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PATROLS SIGNED

Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
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PATROLS project word cloud

Explore the words cloud of the PATROLS project. It provides you a very rough idea of what is the project "PATROLS" about.

mechanism vitro hazard predictive environmental innovative adverse physiologically human nanosafety models prediction tools patrols enm silico safety exposure

Project "PATROLS" data sheet

The following table provides information about the project.

Coordinator	SWANSEA UNIVERSITY Organization address address: SINGLETON PARK city: SWANSEA postcode: SA2 8PP website: www.swan.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	13˙108˙347 €
EC max contribution	12˙714˙180 € (97%)
Programme	1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
Code Call	H2020-NMBP-2017-two-stage
Funding Scheme	/RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SWANSEA UNIVERSITY SWANSEA UNIVERSITY Organization address address: SINGLETON PARK city: SWANSEA postcode: SA2 8PP website: www.swan.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWANSEA)	coordinator	1˙436˙623.00
2	HERIOT-WATT UNIVERSITY HERIOT-WATT UNIVERSITY Organization address address: Riccarton city: EDINBURGH postcode: EH14 4AS website: www.hw.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	1˙166˙363.00
3	DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO Organization address address: LERSO PARKALLE 105 city: KOBENHAVN postcode: 2100 website: www.nrcwe.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	944˙616.00
4	RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA website: www.rivm.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	participant	931˙765.00
5	UNIVERSITE DE FRIBOURG UNIVERSITE DE FRIBOURG Organization address address: AVENUE DE L EUROPE 20 city: FRIBOURG postcode: 1700 website: www.unifr.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (FRIBOURG)	participant	863˙390.00
6	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	850˙467.00
7	BASF SE BASF SE Organization address address: CARL BOSCH STRASSE 38 city: LUDWIGSHAFEN AM RHEIN postcode: 67063 website: www.basf.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUDWIGSHAFEN AM RHEIN)	participant	759˙842.00
8	INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH Organization address address: AUF M HENNEKAMP 50 city: DUESSELDORF postcode: 40225 website: www.iuf.uni-duesseldorf.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUESSELDORF)	participant	597˙252.00
9	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: http://www.exeter.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	participant	590˙886.00
10	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	584˙987.00
11	UNIVERSITE DE NAMUR ASBL UNIVERSITE DE NAMUR ASBL Organization address address: RUE DE BRUXELLES 61 city: NAMUR postcode: 5000 website: www.unamur.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (NAMUR)	participant	538˙712.00
12	INSPHERO AG INSPHERO AG Organization address address: WAGISTRASSE 27 city: SCHLIEREN postcode: 8952 website: www.insphero.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (SCHLIEREN)	participant	481˙961.00
13	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 00185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	441˙845.00
14	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	428˙826.00
15	UNIVERSITA DI PISA UNIVERSITA DI PISA Organization address address: LUNGARNO PACINOTTI 43/44 city: PISA postcode: 56126 website: www.unipi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	participant	384˙930.00
16	INSTITUTE OF OCCUPATIONAL MEDICINE INSTITUTE OF OCCUPATIONAL MEDICINE Organization address address: Research Avenue North, Riccarton 45 city: EDINBURGH postcode: EH14 4AP website: www.iom-world.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	370˙816.00
17	QSAR LAB SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA QSAR LAB SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA Organization address address: UL TRZY LIPY 3 city: GDANSK postcode: 81 172 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (GDANSK)	participant	353˙193.00
18	MISVIK BIOLOGY OY MISVIK BIOLOGY OY Organization address address: KARJAKATU 35 B city: TURKU postcode: 20520 website: www.misvik.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TURKU)	participant	336˙325.00
19	EUROPEAN RESEARCH SERVICES GMBH EUROPEAN RESEARCH SERVICES GMBH Organization address address: ROENTGENSTRASSE 19 city: MUENSTER postcode: 48149 website: www.european-research-services.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	311˙250.00
20	NANOTECHNOLOGY INDUSTRIES ASSOCIATION NANOTECHNOLOGY INDUSTRIES ASSOCIATION Organization address address: AVENUE DE TERVUEREN 143 city: BRUXELLES postcode: 1150 website: www.nanotechia.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	251˙468.00
21	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	88˙656.00
22	HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. Organization address address: OFFICE OF THE GENERAL COUNSEL, HOLYOKE CENTER, SUITE 980, MASSACHUSETTS AVENUE 1350 city: CAMBRIDGE postcode: 02138 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CAMBRIDGE)	participant	0.00
23	KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE Organization address address: GAJEONG-RO YUSEONG-GU 267 city: DAEJEON postcode: 305-340 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	KR (DAEJEON)	participant	0.00
24	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	0.00
25	UNIVERSITY OF SOUTH CAROLINA UNIVERSITY OF SOUTH CAROLINA Organization address address: HAMPTON STREET 1600 ANNEX 208 city: COLUMBIA postcode: SC29208 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (COLUMBIA)	participant	0.00

Mappa

Project objective

Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.

Work performed, outcomes and results: advancements report(s)

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