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PATROLS SIGNED

Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Total Cost €

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EC-Contrib. €

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Partnership

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 PATROLS project word cloud

Explore the words cloud of the PATROLS project. It provides you a very rough idea of what is the project "PATROLS" about.

governmental    threatened    integral    academic    species    scientific    life    drive    strategy    bioassays    safety    accurately    network    environment    endpoints    limitations    biological    commercialization    tract    health    organisms    promises    strategies    lung    agency    regulatory    toxicology    gastrointestinal    linked    establishing    eco    hazard    smart    vitro    reducing    characterization    prediction    vivo    patrols    nanotechnology    physiologically    economic    tools    biology    balance    chronic    extrapolation    environmental    acute    power    frameworks    engineered    nanosafety    societal    exposures    events    shift    unrealistic    liver    world    interspecies    representative    outcome    ngo    industrial    exposure    sme    integrating    caused    risk    food    generation    enm    standardizing    benefits    policy    models    reflect    human    cross    speed    complexity    realistic    detection    paradigm    doses    dosimetry    chain    cellular    3d    predictive    nanomaterials    international    toxicity    adverse    silico    mechanism    informing    ecotoxicity    innovative    experimental   

Project "PATROLS" data sheet

The following table provides information about the project.

Coordinator
SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.patrols-h2020.eu
 Total cost 13˙108˙347 €
 EC max contribution 12˙714˙180 € (97%)
 Programme 1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 1˙436˙623.00
2    HERIOT-WATT UNIVERSITY UK (EDINBURGH) participant 1˙166˙363.00
3    DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DK (KOBENHAVN) participant 944˙616.00
4    RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU NL (BILTHOVEN) participant 931˙765.00
5    UNIVERSITE DE FRIBOURG CH (FRIBOURG) participant 863˙390.00
6    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 850˙467.00
7    BASF SE DE (LUDWIGSHAFEN AM RHEIN) participant 759˙842.00
8    INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH DE (DUESSELDORF) participant 597˙252.00
9    THE UNIVERSITY OF EXETER UK (EXETER) participant 590˙886.00
10    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 584˙987.00
11    UNIVERSITE DE NAMUR ASBL BE (NAMUR) participant 538˙712.00
12    INSPHERO AG CH (SCHLIEREN) participant 481˙961.00
13    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 441˙845.00
14    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 428˙826.00
15    UNIVERSITA DI PISA IT (PISA) participant 384˙930.00
16    INSTITUTE OF OCCUPATIONAL MEDICINE UK (EDINBURGH) participant 370˙816.00
17    QSAR LAB SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA PL (GDANSK) participant 353˙193.00
18    MISVIK BIOLOGY OY FI (TURKU) participant 336˙325.00
19    EUROPEAN RESEARCH SERVICES GMBH DE (MUENSTER) participant 311˙250.00
20    NANOTECHNOLOGY INDUSTRIES ASSOCIATION BE (BRUXELLES) participant 251˙468.00
21    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) participant 88˙656.00
22    HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. US (CAMBRIDGE) participant 0.00
23    KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE KR (DAEJEON) participant 0.00
24    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00
25    UNIVERSITY OF SOUTH CAROLINA US (COLUMBIA) participant 0.00

Map

 Project objective

Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.

 Deliverables

List of deliverables.
Six-monthly E-newsletters documenting updates Websites, patent fillings, videos etc. 2020-04-11 06:50:06
Materials acquisition, physicochemical intrinsic properties and endotoxin evaluation on Tier 1 and 2 ENM Documents, reports 2020-04-11 06:50:06
Critical toxicity data for IVIVE based on existing in vivo sub-acute and (sub)chronic oral and inhalation studies Documents, reports 2020-04-11 06:50:06
Management framework & shared server for information management established Documents, reports 2020-04-11 06:50:06
PATROLS MODA Documents, reports 2020-04-11 06:50:06

Take a look to the deliverables list in detail:  detailed list of PATROLS deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 L. Cacopardo, J. Costa, S. Giusti, L. Buoncompagni, S. Meucci, A. Corti, G. Mattei, A. Ahluwalia
Real-time cellular impedance monitoring and imaging of biological barriers in a dual-flow membrane bioreactor
published pages: 111340, ISSN: 0956-5663, DOI: 10.1016/j.bios.2019.111340
Biosensors and Bioelectronics 140 2020-04-11
2019 Ali Kermanizadeh, David M. Brown, Wolfgang Moritz, Vicki Stone
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43870-8
Scientific Reports 9/1 2020-04-11
2019 Chiara Magliaro, Andrea Rinaldo, Arti Ahluwalia
Allometric Scaling of physiologically-relevant organoids
published pages: , ISSN: 1476-4687, DOI: 10.1101/559682
BioRxiv Regular online 2020-04-11
2018 Fazel Abdolahpur Monikh, Latifeh Chupani, Eliska Zusková, Ruud Peters, Marie Vancová, Martina G. Vijver, Petr Porcal, Willie J.G.M. Peijnenburg
Method for Extraction and Quantification of Metal-Based Nanoparticles in Biological Media: Number-Based Biodistribution and Bioconcentration
published pages: 946-953, ISSN: 0013-936X, DOI: 10.1021/acs.est.8b03715
Environmental Science & Technology 53/2 2020-04-11
2019 Victor C. Ude, David M. Brown, Vicki Stone, Helinor J. Johnston
Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials
published pages: , ISSN: 1477-3155, DOI: 10.1186/s12951-019-0503-1
Journal of Nanobiotechnology 17/1 2020-04-11

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The information about "PATROLS" are provided by the European Opendata Portal: CORDIS opendata.

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