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GRACIOUS SIGNED

GRACIOUS: Grouping, Read-Across, CharacterIsation and classificatiOn framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GRACIOUS project word cloud

Explore the words cloud of the GRACIOUS project. It provides you a very rough idea of what is the project "GRACIOUS" about.

array impossible makers difficult gracious toxicological read stakeholders missing obtain exposure nm surface benefits extensive data engaged systematically curating safe start manufacturing ing nanoscale fit extrinsic assimilating considerations stages decision practical exist policy industrial risks conceptual delivered grouping safety intrinsic purpose adverse leads efficient accepted health environmental sufficient framework innovation tool ways physicochemical materials nms urgent toxicokinetic risk curation regulators actual apart morphology functionalising fate lacks virtually relation regulatory release size nanomaterials collating distinctive varying

Project "GRACIOUS" data sheet

The following table provides information about the project.

Coordinator	HERIOT-WATT UNIVERSITY Organization address address: Riccarton city: EDINBURGH postcode: EH14 4AS website: www.hw.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.h2020gracious.eu/
Total cost	7˙180˙118 €
EC max contribution	6˙999˙368 € (97%)
Programme	1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
Code Call	H2020-NMBP-2017-two-stage
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HERIOT-WATT UNIVERSITY HERIOT-WATT UNIVERSITY Organization address address: Riccarton city: EDINBURGH postcode: EH14 4AS website: www.hw.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	coordinator	787˙325.00
2	BASF SE BASF SE Organization address address: CARL BOSCH STRASSE 38 city: LUDWIGSHAFEN AM RHEIN postcode: 67063 website: www.basf.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUDWIGSHAFEN AM RHEIN)	participant	669˙618.00
3	RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA website: www.rivm.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	participant	522˙787.00
4	BUNDESINSTITUT FUER RISIKOBEWERTUNG BUNDESINSTITUT FUER RISIKOBEWERTUNG Organization address address: MAX DOHRN STRASSE 8-10 city: BERLIN postcode: 10589 website: www.bfr.bund.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	466˙955.00
5	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	449˙787.00
6	DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO Organization address address: LERSO PARKALLE 105 city: KOBENHAVN postcode: 2100 website: www.nrcwe.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	411˙162.00
7	ACONDICIONAMIENTO TARRASENSE ASSOCIACION ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TERRASSA)	participant	383˙287.00
8	GREENDECISION SRL GREENDECISION SRL Organization address address: VIA TORINO 155/A city: VENEZIA postcode: 30172 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VENEZIA)	participant	379˙375.00
9	INSTITUTE OF OCCUPATIONAL MEDICINE INSTITUTE OF OCCUPATIONAL MEDICINE Organization address address: Research Avenue North, Riccarton 45 city: EDINBURGH postcode: EH14 4AP website: www.iom-world.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	327˙475.00
10	JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Organization address address: Rue de la Loi 200 city: BRUSSELS postcode: 1049 website: http://www.jrc.ec.europa.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSELS)	participant	323˙947.00
11	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	309˙037.00
12	EUROPEAN RESEARCH SERVICES GMBH EUROPEAN RESEARCH SERVICES GMBH Organization address address: ROENTGENSTRASSE 19 city: MUENSTER postcode: 48149 website: www.european-research-services.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	301˙537.00
13	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	217˙588.00
14	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	217˙502.00
15	THINKWORKS BV THINKWORKS BV Organization address address: ROTTERDAMSEWEG 183 C city: DELFT postcode: 2629 HD website: www.thinkworks.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	210˙537.00
16	IDEACONSULT LIMITED LIABILITY COMPANY IDEACONSULT LIMITED LIABILITY COMPANY Organization address address: ANGEL KANCHEV 4 city: SOFIA postcode: 1000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BG (SOFIA)	participant	205˙912.00
17	EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT Organization address address: UEBERLANDSTRASSE 129 city: DUBENDORF postcode: 8600 website: www.empa.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (DUBENDORF)	participant	173˙787.00
18	UNILEVER U.K. CENTRAL RESOURCES LIMITED UNILEVER U.K. CENTRAL RESOURCES LIMITED Organization address address: UNILEVER HOUSE, VICTORIA EMBANKMENT 100 city: LONDON postcode: EC4Y 0DY website: www.unilever.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	168˙568.00
19	YORDAS GMBH YORDAS GMBH Organization address address: AUSSERE NURNBERGER STRASSE 62 city: FORCHHEIM postcode: 91301 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FORCHHEIM)	participant	132˙162.00
20	ATHINA-EREVNITIKO KENTRO KAINOTOMIAS STIS TECHNOLOGIES TIS PLIROFORIAS, TON EPIKOINONION KAI TIS GNOSIS ATHINA-EREVNITIKO KENTRO KAINOTOMIAS STIS TECHNOLOGIES TIS PLIROFORIAS, TON EPIKOINONION KAI TIS GNOSIS Organization address address: ARTEMIDOS 6 KAI EPIDAVROU city: MAROUSSI postcode: 151 25 website: www.athena-innovation.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (MAROUSSI)	participant	124˙037.00
21	YORDAS LIMITED YORDAS LIMITED Organization address address: 50-54 BERRY LANE city: LONGRIDGE PRESTON postcode: PR3 3JP website: www.thereachcentre.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONGRIDGE PRESTON)	participant	117˙000.00
22	Nouryon PULP AND PERFORMANCE CHEMICALS AB Nouryon PULP AND PERFORMANCE CHEMICALS AB Organization address address: . city: BOHUS postcode: 445 80 website: www.akzonobel.com/eka contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (BOHUS)	participant	99˙975.00
23	ARIZONA BOARD OF REGENTS ARIZONA BOARD OF REGENTS Organization address address: 660 S MILL AVENUE CENTERPOINT 312 city: TEMPE postcode: 85281 website: www.researchadmin.asu.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (TEMPE)	participant	0.00
24	DUKE UNIVERSITY DUKE UNIVERSITY Organization address address: ALLEN BUILDING 207 city: DURHAM NC postcode: 27708 website: www.duke.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (DURHAM NC)	participant	0.00
25	NATURAL ENVIRONMENT RESEARCH COUNCIL NATURAL ENVIRONMENT RESEARCH COUNCIL Organization address address: Polaris House, North Star Avenue city: SWINDON WILTSHIRE postcode: SN2 1EU website: http://www.nerc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON WILTSHIRE)	participant	0.00

