PATROLS SIGNED
Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment
Total Cost €
0EC-Contrib. €
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0PATROLS project word cloud
Explore the words cloud of the PATROLS project. It provides you a very rough idea of what is the project "PATROLS" about.
Project "PATROLS" data sheet
The following table provides information about the project.
| Coordinator |
SWANSEA UNIVERSITY
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://www.patrols-h2020.eu |
| Total cost | 13˙108˙347 € |
| EC max contribution | 12˙714˙180 € (97%) |
| Programme |
1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies) |
| Code Call | H2020-NMBP-2017-two-stage |
| Funding Scheme | RIA |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
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Project objective
Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.
Deliverables
| Six-monthly E-newsletters documenting updates | Websites, patent fillings, videos etc. | 2020-04-11 06:50:06 |
| Materials acquisition, physicochemical intrinsic properties and endotoxin evaluation on Tier 1 and 2 ENM | Documents, reports | 2020-04-11 06:50:06 |
| Critical toxicity data for IVIVE based on existing in vivo sub-acute and (sub)chronic oral and inhalation studies | Documents, reports | 2020-04-11 06:50:06 |
| Management framework & shared server for information management established | Documents, reports | 2020-04-11 06:50:06 |
| PATROLS MODA | Documents, reports | 2020-04-11 06:50:06 |
Take a look to the deliverables list in detail: detailed list of PATROLS deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
L. Cacopardo, J. Costa, S. Giusti, L. Buoncompagni, S. Meucci, A. Corti, G. Mattei, A. Ahluwalia Real-time cellular impedance monitoring and imaging of biological barriers in a dual-flow membrane bioreactor published pages: 111340, ISSN: 0956-5663, DOI: 10.1016/j.bios.2019.111340 |
Biosensors and Bioelectronics 140 | 2020-04-11 |
| 2019 |
Ali Kermanizadeh, David M. Brown, Wolfgang Moritz, Vicki Stone The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43870-8 |
Scientific Reports 9/1 | 2020-04-11 |
| 2019 |
Chiara Magliaro, Andrea Rinaldo, Arti Ahluwalia Allometric Scaling of physiologically-relevant organoids published pages: , ISSN: 1476-4687, DOI: 10.1101/559682 |
BioRxiv Regular online | 2020-04-11 |
| 2018 |
Fazel Abdolahpur Monikh, Latifeh Chupani, Eliska Zusková, Ruud Peters, Marie Vancová, Martina G. Vijver, Petr Porcal, Willie J.G.M. Peijnenburg Method for Extraction and Quantification of Metal-Based Nanoparticles in Biological Media: Number-Based Biodistribution and Bioconcentration published pages: 946-953, ISSN: 0013-936X, DOI: 10.1021/acs.est.8b03715 |
Environmental Science & Technology 53/2 | 2020-04-11 |
| 2019 |
Victor C. Ude, David M. Brown, Vicki Stone, Helinor J. Johnston Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials published pages: , ISSN: 1477-3155, DOI: 10.1186/s12951-019-0503-1 |
Journal of Nanobiotechnology 17/1 | 2020-04-11 |
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