2019 Pernille Høgh Danielsen, Kristina Bram Knudsen, Janez Štrancar, Polona Umek, Tilen Koklič, Maja Garvas, Esa Vanhala, Sauli Savukoski, Yaobo Ding, Anne Mette Madsen, Nicklas Raun Jacobsen, Ingrid Konow Weydahl, Trine Berthing, Sarah Søs Poulsen, Otmar Schmid, Henrik Wolff, Ulla Vogel
Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice
published pages: 114830, ISSN: 0041-008X, DOI: 10.1016/j.taap.2019.114830
Toxicology and Applied Pharmacology 2020-02-25
2019 M. Schneemilch, N. Quirke
Free energy of adhesion of lipid bilayers on titania surfaces
published pages: 134707, ISSN: 0021-9606, DOI: 10.1063/1.5120810
The Journal of Chemical Physics 151/13 2020-02-25
2019 David Power, Ian Rouse, Stefano Poggio, Erik Brandt, Hender Lopez, Alexander Lyubartsev, Vladimir Lobaskin
A multiscale model of protein adsorption on a nanoparticle surface
published pages: 84003, ISSN: 0965-0393, DOI: 10.1088/1361-651x/ab3b6e
Modelling and Simulation in Materials Science and Engineering 27/8 2020-02-25
2019 Vadim Zhernovkov, Tapesh Santra, Hilary Cassidy, Oleksii Rukhlenko, David Matallanas, Aleksandar Krstic, Walter Kolch, Vladimir Lobaskin, Boris N Kholodenko
An integrative computational approach for a prioritization of key transcription regulators associated with nanomaterial-induced toxicity
published pages: , ISSN: 1096-6080, DOI: 10.1093/toxsci/kfz151
Toxicological Sciences 2020-02-25
2019 M. Schneemilch, N. Quirke
Erratum: “Free energy of adhesion of lipid bilayers on silica surfaces” [J. Chem. Phys. 148, 194704 (2018)]
published pages: 229901, ISSN: 0021-9606, DOI: 10.1063/1.5111197
The Journal of Chemical Physics 150/22 2020-02-25
2019 Laurent Gaté, Kristina Bram Knudsen, Carole Seidel, Trine Berthing, Laëtitia Chézeau, Nicklas Raun Jacobsen, Sarah Valentino, Håkan Wallin, Sébastien Bau, Henrik Wolff, Sylvie Sébillaud, Mylène Lorcin, Stéphane Grossmann, Stéphane Viton, Hervé Nunge, Christian Darne, Ulla Vogel, Frédéric Cosnier
Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure
published pages: 17-31, ISSN: 0041-008X, DOI: 10.1016/j.taap.2019.05.001
Toxicology and Applied Pharmacology 375 2020-02-25

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