Map

Project objective

Manufacturing and functionalising materials at the nanoscale leads to a whole array of nanomaterials (NMs) varying in e.g. size, morphology and surface characteristics. Apart from expected benefits, distinctive properties of NMs may also affect (environmental) health risks. Safety assessment requires sufficient information for each NM, but testing every unique NM for their potential adverse effects is virtually impossible. More efficient ways to obtain safety information are needed, which could be achieved by applying grouping and read-across approaches to NMs. On a conceptual level, regulatory accepted approaches for grouping and read-across for NMs already exist, but actual application remains difficult as the required knowledge is not systematically brought together, lacks data curation or is still missing. GRACIOUS will address this urgent need by developing a framework for grouping and read-across based on physicochemical, release, exposure, environmental fate, toxicokinetic and toxicological information. This framework will be delivered as a practical e-tool, fit-for-purpose for various key (regulatory and industrial) stakeholders, who will be engaged from the start of the project. To develop the framework, GRACIOUS will build upon currently available approaches by collating, curating and assimilating existing and new knowledge on intrinsic and extrinsic physicochemical properties in relation to their (environmental) health risk. The resulting framework will support safe innovation by enabling considerations of safety a.o. via grouping and read-across in industrial decision making at various stages of product development. For regulators and policy makers, GRACIOUS will facilitate actual application of grouping and read-across of NMs to enable risk analysis of NMs without extensive testing.

Publications

List of publications.
year	authors and title	journal	last update
2018	N. Abramenko, T. B. Demidova, Yu. A. Krutyakov, P. M. Zherebin, E. Y. Krysanov, L. M. Kustov, W. Peijnenburg The effect of capping agents on the toxicity of silver nanoparticles to Danio rerio embryos published pages: 1-13, ISSN: 1743-5390, DOI: 10.1080/17435390.2018.1498931	Nanotoxicology 13/1	2020-04-24
2019	G. Basei, D. Hristozov, L. Lamon, A. Zabeo, N. Jeliazkova, G. Tsiliki, A. Marcomini, A. Torsello Making use of available and emerging data to predict the hazards of engineered nanomaterials by means of in silico tools: A critical review published pages: 76-99, ISSN: 2452-0748, DOI: 10.1016/j.impact.2019.01.003	NanoImpact 13	2020-04-24

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GRACIOUS: Grouping, Read-Across, CharacterIsation and classificatiOn framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products